Gene IRAK-0_y-2 (S.moellendorffii)

IRAK-0_y-2

Species: S.moellendorffii
Alias: IRAK-0_y-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_y-2.AA Protein None 801 None Fasta, JSON
IRAK-0_y-2.NA RNA None 2406 None Fasta, JSON
IRAK-0_y-2.kin_dom Protein Kinase Domain None 194 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_y-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_y-2.AA TKL 487-746 20 2e-59 203.73 In-house 1-364 (364) Show / Hide 
Range on Protein: 487-746
Range on HMM: 1-364/364
Sequence Identity: 20% (77 aa)

IGKGAFGMVYKARLPS---------GEILAIKKGKLGKAASFGG------------------------------ELKLLSRLHHTNLVNLIGYCKQEK--
||.|.|| |||...           |.  |.|| |     .|                                |....|||.| |.| ..|||....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------------LLVFEFMGNGS-LYDCLFVKNIKLDWSTRLKIVIQAAHGLEYLHLFAD-----PSIIHRDVKSSNILLDEGFN--------------
              .| |.. .|| |.. .        |. |.......| |..|||         | ||||| ||.|||.|| ..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AHVADFGAST-LGPTENSTHV---------------TSTSLVGTPGYVDPEYFQTM----------------QISPKSDVYSFGVVILELFTGRKAVD-L
. ..||| |. . ...|...                |. . .|||..  || .. .                . |.|.||||||.|. |..|...  . .
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

GQSIVGVV----AWVEKVASEFSSLVPA------LDMEPPVDEEKSRILAEVLELGVCCVRPKAIDRPTMTVVASSL
. . . .     .. ..|....  . .       .   . .    . .. .. .|  .|  ... .||... . . |
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH---K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_y-2.AA IRAK 481-678 37 3.2e-54 186.44 In-house 1-225 (317) Show / Hide 
Range on Protein: 481-678
Range on HMM: 1-225/317
Sequence Identity: 37% (84 aa)

FSSDMVIGKGAFGMVYKARLPSGE-ILAIKKGKLGKAASFGG----------ELKLLSRLHHTNLVNLIGYCKQEKL--LVFEFMGNGSLYDCLFVKNI-
|. | .||.|.|| ||....   . | |.|| | ..  |...          |||...|..| |.| | ||| ..    ||...| |||| | |   .  
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-K---LDWSTRLKIVIQAAHGLEYLHLFA-DPSIIHRDVKSSNILLDEGFNAHVADFGASTLG-PTENSTHVTS----TSLV-GTPGYVDPEYFQ--TMQ
     | | .|..| . .| |...|| .    .|||.|.||.|||||. |..  .|||.   | |.... . |.    ||.| ||  |  ||.    . |
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

ISPKSDVYSFGVVILELFTGRKAVD
...|.||||||.|.||..||..||.
LTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-0_y-2.AA TKL-Unique 486-673 33 2.5e-45 156.91 In-house 4-224 (290) Show / Hide 
Range on Protein: 486-673
Range on HMM: 4-224/290
Sequence Identity: 33% (74 aa)

VIGKGAFGMVYKARLPSGEILAIKKGKL--GKAAS----FGGELKLLSRLH-HTNLVNLIGYCK----QEK--LLVFEFMGNGSLYDCLF---------V
.|| |..| |||.  . |.. |||. ..  ..  .    |  |......|| | |.| ..|||.    ...   .| |..  ||||| |           
KIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

KNIKLDWSTRLKIVIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEG-----FNAHVADFGASTLGPTENSTHVT------STSLVGTPGYVDPEYFQT-
.|.||... |.|..|..| |..|||    | ||||| ||||.|.|..     .|. ..||| |..  ..| . ..       .. .|.. .. || .   
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMN

-MQISPKSDVYSFGVVILELFTG
  |.| ||||||||.|  |..|.
FCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_y-2.AA Pkinase 481-674 27 9.7e-43 152.2 Pfam 1-209 (293) Show / Hide 
Range on Protein: 481-674
Range on HMM: 1-209/293
Sequence Identity: 27% (59 aa)

FSSDMVIGKGAFGMVYKARLPSGEI-LAIKKGKLGKAASFGG-------ELKLLSRLHHTNLVNLIGYC--KQEKLLVFEFMGNG----SLYDCLF-VKN
.    .||.|.|| |||..  . ..  |.|. |. .. |          |.... ||.| | | |....  |..  .|.|....|    .|.| .   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

IKL--DWSTRLKIVIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEGFNA----HVADFGASTLGPTENSTHVTSTSLVGTPGYVDPEYFQ-TMQISPKS
 ..  .. .  ... | . ||||.|     .|||||.|..|||.|.  .     ...||| . .    .   .  |...|||.|. ||  .    ..||.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSFGVVILELFTGR
|..|.|... |...||
DMWSCGCILYEMLCGR
Kinase IRAK-0_y-2.AA MLK 481-674 27 3.3e-39 133.7 In-house 1-233 (291) Show / Hide 
Range on Protein: 481-674
Range on HMM: 1-233/291
Sequence Identity: 27% (66 aa)

FSSDMVIGKGAFGMVYKARLPSGE----ILAIKKGKLGK---------AASFGGELKLLSRLHHTN----LVNLIGYCKQE-K--LLVFEFMGNGSLYDC
.    .||.|.|| |.|.|    .    |.|.|. .  .         .  |  | ..|..| | |     . . | |.|. .  ..| |.. .||||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LFVKN-------------IKLDWSTRLKIVIQAAHGLEYLHLFADPSIIHRDVKSSNILLDE------GFNAHVADFGASTLGPTENSTH-VTSTSLVGT
|  ..             .  | .  ...  | |.|..|||  | . ||||| ||.|||.||      . .. ..|||.|.    . ...  . .|  ||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR----DWHQMCTNMMSNAGT

PGYVDPEYF---QTMQISPKSDVYSFGVVILELFTGR
. .  || .   .  . | |.||.|.|||. |..|..
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_y-2.AA LRRK 481-678 26 2.2e-37 129.82 In-house 1-284 (351) Show / Hide 
Range on Protein: 481-678
Range on HMM: 1-284/351
Sequence Identity: 26% (75 aa)

FSSDMVIGKGAFG-MVYKARLPS---------------------------GEILAIKKGKLG-------------------------------------K
. .   ||.|.||  ||.|.. .                           ..  |||| ...                                     .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

AASFGGELKLLSRLHHTNLVNLIGYCKQEKLLVFEFMGNGSLYDCLFVKN--------IKLDWSTRLKIVIQAAHGLEYLHLFADPSIIHRDVKSSNILL
  .|  |. ..|.|.| |.|.|.|.| .   .| |.. .|.||. |. |         ....|...|||..| | |.||||  ..|.||||| || ||||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNPPIIHRDLKSPNILL

---D---------EGFNAHVADFGASTLGPTENSTHVT-STSLVGTPGYVDPEYFQTM---QISPKSDVYSFGVVILELFTGR-KAVD
   .         .  .|..|||| |.      ..| .    .||.||.. ||  . .   . . |.|.||||... || |..  . |
WSSPQNHSPNYPNAHVCAKIADFGISR--MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_y-2.AA RIPK 487-676 30 2.4e-36 121.37 In-house 1-227 (290) Show / Hide 
Range on Protein: 487-676
Range on HMM: 1-227/290
Sequence Identity: 30% (70 aa)

IGKGAFGMVYKARLPSGEILAIKKGKLGKA----------ASFGGELKLLSRLHHTNLVNLIGYCKQE--------KLLVFEFMGNGSLYDCLFVKNIK-
.|.|.|| |.|||  .    ..|| | .|                | | . .| . . | . | |..|          .| |.| |||| . |  |  . 
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LDWSTRLKIVIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEGFNAHVADFGASTLGPTENSTH--------VTSTSLV--GTPGYVDPEYFQTMQI
   . |. |  .. . . |  |||   .| ||||| | .|||.|  |.. .|||| .|   .  |.           ..|.   ||  | .|| | | . 
HHPDPWPLRCRMIHEISCGMCYLHS-MNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

SP------KSDVYSFGVVILELFTGRKA
.|      |.|||||..|. |..|....
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAK-0_y-2.AA Dicty4 481-673 31 1.3e-33 109.59 In-house 1-213 (277) Show / Hide 
Range on Protein: 481-673
Range on HMM: 1-213/277
Sequence Identity: 31% (67 aa)

FSSDMVIGKGAFGMVYKARLPSGEILAIKKGKLGKAA-------SFGGELKLLSRLHHTNLVNLIGYCK----QE--KLLVFEFMGNGSLYDCLFV----
   .  ||||.|| |||..   | . |.|| .. .         .|  | .... . | |.. . |.|     .    . | |.|  |.||  |      
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--KNIKLDWSTRLK---IVIQAAHGLEYLHLFA-DPSIIHRDVKSSNILLDEGFNAHVADFGASTLGPTENSTHVTSTSLVGTPGYVDPEYFQTMQISPK
  ..|||||.....   . . || |. .||  . .| ||||| ||.|.| |. ... |.||| |..  .. .     .. .|||... ||  .      |
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH--CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEK

SDVYSFGVVILELFTG
.|||||| |  |..|.
ADVYSFGIVLWEILTR
Kinase IRAK-0_y-2.AA HH498 481-674 26 2.1e-32 99.75 In-house 1-223 (284) Show / Hide 
Range on Protein: 481-674
Range on HMM: 1-223/284
Sequence Identity: 26% (61 aa)

FSSDMVIGKGAFGMVYKARLPSGEILAIKKGKLGKAASFGG-----------ELKLLSRLHHTNLVNLIGYCKQEK---LLVFEFMGNGSLYDCL-----
.     || |.|| ||| .   . | |.|  .  .  . .            |  ...|| | . |  .. |  .    ..| ..  ||||.  |     
IEFHEKIGSGSFGKVYKGEW-RNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPI

---------FVKN---IKLDWSTRLKIVIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEGFNAHVADFGASTLGPTENSTHVTSTSLVGTPGYVDPEYF
          . .   . .|   .. | .  ||| .|||  . . |||||  | |||..|   | ||||| |     .     . |.  | . .  || |
GGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRF--VCDMHDDNMTKQPGNLRWMAPEVF

Q-TMQISPKSDVYSFGVVILELFTGR
    . | | ||.|.. .| |..|..
SQCQKYSIKVDVFSYAMCIWEMHTRE
Kinase IRAK-0_y-2.AA DRK 522-672 36 4.3e-32 106.02 In-house 47-197 (258) Show / Hide 
Range on Protein: 522-672
Range on HMM: 47-197/258
Sequence Identity: 36% (56 aa)

ELKLLSRLHHTNLVNLIGYCKQ--EKLLVFEFMGNGSLYDCLFVKNIKLDWSTRLKIVIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEGFNAHVADFG
|  |...| | | .  .| |    . . . |.|  ||||  |    |..||. .... . .| |. |||   .| ||||| || | | || .   |||||
EINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFG

ASTLGPTENSTHVTSTSLVGTPGYVDPEYFQTMQISPKSDVYSFGVVILELFT
 ||      .   . |  .|||. . ||         | |||||..|  |. |
LSTRFKKHKQHKFAMT-MCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT
Kinase IRAK-0_y-2.AA STE 481-674 25 9.8e-32 109.38 In-house 1-265 (359) Show / Hide 
Range on Protein: 481-674
Range on HMM: 1-265/359
Sequence Identity: 25% (69 aa)

FSSDMVIGKGAFGMVYKARLP----------------SGEILAIKKGKLGK--------------------AASFGGELKLLSRLH--HTNLVNLIGYCK
.    .||||||| ||||.                  .||| |||. .| .                      ..  |.|......  | | |. .|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

---------QEKLLVFEFMGNGSLYDCLF---VKNIKLD----------WSTRLKIVIQAAHG-LEYLHLFADPSIIHRDVKSSNILLDEGFNAHVADFG
         .|  .. |.|..||| | .     ..  |.           |   .|. |  .| |.|||      |||||.|..||||     .  .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

ASTLGPTENS------------THV-TSTSLVGTPGYVDPEYFQTMQ------ISPKSDVYSFGVVILELFTGR
 ..    ...            | .  ....|||| .  ||  | ..       . |.|..|.| .|.|. ||.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_y-2.AA S_TKc 481-753 24 2.4e-30 108.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 481-753
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

FSSDMVIGKGAFGMVYKARLPS-GEILAIKKGKLGKAASFGGELKLLSRLHHTNLVNLIGYCK-QEKLLVFEFMGN--GSLYDCLFVKNIK-----LDWS
.    .||||||| |||.|  . |.| |||. |     ..  |...|.. || |.|.|....  ..  .|.|....  |.|.| .  .. .     ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

TRLKIVIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEGFNAHVADFGASTLGPTENSTHVTSTSLVGTPGYVDPEYFQTMQISP-KSDVYSFGVVILEL
.  ... | . .|||.|   .  |||||.| .||||||  .  ..||| ...           |...||| |. || .   . .. |.|..|.|... |.
HARFYMYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

FTGRKAVDLGQSIVGVVAWVEKVASEFSSLVPALDMEPPVDEEKSRILAEVLELGVCCVRPKAIDRPTMTVVAS--SLEKVLKHF
..|.   .       . .  .|.                          |....   | .    .|||   .    .. |    |
LCGYPPFP------QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_y-2.AA Pkinase_Tyr 481-619 29 8.3e-25 84.64 Pfam 1-156 (270) Show / Hide 
Range on Protein: 481-619
Range on HMM: 1-156/270
Sequence Identity: 29% (47 aa)

FSSDMVIGKGAFGMVYKARLP-----SGEILAIKKG--KLGKA----ASFGGELKLLSRL-HHTNLVNLIGYCK--QEK---LLVFEFMGNGSLYDCLFV
 . . ..|.||||.|||...       .   |.|.   .  .     ..|  |.|... | || |.|.|.| |   .|    ..|.|.| .|.|.| |  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K---NIKLDWSTRLKIVIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEGFNAHVADFG
.   . .|. .. |.. .| | |.|||.      .||||.   |.|..|.. . ..|||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFG
Kinase IRAK-0_y-2.AA TyrKc 481-746 23 1.3e-17 62.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 481-746
Range on HMM: 1-280/280
Sequence Identity: 23% (72 aa)

FSSDMVIGKGAFGMVYKARLPSGEILAIKKGKLGKAASFGGELKLLSRL--HHTNLVNLIGYCK---------QEKLLVFEFMGNGSLYDCLFVKNIKLD
 . . ..| |||| |||...   .  |.|. | .. . |  |......|  || |.|.|.|.|          .  ..|.|.| .|.| | |  .  || 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

WSTRLKIVIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEGFNAHVADFGASTLGPTE-------NSTHVTSTSLVG-------TPGYVDPEYFQTMQIS
... |.. .|.| | ||||      .||||    |.|..|.. . ..||| |  .  .          ......          ..    || ...   .
MKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA----PECINYGKFT

PKSDVYSFGVVILELFTGRKAVDLGQSIVGVVAWVE-----KVASEFSSLVPALDMEPPVDE-----EKSRILAEVLELGVCCVRPKAIDRPTMTVVASS
.||||.||||.. |.||            |   . .     . ..|   .| . .. |. ..        .  .|. ..  .| . .. ||||.. . . 
TKSDVWSFGVCMWEIFTY-----------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase IRAK-0_y-2.AA Pkinase_Tyr 646-675 45 0.000704 13.76 Pfam 183-213 (270) Show / Hide 
Range on Protein: 646-675
Range on HMM: 183-213/270
Sequence Identity: 45% (14 aa)

PEYFQTMQISPKSDVYSFGVVILELFT-GRK
|| ....  . ||||.||||.. |.|| |..
PECINYGKFTTKSDVWSFGVLMWEIFTYGEQ
Kinase IRAK-0_y-2.AA IRAK 726-746 33 0.122651 1.78 In-house 297-317 (317) Show / Hide 
Range on Protein: 726-746
Range on HMM: 297-317/317
Sequence Identity: 33% (7 aa)

VCCVRPKAIDRPTMTVVASSL
.||.  .|  |..|. | ..|
CCCGHHRANRRCDMAWVMQQL