Gene IRAK-14_d-1 (S.moellendorffii)

IRAK-14_d-1

Species: S.moellendorffii
Alias: IRAK-14_d-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-14

Sequence

Name Sequence Type Origin Length Description Download
IRAK-14_d-1.AA Protein None 204 None Fasta, JSON
IRAK-14_d-1.NA RNA None 615 None Fasta, JSON
IRAK-14_d-1.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of IRAK-14_d-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-14_d-1.AA TKL 1-194 20 2.5e-38 133.65 In-house 120-364 (364) Show / Hide 
Range on Protein: 1-194
Range on HMM: 120-364/364
Sequence Identity: 20% (55 aa)

MGGGTLMEHLYGSKSPLDWKARVKIAVGAATALDYLHN-----GSDSK--IIHRDVKSTNILLDSGMN--------------AKVADFGLSKHVTRI-DA
. ||.| ..|        |  |...| ..| ...|||.     .   |  ||||| || |||.|. ..              .|..|||||. ...  . 
CPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNM

THV----------------TTLVKGTVGYLDPEYYASN----------------QLTEKSDVYSFGVVLLELICGREPLSDRVPADQYSIITWARPY---
..                 |  . || ... ||    .                . .||.||||||.|| |......                  ||   
NDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------------------PYYDY

LLSGSY---------NEVVDRNIAGRFS------------IGSMAIFANVAAKSVARDPNERPKMSQVLRDL
  .  .           |.|..                     .  ... . .  . ||..|| ....|  |
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-14_d-1.AA IRAK 1-134 36 5.1e-37 128.76 In-house 85-233 (317) Show / Hide 
Range on Protein: 1-134
Range on HMM: 85-233/317
Sequence Identity: 36% (55 aa)

MGGGTLMEHLYGSK---SP--LDWKARVKIAVGAATALDYLHNGS-DSKIIHRDVKSTNILLDSGMNAKVADFGLSKHV----TRIDATH---VTTLVKG
| .|.|   | . .   .|  | |  |..|. |.| .. .||. .    |||.|.|| |||||  ...| .||||  .      . ..|     | .|.|
MPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRG

TVGYLDPEYYA--SNQLTEKSDVYSFGVVLLELICGREPLSDRVPADQY
|  |. ||.    . ||| |.||||||.||||.. |. .  |..|  .|
TTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYY
Kinase IRAK-14_d-1.AA TKL-Unique 1-119 33 1.2e-32 112.5 In-house 82-222 (290) Show / Hide 
Range on Protein: 1-119
Range on HMM: 82-222/290
Sequence Identity: 33% (48 aa)

MGGGTLMEHLY---------GSKSPLDWKARVKIAVGAATALDYLHNGSDSKIIHRDVKSTNILLDSG-----MNAKVADFGLSKHVTRIDATHVT----
. ||.|...|           ....|... |||.|  .| ...|||. .   ||||| ||.|.|.|..     .|.|..||||||  ..|... ..    
CPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKG

---TLVKGTVGYLDPEYYAS--NQLTEKSDVYSFGVVLLELI
   . ..|.  .. ||   .  .| .|||||||||.|| |..
TRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIA
Kinase IRAK-14_d-1.AA Pkinase 1-137 26 3e-27 97.43 Pfam 82-227 (293) Show / Hide 
Range on Protein: 1-137
Range on HMM: 82-227/293
Sequence Identity: 26% (41 aa)

MGGG----TLMEHLY-GSKSPL--DWKARVKIAVGAATALDYLHNGSDSKIIHRDVKSTNILLDSGMNA----KVADFGLSKHVTRIDATHVTTLVKGTV
..||     |....   .. ..  ...   ...   . .|.|.|.    .|||||.|. |||.|. ..     |..||||.|..  .   . .| . || 
CEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTP

GYLDPEYYA-SNQLTEKSDVYSFGVVLLELICGREPLSDR----VPADQYSII
.|. ||    ..  . |.|..|.|..| |..||| | ...      .||. .|
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMI
Kinase IRAK-14_d-1.AA Dicty4 16-124 38 5.9e-26 83.68 In-house 105-216 (277) Show / Hide 
Range on Protein: 16-124
Range on HMM: 105-216/277
Sequence Identity: 38% (43 aa)

PLDWKARVK---IAVGAATALDYLHNGSDSKIIHRDVKSTNILLDSGMNAKVADFGLSK-HVTRIDATHVTTLVKGTVGYLDPEYYASNQLTEKSDVYSF
.|||  . .   .|  ||  . .|| .... ||||| || |.| |  ...||.|||||.   . .| .  .. ..||...  ||  ...  .||.|||||
KLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSF

GVVLLELICGREP
| || |.  . ||
GIVLWEILTRQEP
Kinase IRAK-14_d-1.AA Dicty5 4-124 32 9.4e-26 85.61 In-house 84-202 (260) Show / Hide 
Range on Protein: 4-124
Range on HMM: 84-202/260
Sequence Identity: 32% (41 aa)

GTLMEHLYGSKS----PLDWKARVKIAVGAATALDYLHNGSDSKIIHRDVKSTNILLDSGMNAKVADFGLSKHVTRIDATHVTTLVKGTVGYLDPEYYAS
|.| . |   .     |. .  .. .|...| .. .||  .   |||||.|| |.|.     .|. ||| |  |    . | |. | ||  .  .| . .
GSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMNFLITENWKIKIIDFGTSRFVDN--RYHMTMHV-GTQCWMACELFNG

NQLTEKSDVYSFGVVLLELICGREP
.  ..| ||||||.|| |..   ||
QPYHQKCDVYSFGIVLWEMFTRKEP
Kinase IRAK-14_d-1.AA Dicty4-Unclassified 23-124 40 1.2e-24 81.31 In-house 112-207 (263) Show / Hide 
Range on Protein: 23-124
Range on HMM: 112-207/263
Sequence Identity: 40% (41 aa)

VKIAVGAATALDYLHNGSDSKIIHRDVKSTNILLDSGMNAKVADFGLSKHVTRIDATHVTTLVKGTVGYLDPEYYASNQLTEKSDVYSFGVVLLELICGR
.|.|   |  . .||      .||||.|| |||.|   |.|.||||.|     || .   | . ||.    ||       . ||||||....| ||. | 
IKYAFDIAQGMQHLHT---RNFIHRDIKSSNILMDKHFNIKIADFGISRV---IDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGD

EP
||
EP
Kinase IRAK-14_d-1.AA MLK 1-124 29 5.2e-24 80.26 In-house 92-235 (291) Show / Hide 
Range on Protein: 1-124
Range on HMM: 92-235/291
Sequence Identity: 29% (43 aa)

MGGGTLMEHLYGSKS-------------PLDWKARVKIAVGAATALDYLHNGSDSKIIHRDVKSTNILLDS------GMNAKVADFGLSKHVTRIDATHV
. || | . |.| .|               |    ...|.  | ...|||.    .||||| || |||.|       ....|..|||.|. ........ 
CEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNM-

TTLVKGTVGYLDPEYY---ASNQLTEKSDVYSFGVVLLELICGREP
 .  .||. .  ||      ... .||.||.|.|||| |.. ...|
-MSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-14_d-1.AA LRRK 4-127 32 1.8e-21 72.71 In-house 140-285 (351) Show / Hide 
Range on Protein: 4-127
Range on HMM: 140-285/351
Sequence Identity: 32% (48 aa)

GTLMEHLYGSK-SP-------LDWKARVKIAVGAATALDYLHNGSDSK--IIHRDVKSTNILL---D---------SGMNAKVADFGLSKHVTRIDATHV
|.| ..|  .| ..       ..|  . |||.  | ...|||.   ..  ||||| || ||||   .           ..||.||||.|  .  .. . |
GDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS---HNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQCFHMGV

TTLVKGTVGYLDPEYYASN---QLTEKSDVYSFGVVLLELICGR-EPLSD
.  . |. |.. ||    |   . |||.|.||||..| ||. ..  |  .
AKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDE
Kinase IRAK-14_d-1.AA LISK 1-71 38 1.2e-20 63.58 In-house 79-153 (296) Show / Hide 
Range on Protein: 1-71
Range on HMM: 79-153/296
Sequence Identity: 38% (30 aa)

MGGGTLMEHLYGSKS---PLDWKARVKIAVGAATALDYLHNGSDSKIIHRDVKSTNILLD----SGMNAKVADFGLSK
..||.| . |  ...   || |. |||||.. | .. |||   . .||||| ||.|.|..    .. ..||.|||. .
INGGDLHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLH---SMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFAR
Kinase IRAK-14_d-1.AA Pkinase_Tyr 1-132 27 1.7e-15 53.11 Pfam 89-223 (270) Show / Hide 
Range on Protein: 1-132
Range on HMM: 89-223/270
Sequence Identity: 27% (38 aa)

MGGGTLMEHLYGS---KSPLDWKARVKIAVGAATALDYLHNGSDSKIIHRDVKSTNILLDSGMNAKVADFGLSKHVTRIDAT-HVTTLVKGTVGYLDPEY
| .| | ..|      | ||. |  .....  | ...||..     .||||.   |.|..... .|..||||.. ..  |   ....  |  .  . || 
MPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC

YASNQLTEKSDVYSFGVVLLELIC-GREP-LSDRVPAD
 . .  |.||||.||||.. |..  |..|   .  ...
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE
Kinase IRAK-14_d-1.AA LISK-DD1 14-69 50 3.5e-15 51.52 In-house 117-173 (290) Show / Hide 
Range on Protein: 14-69
Range on HMM: 117-173/290
Sequence Identity: 50% (30 aa)

KSPLDWKARVKIAVGAATALDYLHNGSDSKIIHRDVKSTNILLDSG----MNAKVADFGL
|.|. || |||||.. | |  |||     .||||| ||.|||.|        .|| |||.
KIPIPWKLRVKIALDIACAMAYLH---SKNIIHRDLKSKNILVDENGDSQWRIKVCDFGF
Kinase IRAK-14_d-1.AA S_TKc 1-200 17 1.3e-09 -35.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-200
Range on HMM: 1-231/231
Sequence Identity: 17% (49 aa)

M--------------------------------------------------------------------GG--GTLMEHLYGSKSP-----LDWKARVKI
                                                                     .|  |.|....   ...     ..     ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

AVGAATALDYLHNGSDSKIIHRDVKSTNILLDSGMNAKVADFGLSKHVTRIDATHVTTLVKGTVGYLDPEYYASNQLTE-KSDVYSFGVVLLELICGREP
.   . ||.|.|   . .|||||.|  |||||.  . |..||||....         | . ||  |. ||     . .  |.|..|.|..| |..||. |
MYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPP

LSDRVPADQYSIITWARPYLLSGSYNEVVDRNIAGRFSIGSMAIFANVAAKSVARDPNERPKMSQVLR---DLKEAQAF
 .   ..  . .|                           |         |   .||..||   ..|.   | |  . |
FP--QMQMMFKKIG--------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-14_d-1.AA TyrKc 2-194 15 9.7e-09 -81.35 SMART 8-280 (280) Show / Hide 
Range on Protein: 2-194
Range on HMM: 8-280/280
Sequence Identity: 15% (46 aa)

GGG-------------------------------TLMEHL--------------YGS---------------------------KSP--LDWKARVKIAV
| |                                .| .|                .                           |.   | .|  .....
GEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCW

GAATALDYLHNGSDSKIIHRDVKSTNILLDSGMNAKVADFGLSKHVTRI-------DATHVTT--LVK--GTVGYLDPEYYASNQLTEKSDVYSFGVVLL
 .|   .|||     ..||||    |.|....  .|..|||||. ..         |  ....    |    .  . ||    .  |.||||.||||.. 
QIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMW

ELI-CGREPLSD-----RVPADQYSIITWARPYLLSGSYNEVVDRNIAGRFSI----GSMAIFANVAAKSVARDPNERPKMSQVLRDL
|.   | .| ..       ...       .. |. .| . .  . .      .     . ...  .  .  ..||..|| .|.. ...
EIFTYGQQPYPGMIQQMMSNQE-------VIEYVKQGYRMPQPPNDY---P-MSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-14_d-1.AA LISK 103-124 45 1.2e-08 24.05 In-house 217-238 (296) Show / Hide 
Range on Protein: 103-124
Range on HMM: 217-238/296
Sequence Identity: 45% (10 aa)

TEKSDVYSFGVVLLELICGREP
.|..||.|||.||.|.|.....
DESCDVFSFGIVLCEIITRVKA
Kinase IRAK-14_d-1.AA LISK-DD1 106-124 63 2.5e-07 22.78 In-house 212-230 (290) Show / Hide 
Range on Protein: 106-124
Range on HMM: 212-230/290
Sequence Identity: 63% (12 aa)

SDVYSFGVVLLELICGREP
.||.|||.||||||... |
CDVFSFGMVLLELITRKKP
Kinase IRAK-14_d-1.AA LRRK 180-196 41 0.001238 8.71 In-house 335-351 (351) Show / Hide 
Range on Protein: 180-196
Range on HMM: 335-351/351
Sequence Identity: 41% (7 aa)

DPNERPKMSQVLRDLKE
||..||..||..  |..
DPKKRPHFSQIVKRLSQ
Kinase IRAK-14_d-1.AA MLK 180-194 40 0.001846 8.02 In-house 277-291 (291) Show / Hide 
Range on Protein: 180-194
Range on HMM: 277-291/291
Sequence Identity: 40% (6 aa)

DPNERPKMSQVLRDL
||..||...|..  |
DPHKRPSFRQIVQHL
Kinase IRAK-14_d-1.AA Pkinase_Tyr 178-194 35 0.035593 7.99 Pfam 254-270 (270) Show / Hide 
Range on Protein: 178-194
Range on HMM: 254-270/270
Sequence Identity: 35% (6 aa)

ARDPNERPKMSQVLRDL
. ||..|| .|.....|
HYDPEDRPTFSEIHEQL
Kinase IRAK-14_d-1.AA Dicty4-Unclassified 180-194 53 0.054236 2.57 In-house 249-263 (263) Show / Hide 
Range on Protein: 180-194
Range on HMM: 249-263/263
Sequence Identity: 53% (8 aa)

DPNERPKMSQVLRDL
||| || | |.   |
DPNKRPTMNQIIQYL
Kinase IRAK-14_d-1.AA Dicty4 180-196 26 0.122133 1.44 In-house 259-277 (277) Show / Hide 
Range on Protein: 180-196
Range on HMM: 259-277/277
Sequence Identity: 26% (5 aa)

DPNERPKMSQVLRD--LKE
||. || .....    | .
DPQHRPSFEEIIQRRILEH
Kinase IRAK-14_d-1.AA TKL-Unique 178-194 29 0.154671 1.41 In-house 274-290 (290) Show / Hide 
Range on Protein: 178-194
Range on HMM: 274-290/290
Sequence Identity: 29% (5 aa)

ARDPNERPKMSQVLRDL
..|| .||  ....  |
HHDPSQRPSFDEIIHRL
Kinase IRAK-14_d-1.AA IRAK 182-194 38 0.203581 0.99 In-house 305-317 (317) Show / Hide 
Range on Protein: 182-194
Range on HMM: 305-317/317
Sequence Identity: 38% (5 aa)

NERPKMSQVLRDL
|.|..| .|.  |
NRRCDMAWVMQQL
Kinase IRAK-14_d-1.AA LISK-DD1 180-194 40 0.303884 0.55 In-house 276-290 (290) Show / Hide 
Range on Protein: 180-194
Range on HMM: 276-290/290
Sequence Identity: 40% (6 aa)

DPNERPKMSQVLRDL
|||.||. . ..  |
DPNNRPSFKEIVQTL