Gene IRAK-Un_k-1 (S.moellendorffii)

IRAK-Un_k-1

Species: S.moellendorffii
Alias: IRAK-Un_k-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_k-1.AA Protein None 646 None Fasta, JSON
IRAK-Un_k-1.NA RNA None 1941 None Fasta, JSON
IRAK-Un_k-1.kin_dom Protein Kinase Domain None 194 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_k-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LysM IRAK-Un_k-1.AA LysM 56-82 28 0.001283 16.01 Pfam 18-45 (45) Show / Hide 
Range on Protein: 56-82
Range on HMM: 18-45/45
Sequence Identity: 28% (8 aa)

VNFAQLQQYN-DLRSQDFVQAGQFVKIP
.. .|....|  |.|.. ...||  .||
TTVQQIMEWNPNLKSPNHIYPGQKLCIP
LysM IRAK-Un_k-1.AA LysM 165-206 38 9e-06 23.41 Pfam 4-45 (45) Show / Hide 
Range on Protein: 165-206
Range on HMM: 4-45/45
Sequence Identity: 38% (16 aa)

QRGDLVRDVATRFNTTVQNLTNYNPSLGNINSLSPDDRLFIP
..||   . | |..||||.. ..|| | . | . | ..| ||
KKGDTLWKIAQRYGTTVQQIMEWNPNLKSPNHIYPGQKLCIP
SKG6 IRAK-Un_k-1.AA SKG6 222-260 20 4.5e-05 21.09 Pfam 1-40 (40) Show / Hide 
Range on Protein: 222-260
Range on HMM: 1-40/40
Sequence Identity: 20% (8 aa)

DGSGSSNTGLIA-GVAVGVGVVVLAAAVSLVWFFMRRSKK
. ......   | ...|...|.|..... .. |. .|.||
KPTDKHWKTTVAIACGVVIPVGVIILVLICFLFCWWRRKK
Kinase IRAK-Un_k-1.AA TKL 341-617 22 1.3e-67 230.96 In-house 1-364 (364) Show / Hide 
Range on Protein: 341-617
Range on HMM: 1-364/364
Sequence Identity: 22% (88 aa)

IGEGGYGAVYYGEIRD----------QKLAIKKMNMQ------------------------------ATREFMSELKVLTHVHHTNLVQLIGYCTVDS--
||.||.| || |. |           .  |.||....                              .  ..  |....   .| |.||..|||.  .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LFLVYEYVDNGTLSHHLRGSAPSRLTWNQRIQIALDAARGLEYIHEHT-----KPTYIHRDVKSPNILIDKRLR--------------
            |..|.||...|.| |.|         |.||...|||.|||..| | ..     ||  |||| ||.|||.|. ..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKVADFGLTK-LTESG--------------AGSVSLTQPTRLVGTFGYMPPEYAR----------------FGDVSPKIDVYSFGVVLYEIISAKDAIVR
.|..|||| . ...||              .  .. ..  . .||...|.||  |                ... |.|.||||||.||.||.. .     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----

TVEGDDSNPDPTQRVAKGLVMMFDTALKSPDA---------TENLKKLVDPALGTD-------YPFDSIWK-LAKLAEACTQETPENRPNMRAVVVAL
                      ..    .|             . .|   | . .        .| ..... ..||.. | .. ||.||..  ..  |
---------------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-Un_k-1.AA IRAK 335-529 34 1.9e-57 197.2 In-house 1-219 (317) Show / Hide 
Range on Protein: 335-529
Range on HMM: 1-219/317
Sequence Identity: 34% (75 aa)

FSISKKIGEGGYGAVYYGEIRDQK--LAIK---KMNM----QATREFMS---ELKVLTHVHHTNLVQLIGYCTVDSLF-LVYEYVDNGTLSHHLRGSAP-
|. . .|||||.| || |... .    |.|   .|..    .  ..| .   ||||..  .| |.| | ||||  . . |||.|  ||.|   |.. .. 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-SR--LTWNQRIQIALDAARGLEYIHEHT-KPTYIHRDVKSPNILIDKRLRAKVADFGLTKLT----ESGAGSVSLTQPTRLVGTFGYMPPEYAR--FGD
 .   |.| ||. |.. .|.|... |.   .   ||.|.|| ||| |... .| .||||        .. .....     ...||  |||||. |  .| 
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

VSPKIDVYSFGVVLYEIIS
 ..| ||||||.|| |...
LTKKTDVYSFGIVLLEVLT
Kinase IRAK-Un_k-1.AA TKL-Unique 337-531 33 4.5e-51 176.0 In-house 1-225 (290) Show / Hide 
Range on Protein: 337-531
Range on HMM: 1-225/290
Sequence Identity: 33% (76 aa)

ISKKIGEGGYGAVYYGEIRDQKLAIKKMNM------QATREFMSELKVLTHVH-HTNLVQLIGYCT---VDSL--FLVYEYVDNGTLSHHLRG-------
...||||||||.|| |. |  . |||. .       . ..|| .|....   | | |.|...|||.   |.    ..| ||.. |.|  .|         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-SAPSRLTWNQRIQIALDAARGLEYIHEHTKPTYIHRDVKSPNILIDKR-----LRAKVADFGLTKLTESGAGSVSLTQ----PTRLVGTFGYMPPEYAR
 .  . |...||...|.|.|.|..|.|   .|  |||| ||.|.|.| .     ...|..|||| |.  .   . . .      .  .|.| .|.||  |
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

F--GDVSPKIDVYSFGVVLYEIISAK
    . | |.||||||.||.||.. |
MNFCQYSEKSDVYSFGIVLWEIATRK
Kinase IRAK-Un_k-1.AA MLK 335-529 27 2.5e-44 151.7 In-house 1-231 (291) Show / Hide 
Range on Protein: 335-529
Range on HMM: 1-231/291
Sequence Identity: 27% (65 aa)

FSISKKIGEGGYGAVYYGEIRDQK-----LAIKKMNMQA---------TREFMSELKVLTHVHHTN----LVQLIGYCTVD-S-LFLVYEYVDNGTLSHH
. ....||.|..|.|. |. | .      .|.|. .  .          ..|  | . | .. | |     .|. | |. . . ...| ||...| |.. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LRG--SAPS----------RLTWNQRIQIALDAARGLEYIHEHTKPTYIHRDVKSPNILID------KRLRAKVADFGLTKLTESGAGSVSLTQP----T
|.|  | ..          . .  . ...||. |||..| |.. ....|||| ||.|||||      . . .|..|||.         | ...|     .
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGT---------SRDWHQMCTNMM

RLVGTFGYMPPEY---ARFGDVSPKIDVYSFGVVLYEIIS
   ||. .| ||    .| . .| | ||.|.||||.|...
SNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLT
Kinase IRAK-Un_k-1.AA TK 335-529 17 4.1e-43 141.88 In-house 1-389 (486) Show / Hide 
Range on Protein: 335-529
Range on HMM: 1-389/486
Sequence Identity: 17% (67 aa)

FSISKKIGEGGYG---AVYYGEIRD---------------------------QKLAIKKMN----MQATREFM----------------SELKVLTH--V
  . ||.||| .|    || || |.                           .. |.| .     |.....|.                .|.|.. |   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHTNLVQLIGYCTVDS-------------LFLVYEYVDNGT----LSHHLRGSAP---------------------------------------------
|| |.|.|.|.|| .              . .| ||...|     | ..|| . |                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------SRLTWNQRIQIALDAARGLEYIHEH----TKPTYIHRDVKSPNILIDKRLR-----------AKVADFG--
                             ..||  |.. .....|.|.||.|..      . ..|||.   |.|......           .|.||||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LTKLTESGAGSVSLTQPTRLVGTFG----------------------YMPPEYAR---------FGDVSPKIDVYSFGVVLYEIIS
      |..  .|.   .. ..... ..                         .|.||  .         .|  ..| ||.||||...|| .
RQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-Un_k-1.AA LRRK 335-529 27 9.8e-42 144.98 In-house 1-277 (351) Show / Hide 
Range on Protein: 335-529
Range on HMM: 1-277/351
Sequence Identity: 27% (78 aa)

FSISKKIGEGGYG-AVYYGEIRD----------------------------QKLAIKKMNM-------------------------------------QA
. | ..||.||.|  || .. |.                            |. ||||.|.                                      |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

TREFMSELKVLTHVHHTNLVQLIGYCTVDSLFLVYEYVDNGTLSHHLRGSAPSR-------LTWNQRIQIALDAARGLEYIHEHTKPTYIHRDVKSPNIL
 |||  |. .. | .| |.|.|.|.|  . | .| ||...|.|.|.|. .. ..       ..|. ...|||. |.|.|| | |. |  |||| ||||||
FREFRHEVWIMSHLNHPNIVSLKGFCI-HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHN-PPIIHRDLKSPNIL

I---D---------KRLRAKVADFGLTK----LTESGAGSVSLTQPTRLVGTFGYMPPEYARFG---DVSPKIDVYSFGVVLYEIIS
.   .             ||.||||..     .....|         ..||..|.| ||  |..     . |.|.||||..|.|...
LWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAK--------GCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLT
Kinase IRAK-Un_k-1.AA Pkinase 335-617 21 5.1e-41 146.13 Pfam 1-293 (293) Show / Hide 
Range on Protein: 335-617
Range on HMM: 1-293/293
Sequence Identity: 21% (70 aa)

FSISKKIGEGGYGAVYYGEIRDQK--LAIKKMNMQATREFM-------SELKVLTHVHHTNLVQLIGYC-TVDSLFLVYEYVDNG----TLSHHLRGSAP
. | .|||.|..| || .  ..     |.|... . ... .       ||.... ...| | |.|.... . |.. .| ||...|     |........ 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

SRL--TWNQRIQIALDAARGLEYIHEHTKPTYIHRDVKSPNILIDKRLRA----KVADFGLTKLTESGAGSVSLTQPTRLVGTFGYMPPEYAR-FGDVSP
 ..  .... . ...  .|||||.|..     ||||.|. |||||..       |..|||| |. .      . . .| ..|| .||.||  |   . .|
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KIDVYSFGVVLYEIISAKDAIVRTVEGDDSNPDPTQRVAKGLVMMFDTALKSPDATENLKKLVDPALGTDYPFDSIWK----------------------
|.|..|.|..||| .. .                           |. .   .|   . .....  .|....||. |.                      
KVDMWSCGCILYEMLCGR-------------------------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSE

-LAKLAEACTQETPENRPNMRAVVVA--L
 . .. . | .  |. ||. . ..    .
ECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase IRAK-Un_k-1.AA TyrKc 335-617 23 6.1e-40 139.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 335-617
Range on HMM: 1-280/280
Sequence Identity: 23% (72 aa)

FSISKKIGEGGYGAVYYGEIRDQKLAIKKMNMQATREFMSELKVLTHV--HHTNLVQLIGYCTV--------DSLFLVYEYVDNGTLSHHLRGSAPSRLT
 .  ||.||| .| || |. . .. |.|...  | ..||.|.......  || |.|.|.|.||         . |..| ||...| | ..|| . |  |.
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-LC

WNQRIQIALDAARGLEYIHEHTKPTYIHRDVKSPNILIDKRLRAKVADFGLTKLTESG------AGSVSLTQ--PTRLVGTFGYMPPEYARFGDVSPKID
. . .......|.| ||.|..    .||||    |.|.......|..||||..  ...          . ..   .. .     |.||  ..|  ..| |
MKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VYSFGVVLYEIISAKDAIVRTVEGDDSNPD-----PTQRVAKGLVMMFDTALKSPD----ATENLKKLVDPALGTDYPFDSIWKLAKLAEACTQETPENR
|.||||...|| .          |.   |.      . . .  .|.  .   . |.    .               ..  .  .. .. . | .| ||.|
VWSFGVCMWEIFT---------YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------FVCCPD-EMYQIMKQCWHEDPEDR

PNMRAVVVAL
|......  .
PTFSEIHECF
Kinase IRAK-Un_k-1.AA Pkinase_Tyr 335-478 30 2.1e-39 134.1 Pfam 1-160 (270) Show / Hide 
Range on Protein: 335-478
Range on HMM: 1-160/270
Sequence Identity: 30% (50 aa)

FSISKKIGEGGYGAVYYGEIR------DQKLAIKKMNMQATRE------FMSELKVLTHV-HHTNLVQLIGYCT-V-DS--LFLVYEYVDNGTLSHHLRG
 .. ||.||| .| || |. .      ... |.|... .|. |      ||.|.|....  || |.|.|.| ||   ..  ...| ||. .| | ..|| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S--APSRLTWNQRIQIALDAARGLEYIHEHTKPTYIHRDVKSPNILIDKRLRAKVADFGLTKL
    . .||  . .|.... |.|.|| ...    .||||.   |.|... . .|..||||...
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARD
Kinase IRAK-Un_k-1.AA S_TKc 335-619 23 1.1e-36 129.05 SMART 1-231 (231) Show / Hide 
Range on Protein: 335-619
Range on HMM: 1-231/231
Sequence Identity: 23% (70 aa)

FSISKKIGEGGYGAVYYGEIRD--QKLAIKKMNMQATREFMSELKVLTHVHHTNLVQLIGYCTVDSLFLVYEYVDN--GTLSHHLRGSAP----SRLTWN
. | .|||.|..| || .  ..  .. |||...    . ...|...| . || |.|.|....  |.|..| ||.|.  |.| ....   .    ....  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

QRIQIALDAARGLEYIHEHTKPTYIHRDVKSPNILIDKRLRAKVADFGLTKLTESGAGSVSLTQPTRLVGTFGYMPPEYARFGDVSP-KIDVYSFGVVLY
.   ..   ...|||.|.| .   ||||.|  |||.|.  . |..|||| ..             | ..||  ||.||       .. |.|..|.|..||
HARFYMYQICCALEYCHSH-G--IIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EIISAKDAIVRTVEGDDSNPDPTQRVAKGLVMMFDTALKSPDATENLKKLVDPALGTDYPFDSIWKLAK-LAEACTQETPENRPNMRAVVV-------AL
| ..      .                  . |||.  .                           . || . . | |  ||.||    .           
EMLC-GYPPFP-----------------QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

MT
  
WF
Kinase IRAK-Un_k-1.AA Ciliate-E2 335-529 19 1.2e-35 119.87 In-house 1-291 (365) Show / Hide 
Range on Protein: 335-529
Range on HMM: 1-291/365
Sequence Identity: 19% (57 aa)

FSISKKIGEGGYGAVYYG-EIRDQK------------------------LAIKKMNMQATREFMSELKVLTHVH----------------HTNLVQLIGY
. . ||||.|..| ||..  ...||                         |.| |. .  .....|....  ..                | |..... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

C---TVDSLFLVYEYVDNGTLSHHLRGS----------APSRLTWNQRIQIALDAAR---------------GLEYIHEHTKPTYIHRDVKSPNILIDKR
    . ....|| ||.. |.| .... .          .  ..|......|    ..               .|||.|.  .   |||| |  |||.   
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF---

LRAKVADFGL------------------TKLTESGAGSVSLT---------QPTRLVGTFGYMPPEYARFGD---------VSPKIDVYSFGVVLYEIIS
   |..||||                   ..  ..  |.. .         .  ...|| |||.||  . ..          . |.|..|.||.||| ..
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF
Kinase IRAK-Un_k-1.AA TK-Unique 335-529 24 1.4e-35 120.21 In-house 1-234 (294) Show / Hide 
Range on Protein: 335-529
Range on HMM: 1-234/294
Sequence Identity: 24% (58 aa)

FSISKKIGEGGYGAVYYGEIR--------DQKLAIKKMNMQATRE----FMSELKVLTHVH-HTNLVQLIGYCT-VD-SLFLVYEYVDNGTLSHHLRGSA
. . ..|||| .| |. ||..        ... |.|. .  || .    |..|.... ..  | |.||..|.||  | . ....||. .|.| |.|| ..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

P------------------------SRLTWNQRIQIALDAARGLEYIHE--HTKPTYIHRDVKSPNILIDKRLRAKVADFGLTKLTESGAGSVSLTQPTR
|                        . ..  . ...| . |.|.||...  .     .|||. . |.|.  ....|..|||... .. .   .. ..  |
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI---VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

LVGTFGYMPPEYAR--FGDV-SPKIDVYSFGVVLYEIIS
.     .|.||. .   |   ..| ||.||||...|| .
IP--IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAK-Un_k-1.AA STE 335-531 21 1.5e-35 123.04 In-house 1-265 (359) Show / Hide 
Range on Protein: 335-531
Range on HMM: 1-265/359
Sequence Identity: 21% (60 aa)

FSISKKIGEGGYGAVYYGEIRDQK-----------------LAIKKMNMQATR--------------------EFMSELKVLTHVH--HTNLVQLIGYCT
. . .|||.|..| ||..  ...                   |||.||..  .                    ... |.|.. . .  | | |. .|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VD--------SLFLVYEYVDNGTLSHHLRG--SAPSRLT----------WNQRIQIALDAARG-LEYIHEHTKPTYIHRDVKSPNILIDKRLRAKVADFG
..        .|... ||.|.|.|.  ..   . . .|.           .| . |. .  .| |.|.|.|    .||||.|. |||.     .| .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LTK-LTESGAGSVSLT------------QPTRLVGTFGYMPPEYAR------FGDVSPKIDVYSFGVVLYEIISAK
. . ||.|.|.. . .            . . .|||  .| ||  .       .. . | |..|.| .. | .  |
VCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-Un_k-1.AA Fer 335-529 27 3e-32 107.18 In-house 1-213 (283) Show / Hide 
Range on Protein: 335-529
Range on HMM: 1-213/283
Sequence Identity: 27% (62 aa)

FSISKKIGEGGYGAVYYGE-----IRD-------QKLAIKKMNMQ-ATRE----FMSELKVLTH-VHHTNLVQLIGYCTVDS-LFLVYEYVDNGTLSHHL
. . ||.||| .| || |.     ...        . . ||...  ||.|    || | ...     | | |...|.|. .  . .| |....| |  .|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RGSAPSR-LTWNQRIQIALDAARGLEYIHEHTKPTYIHRDVKSPNILIDK-RLRAK--VADFGLTKLTESGAGSVSLT-----QPTRLVGTFGYMPPEYA
.   ... .. |..|.....||.|.||.|..     ||||. . |.|..|  .  |  ..|||. . .. .  . ..       |.|      ...||  
K-KNKNKTVSDNEKIRMCYQAACGMEYLHSKN---CIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIR------WLAPETW

RFGDVSPKIDVYSFGVVLYEIIS
..|  ||| ||.||||...|| .
QTGIYSPKTDVWSFGVMCWEIFT
Kinase IRAK-Un_k-1.AA Fer 590-618 26 0.000832 8.97 In-house 254-283 (283) Show / Hide 
Range on Protein: 590-618
Range on HMM: 254-283/283
Sequence Identity: 26% (8 aa)

WKLAKLAE-ACTQETPENRPNMRAVVVALM
. .... .  | |. ||.||.|  ..  | 
PEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase IRAK-Un_k-1.AA TK 595-617 30 0.0012 7.25 In-house 464-486 (486) Show / Hide 
Range on Protein: 595-617
Range on HMM: 464-486/486
Sequence Identity: 30% (7 aa)

LAEACTQETPENRPNMRAVVVAL
|   | .. || ||...... .|
LMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-Un_k-1.AA Pkinase_Tyr 501-529 44 0.001887 12.31 Pfam 181-209 (270) Show / Hide 
Range on Protein: 501-529
Range on HMM: 181-209/270
Sequence Identity: 44% (13 aa)

MPPEYARFGDVSPKIDVYSFGVVLYEIIS
|.||  ..|  . | ||.||||...||..
MAPECINYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-Un_k-1.AA MLK 592-617 34 0.002146 7.79 In-house 266-291 (291) Show / Hide 
Range on Protein: 592-617
Range on HMM: 266-291/291
Sequence Identity: 34% (9 aa)

LAKLAEACTQETPENRPNMRAVVVAL
..|| . | .. |..||..| .|  |
WKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase IRAK-Un_k-1.AA TK-Unique 599-617 42 0.031321 3.64 In-house 276-294 (294) Show / Hide 
Range on Protein: 599-617
Range on HMM: 276-294/294
Sequence Identity: 42% (8 aa)

CTQETPENRPNMRAVVVAL
|.|. || ||. |...  |
CWQWEPEERPSFRQIKHRL
Kinase IRAK-Un_k-1.AA Pkinase_Tyr 601-617 29 0.769065 3.47 Pfam 254-270 (270) Show / Hide 
Range on Protein: 601-617
Range on HMM: 254-270/270
Sequence Identity: 29% (5 aa)

QETPENRPNMRAVVVAL
.. ||.|| .....  |
HYDPEDRPTFSEIHEQL