Gene IRAK-Un_bw (S.moellendorffii)

IRAK-Un_bw

Species: S.moellendorffii
Alias: IRAK-Un_bw
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_bw.AA Protein None 446 None Fasta, JSON
IRAK-Un_bw.NA RNA None 1329 None Fasta, JSON
IRAK-Un_bw.kin_dom Protein Kinase Domain None 116 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_bw.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_bw.AA TKL 259-347 30 5e-24 83.41 In-house 123-243 (364) Show / Hide 
Range on Protein: 259-347
Range on HMM: 123-243/364
Sequence Identity: 30% (39 aa)

GSLLRSMKQQALRWERRWRIAADIARGLDYLHG------GCKDQVLHLDIKPQNILLDASFG--------------AKICDFGL*ERVDHEKN-------
||||  .      |..| |.| |||||..|||       . | ...| |.|..|||.|  .               .|||||||  ......|       
GSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTT

-----------SVSTVMRGTPGYMAPE
           . .   .|||..||||
MMESAEHQNNRKTTMTQCGTPRWMAPE
Kinase IRAK-Un_bw.AA Dicty4 272-347 38 5.9e-20 63.39 In-house 108-187 (277) Show / Hide 
Range on Protein: 272-347
Range on HMM: 108-187/277
Sequence Identity: 38% (31 aa)

WERRWR---IAADIARGLDYLHGGCKDQVLHLDIKPQNILLDASFGAKICDFGL*E-RVDHEKNSV-STVMRGTPGYMAPE
|... |   .| |.|||. .||. |   ..|.|.|. |.| |... .|.|||||      || ..   . . |||..||||
WPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPE
Kinase IRAK-Un_bw.AA Pkinase 277-349 42 2.8e-19 69.25 Pfam 112-183 (293) Show / Hide 
Range on Protein: 277-349
Range on HMM: 112-183/293
Sequence Identity: 42% (33 aa)

RIAADIARGLDYLHGGCKDQVLHLDIKPQNILLDASFGA----KICDFGL*ERVDHEKNSVSTVMRGTPGYMAPEWL
...  |.|||.|.|  .   ..| |.||.|||.|         ||||||| . .|. .||  |.  |||.|||||..
FYMYQILRGLEYCHS-M--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVI
Kinase IRAK-Un_bw.AA MLK 277-347 33 2e-17 57.11 In-house 128-203 (291) Show / Hide 
Range on Protein: 277-347
Range on HMM: 128-203/291
Sequence Identity: 33% (26 aa)

RIAADIARGLDYLHGGCKDQVLHLDIKPQNILLDA------SFGAKICDFGL*ERVDHEKNSVSTVMRGTPGYMAPE
..| ..|||..|||   .... | |.|..|||.|.         .||||||.   . . . .  . ..||. .||||
NWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPE
Kinase IRAK-Un_bw.AA STE 277-347 32 2.1e-17 58.14 In-house 155-232 (359) Show / Hide 
Range on Protein: 277-347
Range on HMM: 155-232/359
Sequence Identity: 32% (28 aa)

RIAADIARG-LDYLHGGCKDQVLHLDIKPQNILLDASFGAKICDFGL*ERVDHE--------------KNS-VSTVMRGTPGYMAPE
.|. .| .| |.|||      . | ||||.||||     .|.||||.  .....               ..  .. . ||| .||||
YICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase IRAK-Un_bw.AA CAMK 297-349 26 3.2e-17 51.37 In-house 200-292 (425) Show / Hide 
Range on Protein: 297-349
Range on HMM: 200-292/425
Sequence Identity: 26% (25 aa)

VLHLDIKPQNILLDASF----------------G-AKICDFGL*ERVDHEKNSV----------------------STVMRGTPGYMA-PEWL
. |.|.|| ||||| ..                .  ||.|||.  ..|. .|.                        . . |||.||| ||.|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVL
Kinase IRAK-Un_bw.AA TKL-Unique 272-349 31 3.4e-16 53.78 In-house 109-198 (290) Show / Hide 
Range on Protein: 272-349
Range on HMM: 109-198/290
Sequence Identity: 31% (29 aa)

WERRWRIAADIARGLDYLHGGCKDQVLHLDIKPQNILLDAS-----FGAKICDFGL*ERVDHE-KNSVS-------TVMRGTPGYMAPEWL
...| ..| |||.|..|||   .  ..|.|.|..|.|.|       . .|||||||    . . |....       ..  |.. .|||| |
MQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL
Kinase IRAK-Un_bw.AA CAMKK 281-357 28 7.5e-16 46.37 In-house 184-290 (396) Show / Hide 
Range on Protein: 281-357
Range on HMM: 184-290/396
Sequence Identity: 28% (31 aa)

DIARGLDYLHGGCK-----------------DQVLHLDIKPQNILLDASFG----AKICDFGL*ERVDHEKNSVSTV----------MRGTPGYMAPEWL
|.. ||.|||   |                 . . | ||||||||.| . |    .||.|||    ..... ..|             .||| .|||| .
DCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILID-EEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELC

HSGVGGFG
. . ....
SKENQKEN
Kinase IRAK-Un_bw.AA TKL-Sp1 270-349 35 1.9e-15 44.36 In-house 95-175 (263) Show / Hide 
Range on Protein: 270-349
Range on HMM: 95-175/263
Sequence Identity: 35% (30 aa)

LRWERRWRIAADIARGLDYLHGGCKDQVLHLDIKPQNILLD-ASFGAKICDFGL*ERVDHEKNSVST---VMRGTPGYMAPEWL
| |... .|  ..   . ..| .|.  .||||||| |.. . |.  . ||| ||         | ||    ||||| .|.|| .
LDWAKKMQISCEVLQAVTFMH-ACN--ILHLDIKPANVMVERATRRPYICDLGLAHIKNRNHMSQSTSMVNMRGTPCHMPPEMV
Kinase IRAK-Un_bw.AA IRAK 268-352 36 2e-15 51.25 In-house 104-199 (317) Show / Hide 
Range on Protein: 268-352
Range on HMM: 104-199/317
Sequence Identity: 36% (35 aa)

QALRWERRWRIAADIARGLDYLHGGC-KDQVLHLDIKPQNILLDASFGAKICDFGL*ERV----DHEKNSV----STVMRGTPGYMAPEWLH--SG
..| | .|  |.  .|.|. .||    .  . | |||. |||||. | .|||||||        . || ..      . |||  ||.|| .   .|
KPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG
Kinase IRAK-Un_bw.AA Fused 277-347 47 6.4e-15 47.48 In-house 101-167 (251) Show / Hide 
Range on Protein: 277-347
Range on HMM: 101-167/251
Sequence Identity: 47% (34 aa)

RIAADIARGLDYLHGGCKDQVLHLDIKPQNILLDASFGAKICDFGL*ERVDHEKNSVSTVMRGTPGYMAPE
|||.     | |||      .|| |.||||||||   ..| ||||.  |       | |  .||| |||||
RIACHLVSALYYLHS---HRILHRDMKPQNILLDKNMHIKLCDFGFA-RNMSINTHVLTSIKGTPLYMAPE
S_TKc IRAK-Un_bw.AA S_TKc 179-445 19 1.8e-11 -8.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 179-445
Range on HMM: 1-231/231
Sequence Identity: 19% (58 aa)

YFKLKEL-------CEIASNIERKLDEDLALFSRELSKVVVKRLEAARQGLKQFM*RTIGSVRHQNLVKLQGYGAHGQHYYRV--CGIS--GSLLRSMKQ
| .|...       .  . ...               .| .|..       .    . | . .| |.||| ..  . .|.| |  .     |.|.. .|.
YEILRKIGKGAFGKVYKCRHKK------------TGRIVAIKIIK-----EHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

QA-------LRWERRWRIAADIARGLDYLHGGCKDQVLHLDIKPQNILLDASFGAKICDFGL*ERVDHEKNSVSTVMRGTPGYMAPEWLHSGVGGFG*--
.        .   . ..... |...|.|.|   . ...| |.||.|||||     |||||||  ..        | . ||| ||||| |     |.|   
RGRHGLRFPFPE-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-----GYGKCK

---------LLELVSGRKVVALPSSAVITSPGEDGLIMSSCWEQKRLSGVTCCSITLIEEDLSEQRAKEM*LLCACHEQLQRPSIGGALK-----MLEEV
         | |...|.               .. ...  .                       . ||..   | . .  .||..  ||.     .. . 
CDWWSCGCILYEMLCGYPPFP-----------QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

A
 
F
TyrKc IRAK-Un_bw.AA TyrKc 190-405 18 4.3e-09 -75.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 190-405
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

SNIERKLDE------DLALFSRELSKVVVKRLEAARQGLKQFM--*RTIGSV--RHQNLVKLQGYGAHG-------QHYYRV----CGISGSLLRSMKQQ
   ..|| |       ..  .    .| || | .    .. ||   |   ..  .|.|.|.| |.  ..       . .. |    ..  |.|.   .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLKDYLRKH

A--LRWERRWRIAADIARGLDYLHGGCKDQVLHLDIKPQNILLDASFGAKICDFGL*ERVDHE----KNSVSTVMR---GTPG-----YMAPEWLHSG--
   | ..    .. .||.| .|||     .. | |.   |.|... . .||.||||   ....     ..   ...   |. .      |||| .  |  
RPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

-----VGGFG*LL-----------EL-----VSGRKVVALPSSA-----VIT--------SPGEDGLIMSSCWEQ---KRLSGVTCCSIT
     |  || ..           .      .| . |...  .                  | |   ||..||.    .| .  ..... 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF