Gene IRAKg_g (S.moellendorffii)

IRAKg_g

Species: S.moellendorffii
Alias: IRAKg_g
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_g.AA Protein None 164 None Fasta, JSON
IRAKg_g.NA RNA None 495 None Fasta, JSON
IRAKg_g.kin_dom Protein Kinase Domain None 144 None Fasta, JSON

Protein domain

Protein domains of IRAKg_g.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKg_g.AA TKL 6-149 23 6.9e-32 112.1 In-house 79-279 (364) Show / Hide 
Range on Protein: 6-149
Range on HMM: 79-279/364
Sequence Identity: 23% (50 aa)

LGKIHHISLVRMLGYCAEGSH-------------RLLVYEYM-----ANSLQVDEASSQIPQTLCKWKTRLAIALSISRGITYLHQ------QCQECIIH
. ...|  .|...||| ....               .|.||.      . |.              |  |. .||.|.||. |||.      .    |||
MSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIH

CDVKPQNILFDDNFH--------------PKVSDFGLAKLMKRESS------------------ANVTTARDTRGYMAPEWISMV---------------
.| |..||| |.|..              .|..||||.. |.....                   .  | . | ..|||| . .                
RDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKG

-AIAPKVDVYSFGMVL
    .|.||||||.||
FEYSEKCDVYSFGIVL
Kinase IRAKg_g.AA IRAK 5-150 36 1.6e-31 109.03 In-house 56-215 (317) Show / Hide 
Range on Protein: 5-150
Range on HMM: 56-215/317
Sequence Identity: 36% (58 aa)

TLGKIHHISLVRMLGYCAEGSHRLLVYEYMAN-SLQVDEASSQIPQTL---CKWKTRLAIALSISRGITYLHQQC-QECIIHCDVKPQNILFDDNFHPKV
.. ...|  .|  .|||.|..   |||.||.| ||. |  . | .|.      | .|. |.. ...|| .|||      ||| |.|. ||| |..| || 
VCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLE-DRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKI

SDFGLAK------LMKRESS--ANVTTARDTRGYMAPEWIS--MVAIAPKVDVYSFGMVLL
.||||.        ... ..  . . . | |  ||.|| |      ...|.|||||| |||
CDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLL
Kinase IRAKg_g.AA Pkinase 15-149 31 1.1e-27 98.93 Pfam 63-202 (293) Show / Hide 
Range on Protein: 15-149
Range on HMM: 63-202/293
Sequence Identity: 31% (47 aa)

VRMLGYCAEGSHRLLVYEYMAN-----SLQ----VDEASSQIPQTLCKWKTRLAIALSISRGITYLHQQCQECIIHCDVKPQNILFDDNFHP----KVSD
||..... ...|  .| ||. .     .|     .   ... . .   ...   ... | ||. |.|..    |||.|.||.|||.|.| |.    |..|
VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---WRHGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICD

FGLAKLMKRESSANVTTARDTRGYMAPEWIS-MVAIAPKVDVYSFGMVL
|||||...  ..   ||   |..|||||.|     . ||||..|.| .|
FGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL
Kinase IRAKg_g.AA TKL-Unique 5-149 28 4.8e-24 81.8 In-house 48-218 (290) Show / Hide 
Range on Protein: 5-149
Range on HMM: 48-218/290
Sequence Identity: 28% (50 aa)

TLGKIH-HISLVRMLGYCA----EGSHRLLVYEYMA-NSLQVDEASSQ--------IPQTLCKWKTRLAIALSISRGITYLHQQCQECIIHCDVKPQNIL
.. |.| |. .|.  |||.      ... .| ||.  .||  .. ..|        .. .   .. |. .|. |..|  |||      |||.| |..|.|
WMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSL--YDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFL

FDDN-----FHPKVSDFGLAKLMKRESSANVT--------TARDTRGYMAPEWISM--VAIAPKVDVYSFGMVL
 | |     .  |..||||.|. ....  ...        |  ..  .|||| ..|    .  |.||||||.||
VDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVL
Kinase IRAKg_g.AA Dicty4 54-149 39 1.2e-23 75.93 In-house 108-207 (277) Show / Hide 
Range on Protein: 54-149
Range on HMM: 108-207/277
Sequence Identity: 39% (40 aa)

WKTRLA---IALSISRGITYLHQ-QCQECIIHCDVKPQNILFDDNFHPKVSDFGLAKLMKRES--SANVTTARDTRGYMAPEWISMVAIAPKVDVYSFGM
| ....   .|... ||...||   .   ||| | |. |.| |.|.  ||.||||...||...  ..| .||  | ..||||     .   |.||||||.
WPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGI

VL
||
VL
Kinase IRAKg_g.AA RIPK 64-149 38 4.8e-20 64.98 In-house 116-218 (290) Show / Hide 
Range on Protein: 64-149
Range on HMM: 116-218/290
Sequence Identity: 38% (40 aa)

ISRGITYLHQQCQE-CIIHCDVKPQNILFDDNFHPKVSDFGLAKLMKRESSAN---------VTTARD---TRGYMAPEWISMVAIAP------KVDVYS
||.|  |||  ..   ||| | ||.||| | ||| |..|||||. |   .| .          .. ..   |  ||.|| .  .  .|      | ||||
ISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYS

FGMVL
|..|.
FAIVM
Kinase IRAKg_g.AA CAMK 67-149 22 6.1e-18 53.73 In-house 191-324 (425) Show / Hide 
Range on Protein: 67-149
Range on HMM: 191-324/425
Sequence Identity: 22% (31 aa)

GITYLHQQCQECIIHCDVKPQNILFDDN-----------------FHPKVSDFGLAKLMKRES----------------------SANVTTARDTRGYMA
.. |.|..    |.|.| || |||.|||                 .  |..|||.|. ... .                          .|   | .|||
AVHYCHSH---NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA

-PEWISM--------------VAIAPKVDVYSFGMVL
 ||...                 . ||.|. | | .|
APEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase IRAKg_g.AA CZAK 57-149 33 6.6e-18 61.74 In-house 107-212 (279) Show / Hide 
Range on Protein: 57-149
Range on HMM: 107-212/279
Sequence Identity: 33% (36 aa)

RLAIALSISRGITYLHQQCQE-CIIHCDVKPQNILFDDNFH-------------PKVSDFGLAKLMKRESSANVTTARDTRGYMAPEWISMVAIAPKVDV
.. .|..| ||  |||    .  |.| |   .||| |..                |..|||| ..|. |     | .     .||||        .||||
QWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMM-EQPFEMTQTMGCLCWMAPECFKGENYTEKVDV

YSFGMVL
|||||.|
YSFGMIL
Kinase IRAKg_g.AA MLK 60-149 34 2.5e-17 56.78 In-house 129-226 (291) Show / Hide 
Range on Protein: 60-149
Range on HMM: 129-226/291
Sequence Identity: 34% (34 aa)

IALSISRGITYLHQQCQECIIHCDVKPQNILFDD------NFHPKVSDFGLAKLMKRESSANVTTARDTRGYMAPEWI---SMVAIAPKVDVYSFGMVL
.|| ..||. |||.. .  ||| | |..||| |.      . . |..|||... ...   .| . .. |  .|||| |          |.||.|.|.||
WALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVL
Kinase IRAKg_g.AA Dicty4-Unclassified 58-149 33 1.3e-16 53.42 In-house 112-198 (263) Show / Hide 
Range on Protein: 58-149
Range on HMM: 112-198/263
Sequence Identity: 33% (31 aa)

LAIALSISRGITYLHQQCQECIIHCDVKPQNILFDDNFHPKVSDFGLAKLMKRESSANVTTARDTRGYMAPEWISMVAIAPKVDVYSFGMVL
...|..| .|. .||      .|| |.|  ||| | .|  |. |||..     .   | ||   |    .||     .   | ||||..|.|
IKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMML
Kinase IRAKg_g.AA Ciliate-E2-Unclassified 79-149 30 2.2e-16 53.35 In-house 165-260 (352) Show / Hide 
Range on Protein: 79-149
Range on HMM: 165-260/352
Sequence Identity: 30% (29 aa)

IIHCDVKPQNILFDDN---FHPKVSDFGLAK--------------LMKRESSANVTTARDTRGYM----APEWISMVAIAPK----VDVYSFGMVL
||| | ||.|||||.|   ...|..|||..|               |.. .. . .|   | .||    ||| .       .    .|..|.|..|
IIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL
S_TKc IRAKg_g.AA S_TKc 1-158 18 5.6e-07 -74.56 SMART 18-231 (231) Show / Hide 
Range on Protein: 1-158
Range on HMM: 18-231/231
Sequence Identity: 18% (43 aa)

MEDAT--------------------LGKIHHISLVRMLGYCAEGSHRLLVYEYMAN---SLQVDEASSQIP---QTLCKWKTRLAIALSISRGITYLHQQ
  .                      | | ||  .|...... . .|  .| ||. .   .|     . . .   . .    .|  ..  | ... |.|..
CRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF-YMYQICCALEYCHSH

CQECIIHCDVKPQNILFDDNFHPKVSDFGLAKLMKRESSANVTTARDTRGYMAPEWISMVAIAP-KVDVYSFG---------------------------
    |||.|.||.|||.|.  | |..|||||...        ||   |. ||||| .      . |.|..|.|                           
G---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPE

----------------MVLLGSGR-------DKFM
                .      .       . ..
AKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc IRAKg_g.AA TyrKc 1-164 17 4e-06 -123.55 SMART 2-265 (280) Show / Hide 
Range on Protein: 1-164
Range on HMM: 2-265/280
Sequence Identity: 17% (49 aa)

MEDATLG-------------------------------------KI--HHISLVRMLGYCAEG-------SHRLLVYEYMAN-----SLQVDEASSQIPQ
  . .||                                     |.  ||  .||..|.| ..          ..| |||..      |.  .       
TLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-----

TLCKWKTRLAIALSISRGITYLHQQCQECIIHCDVKPQNILFDDNFHPKVSDFGLAKLMKRE----SSANVTTAR---DTRG-----YMAPEWISMVAIA
   ..|. | ... |..|  |||..   ..|| |    |.| ..|.. |.|||||..  . .     |  . ...   ....      |||| |      
--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYG

---PKVDVYSFGMVL-----------LG--------------SGRDKFMFFPSH----------------------E
   .| ||.||| ..            |                . . |  | .                      |
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE
Pkinase_Tyr IRAKg_g.AA Pkinase_Tyr 4-36 29 0.000899 13.4 Pfam 55-91 (270) Show / Hide 
Range on Protein: 4-36
Range on HMM: 55-91/270
Sequence Identity: 29% (11 aa)

ATLGKI-HHISLVRMLGYCA-EGSH--RLLVYEYMAN
... .. ||  .||..| |  .| .   ..| |||..
KIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH
Kinase IRAKg_g.AA Pkinase_Tyr 55-149 29 0.014807 9.28 Pfam 111-204 (270) Show / Hide 
Range on Protein: 55-149
Range on HMM: 111-204/270
Sequence Identity: 29% (29 aa)

KTRLAIALSISRGITYLHQQCQECIIHCDVKPQNILFDDNFHPKVSDFGLAKLMKRESSANVTTARDTRG---YMAPEWISMVAIAPKVDVYSFGMVL
|. | ... |..|  ||...    .|| |.   |.| ..|.. |..|||||...  ..   .... ...     |||| |.      | ||.||| ..
KDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLM