Gene IRAK-14_b-2 (S.moellendorffii)
IRAK-14_b-2
Species: S.moellendorffii
Alias: IRAK-14_b-2
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| IRAK-14_b-2.AA | Protein | None | 862 | None | Fasta, JSON |
| IRAK-14_b-2.NA | RNA | None | 2589 | None | Fasta, JSON |
| IRAK-14_b-2.kin_dom | Protein Kinase Domain | None | 201 | None | Fasta, JSON |
Protein domains of IRAK-14_b-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | IRAK-14_b-2.AA | IRAK | 519-715 | 39 | 2.5e-68 | 233.32 | In-house | 1-218 (317) | Show / Hide |
Range on Protein: 519-715 Range on HMM: 1-218/317 Sequence Identity: 39% (86 aa) FDETLLLGVGGFGKVYRGELFDGTK--VAVK----RGNPRSEQGLTEFQT---EIEMLSKLRHLHLVSLIGYCEEHCEMILVYECMANGTLRAHLYGSDL |.. ...| |||| ||||. ...| .||| .. .. .||. |.. ....|| ..|.| ||| | . |||. |.||.|.. | . | FHKDNRIGEGGFGCVYRGQ-WKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDG --PP--LSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENFVAKVSDFGLSKTG---PSLDRTHV----STAVKGSFGYLDPEYFR--RQ || ||| ||..||.|.|.|...||. |||.|.|. |||||..|..| .|||| | ... .. . |.|. |. ||. | QCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG QLTEKSDVYSFGVVLFEVL ||| |.||||||.|| ||| QLTKKTDVYSFGIVLLEVL |
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| Kinase | IRAK-14_b-2.AA | TKL | 525-790 | 22 | 4.2e-58 | 199.33 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 525-790
Range on HMM: 1-364/364
Sequence Identity: 22% (83 aa)
LGVGGFGKVYRGELFD---------GTKVAVKRGNPRSEQGLTE---------------------------FQTEIEMLSKLRHLHLVSLIGYCEEH-C-
.| ||||.||.|.. |. ||||. . .... |. . || |.|.||| ..|...||| . |
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
-----------EMILVYECMANGTLRAHLYGSDLPPLSWKQRLEICIGAARGLHYLHT-----GAEQGT--IIHRDVKTTNILLDENFV-----------
.. .|.| . .|.|. .| | ||. .....|||..|||. . . ||||| |. |||.|||.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCT---KPPIIHRDLKSKNILVDENWTNVSNYMYNPNA
---AKVSDFGLSK-TGPSLDRTHVSTA----------------VKGSFGYLDPEYFRRQ----------------QLTEKSDVYSFGVVLFEVLCARPAI
.|..|||||. .| . .. .|. . |..... || .| | . .||.||||||.||.|.|. ..
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY
NPALPREQV------NIAEWAMQYQRMGALEQIVDA--NLKGQCSQESLQKFGETAEKCLAEQGIDRPAMGDVLWNL
..... ..... . .. . | . .. .. . . ...| .. .|| . ..| |
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHK-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | IRAK-14_b-2.AA | TKL-Unique | 524-715 | 32 | 4e-49 | 169.52 | In-house | 4-222 (290) | Show / Hide |
Range on Protein: 524-715 Range on HMM: 4-222/290 Sequence Identity: 32% (73 aa) LLGVGGFGKVYRGELFDGTKVAVKRGNPRSEQGLT---EFQTEIEMLSKLR-HLHLVSLIGYCE----EHCEMILVYECMANGTLRAHLYG--------S ..| ||.|.||.|. . |..||.|. .| ... .. || |. ..||. | .| ..||| .|..| |.. |.|. .| . KIGEGGYGQVYKGK-WRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN DLPPLSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDEN-----FVAKVSDFGLSKTGPSLDRTHVS-------TAVKGSFGYLDPEYFRR . .|...||. . | .|.|..|||. ....||||| |..|.|.|.| . .|..||||||. . ... .. . ..||| .. || .|. NNCKLNMQQRVKMAIDIAQGMYYLHH--CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM --QQLTEKSDVYSFGVVLFEVL | .|||||||||.|| | . NFCQYSEKSDVYSFGIVLWEIA |
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| Kinase | IRAK-14_b-2.AA | Pkinase_Tyr | 519-715 | 30 | 3.8e-40 | 136.61 | Pfam | 1-208 (270) | Show / Hide |
Range on Protein: 519-715
Range on HMM: 1-208/270
Sequence Identity: 30% (64 aa)
FDETLLLGVGGFGKVYRGELF-----DGTKVAVKRGNPRSEQG---LTEFQTEIEMLSKL-RHLHLVSLIGYCE-EHCE--MILVYECMANGTLRAHLYG
|| | ||.||.|... ....|||| .. . . . .| |......| .| ..|.|.| | . ...| | |..| |. .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK
S--DLPPLSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENFVAKVSDFGLSKTGPSLDRT-HVSTAVKGSFGYLDPEYFRRQQLTEKSD
| .||. |. |..|. |.|. ||. .||||. . |.|..||.|.|..||||... . | .... | . || .. |.|||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN----CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD
VYSFGVVLFEVL
|.||||...|..
VWSFGVLMWEIF
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| Kinase | IRAK-14_b-2.AA | Dicty4 | 519-715 | 33 | 5.9e-40 | 131.05 | In-house | 1-211 (277) | Show / Hide |
Range on Protein: 519-715 Range on HMM: 1-211/277 Sequence Identity: 33% (72 aa) FDETLLLGVGGFGKVYRGELFDGTKVAVKRG---NPR-SEQGLTEFQTEIEMLSKLRHLHLVSLIGYCE----EHCEMILVYECMANGTLRAHLYGS--- . . ..| |.||.||.| |..|||| | .| |.|| |.. ..|.|| ... . |.| . .| | | | |.| . | . INIEQRIGKGSFGEVYKGT-WRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNL-YSLLHDKPS ---DLPPLSWKQRLE---ICIGAARGLHYLHTGAEQGT--IIHRDVKTTNILLDENFVAKVSDFGLSK-TGPSLDRTHVSTAVKGSFGYLDPEYFRRQQL . .|.| .. ... ||||. .||. . ||||| |. |.| |.|...||.|||||. . | . ....|. .. || . | EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC----CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPY TEKSDVYSFGVVLFEVL .||.|||||| ||.| | NEKADVYSFGIVLWEIL |
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| Kinase | IRAK-14_b-2.AA | TK | 519-715 | 16 | 1.2e-38 | 126.71 | In-house | 1-388 (486) | Show / Hide |
Range on Protein: 519-715
Range on HMM: 1-388/486
Sequence Identity: 16% (66 aa)
FDETLLLGVGGFG---KVYRGELFDG--------------------------TKVAVKRGNPRSEQGLTEFQT-----------------EIEMLS--KL
|| | || .||.||.... |.|||| . ... .||. |..|.. ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
RHLHLVSLIGYCEEHCE------------MILVYECMANGT----LRAHLYGSDLP--------------------------------------------
.| ..|.|.|.| .. . ...| |.|..| || .| .. .
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
------------------------------PLSWKQRLEICIGAARGLHYLHTGAEQG-----TIIHRDVKTTNILLDENFV-----------AKVSDFG
.|. .|.| .| .|.|. ||| ... ..|||. . |.|..|| | .|..|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH---SKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG
LSKTG-----PSLDRTHVSTAVKGSFG---------------------------YLDPEYFRRQQ---------LTEKSDVYSFGVVLFEVL
||..| ... . ..... . .. || .. .. |.||||.||||...|..
LSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF
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| Kinase | IRAK-14_b-2.AA | MLK | 519-715 | 27 | 2.4e-37 | 127.13 | In-house | 1-230 (291) | Show / Hide |
Range on Protein: 519-715 Range on HMM: 1-230/291 Sequence Identity: 27% (66 aa) FDETLLLGVGGFGKVYRGELFDGTK-----VAVKR--GNPRSEQGLTE-----FQTEIEMLSKLRHLH----LVSLIGYCEEH-CEMILVYECMANGTLR ... .|.|.||||..|. . .. ||||| ... . . |. |..|.. |..|.|. . . | | .. |. .| | ...| | IQFHEWIGSGSFGKVWKGR-WRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY AHLYG-SDLPP-----------LSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDE------NFVAKVSDFGLSKTGPSLDRTHVS--TAV |.| .. . . . . .. |||.|||| | . .||||| | |||.|| . ..|..|||.|. .. ... . . NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPK-PIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR---DWHQMC-TNMMSN KGSFGYLDPEYF---RRQQLTEKSDVYSFGVVLFEVL .|.. . || . | .. .||.||.|.|||| |.| AGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML |
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| Kinase | IRAK-14_b-2.AA | Pkinase | 519-719 | 29 | 6.1e-37 | 131.71 | Pfam | 1-210 (293) | Show / Hide |
Range on Protein: 519-719 Range on HMM: 1-210/293 Sequence Identity: 29% (65 aa) FDETLLLGVGGFGKVYRGELFDGTK-VAVKRGNPRSEQGLTEFQT-----EIEMLSKLRHLHLVSLIGYCEEHCEMILVYECMANG----TLRAHLYGSD . .| |.||.||.. . | ||||. . | .. . || ||... .|.| . | |....|.. .. .| |.. .| | ... ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR LPPL--SWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENFVA----KVSDFGLSKTGPSLDRTHVSTAVKGSFGYLDPEYFR-RQQLTEK .. |... .. .||| |.| |||||.| |||.|.| . |..||||.| . . . | . |. .|. || | .| . | HGCFYFSEWECKFYMYQILRGLEYCHS-M---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK SDVYSFGVVLFEVLCARP .|..|.|..|.|.|| || VDMWSCGCILYEMLCGRP |
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| Kinase | IRAK-14_b-2.AA | LRRK | 519-715 | 24 | 6.7e-35 | 120.89 | In-house | 1-276 (351) | Show / Hide |
Range on Protein: 519-715 Range on HMM: 1-276/351 Sequence Identity: 24% (70 aa) FDETLLLGVGGFG-KVYRGELFD---------------------------GTKVAVKRGNPR---------SEQG------------------------- . . ..|.|||| .|||... . ...||.| | . . LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA LTEFQTEIEMLSKLRHLHLVSLIGYCEEHCEMILVYECMANGTLRAHLY---GSDL----PPLSWKQRLEICIGAARGLHYLHTGAEQGT--IIHRDVKT . ||. |. ..|.|.| ..|||.|.| ... |.. | . .|.| .| . . . .|| .|.| . |.|. ||| . ||||| |. FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVM--EYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH----SHNPPIIHRDLKS TNILL---D---------ENFVAKVSDFGLSKTGPSLDRTHVSTAVKGSFGYLDPEYFR---RQQLTEKSDVYSFGVVLFEVL |||| . .. .||..|||.| . ... | . | .|.. || | . . |||.|.||||..|.| | PNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELL |
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| Kinase | IRAK-14_b-2.AA | TyrKc | 519-790 | 25 | 8.1e-35 | 122.91 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 519-790
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)
FDETLLLGVGGFGKVYRGELFDGTKVAVKRGNPRSEQGLTEFQTEIEMLSKL--RHLHLVSLIGYCEEH-------CEMILVYECMANGTLRAHLYGSDL
|| | ||.||.|.. ..|||| .. . . .| |.....|| .| ..| |.|.| .. . .| | |..| |. .| .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP
PPLSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENFVAKVSDFGLSKTGPSL-------DRTHVST--AVK--GSFGYLDPEYFRRQQL
|..|. |..|. .|.| ||| .|||| . |.|..||...|.||||||. . . | .... | . || ..
K-LCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF
TEKSDVYSFGVVLFEV--LCARPAINPAL-PREQVNIAEWAMQYQRMGALEQ---IVDANLKGQCSQESLQKFGETAEKCLAEQGIDRPAMGDVLWNL
|.||||.||||...|. ... | .... . . . |. .| || . . . . .. . ..| .|. ||| . .. .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | IRAK-14_b-2.AA | DRK | 526-715 | 34 | 2.1e-34 | 113.97 | In-house | 8-196 (258) | Show / Hide |
Range on Protein: 526-715 Range on HMM: 8-196/258 Sequence Identity: 34% (68 aa) GVGGFGKVYRGELFDGTKVAVKRGNPRSEQ---GLTEFQTEIEMLSKLRHLHLVSLIGYCEEHCEMILVYECMANGTLRAHLYGSDLPPLSWKQRLEICI | |..| |.|| ||.||||. . | ||. ||.....||| . .| | . . . | | | | | . ..| .. . . GRGNYGEVFRGT-WRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESI-EMDWPLMKQMMF GAARGLHYLHTGAEQGTIIHRDVKTTNILLDENFVAKVSDFGLSKT--GPSLDRTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLFEVL .|.|. ||| ||||| |. | | ||.. ||.||||| | .... |.. | . || | | ||| |||||..|| |.. DCAKGMIYLH--CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLS-TRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV |
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| Kinase | IRAK-14_b-2.AA | RIPK | 525-715 | 31 | 9.9e-34 | 112.31 | In-house | 1-222 (290) | Show / Hide |
Range on Protein: 525-715 Range on HMM: 1-222/290 Sequence Identity: 31% (71 aa) LGVGGFGKVYRGELFD-GTKVAVKR--GNPRS----EQGLTEFQTEIEMLSKLRHLHLVSLIGYCEEH-----CE-MILVYECMANGTLRAHLYGSDL-- .| ||||.|.. . |. ||.| . .. .| .. | ... |||. | |.. | |.. |. . .| | |.|| | .|. . VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSL-WHFLHTKWPY --PPLSWKQRLEICIGAARGLHYLHTGAEQG-TIIHRDVKTTNILLDENFVAKVSDFGLSK-TGPS---LDRT-----HVSTAVK--GSFGYLDPEYFR- .|. |. | . ..| .||| .. ||||| |. |||.| || .|..||||.. . | || .. . | |..|| || QHHPDPWPLRCRMIHEISCGMCYLH---SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRT --RQQ---LTEKSDVYSFGVVLFEVL . |.|.|||||..|..||| DNKKPIKVVTPKYDVYSFAIVMWEVL |
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| Kinase | IRAK-14_b-2.AA | TK-Unique | 519-716 | 24 | 2.6e-30 | 101.76 | In-house | 1-234 (294) | Show / Hide |
Range on Protein: 519-716 Range on HMM: 1-234/294 Sequence Identity: 24% (58 aa) FDETLLLGVGGFGKVYRGELFDGT-------KVAVKRGN-PRSEQGLTEFQTEIEMLSKLR-HLHLVSLIGYCEEHC-EMILVYECMANGTLRAHLYGSD . ..| | || |.|||.. .. .|||| . . ... .| ||.|...| | ..|...|.| . . ...| ...|.|. .| . LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR LP------------------------PLSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENFVAKVSDFGLSK---TGPSLDRTHVSTA- . |.| |. . .... |.|. ||. .. |.|||. . |.|| |..|.|..|||... | .. .... PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKK--IVHRDLCARNVLLTEDKVCKICDFGMARDVYT----NGVYSMMCS -VKGSFGYLDPEYFR--RQQL-TEKSDVYSFGVVLFEVLC . . .. ||... ... |.||||.||||...|... QGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT |
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| Kinase | IRAK-14_b-2.AA | S_TKc | 519-793 | 22 | 4.5e-26 | 93.85 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 519-793 Range on HMM: 1-231/231 Sequence Identity: 22% (65 aa) FDETLLLGVGGFGKVYRGELFD-GTKVAVKRGNPRSEQGLTEFQTEIEMLSKLRHLHLVSLIGYCEEHCEMILVYECMAN--GTLRAHLYGSDLPP---- .. ..| |.|||||.. . | .||.|. . .. ||..|.| .| ..| |...... .. .| |.. . |.|. .. .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP LSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENFVAKVSDFGLSKTGPSLDRTHVSTAVKGSFGYLDPEYFRRQQLTE-KSDVYSFGVV .. . .. ...| |.| .. |||||.| |||||| . |..||||.. | . |. |. || . . . |.|..|.|.. FPE-HARFYMYQICCALEYCH---SH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI LFEVLCARPAINPALPREQVNIAEWAMQYQRMGALEQIVDANLKGQCSQESLQKFGETAEKCLAEQGIDRPAMGDVLW------NLEYA |.| || .| . .| ....| | . .||| .|| ..| . .. LYEMLCGYPPFP-----------QMQMMFKKIG-----------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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