Gene IRAK-0_bo (S.moellendorffii)

IRAK-0_bo

Species: S.moellendorffii
Alias: IRAK-0_bo
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_bo.AA Protein None 318 None Fasta, JSON
IRAK-0_bo.NA RNA None 957 None Fasta, JSON
IRAK-0_bo.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_bo.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_bo.AA TKL 8-272 20 3.9e-62 212.73 In-house 1-364 (364) Show / Hide 
Range on Protein: 8-272
Range on HMM: 1-364/364
Sequence Identity: 20% (77 aa)

LGQGGFGVVYKGTLPD---------GRRIAIKRLTTQS---------------------------QKGKQEFLNEVKLVSSVQHRNLVKLYGCCTEESE-
.|.||||.||||..           |. .|.|.. ...                           .. .... .|... |. .| |.|...|.|....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYELLENNS-LSRVLFQGNLCLSWEQRYNVILGVARGLAYLHEDS-----QVKIIHRDIKAGNVLLDEKFE--------------
              .|.|. .. | |....        |.|| . .|..|||..||| .        .|||||.|  |.|.||...              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKIADFGLARLYSDERS-------------------INTQIAGTLGYMAPEYAL----------------HGHLTDKADVFSFGILSLEIVSGRRSTDLN
.||.||||.|  | . .                    .  . ||...||||                   ..  . |.||.||||.  ||....|     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----

QPIERQYLLEWAWKSHERNEQLDLVDA--GLNTVPPSF-------DKEQAI--RVICVGLLCTQATPSQRPSMSRVVTMI
 | . .   .. .      |.   ...  ||   .|.         ..  .  ...     | .. |..|||.....  .
-PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_bo.AA IRAK 3-198 37 8e-56 191.77 In-house 2-222 (317) Show / Hide 
Range on Protein: 3-198
Range on HMM: 2-222/317
Sequence Identity: 37% (83 aa)

SDDNKLGQGGFGVVYKGTLPDGRR--IAIKRL----TTQSQKGKQEFLN---EVKLVSSVQHRNLVKLYGCCTEESERLLVYELLENNSLS-RVLFQGN-
. ||..|.||||.||.| . ..     |.|.|     ..  . .|.|.    |.|. .. .| |.| ||| |||...  |||... | ||  |   |.. 
HKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

--L-CLSWEQRYNVILGVARGLAYLHEDS-QVKIIHRDIKAGNVLLDEKFEAKIADFGLARL-----YSDERSI---NTQ-IAGTLGYMAPEYAL--HGH
  .  ||| ||  . .| |.|. .||...  . |||.|||  |.|||. |..||.||||.|       .   ..    |. . ||. ||.||.     | 
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTDKADVFSFGILSLEIVSGRR
|| | ||.||||  ||...|.|
LTKKTDVYSFGIVLLEVLTGCR
Pkinase IRAK-0_bo.AA Pkinase 2-197 28 1.5e-51 182.37 Pfam 1-209 (293) Show / Hide 
Range on Protein: 2-197
Range on HMM: 1-209/293
Sequence Identity: 28% (60 aa)

LSDDNKLGQGGFGVVYKGTLPDGRR-IAIKRLTTQSQKGKQE--FLN--EVKLVSSVQHRNLVKLYGCCTEESERLLVYELLENN----SLSRVLF---Q
.    |.|.|.||.|||..  . ..  |.|..  ...| ...   ..  |...  ...| | |.||........  .| |..|.     .|....    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GNLCLSWEQRYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEKFEA----KIADFGLARLY-SDERSINTQIAGTLGYMAPEYAL-HGHLTDKADV
|.. .|...  .... ..|||.|.|.    .|||||.|  |.|.|.. .     ||.|||||...     | .| ..||..|||||  . . . . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

FSFGILSLEIVSGR
.|.|..  | ..||
WSCGCILYEMLCGR
Kinase IRAK-0_bo.AA TKL-Unique 4-188 32 9.4e-44 151.67 In-house 1-216 (290) Show / Hide 
Range on Protein: 4-188
Range on HMM: 1-216/290
Sequence Identity: 32% (71 aa)

DDNKLGQGGFGVVYKGTLPDGRRIAIKRLTT---QSQKGKQEFLNEVKLVSSVQ-HRNLVKLYGCCT----EESERLLVYELLENNSLSRVLF-------
. ||.|.||.|.||||. . |  .|||..     .| . .||| |||.. .  . | |.|...| |.     .... .| | .. .||  ||        
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--QGNLCLSWEQRYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEK-----FEAKIADFGLARLYSDE-RSINTQI--------AGTLGYMAPEYA
    |. |...||.. .. .|.|. |||  .   |||||.|  |.|.|..     . .||.||||... | . ...|. .         |.. .||||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV-

LHG---HLTDKADVFSFGI
| .   . . |.||.||||
LRMNFCQYSEKSDVYSFGI
Kinase IRAK-0_bo.AA MLK 2-189 26 9.8e-44 149.6 In-house 1-225 (291) Show / Hide 
Range on Protein: 2-189
Range on HMM: 1-225/291
Sequence Identity: 26% (61 aa)

LSDDNKLGQGGFGVVYKGTLPDGRR-----IAIKRLT--TQSQKGK-----QEFLNEVKLVSSVQHRN----LVKLYGCCTEE-SERLLVYELLENNSLS
.    ..| |.||.|.||.   ...     .|.|| .  .   |..     ..|  |..... ..|.|     ...||.|... .. ..| | .|. ||.
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

RVLFQGN-------------LCLSWEQRYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDE------KFEAKIADFGLAR-LYSDERSINTQIAGTL
.||  ..                . ..  |  | .|||..|||.. ...|||||.|  |.|.||      .  .||.|||..| ... . .  .  |||.
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTY

GYMAPEY---ALHGHLTDKADVFSFGIL
 .||||    . ..  . |.||.|.|..
AWMAPEVIQQFRCEKYSEKCDVWSWGVV
Kinase IRAK-0_bo.AA Pkinase_Tyr 2-189 31 3.5e-41 140.09 Pfam 1-203 (270) Show / Hide 
Range on Protein: 2-189
Range on HMM: 1-203/270
Sequence Identity: 31% (65 aa)

LSDDNKLGQGGFGVVYKGTLP-----DGRRIAIKRL--TTQSQK-GKQEFLNEVKLVSSV-QHRNLVKLYGCCT-EESE--RLLVYELLENNSLSRVLFQ
.. . |||.| ||.|||||.      ..   |.| |  .. ..   ...|..|.|. ..  .| |.|.|||.|| ..     ..| |. .. .|   | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

G---NLCLSWEQRYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEKFEAKIADFGLARLY-SDERSINTQIAGTLG---YMAPEYALHGHLTDKAD
    .  |. ..  .  . .|.|..||..    ..||||. | |.|..|.. .||.||||||.  .|.    ..  |.      ||||   .|  | | |
HREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSD

VFSFGIL
| |||.|
VWSFGVL
Kinase IRAK-0_bo.AA STE 2-197 22 1.4e-39 137.45 In-house 1-265 (359) Show / Hide 
Range on Protein: 2-197
Range on HMM: 1-265/359
Sequence Identity: 22% (62 aa)

LSDDNKLGQGGFGVVYKGTLPD----------------GRRIAIKRLTTQSQKG-----------------KQEFLNEVKLVSSVQ--HRNLVKLYGCCT
. .  |.|.|.||.|||.   .                |...|||..  ....                  .|..|.|.|. .  .  | | || |||. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EE-------SERLLVYELLENNSLSRVLFQGNLCLS-------------WEQRYNVILGVARG-LAYLHEDSQVKIIHRDIKAGNVLLDEKFEAKIADFG
 |       .|  .. |.... ||. .. .   |.               .|   ..  . .| |.|||.     |||||||..|.||     .|..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LARLYSDE----------------RSINTQIAGTLGYMAPEYALH------GHLTDKADVFSFGILSLEIVSGR
..   .|.                 . .. ..||  .||||  .       .. . |.|. |.|.. .| . |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_bo.AA TK 2-195 17 5.3e-39 127.87 In-house 1-389 (486) Show / Hide 
Range on Protein: 2-195
Range on HMM: 1-389/486
Sequence Identity: 17% (70 aa)

LSDDNKLGQGGFG---VVYKGTLPDGR--------------------------RIAIKRLT---TQSQKGKQE--------------FLNEVKLVSS--V
.   .|||.| ||   .||||.. ...                          . |.| |.   ..||. ...              ...| |. ..   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHRNLVKLYGCCTEE------------SERLLVYELLENNS----LS------RVLFQGNLC--------------------------------------
.| |.|.|||.||..               ..| |. .. .    |       |  || ..                                       
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSWEQRYNVILGVARGLAYLHED--SQV--KIIHRDIKAGNVLLDEKFE-----------AKIADFGLA
                               |. .|.    . .|.|..|||.   .    ...|||. | |.|..|.             .|||||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

R-----LYSDERSINTQIAGTLGY-----------------------------MAPEYALHGH---------LTDKADVFSFGILSLEIVS
|     |  |  |     . . ..                             ||||  ....          | | ||.|||.|  ||..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_bo.AA Dicty4-Unclassified 2-196 31 8.5e-39 130.48 In-house 1-204 (263) Show / Hide 
Range on Protein: 2-196
Range on HMM: 1-204/263
Sequence Identity: 31% (65 aa)

LSDDNKLGQGGFGVVYKGTLPDGRRIAIKRLTTQSQKGK----QEFLNEVKLVSSVQHRNLVKLYGCCTEE----SERLLVYELLENNSLSRVLF----Q
.  |  .|.| |  |.||    |. .|.| .   . |      |.|. || .  |.|| ||||.|| |       |    | |..    |  |       
IQIDQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

GNLCLSWEQ--RYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEKFEAKIADFGLARLYSDERSINTQIAGTLGYMAPEYALHGHLTDKADVFSFG
 .  .. .      . . .|.|...||    . .||||||. |.|.|  | .||||||..|  .      | ||||    .||   |   . |.||.|..
QQQPIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNM-TTIAGTPKWESPECLMHESYNQKSDVYSYA

ILSLEIVSG
..  | . |
MMLYELATG
Kinase IRAK-0_bo.AA Dicty4 2-189 30 1.4e-38 126.37 In-house 1-206 (277) Show / Hide 
Range on Protein: 2-189
Range on HMM: 1-206/277
Sequence Identity: 30% (63 aa)

LSDDNKLGQGGFGVVYKGTLPDGRRIAIKRL--TTQS--QKGKQEFLNEVKLVSSVQHRNLVKLYGCCT----EESERLLVYELLENNSLSRVLFQ----
.  ....|.|.|| |||||   |   |.| |  . |   ..  .||..||.. .. .| |.....| ||    . .. . | |..   .| ..|      
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--GNLCLSWEQRYN---VILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEKFEAKIADFGLARLYSDERSINT---QIAGTLGYMAPEYALHGHLTDKA
   .  |.|. .       . .|||...||. . . |||||.|. | | |. . .|..||||...   . . ..     .|| ..||||   |   . ||
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVFSFGIL
||.||||.
DVYSFGIV
Kinase IRAK-0_bo.AA S_TKc 2-272 23 2.3e-37 131.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 2-272
Range on HMM: 1-231/231
Sequence Identity: 23% (68 aa)

LSDDNKLGQGGFGVVYKGTLPD-GRRIAIKRLTTQSQKGKQEFLNEVKLVSSVQHRNLVKLYGCCTEESERLLVYELLEN--NSLSRVLFQGN-------
    .|.|.|.||.|||..  . ||. |||..        . ...|... .. .| |.||||... . ..  .| |....   .| ... . .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LCLSWEQRYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEKFEAKIADFGLARLYSDERSINTQIAGTLGYMAPEYALHGHLTD-KADVFSFGILS
.   . ..|  .  ....|.|.|  |. .|||||.|  |.||||  . ||.||||||..       | . ||. |||||     . .  |.|. |.|.. 
FPE-HARFY--MYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

LEIVSGRRSTDLNQPIERQYLLEWAWKSHERNEQLDLVDAGLNTVPPSFDKEQAIRVICVGLLCTQATPSQRPSMSRVVT---------MI
 | ..|.   . ..    . ..                             ..|.  |.    | |  |..||.   . .          .
YEMLCGYPPFP-QMQMMFKKIG----------------------------SPEAKDFIR---KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_bo.AA LISK 7-198 28 2.8e-37 118.56 In-house 1-237 (296) Show / Hide 
Range on Protein: 7-198
Range on HMM: 1-237/296
Sequence Identity: 28% (69 aa)

KLGQGGFGVVYKGTLP-DGRRIAIKRLTT-----QSQKGKQEFLNEVKLVSSVQHRNLVKLYGCCTE-ESERLLVYELLENNSLSRVLFQGNL---CLSW
..|.|.|| |||||.  .|. .||| ...             .| ||..  . .|.| |. .| | . ...  .| |. .   | . |.  ..    |.|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

EQRYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEK----FEAKIADFGLARLYSDER------------------------SINTQ---------
.|| .  |..|.|..|||.    .||||| |. |.|..|.    ...|..|||.||. ..|.                        .|.           
PQRVKIALDIACGMSYLHSM---NIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

-IAGTLGYMAPEYALHGHLTDKADVFSFGILSLEIVSGRR
 | ||   ||||  |    ....|||||||. .||. ...
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAK-0_bo.AA TK-Unique 2-195 27 1.9e-36 123.2 In-house 1-234 (294) Show / Hide 
Range on Protein: 2-195
Range on HMM: 1-234/294
Sequence Identity: 27% (67 aa)

LSDDNKLGQGGFGVVYKGTLPD-------GRRIAIKRLT-TQSQKGKQEFLNEVKLVSSVQ-HRNLVKLYGCCTEES-ERLLVYELLENNSLSRVLFQGN
|  ....|.| || |..|..          ...|.| |    ..  ||.||.| .. ...  | |.|...||||. .   ....| ... .| . ... .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNL-QHYLRTC

LC--------------------------LSWEQRYNVILGVARGLAYLHEDSQ--VKIIHRDIKAGNVLLDEKFEAKIADFGLAR------LYSDERSIN
 .                          .| .. |. . ..|.|..||.   .   ||.|||. | |||| |....||.|||.||       || ..| .
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLA---SQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG

TQIAGTLGYMAPEYAL--HGHL-TDKADVFSFGILSLEIVS
. .   . .||||. .  ||.  | | || |||.|  ||..
RIP---IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_bo.AA TyrKc 2-272 25 7e-32 113.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 2-272
Range on HMM: 1-280/280
Sequence Identity: 25% (76 aa)

LSDDNKLGQGGFGVVYKGTLPDGRRIAIKRLTTQSQKGKQEFLNEVKLVSSV--QHRNLVKLYGCCTEE-------SERLLVYELLENNSLSRVL-FQGN
.. . ||| | ||.|||||.   .  |.| |   .   ...|..| .. ...  .| |.|.|||.||..          ..| |. .. .|   |   ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

LCLSWEQRYNVILGVARGLAYLHEDSQVKIIHRDIKAGNVLLDEKFEAKIADFGLARLYSDE-------RSINTQ---IA---GTLGYMAPEYALHGHLT
  |....  .  . .|.| .|||.    ..||||. | |.|..|.. .||.||||.|   |.         . ..    .     .  ||||   .|  |
K-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

DKADVFSFGILSLEIVSGRRSTDLN---QPIERQYLLEWAWKSHERNEQLDL----VDAGLNTVPPSFDKEQAIRVICVGLLCTQATPSQRPSMSRVVTM
 | ||.|||..  || .   .   .   |... | ..|.  |. .| .| .                |  .    .  . . | .. |..||..| ..  
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV-KQGYRMPQPPNDYPMS----------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

I
.
F
Kinase IRAK-0_bo.AA TK 252-272 23 0.001637 6.79 In-house 466-486 (486) Show / Hide 
Range on Protein: 252-272
Range on HMM: 466-486/486
Sequence Identity: 23% (5 aa)

LLCTQATPSQRPSMSRVVTMI
. | .. |..||..| .. ..
QQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_bo.AA TK-Unique 254-272 31 0.015579 4.7 In-house 276-294 (294) Show / Hide 
Range on Protein: 254-272
Range on HMM: 276-294/294
Sequence Identity: 31% (6 aa)

CTQATPSQRPSMSRVVTMI
|.|  |..||| . .. ..
CWQWEPEERPSFRQIKHRL
Kinase IRAK-0_bo.AA MLK 254-272 31 0.092136 2.05 In-house 273-291 (291) Show / Hide 
Range on Protein: 254-272
Range on HMM: 273-291/291
Sequence Identity: 31% (6 aa)

CTQATPSQRPSMSRVVTMI
| .. |..|||.. .|.  
CWNQDPHKRPSFRQIVQHL
Kinase IRAK-0_bo.AA TKL-Unique 259-272 42 0.304329 0.36 In-house 277-290 (290) Show / Hide 
Range on Protein: 259-272
Range on HMM: 277-290/290
Sequence Identity: 42% (6 aa)

PSQRPSMSRVVTMI
|||||| . ... .
PSQRPSFDEIIHRL
Kinase IRAK-0_bo.AA Pkinase_Tyr 252-272 23 0.477839 4.17 Pfam 250-270 (270) Show / Hide 
Range on Protein: 252-272
Range on HMM: 250-270/270
Sequence Identity: 23% (5 aa)

LLCTQATPSQRPSMSRVVTMI
..| .. |..||..| .. ..
KQCWHYDPEDRPTFSEIHEQL