Model Organism Databases: FlyBase, Wormbase, and Saccharomyces Genome Database. Databases for emerging model systems include DictyBase for Dictystelium, and the Tetrahymena Genome Database. Signalling databases: STKE from Science, and the AfCS/Nature-affiliated Signaling Gateway. Protein Kinase Resource, a general site about kinases and KinG another site containing genomic analyses of protein kinases. Prediction of phosphorylation sites: NetPhos and Scansite, and a comprehensive database of mammalian protein phosphorylation sites at PhosphoSite. Cell Signaling Technology has useful reference material and diagrams, including an interactive human kinome tree. The Rice Kinome Database and PlantsP explore plant kinases and kinomes. Domain Profile Searches by Pfam and SMART-HMMR. For Macintosh bioinformatics resources: macbio.info