Gene LRR8_ah (S.moellendorffii)

LRR8_ah

Species: S.moellendorffii
Alias: LRR8_ah
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_ah.AA Protein None 233 None Fasta, JSON
LRR8_ah.NA RNA None 702 None Fasta, JSON
LRR8_ah.kin_dom Protein Kinase Domain None 153 None Fasta, JSON

Protein domain

Protein domains of LRR8_ah.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LRR8_ah.AA TKL 57-203 20 8.5e-34 118.6 In-house 1-202 (364) Show / Hide 
Range on Protein: 57-203
Range on HMM: 1-202/364
Sequence Identity: 20% (44 aa)

LDRGSFSTVYKGVFPD---------GNVVAVKKLELGRRELRPV-----------------------RHKSFFTELHVLGRIRHRNILPVLGYFSNLDF-
. .|.|..||||..           |..|||||.      ..                           . .  |. .. |.|| ||.. .||  . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------MAVIVQFMPKGSLHSKLQQRHTYISLDWSKRYKIAVGVAQGLTYLHHNC-----KQQFVHCDLNPSNILLDDEFE-------------
            .. . ...|.|||.. |.         |..| ..| ..|.|. ||| .      | . .|.||...|||.|. ..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-AHIGNFGFAK
 . |. ||...
CCKICDFGLSR
Kinase LRR8_ah.AA IRAK 51-202 31 6e-33 114.15 In-house 1-160 (317) Show / Hide 
Range on Protein: 51-202
Range on HMM: 1-160/317
Sequence Identity: 31% (51 aa)

FSSSNILDRGSFSTVYKGVFPDGNV--VAVKKLELGRRELRPVRHKSFFT---ELHVLGRIRHRNILPVLGYFSNLDFMAVIVQFMPKGSLHSKLQQRHT
|. .| .  | | .||.|.. ...   .|||||  ..        ..| .   || |. |.|| ||.|..||..  ..   . ..|| |||.  |. . .
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDG

YIS---LDWSKRYKIAVGVAQGLTYLHHNC-KQQFVHCDLNPSNILLDDEFEAHIGNFGFA
  .   | | .| .|. | | |. .|| |  .  . | |  ..|||||. |.. |. || .
QCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLH
Kinase LRR8_ah.AA Pkinase 51-203 23 3e-22 79.77 Pfam 1-160 (293) Show / Hide 
Range on Protein: 51-203
Range on HMM: 1-160/293
Sequence Identity: 23% (39 aa)

FSSSNILDRGSFSTVYKGVFPDGNV-VAVKKLELGRRELRPVRHKSFFT--ELHVLGRIRHRNILPVLGYFSNLDFMAVIVQFMPKG----SLHSKLQ-Q
.    .. .|||..|||..  . .  ||||....  |. ..  ... .   |.... |..| ||.  ...| . | . ..  ....|    .|.. .. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKK--RHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

RHTYISLDWSKRYKIAVGVAQGLTYLHHNCKQQFVHCDLNPSNILLDDEFEA----HIGNFGFAK
||. .....    ...  ...|| |.| .    ..|.|| |.|||.|.. .     .|. ||.||
RHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAK
Kinase LRR8_ah.AA TKL-Unique 53-222 24 1.1e-21 73.41 In-house 1-194 (290) Show / Hide 
Range on Protein: 53-222
Range on HMM: 1-194/290
Sequence Identity: 24% (49 aa)

SSNILDRGSFSTVYKGVFPDGNVVAVKKLELGRRELRPVRHKSFFTELHVLGRIR-HRNILPVLGYFS----NLDFMAVIVQFMPKGSLHSKLQQ-----
 .| . .|....||||... |  ||.|....   ....   . |  |. .. ... | ||.   ||          |  .. ..| |||.. |.|     
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

--RHTYISLDWSKRYKIAVGVAQGLTYLHHNCKQQFVHCDLNPSNILLDDE-----FEAHIGNFGFAKAVEQQLRQKKR----------ITSFLLMP
      . |....|.|.|  .|||. ||||. .    |.|| .||.|.| .     . . |  ||..|   . .. ...          ..||. |.
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMA
Kinase LRR8_ah.AA Dicty4-Unclassified 54-206 33 7.2e-21 68.18 In-house 4-160 (263) Show / Hide 
Range on Protein: 54-206
Range on HMM: 4-160/263
Sequence Identity: 33% (54 aa)

SNILDRGSFSTVYKGVFPDGNVVAVKKLELGRRELRPVRHKSFFTELHVLGRIRHRNILPVLGYFSNL----DFMAVIVQFMPKGSL----HSKLQQRHT
   . .| || |.||.   |  |||||.  ..   |    . |  |  .|| | | | . . ||  |       | ..  ||.|| |    |||   .  
DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

YISLDWSKRYKIAVGVAQGLTYLHHNCKQQFVHCDLNPSNILLDDEFEAHIGNFGFAKAVE
 |.||     |.|  .|||. .||      |.| |.  ||||.|  | . |. || .  ..
PIKLDDTLIIKYAFDIAQGMQHLHT---RNFIHRDIKSSNILMDKHFNIKIADFGISRVID
Kinase LRR8_ah.AA RAF 51-204 30 1.2e-19 60.12 In-house 1-152 (282) Show / Hide 
Range on Protein: 51-204
Range on HMM: 1-152/282
Sequence Identity: 30% (48 aa)

FSSSNILDRGSFSTVYKGVFPDGNVVAVKKLELGRRELRPVRHKSFFT-ELHVLGRIRHRNILPVLGYFSNLD--FMAVIVQFMPKGSLHSKLQQRHTYI
.  ..    ||| |||.| .  |. ||||.| .       ..   ||. |. |. . || |||  .|| |.     .|.. |.    ||  ..    |  
VMVMTRIGSGSFGTVYRGHW-HGD-VAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETRE

SLDWSKRYKIAVGVAQGLTYLHHNCKQQFVHCDLNPSNILLDDEFEAHIGNFGFAKA
 .| ..   |.  |.||. |||   . . .| ||   ||.|...    || || ...
KFDMHWLIDISRQVCQGMDYLH---AKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTV
Kinase LRR8_ah.AA TK 51-207 13 3.4e-19 60.29 In-house 1-311 (486) Show / Hide 
Range on Protein: 51-207
Range on HMM: 1-311/486
Sequence Identity: 13% (43 aa)

FSSSNILDRGSFS---TVYKGVFPDGN--------------------------VVAVKKLELGRRELRPVRHKSFFT----------ELHVLGRIR----
    . | .| |    .||||   ..|                           |||| | .|  .    ..  ...          |....   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNILPVLGYFSNLDF------------MAVIVQFMPKGS----LHSKLQQ-RHTYIS-----------------------------------------
 | ||.  .|. .  .             . ... .||.|.    |.. |.. |.. .                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWSKRYKIAVGVAQGLTYLHHN----CKQQFVHCDLNPSNILLDDEFE-----------AHIGNFG--
                               |.   .  ... .|.|. ||| .      |.||| ||   |.|....             . |. ||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------FAKAVEQ
       |.....
RQGSGVLARDIYS
Kinase LRR8_ah.AA LRRK 51-188 17 1.1e-18 62.74 In-house 1-199 (351) Show / Hide 
Range on Protein: 51-188
Range on HMM: 1-199/351
Sequence Identity: 17% (36 aa)

FSSSNILDRGSFS-TVYKGVFPD---------------------------GNVVAVKKLELGR------------------------------RELRPVR
. . . . ||.|  .||.. . .                           .. ||.||.....                               | ..  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

HKSFFTELHVLGRIRHRNILPVLGYFSNLDFMAVIVQFMPKGSLHSKLQQRHTY------ISLDWSKRYKIAVGVAQGLTYLHHNCKQQ--FVHCDLNPS
. .|  |.... . .| ||.. .|.   .. .. .  ..| |.|.. |. .. .      ....|. ..|||. .| |. |||   ..   ..|.|| . 
FREFRHEVWIMSHLNHPNIVSLKGF--CIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH---SHNPPIIHRDLKSP

NILL
||||
NILL
Kinase LRR8_ah.AA MLK 51-198 21 1.2e-18 61.47 In-house 1-169 (291) Show / Hide 
Range on Protein: 51-198
Range on HMM: 1-169/291
Sequence Identity: 21% (37 aa)

FSSSNILDRGSFSTVYKGVFPDGN----VVAVKKLELGRRELRPVR----HKSFFTELHVLGRIRHRN----ILPVLGYFSNLDF-MAVIVQFMPKGSLH
.  . ..  |||  |.||..   .    .||||. .  | .   ..     . | .|   | ...|.|    | ...|  ..     ... .....|||.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRA-RIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

SKL------------QQRHTYISLDWSKRYKIAVGVAQGLTYLHHNCKQQFVHCDLNPSNILLDDEFEAHIGN
. |            .|.  ..  | .   ..|. .|.|. ||| . ... .| ||...|||.|.  . ....
NVLHGARSKWMDANHNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICHDMHH
Kinase LRR8_ah.AA Dicty4 51-208 28 1.7e-17 55.11 In-house 1-170 (277) Show / Hide 
Range on Protein: 51-208
Range on HMM: 1-170/277
Sequence Identity: 28% (50 aa)

FSSSNILDRGSFSTVYKGVFPDGNVVAVKKLELGRRELRPVRHKSFFTELHVLGRIRHRNILPVLGYFS----NLDFMAVIVQFMPKGSLHSKLQQ----
    ... .|||..||||    |  |||||| .    ..  . ..|  | | .. ||| ||.  .|.      .   |     .||||.|.| |      
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

RHTYISLDWSKRYK---IAVGVAQGLTYLHH-NCKQQFVHCDLNPSNILLDDEFEAHIGNFGFAK---AVEQQ
    |.|||. . .   .|  .|.|...||  |.   ..| || ..|.| |. . . .. ||...    .|..
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNP--VIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDH
Kinase LRR8_ah.AA Pkinase_Tyr 59-181 22 3.3e-15 52.15 Pfam 9-137 (270) Show / Hide 
Range on Protein: 59-181
Range on HMM: 9-137/270
Sequence Identity: 22% (30 aa)

RGSFSTVYKGVFP-----DGNVVAVKKL--ELGRRELRPVRHKSFFTELHVLGRI-RHRNILPVLGYFS-NLDF--MAVIVQFMPKGSLHSKLQQR-HTY
.|.| .||||.       ..  ||||.|      ...    ...|. |. ..  . .| ||.  .|  .   .   . ... .||.|.|.. |... .  
EGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDK

ISLDWSKRYKIAVGVAQGLTYLHHNCKQQFVHCDL
 .|. .   .... .|.|. ||. .    ..| ||
QPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDL
Kinase LRR8_ah.AA TyrKc 51-233 13 1.2e-10 -50.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 51-233
Range on HMM: 1-280/280
Sequence Identity: 13% (40 aa)

FSSSNILDRGSFSTVYKGVFPDGNVVAVKKLELGRRELRPVRHKSFFTELHVLGRI--RHRNILPVLGYFSNL-------DFMAVIVQFMPKGSLHSKLQ
 .   .| .| | .||||.      ||||.|  .        .. |  |. .. ..  .| ||.  .|. .         . . ... .||.|.|.. |.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QRHTYISLDWSKRYKIAVGVAQGLTYLHHNCKQQFVHCDLNPSNILLDDEFEAHIGNFGFAKAVE---------QQLR-----QKK--------------
 ..    | ...  .... .|.|  |||..   ...| ||   |.|..... . |. || .....         .  |     ..|              
KHRPK--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

---------------------------------------RITSFLLMPGYTAPGKT-----------------------------------QRF
                                       ..  ..   ..  . .                                    ..|
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LRR8_ah.AA LISK 134-208 31 2.4e-10 29.63 In-house 82-158 (296) Show / Hide 
Range on Protein: 134-208
Range on HMM: 82-158/296
Sequence Identity: 31% (25 aa)

GSLHSKLQQRHT-YISLDWSKRYKIAVGVAQGLTYLHHNCKQQFVHCDLNPSNILLDDE----FEAHIGNFGFAKAVEQQ
| ||  |  .    | | |..| |||...|.|..||| ..    .| ||.  |.|...     ... .. ||||. ....
GDLHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCE
Kinase LRR8_ah.AA S_TKc 51-233 16 2.7e-09 -40.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 51-233
Range on HMM: 1-231/231
Sequence Identity: 16% (41 aa)

FSSSNILDRGSFSTVYKGVFPD-GNVVAVKKLELGRRELRPVRHKSFFTELHVLGRIRHRNILPVLGYFSNLDFMAVIVQFMPK--GSLHSKLQQRHT--
.   ... .|.|..|||..  . | .||.|..            ...  |. .| . .| ||   ...| . |.. ..  ...   |.|.. ...| .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

---YISLDWSKRYKIAVGVAQGLTYLHHNCKQQFVHCDLNPSNILLDDEFEAHIGNFGFAKAV-------------------------------------
   ...  . ..|  .  ....| |.|   .....|.|| |.|||||.  .  |. ||.|. .                                     
LRFPFPE-HARFY--MYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCG

------EQQLRQKKRITSFLLM--------------PGYTAPGK-------TQRF
      .|.. .| .  |  .               |.     .        . |
YPPFPQMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_ah.AA LISK 56-112 26 6.2e-09 24.95 In-house 1-59 (296) Show / Hide 
Range on Protein: 56-112
Range on HMM: 1-59/296
Sequence Identity: 26% (17 aa)

ILDRGSFSTVYKGVFP-DGNVVAVKKLEL-----GRRELRPVRHKSFFTELHVLGRIRHRNIL
.. .|.|. ||||    .|.|.|.|...       ..|..    | .  |. .. ..||.||.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQ----KFMLREVQMMKNLRHPNIV