CLUSTAL W (1.83) multiple sequence alignment YakA_Ddis MGSTTQMSD---------YLVSTTTTSSASSMVTMTSQIENNS----------------- YAK1_Scer MNSSNNNDSSSSNSNMNNSLSPTLVTHSDASMGSGRASPDNSHMGRGIWNPSYVNQ--GS 22349_Tthe ------------------------------------------------------------ CC1G_14245_Ccin MQDSNESSFD----------LPRWQTHVEPA---AQATP-------YLYGPPPPSQHSMS YAK_b_Smoe ------------------------------------------------------------ YAK_a_Smoe IC---------------------------------------------------------- YAK_d_Smoe MY---------------------------------------------------------- YakA_Ddis ---------------------------------LNSNDNTNTTNNNNNNN---------- YAK1_Scer QRSP---QQQHQNHHQQQQQQQQQQQQNSQFCFVNPWNEEKVTNSQQNLVYPPQ------ 22349_Tthe ------------------------------------------------------------ CC1G_14245_Ccin GSSPQRIQPVHQSHTGSSTRQPRISQLLEQEHSLSPPSNQYTPSNQAPLSRSASLGGTSA YAK_b_Smoe ------------------------------------------------------------ YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis ---------------NNNNNNNNNNNN---------------------NNNNNNINNNNN YAK1_Scer -------YDDLNSNESLDAYRRRKSSLVVPPARAPAPNPFQYDSYPAYTSSNTSLAGN-S 22349_Tthe ------------------------------------------------------------ CC1G_14245_Ccin SNLASRLVRRHNQPDDLEAYNTDNQGLSGPRQQPQLSQNTFYNPSVGY--QSPSMTGNVS YAK_b_Smoe ------------------------------------------------------------ YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis NGGMVGVNHKTHKKTASIGGGKNRAILHDFTF-SYFIPNQNRSE---------------- YAK1_Scer SGQYPSGYQQQQQQVYQQG------AIHPSQFGSRFVPSLYDRQDFQRRQSLAATNYSSN 22349_Tthe ------------------------------------------------------------ CC1G_14245_Ccin SGTTAGSTSDSYSDLYYNG------SAS------------------QPPKRIQDPNRAAG YAK_b_Smoe ------------------------------------------------------------ YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis ---DN-------------------------------------------------SNENE- YAK1_Scer FSSLNSNTNQGTNSIPVMSPYR-RLSAYPPSTS-------PPLQPPFKQLRRD--EVQGQ 22349_Tthe ------------------------------------------------------------ CC1G_14245_Ccin RSP--HRAANPTNSTGLIDAYAQQQSQYSPTTATYSYGPGPPQSTGYQTHGRSNSQVKQ- YAK_b_Smoe ------------------------------------------------------------ YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis --------------------------LGLNNHNVQHQGPIIHLTKNLLHFYKKCNSNFNY YAK1_Scer KLSIPQMQLCNSKNDLQPVLNATPKF-RRASLNSKTISPLVSVTKSLITTYSLCSPEFTY 22349_Tthe --------------------------------------------------MKRCNQEFKF CC1G_14245_Ccin -------------------EQATPPIASPYAPQNQSHQPLRQLTTNIVETYRICNPSYRY YAK_b_Smoe -----------------------------------------RLTKFIVETYRSCNPSFTY YAK_a_Smoe ----------------------------------------VRLTKFIVETYRSCNPSFTY YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis ISSLNPRRVLTHPSEPLSNDGYDNVNSDYIVYVNDIITNNESGQ---------------- YAK1_Scer QTSKNPKRVLTKPSEGKCNNGFDNINSDYILYVNDVLGVEQ-NR---------------- 22349_Tthe DQSLIPRRFLTVPNEGVSNNNYDNEQSDYIMRVKDIIYNDQ-RKMFLIKEKFEIQKQQIK CC1G_14245_Ccin ESAHNPRRVLTKPSKPVHNEGYDNEDYDYILYVNDWLGTEE-GH---------------- YAK_b_Smoe SDTFNPKRYLTNPSAGVSNNGLDNKNSDLILAVNGIIYNP--KH---------------- YAK_a_Smoe SDTFNPKRYLTNPSAGVSNNGLDNKNSDLILAVNGIIYNP--KH---------------- YAK_d_Smoe --------------------------------VSD------------------------- *.. YakA_Ddis ------------------------------------------------------------ YAK1_Scer ------------------------------------------------------------ 22349_Tthe IELNALFCIKLLRNVELIPYKEKKHALYQIASVVSQHQKILFDMQKAQNTRHFNQINQEK CC1G_14245_Ccin ------------------------------------------------------------ YAK_b_Smoe ------------------------------------------------------------ YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis ----------------------------KYKVLDSLGQGTFGQVVKCKNCDTDELVAIKI YAK1_Scer ----------------------------KYLVLDILGQGTFGQVVKCQNLLTKEILAVKV 22349_Tthe SLILQSNRWFINDQQDLNYYIQYINWLIEYIIEDMLGKGTFGQVAKCSKNGTNDLFAVKV CC1G_14245_Ccin ----------------------------KYLILDILGQGTFGQVVKCQNMKTHEIVAVKV YAK_b_Smoe ----------------------------RYVVKEMLGQGTFGQVVKCWSDRENGYVAVKV YAK_a_Smoe ----------------------------RYVVKEMLGQGTFGQVVKCWSDRENGYVAVKV YAK_d_Smoe ----------------------------------------------------QGIVTRKT . .: * YakA_Ddis LKNKQAYFQQGRLEIQTLKSLNDQHDPEDKN---HILRLLDSFIHKMHLCIVFELLSVNL YAK1_Scer VKSRTEYLTQSITEAKILELLNQKIDPTNKH---HFLRMYDSFVHKNHLCLVFELLSNNL 22349_Tthe IKNRPAYFQQAKNEILLLRVLNKQEEQNGENYQKRIVNLVDFFVFRNHFCLVFEMLELSL CC1G_14245_Ccin IKNKPAYFNQSMMEVTILEMLNKTCDPNDEH---HLLRLRDSFIHRSHLCLVFELLSSNL YAK_b_Smoe IKNQPAYYQQALVEIEILKMLNRDFDPDNQH---HIVRILDWFLFEQHLCIAFELLSHNL YAK_a_Smoe IKNQPAYYQQALVEIEILKMLNRDFDPDNQH---HIVRILDWFLFEQHLCIAFELLSHNL YAK_d_Smoe VDDK-------------------------------------------------------- :..: YakA_Ddis FELIKQNNFRGLSTNLIKVFLIQILDALIVLANANIIHCDLKPENILLQN-VNS-PAIKI YAK1_Scer YELLKQNKFHGLSIQLIRTFTTQILDSLCVLKESKLIHCDLKPENILLCA-PDK-PELKI 22349_Tthe YDYLKNTKFCGFSFSVIAQWTKSILEGMVIAESKQIIHCDLKPENIMLKKQLILNQTLKM CC1G_14245_Ccin YELIKQNQFQGLSTQLVKVFMAQLLDALTVLKEARLIHCDLKPENILLKS-LQS-PQIKV YAK_b_Smoe YELIKVNRHRGISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKS-GEIKL YAK_a_Smoe YELIKVNRHRGISLHLLRIFTKQILDSLGVLRNAGVIHCDLKPENILLSTSLKS-GEIKL YAK_d_Smoe -----------------MSIMTQLLEALQVLERHGVVHRDLKPENIVLSS---Q-GELRL .:*:.: : ::* *******:* ::: YakA_Ddis IDFGSACYEKSTLYTYIQSRHYRSPEVLVGTVYCASIDMWSLGCISAELFLGLPLFPGNS YAK1_Scer IDFGSSCEEARTVYTYIQSRFYRAPEIILGIPYSTSIDMWSLGCIVAELFLGIPIFPGAS 22349_Tthe AT------------KFSQQK---------WMIYTTAIDMWSLGCILVELFLGLPIFPGNS CC1G_14245_Ccin IDFGSACHERQTVYTYIQSRFYRSPEVLLGMPYTAAIDMWSLGCIAVELFLGLPLFPGTS YAK_b_Smoe IDFGSACLEHRTVYKYIQFC-------------------------------------NPS YAK_a_Smoe IDFGSACLEHRTVYKYIQSRYYRSPEVVLGHPYTTAIDMWSLGCVAAELFLGLPLFSGES YAK_d_Smoe IDFGSAVDSGREMLS--------------------------------------------- . YakA_Ddis EYNQISRIVEMRGI-FPSDLLDKGKSSTRYFHRHLGSNSDDNNNNNNNNNGKPYYYTLKS YAK1_Scer EYNQLTRIIDTLGY-PPSWMIDMGKNSGKFMKKLAPE-ESS--------SSTQ-KHRMKT 22349_Tthe EYDQIKRIIDILGK-PTNEVIEQGRFKNKFFKCLDGE------------------YIFKT CC1G_14245_Ccin EYNQLTRIIEMLGM-PPLSMLNSGKQ---------------------------------- YAK_b_Smoe CYCE-----------------------------------------------------FTS YAK_a_Smoe EYDLLRRMIDTLGCQPPDQLLRDSANTSKYFKTVSAAPPSS--------GGMA-VYQFLT YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis EED-YQRDSKTTLLPSKKYFNYKTLPEIIQNYGFKKSMSP--QDIEKEKQHRI-VFTDFI YAK1_Scer IEE-FCREYNIVEKPSKQYFKWRKLPDIIRNYRYPKSIQNSQELIDQEMQNRE-CLIHFL 22349_Tthe KQE-FEISEGIQLKESKTYFQVACLNDL-KNYMYNSQFRR--NEDDTKNNRQFDLFLDLA CC1G_14245_Ccin ----------------------------------------------TKLNNRA-AFIDFC YAK_b_Smoe LC-ALQRE-AKEPLVGKSYFRHTKLEDIISKYPYKSSLSA--EEQEAERQRRL-SFLDFL YAK_a_Smoe VSEVKARE-SKEPLVGKSYFRHTKLEDIISKYPYKSSLSA--EEQEAERQRRL-SFLDFL YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis NGLLQLDPNERWSPMQ---------------------AKEHPFITGQPYN--G------- YAK1_Scer GGVLNLNPLERWTPQQ---------------------AMLHPFITKQEFT--G------- 22349_Tthe TQLLELNPRKRVKASI---------------------AMQHPFLNQDENNFYSSLTNQKI CC1G_14245_Ccin KGLLDLNPVTRWTPQQ---------------------ARLHPFITGEKFT--K------- YAK_b_Smoe RGLVRFDPKSRWTPHQVCLLFFIFVYLSNNISHVAFQAAQHPFVTEQPFT--G------- YAK_a_Smoe RGLVRFDPKSRWTPHQ---------------------AAQHPFVTEQPFT--G------- YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis ----PFIPDPSKK--RHFTY-SQPKQI--------------------------------- YAK1_Scer ----EWFPPGSSL--PGPSEK--------------------------------------- 22349_Tthe ENTKEFSLDQSTSDERHNDIKQQQQQSNQNTDFNLFKVSDQNAAIVKKAIQNQKENQEKL CC1G_14245_Ccin ----PFVPEGLAP--SQPSSSSSPNT---------------------------------- YAK_b_Smoe ----PFEPLPETP--RTPVG--HPMTVE-------------------------------- YAK_a_Smoe ----PFEPLPETP--RTPVG--HPMTVE-------------------------------- YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis ------PQHSM-------------------LNGNQILNQHQLFQQLQQQQQQQQQQQQQQ YAK1_Scer ------------------------------------------------------------ 22349_Tthe KPNQLTSDPQQQQINNLLSEIGQEQNLQSQYYLNQYPLQQQQG-Q------YQN-DPYNF CC1G_14245_Ccin ------PDPKR-------------------PYGGLVPSQ------PKGTRAYQDAATYNH YAK_b_Smoe ----HNPGAGH-------------------WFGAGLSPQ------V-------------- YAK_a_Smoe ----HNPGAGH-------------------WFGAGLSPQ------V-------------- YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis QQQQ--------QQQQQQQQQQQQHNQF------------QQQQQQQQQQQQSSSQQHIQ YAK1_Scer ------------------------------------------------------------ 22349_Tthe HTQQPGIQQIPFNQSFT--QQPQIYNNYLNQNMYQYPYQFQQQQYAQQ----MSQMLPQQ CC1G_14245_Ccin HLAQ--------HQAYTAQQASQAANTFR--NPYINP-PAQQQQSQQQHQQQ-----PPS YAK_b_Smoe -----------------------CAHVIC--LFLLNA-LVLQ----VSHIPV-------- YAK_a_Smoe -----------------------CAH---------------------------------- YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis IQPLQLFST--PYTSTNNTPNLSSSNSGSSLNNLKKLNLPPFKQQQQQQ-FSTSQ-NSDS YAK1_Scer ------------------------------------------HDDAKGQ-Q-------SE 22349_Tthe QQPVQQSTF--PYQ-------------------------QPYNQVQQQQQMSTDQ-LANL CC1G_14245_Ccin QPPVAQTTYTNPP-------------------------ADPYHPQSQQQ-QSQSQHLSGQ YAK_b_Smoe --------------------------------------PLP-------Q-YSSPQYYGGQ YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis FNFPNESFSPRGIYIPSSASNIQQQQQPININNNQNGVGSQVSQLALGQSPSLFGTPTNI YAK1_Scer YGS----------------AN--------------------------------------- 22349_Tthe FSQ---------------QLNLQTSNQFQNQKQS--FRNQKQSKKCLSQQDSLD-YQKEF CC1G_14245_Ccin YGS----------------GAAQTAHRALAHANS-------ANQLGSGASG-------SQ YAK_b_Smoe FSF----------------ASSYGSCG-----SY-------GSCDGYGMGG-------SY YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis YPPYSSMYNNSP-VATPNSLSFYGSSWGSDSSSISLNPSTPTQKQMFQQQQYSNNNNNNN YAK1_Scer ------------------------------------------------------------ 22349_Tthe YDDYPNQFQNNQ-I---------------------------QDKNMWSTNQFTNIQNQGN CC1G_14245_Ccin YPSHSSATNLSSSHLNP------------------------------------NV-SSGS YAK_b_Smoe AGSYTEASNMYCNYPT-------------------------------------------- YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis NNNNNNSNN-NNGNNTNNINSNNNNNNVNR-RNRSKSD-----IPSDSFSSSEGMDPQFN YAK1_Scer ------------------------------------------------------------ 22349_Tthe FYKNSNYNYQKTGTNQGFQQGISNIENIQD-QQVPPAN-----I-KDIFDNVDDNFPK-- CC1G_14245_Ccin YYPNSRAR----------------ANTINQMDTIPPALARLQHMNQDIIGGRNALTPVLN YAK_b_Smoe ----------------------------------PPQIG--------------------- YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis LYQQQQQQQQQQQQQQQQQQQQQ--QQQQQQQQQQQQQLQYQQQFQTLQ---DLNIEGEK YAK1_Scer ------------------------------------------------------------ 22349_Tthe -------QQLNQQPQQLIHLQNYQQGNQQQMPQGFLLNSQYIQNFYNPQQQLGMNI---- CC1G_14245_Ccin RDDAMKEWERRQS----------------------------------------------- YAK_b_Smoe ----YEQWRR-------------------------------------------------- YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis PPIYPNSPHRKRSHSGYLDQYANGYNSQQTNNTQQQQQQQQQQQQQQQQQ--QQQQQHPS YAK1_Scer ------------------------------------------------------------ 22349_Tthe ------------------------GNLQPNNNLLGNQFQVQDQPQQQNQQYQLFQQ---- CC1G_14245_Ccin ------------------------------------------------------------ YAK_b_Smoe ------------------------------------------------------------ YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis FFSTRMHLDHFNGGSRYRSQSYGDQQFQQQQYKQQQKNLHHQQQQQQ-RFMQVGSPPTSH YAK1_Scer ------------------------------------------------------------ 22349_Tthe ---------------QFNQQNYGFNQFNNQQNMRQNYQLFNQNNLQQNLFLQ-------- CC1G_14245_Ccin ------------------------------------------------------------ YAK_b_Smoe ------------------------------------------------------------ YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis LSPPIPQSPLMMSQPLHQTYIPQQ-QQQQQQ--QQ---QQSQPTPFTPQMISQEPISPAL YAK1_Scer ------------------------------------------------------------ 22349_Tthe ----------------NQQYYQQQQQQLQQQ--Q---------QPLNQQ-NSQFPQ---- CC1G_14245_Ccin GKPPAAQPY------------PQL-EYLQQQ--AEIVAASGLANWASGP-HTRYPA---- YAK_b_Smoe LHPPIPAGY------------GQL-GRSPSSSVFTPMSLGGSPSQFTPP-SSQFPS---- YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis MGDASSIWNPSPTEELLFTIDLPNQQNTPHLTPSNSSTNLLGKSASSPLKNSSGGAIPPT YAK1_Scer ------------------------------------------------------------ 22349_Tthe ---------------------QTNQQQTYYNKPYQN------QKQNNKYKNSSNGKNSNN CC1G_14245_Ccin ---------------------QPSKLQHSYQ-PH-------------------------- YAK_b_Smoe ---------------------PGS------------------------------------ YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis PTIPINMEEINNGFSKFHFNDQPSWNSNGNSPWMIQQ----------------QQQHQQG YAK1_Scer ------------------------------------------------------------ 22349_Tthe NTKQADMNANNN-F-----NNNNNNNNSNNSQKFYQNNKKFRRHYSDSEFQQYQPEQNEI CC1G_14245_Ccin ------------------------------------------------------------ YAK_b_Smoe ------------------------------------------------------------ YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis FNGNSESMYNDDLIGFSPYNNYSNDYRPQLFNKQS---PPSSYNSNKSFYGGSGGGGNNN YAK1_Scer ------------------------------------------------------------ 22349_Tthe FNDIKAPFLESDQIENQSQNLGKSSDNIQEDNKQERHGEESASNNSSNFNNNSNNTGNQK CC1G_14245_Ccin ------------TIMVDDENGNTSRRDVVMSNVRAAAGGGARTDQQSGLGSYSGSTGNLI YAK_b_Smoe ------------------------------------SPGRC------------------- YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis NNNNSRPTNQNFSNS----LLPSQQQN---V-----IFPQNSP-PSSYNSS--------- YAK1_Scer ----------------------------------------------------DSSNNAGH 22349_Tthe QNQNFKRQNSNYNNN----QNYSNQKNQQKFKKPNQGQAQQ--QQQHNNTFNSNS-NNNN CC1G_14245_Ccin TSP-----PQAYSGNTAAGSRYTTSY----------GQPQHPPPPASSNSFDTVD-RRTD YAK_b_Smoe ----------------------------------------GPPSPARYGKAASVSHYKQR YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis ------------------------NSLSKSGGNTVKNNSNTGGRPRGDSMKQRFNSTNNL YAK1_Scer NYVYNPSS--ATGGAD------------------S---V-------------DIGAISKR 22349_Tthe YSQNFPNQNT------------------QFQANLSNNNNNSNSSSNNNNNNSSILNNNSS CC1G_14245_Ccin IGMYVPMQPDQYQGYP------------------ASTSTNRHAPPAGPPVPTSFYGPSIV YAK_b_Smoe RGLYAPMN--QSPGYDGSWQHMPANGSFEAGSHLEAGPSGSYSRPYGQSHLRPAMKSSSY YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis LS-GGSYQYQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYKKDTPSLMMSPPMNGLKTS YAK1_Scer KENT-SGDIS--------NNFAVTHSVQEGPTS--------------------------- 22349_Tthe NQ-G-QIQTQNMKTSQQNNNNSNNSNDQQNQHNPQDNNNNFKKGQNKF------------ CC1G_14245_Ccin PS-G-SQQQR--------NPFNVQENAQQSMGQ--------------------------- YAK_b_Smoe KA-G-SL--A--------SYLSTSETIVEAAESHQDAGDWF------------------- YAK_a_Smoe ------------------------------------------------------------ YAK_d_Smoe ------------------------------------------------------------ YakA_Ddis SEIGIPSEEIRYQYQQQQLQQQFQQQQQQQQQQQIQQQLQQQQAPPQNRKQVVIGSYRET YAK1_Scer ----------------------------A-------FNK---------------LHIVEE 22349_Tthe ------------KNQNKKSFTNHKYQQQNAQQQQFS-QGQKQYSP-------INENPSQS CC1G_14245_Ccin ----------------------------P-------KDN---------------R-NWPR YAK_b_Smoe ----------------------------P-------NDRLERFTPGFLRDI--LVLVSAV YAK_a_Smoe -----------------------------------------------------VNCHFFT YAK_d_Smoe ---------------------------------------------------------HSR