Gene IRAKg_s (S.moellendorffii)

IRAKg_s

Species: S.moellendorffii
Alias: IRAKg_s
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_s.AA Protein None 206 None Fasta, JSON
IRAKg_s.NA RNA None 621 None Fasta, JSON
IRAKg_s.kin_dom Protein Kinase Domain None 142 None Fasta, JSON

Protein domain

Protein domains of IRAKg_s.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKg_s.AA IRAK 3-145 38 6.7e-31 106.82 In-house 56-220 (317) Show / Hide 
Range on Protein: 3-145
Range on HMM: 56-220/317
Sequence Identity: 38% (63 aa)

TLGRVHHVNLVKLLGYCAEGSHRLLVYEFLSNGSLD-----QDLSTKL-----VCRFSIALGVAKRITYLH-KE-CYDCILRDIKPQNILLHENFCPKVS
.. | .| |.| |.|||.|..   |||....||||      || .. .       |.||..| |. | .|| .. |   | .|||. |||| ..| || .
VCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKIC

DFGLAKLI----DKERALD----VTTIRGTRGYMAPEWVG--DRPITSKVDVYIYGMVLLELLSG
||||.       .||..      . ..|||  ||.||      . .| |.|||  | ||||.|.|
DFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTG
Kinase IRAKg_s.AA TKL 4-145 23 1.4e-30 107.31 In-house 79-285 (364) Show / Hide 
Range on Protein: 4-145
Range on HMM: 79-285/364
Sequence Identity: 23% (50 aa)

LGRVHHVNLVKLLGYCAEGSH-------------RLLVYEFLSNGSLDQDLSTKLVCRFSIALGVAKRITYLHKECY------DCILRDIKPQNILLHEN
. | .| |.|...||| ....               .|.|. ..|||  .|   .  |...||..|. . ||| .          | ||.|..|||..||
MSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDEN

FC--------------PKVSDFGLAKLIDKE------------------RALDVTTIRGTRGYMAPEWVGDR----------------PITSKVDVYIYG
.               .|..||||.. ....                  ..    |..|| ..||||   .                 . . |.||| .|
WTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG

MVLLELLSG
.|| |.|..
IVLWEILTR
Kinase IRAKg_s.AA Pkinase 4-146 28 5.9e-30 106.99 Pfam 54-209 (293) Show / Hide 
Range on Protein: 4-146
Range on HMM: 54-209/293
Sequence Identity: 28% (46 aa)

LGRVHHVNLVKLLGYCAEGSHRLLVYEFLSNG----SLD------QDLST--KLVCRFSIALGVAKRITYLHKECYDCILRDIKPQNILLHENFCP----
. |..| | |.|.... ...|  .| |.. .|    .|       .. .         .... ... . |.|..   .| ||.||.|||...|  .    
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACV

KVSDFGLAKLIDKERALDVTTIRGTRGYMAPEWVG-DRPITSKVDVYIYGMVLLELLSGN
|..||||||..|  .    ||. ||..|||||..  ......|||.. .| .| |.|.|.
KICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAKg_s.AA Dicty4-Unclassified 1-146 35 2.7e-23 76.59 In-house 49-205 (263) Show / Hide 
Range on Protein: 1-146
Range on HMM: 49-205/263
Sequence Identity: 35% (57 aa)

VTTLGRVHHVNLVKLLGYCAEG-SHR---LLVYEFLSNGSL----D-----QDLSTKLVC--RFSIALGVAKRITYLHKECYDCILRDIKPQNILLHENF
|  || . | ||||. |||    ||.     | ||.  | |    .     |. . ||       .|. .|. . .||    . | ||||  |||.  .|
VEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLH--TRNFIHRDIKSSNILMDKHF

CPKVSDFGLAKLIDKERALDVTTIRGTRGYMAPEWVGDRPITSKVDVYIYGMVLLELLSGN
  |. |||..  ||    .  ||| ||    .||       ..| ||| |.|.| ||. |.
NIKIADFGISRVIDFNFNM--TTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGD
Kinase IRAKg_s.AA Ciliate-E2b 57-145 35 3.7e-20 58.11 In-house 113-206 (272) Show / Hide 
Range on Protein: 57-145
Range on HMM: 113-206/272
Sequence Identity: 35% (34 aa)

KRITYLHKECYDCILRDIKPQNILLHENFCPKVSDFGLAKLIDKERALD--VTTIRGTRGYMAPEWVG-----DRPITSKVDVYIYGMVLLELLSG
. . |||      | ||||| ||.....  .|  |.|.||...|.  .    .||.||  ||||| .       .. | |||..  | .| |...|
LCLEYLH--NQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCG
Kinase IRAKg_s.AA Dicty4 11-143 30 4.5e-20 63.81 In-house 59-211 (277) Show / Hide 
Range on Protein: 11-143
Range on HMM: 59-211/277
Sequence Identity: 30% (46 aa)

NLVKLLGYCA----EGSHRLLVYEFLSNGSL-----D------QDLSTK--LVCR-FSIALGVAKRITYLHKECYDCILRDIKPQNILLHENFCPKVSDF
|.....|.|     . .  . | |... |.|     |      |  .    |. |   .|. .|. ...||    . | ||.|. |.|  .|.  ||.||
NICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDF

GLAKLIDKERALDV--TTIRGTRGYMAPEWVGDRPITSKVDVYIYGMVLLELL
||.... |.  .    .|  || ..||||    .| ..|.||| .|.|| |.|
GLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEIL
Kinase IRAKg_s.AA TKL-Unique 1-145 26 7.6e-20 66.8 In-house 46-224 (290) Show / Hide 
Range on Protein: 1-145
Range on HMM: 46-224/290
Sequence Identity: 26% (47 aa)

VTTLGRVH-HVNLVKLLGYCA----EGSHRLLVYEFLSNGSLDQDLST--------KLVCRFS------IALGVAKRITYLHKECYDCILRDIKPQNILL
|... . | | |.|.. |||.      ... .| |... |||.  |..        .  | ..      .|. .|.   ||| .    | ||.|..|.|.
VNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLV

HEN-----FCPKVSDFGLAKLIDKERALDVTTI--------RGTRGYMAPEWVGD--RPITSKVDVYIYGMVLLELLSG
 .|     .  |..||||.|. .|. .  ....         |.  .||||   .    .. |.||| .|.|| |....
DNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKg_s.AA MLK 4-145 25 1.2e-17 57.92 In-house 59-232 (291) Show / Hide 
Range on Protein: 4-145
Range on HMM: 59-232/291
Sequence Identity: 25% (44 aa)

LGRVHHVN----LVKLLGYCAE-GSHRLLVYEFLSNGSLDQDLSTK------------------LVCRFSIALGVAKRITYLHKECYD-CILRDIKPQNI
| .. | |     ....| |.. ..| ..| |....|||   | ..                  .   ...|| .|. . |||..  .  | ||.|..||
LRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNI

LLHE------NFCPKVSDFGLAKLIDKERALDVTTIRGTRGYMAPEWV---GDRPITSKVDVYIYGMVLLELLSG
|..|      .   |..|||... . .      .  .||  .||||        . . |.||. .|.|| |.|..
LIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAKg_s.AA ULK 72-145 31 2.5e-17 57.11 In-house 154-252 (329) Show / Hide 
Range on Protein: 72-145
Range on HMM: 154-252/329
Sequence Identity: 31% (31 aa)

RDIKPQNILLHENF------------CPKVSDFGLAKLIDKE---RALDVTTI-----RGTRGYMAPEWVGDR----PIT-SKVDVYIYGMVLLELLSG
|||||||||.|...            . |..|||.|| .|..    .. .|.      .||  ||||. . ..    | . .|.|..  |... |.| |
RDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG
Kinase IRAKg_s.AA STE 8-146 24 4.6e-17 56.88 In-house 87-265 (359) Show / Hide 
Range on Protein: 8-146
Range on HMM: 87-265/359
Sequence Identity: 24% (46 aa)

H-HVNLVKLLGYCAEG-------SHRLLVYEFLSNGSLDQDLSTKLVCRFS------------------IALGVAKR-ITYLHKECYDCILRDIKPQNIL
| | | || .|..  .       ..  .. |....||||. . .|  | ..                  |.  . |    |||.     | |||||.|||
HMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANIL

LHENFCPKVSDFGLAKLIDKERA--------------LDVT-TIRGTRGYMAPEWVG------DRPITSKVDVYIYGMVLLELLSGN
|      | .|||... .... |                 . |. ||  .|||| .       | . . |.|..  | ...|.. |.
L-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAKg_s.AA ULK 72-145 32 4.7e-17 57.09 In-house 150-248 (324) Show / Hide 
Range on Protein: 72-145
Range on HMM: 150-248/324
Sequence Identity: 32% (32 aa)

RDIKPQNILLHENF------------CPKVSDFGLAKLID---KERALDVTTI-----RGTRGYMAPEWVGDR----PIT-SKVDVYIYGMVLLELLSG
|||||||||.|...            . |..|||.|| .|   .|  .  |.      .||  ||||. . ..    | . .|.|..  |... |.| |
RDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG
Kinase IRAKg_s.AA S_TKc 2-201 19 2.7e-09 -40.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 2-201
Range on HMM: 1-231/231
Sequence Identity: 19% (53 aa)

TTLGRV---------------------------------------HHVNLVKLLGYCAEGSHRLLVYEFLSN--GSLDQDLSTKLV--CRFSIALGVAKR
 ...|.                                       || |.|||.... . .|  .| |....  |.| . .  .     || .   .|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

IT--------YLHKECYDCILRDIKPQNILLHENFCPKVSDFGLAKLIDKERALDVTTIRGTRGYMAPEWVGDRPITS-KVDVYIYGMVLLELLS-----
..        |.|.     | ||.||.|||| |  . |..|||||...        ||. ||. ||||| .   . .  |.|..  | .| |.|.     
YMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPF

GNDKSRISQNRYFPVWAFQKYVAGEQVELDASKRHLDHPLELVPLQVFKPRSAMA---------WT
  .  .. ..                   .  |  ... |.  | .      |..         | 
P-QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKg_s.AA TyrKc 2-186 17 1.3e-08 -83.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 2-186
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

TTLGRV-------------------------------------------HHVNLVKLLGYCAEG-------SHRLLVYEFLSNGSLDQDL-STK----LV
 |||..                                           || |.|.|.|.| ..          ..| |. ..|.|.. | ...    . 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

CRFSIALGVAKRITYLHKECYDCILRDIKPQNILLHENFCPKVSDFGLAKLIDKE----RALDVTTIR---GTRG-----YMAPEWVGDRPITSKVDVYI
   |... .|.   |||.    || ||.   |.|..||.. |.|||||.. |. .     . |. . .   |...      ||||   ..  |.| ||. 
DLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWS

YGMVLLELLSGNDKSR-------ISQNRYFPVWAFQKYVAGEQV---------------------ELDASKRH--LDHPLEL
.| .. |...  ..         .|  . .      ..    .                      . |...|    .   ..
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKg_s.AA Pkinase_Tyr 3-38 30 5e-06 21.01 Pfam 56-95 (270) Show / Hide 
Range on Protein: 3-38
Range on HMM: 56-95/270
Sequence Identity: 30% (12 aa)

TLGRV-HHVNLVKLLGYCA-EGSH--RLLVYEFLSNGSLD
..    || |.|.|.| |  .| .   ..| |.  .|.|.
IMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL
Kinase IRAKg_s.AA Pkinase_Tyr 78-101 44 0.001003 13.24 Pfam 141-165 (270) Show / Hide 
Range on Protein: 78-101
Range on HMM: 141-165/270
Sequence Identity: 44% (11 aa)

NILLHENFCPKVSDFGLAKLI-DKE
|.|..||.. |..|||||..| ...
NCLVTENNVVKICDFGLARDIYNDD