Gene IRAKg_q (S.moellendorffii)

IRAKg_q

Species: S.moellendorffii
Alias: IRAKg_q
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_q.AA Protein None 251 None Fasta, JSON
IRAKg_q.NA RNA None 756 None Fasta, JSON
IRAKg_q.kin_dom Protein Kinase Domain None 141 None Fasta, JSON

Protein domain

Protein domains of IRAKg_q.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKg_q.AA IRAK 5-146 40 2.3e-37 130.04 In-house 56-220 (317) Show / Hide 
Range on Protein: 5-146
Range on HMM: 56-220/317
Sequence Identity: 40% (66 aa)

TLGRVHHVNLVKLLGYCAEGSHRLLVYEFLSNGSLDQ--ECID----L----WGTRFSIALGVAKGITYLHECYDC---ILRDIKPQNILLDENFCPKVL
.. | .| |.| |.|||.|..   |||....||||    .| |    .    | .|.||..| |.|| .||.   |   | .|||. |||||..| ||  
VCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKIC

DFGLAKLI----DKERALD----VTTIRGTRGYMAPVWVG--DRPITSKVDVYSYGMVLLELLSG
||||.       .||..      . ..|||  ||.|       . .| |.|||| | ||||.|.|
DFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTG
Kinase IRAKg_q.AA TKL 6-146 26 3.7e-37 129.77 In-house 79-285 (364) Show / Hide 
Range on Protein: 6-146
Range on HMM: 79-285/364
Sequence Identity: 26% (55 aa)

LGRVHHVNLVKLLGYCAEGSH-------------RLLVYEFLSNGSLDQECIDLWGTRFSIALGVAKGITYLHECY-------DCILRDIKPQNILLDEN
. | .| |.|...||| ....               .|.|. ..|||    .  |  |...||..|.|. ||| .          | ||.|..|||.|||
MSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDEN

FC--------------PKVLDFGLAKLIDKE------------------RALDVTTIRGTRGYMAP-V---------WVG------DRPITSKVDVYSYG
.               .|. ||||.. ....                  ..    |..|| ..||| |         .||       .. . |.||||.|
WTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG

MVLLELLSG
.|| |.|..
IVLWEILTR
Kinase IRAKg_q.AA Pkinase 6-147 31 1e-32 116.76 Pfam 54-209 (293) Show / Hide 
Range on Protein: 6-147
Range on HMM: 54-209/293
Sequence Identity: 31% (51 aa)

LGRVHHVNLVKLLGYCAEGSHRLLVYEFLSNG----SLD-------QECI--DLWGTRFSIALGVAKGITYLHECYDCILRDIKPQNILLDENFCP----
. |..| | |.|.... ...|  .| |.. .|    .|        . |.  . |  .| ... ...|. |.|.   .| ||.||.|||.|.|  .    
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKF-YMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACV

KVLDFGLAKLIDKERALDVTTIRGTRGYMAPVWVG-DRPITSKVDVYSYGMVLLELLSGN
|. ||||||..|  .    ||. ||..|||| ..  ......|||..|.| .| |.|.|.
KICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAKg_q.AA Dicty4 13-144 32 2.5e-25 81.56 In-house 59-211 (277) Show / Hide 
Range on Protein: 13-144
Range on HMM: 59-211/277
Sequence Identity: 32% (50 aa)

NLVKLLGYCA----EGSHRLLVYEFLSNGSL-----D-----QECIDL-WGTRFS---IALGVAKGITYLHECY-DCILRDIKPQNILLDENFCPKVLDF
|.....|.|     . .  . | |... |.|     |     |. | | |... .   .|. .|.|...||.|  . | ||.|. |.| |.|.  || ||
NICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDF

GLAKLIDKERALDV--TTIRGTRGYMAPVWVGDRPITSKVDVYSYGMVLLELL
||.... |.  .    .|  || ..|||     .| ..|.||||.|.|| |.|
GLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEIL
Kinase IRAKg_q.AA Dicty4-Unclassified 6-147 37 4.7e-25 82.72 In-house 52-205 (263) Show / Hide 
Range on Protein: 6-147
Range on HMM: 52-205/263
Sequence Identity: 37% (59 aa)

LGRVHHVNLVKLLGYCAEG-SHR---LLVYEFLSNGSL----------DQECIDLWGTR-FSIALGVAKGITYLHECYDCILRDIKPQNILLDENFCPKV
|| . | ||||. |||    ||.     | ||.  | |           |  | |  |    .|. .|.|. .||   . | ||||  |||.| .|  |.
LGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLH-TRNFIHRDIKSSNILMDKHFNIKI

LDFGLAKLIDKERALDVTTIRGTRGYMAPVWVGDRPITSKVDVYSYGMVLLELLSGN
 |||..  ||    .  ||| ||    .|        ..| |||||.|.| ||. |.
ADFGISRVIDFNFNM--TTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGD
Kinase IRAKg_q.AA Ciliate-E2b 59-146 36 2.3e-22 64.9 In-house 113-206 (272) Show / Hide 
Range on Protein: 59-146
Range on HMM: 113-206/272
Sequence Identity: 36% (35 aa)

KGITYLHECYDCILRDIKPQNILLDENFCPKVLDFGLAKLIDKERALD--VTTIRGTRGYMAPVWVG-----DRPITSKVDVYSYGMVLLELLSG
... |||     | ||||| ||..|..  .|  |.|.||...|.  .    .||.||  ||||  .       .. | |||..| | .| |...|
LCLEYLH-NQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCG
Kinase IRAKg_q.AA DRK 11-144 32 1.7e-21 69.56 In-house 56-196 (258) Show / Hide 
Range on Protein: 11-144
Range on HMM: 56-196/258
Sequence Identity: 32% (47 aa)

HVNLVKLLGYCAEGSHRLLVYEFLSNGSLDQ----ECIDL-WGTRFSIALGVAKGITYLHECYDCIL-RDIKPQNILLDENFCPKVLDFGLAK----LID
| | .  .| | . .  . . |... ||| .    | | . |. . .... .|||..||| |   |. || |  | | ||..  || ||||.       .
HPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQ

KERALDVTTIRGTRGYMAPVWVGDRPITSKVDVYSYGMVLLELL
.  |    |  || .  ||    . . | | ||||.. || |..
HKFAM---TMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV
Kinase IRAKg_q.AA TKL-Unique 4-146 26 2e-21 72.4 In-house 47-224 (290) Show / Hide 
Range on Protein: 4-146
Range on HMM: 47-224/290
Sequence Identity: 26% (48 aa)

TTLGRVH-HVNLVKLLGYCA----EGSHRLLVYEFLSNGSLDQECID---------------LWGTRFSIALGVAKGITYLHECYD-CILRDIKPQNILL
... . | | |.|.. |||.      ... .| |... |||. . ..                .  | ..|. .|.|  ||| |    | ||.|..|.|.
NWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLY-DVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLV

DEN-----FCPKVLDFGLAKLIDKERALDVTTI--------RGTRGYMAPVWVGD--RPITSKVDVYSYGMVLLELLSG
|.|     .  |. ||||.|. .|. .  ....         |.  .|||    .    .. |.||||.|.|| |....
DNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKg_q.AA Dicty5 46-144 32 3.1e-19 62.85 In-house 102-197 (260) Show / Hide 
Range on Protein: 46-144
Range on HMM: 102-197/260
Sequence Identity: 32% (32 aa)

LWGTRFSIALGVAKGITYLHECYDCILRDIKPQNILLDENFCPKVLDFGLAKLIDKERALDVTTIRGTRGYMAPVWVGDRPITSKVDVYSYGMVLLELL
..... ..|...|... .||     | ||.|  |.|. ||.  |. |||    .|   ..  |.  ||  .||.     .| . |.||||.| || |..
AYFQQLHMAIDIAQSMRHLH-SMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDN--RYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMF
Kinase IRAKg_q.AA CZAK 11-148 30 9.4e-19 64.84 In-house 59-220 (279) Show / Hide 
Range on Protein: 11-148
Range on HMM: 59-220/279
Sequence Identity: 30% (50 aa)

HVNLVKLLGYCAEGS--HRLLVYEFLSNGSLDQ---ECIDLWGT----RFSIALGVAKGITYLHECYDC--IL-RDIKPQNILLDENFC-----------
| | |  || | |.   |.  | |.   |||..   .   .       . ..|. .|.|  |||  .    || ||   .|||||..             
HPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQD

--PKVLDFGLAKLIDKERALDVTTIRGTRGYMAP-VWVGDRPITSKVDVYSYGMVLLELLSGND
   |. |||| ..  .| . . |   |   .||| .  |.   | ||||||.||.| ... . .
IICKINDFGLSREM-MEQPFEMTQTMGCLCWMAPECFKGEN-YTEKVDVYSFGMILWCIITCDQ
Kinase IRAKg_q.AA LRRK 10-146 30 1e-17 59.22 In-house 115-278 (351) Show / Hide 
Range on Protein: 10-146
Range on HMM: 115-278/351
Sequence Identity: 30% (52 aa)

HHVNLVKLLGYCAEGSHRLLVYEFLSNGSLDQECI----D-L--------WGTRFSIALGVAKGITYLHECY-DCILRDIKPQNILL---D---------
.| |.|.|.|.| .  .. .| |....|.|.. .     | .        |...  ||| .|||. ||| .    | || |. ||||   .         
NHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPN

ENFCPKVLDFGLAK--LIDKER-ALDVTTIRGTRGYMAPVWVGDR---PITSKVDVYSYGMVLLELLSG
.. | |. |||.     ....  | ...   |. |.|||  ...      | |||.||.||.| |||..
AHVCAKIADFGISRMFQCFHMGVAKGCV---GNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTR
S_TKc IRAKg_q.AA S_TKc 1-223 19 4.4e-11 -14.44 SMART 18-231 (231) Show / Hide 
Range on Protein: 1-223
Range on HMM: 18-231/231
Sequence Identity: 19% (54 aa)

ARNTT--------------------LGRVHHVNLVKLLGYCAEGSHRLLVYEFLSN--GSLDQECIDLWG----TRFS-----IALGVAKGITYLHECYD
.|..                     | . || |.|||.... . .|  .| |....  |.| .   .  .     .|.     ..  ..... |.|.   
CRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSH-G

CILRDIKPQNILLDENFCPKVLDFGLAKLIDKERALDVTTIRGTRGYMAPVWVGDRPITS-KVDVYSYGMVLLELLS-----GNDKSRIGQNRYFPVWAF
 | ||.||.||||||  . |. |||||...        ||. ||. ||||  .   . .  |.|..| | .| |.|.       .  .. ..        
IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG------

QKYVAGERVELDASKRHLDHPLELVPLQVFKPRVRNGVDSSRPVVKMLE-QPD-------LE-----VAVPPF
                                      .    . |.|.  |.       |.      . | |
------------------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase IRAKg_q.AA TyrKc 4-216 17 3.4e-09 -74.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-216
Range on HMM: 1-280/280
Sequence Identity: 17% (52 aa)

TTLGRV-------------------------------------------HHVNLVKLLGYCAEG-------SHRLLVYEFLSNGSLD---QECI--DLWG
 |||..                                           || |.|.|.|.| ..          ..| |. ..|.|.   ...     . 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

TRFSIALGVAKGITYLHECYDCILRDIKPQNILLDENFCPKVLDFGLAKLIDKE----RALDVTTIR---GTRG-----YMAPVWVGDRPITSKVDVYSY
.  |... .|.|  |||.   || ||.   |.|..||.. |. ||||.. |. .     . |. . .   |...      |||    ..  |.| ||.|.
DLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF

GMVLLELLSGNDKSRIGQNRYFPVWAFQKYVAGERVELDASKRHLDHPLEL--------VPLQVFKPRVR---NGVDSSRPVVKMLEQPDL
| .. |...  ..   |.       ..|  .  ..|  .  ...   . .          |  ...   .   .   ..||  . .   ..
GVCMWEIFTYGQQPYPGM-------IQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI-HECF
Kinase IRAKg_q.AA Pkinase_Tyr 5-102 28 9.5e-08 26.86 Pfam 56-165 (270) Show / Hide 
Range on Protein: 5-102
Range on HMM: 56-165/270
Sequence Identity: 28% (32 aa)

TLGRV-HHVNLVKLLGYCA-EGSH--RLLVYEFLSNGSLD---------QECIDLWGTRFSIALGVAKGITYLHECYDCILRDIKPQNILLDENFCPKVL
..    || |.|.|.| |  .| .   ..| |.  .|.|.         .. ...     .... .|||  ||..   || ||.   |.|..||.. |. 
IMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKD-LLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKIC

DFGLAKLI-DKE
|||||..| ...
DFGLARDIYNDD
Kinase IRAKg_q.AA Pkinase_Tyr 128-145 38 0.558716 3.94 Pfam 192-209 (270) Show / Hide 
Range on Protein: 128-145
Range on HMM: 192-209/270
Sequence Identity: 38% (7 aa)

TSKVDVYSYGMVLLELLS
|.| ||.|.| .. |...
TTKSDVWSFGVLMWEIFT