Gene LRR8_p-2 (S.moellendorffii)

LRR8_p-2

Species: S.moellendorffii
Alias: LRR8_p-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_p-2.AA Protein None 1010 None Fasta, JSON
LRR8_p-2.NA RNA None 3033 None Fasta, JSON
LRR8_p-2.kin_dom Protein Kinase Domain None 211 None Fasta, JSON

Protein domain

Protein domains of LRR8_p-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_p-2.AA LRRNT_2 38-83 36 2.2e-11 39.87 Pfam 1-46 (46) Show / Hide 
Range on Protein: 38-83
Range on HMM: 1-46/46
Sequence Identity: 36% (18 aa)

VASEPQILLSFKASIS--DP-LGHLGDWQLPQNGSSSFEHCSWSGVSCD
 ... | ||.||.|..  || .| | .|    .   .  .|||.||.||
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSS---DSDCCSWTGVTCD
LRR_1 LRR8_p-2.AA LRR_1 88-110 29 43.881042 0.92 Pfam 1-26 (26) Show / Hide 
Range on Protein: 88-110
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SVTGLDLQSR---NLSGALDST-VCNL
. . |||..    ||.| . .    ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 112-134 28 0.649702 7.41 Pfam 1-26 (26) Show / Hide 
Range on Protein: 112-134
Range on HMM: 1-26/26
Sequence Identity: 28% (8 aa)

GLASLSLSD-N--NFT-QLFPVG-LYSC
 | .|.||. |  |.| . .| . . ..
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 136-158 40 0.00029 19.29 Pfam 1-26 (26) Show / Hide 
Range on Protein: 136-158
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLVFLDLSY-N--NFFGPLPDN-ISSL
||  ||||. |  |. | .|.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 160-182 37 0.000632 18.09 Pfam 1-26 (26) Show / Hide 
Range on Protein: 160-182
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLEYLDLEY-N--AFTGPMPDD-IGNL
.|..||| . |   .||  |.. . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 184-205 29 0.43156 8.04 Pfam 1-26 (26) Show / Hide 
Range on Protein: 184-205
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

QLQYFNVWEC---LLT-TISPA-LGKL
.||. ..  |    || .|.|  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 207-229 32 0.01237 13.51 Pfam 1-26 (26) Show / Hide 
Range on Protein: 207-229
Range on HMM: 1-26/26
Sequence Identity: 32% (9 aa)

RLTNLTLSY-N--PFT-TPLPPE-LRHL
.|. | ||. |  ..| . .||. . .|
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 231-253 40 0.001696 16.57 Pfam 1-26 (26) Show / Hide 
Range on Protein: 231-253
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLQSLKCGGC---QLTGSIPDW-LGEL
.||.|  .||   .|||.||.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 255-277 40 0.021905 12.63 Pfam 1-26 (26) Show / Hide 
Range on Protein: 255-277
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLDFLELTW-N--SLSGIIPSS-IMHL
||  | |   |  .|.| ||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 279-301 37 0.022628 12.58 Pfam 1-26 (26) Show / Hide 
Range on Protein: 279-301
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

KLTSLELYS-N--KLTGPIPSE-VEFL
.|..| | . |  .||| ||..    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 303-325 33 0.016461 13.07 Pfam 1-26 (26) Show / Hide 
Range on Protein: 303-325
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLTDLDLNS-N--FLNGSIPDT-LAKI
.|. |||.. |   | |.||.  . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 327-349 40 0.022048 12.62 Pfam 1-26 (26) Show / Hide 
Range on Protein: 327-349
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLGLLHLWN-N--SLTGEIPQG-LARL
||  |.| . |  .|||.|| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 351-373 37 1.204008 6.46 Pfam 1-26 (26) Show / Hide 
Range on Protein: 351-373
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

KLYDLSLFG-N--QLTGIIPAE-LGLH
.|  |.| | |  .||| || . .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 375-394 34 2.800494 5.16 Pfam 1-26 (26) Show / Hide 
Range on Protein: 375-394
Range on HMM: 1-26/26
Sequence Identity: 34% (9 aa)

SLEIFDVST-N--LLTGAVPS---GL
.|.. |.|  |   ||| .|.   .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 LRR8_p-2.AA LRR_1 399-421 29 2.159911 5.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 399-421
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RLQKLIFFN-N--SLSGGIPSA-YEDC
.||.| . . |  .|.| ||.     .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 423-445 22 0.466535 7.92 Pfam 1-26 (26) Show / Hide 
Range on Protein: 423-445
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

SLVRVRMYH-N--KLSGALPSG-MWGL
.| .  . . |  .|.| .|..   .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 447-469 22 0.92859 6.86 Pfam 1-26 (26) Show / Hide 
Range on Protein: 447-469
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

RMTILEIYD-N--NFQGSVPPQ-LGHA
. ..| . . |  |..|..||  . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 471-493 37 0.000281 19.34 Pfam 1-26 (26) Show / Hide 
Range on Protein: 471-493
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLETLRIHN-N--KLTGTIPTD-IDKL
||..| . . |  .|||.|| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 495-517 25 3.007834 5.05 Pfam 1-26 (26) Show / Hide 
Range on Protein: 495-517
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

VLDEFTAYG-N--KLSGTIPDN-LCKC
 | .    | |  .|.|.||.. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 519-541 29 0.143088 9.74 Pfam 1-26 (26) Show / Hide 
Range on Protein: 519-541
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SMSKLLLGS-N--QLEGEIPSN-IGDL
.  .| |.. |  .|.|.||.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 543-565 44 8.7e-05 21.14 Pfam 1-26 (26) Show / Hide 
Range on Protein: 543-565
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

SLAILDLSN-N--HLSGSIPPS-IVKM
.| .||||. |  .|.|.|||| . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_p-2.AA LRR_1 567-589 40 0.000401 18.79 Pfam 1-26 (26) Show / Hide 
Range on Protein: 567-589
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLNSLDLSR-N--NFSGDIPPV-LTRM
.| .||||. |  |..|.|||  .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Kinase LRR8_p-2.AA TKL 721-998 21 6.7e-58 198.67 In-house 1-364 (364) Show / Hide 
Range on Protein: 721-998
Range on HMM: 1-364/364
Sequence Identity: 21% (82 aa)

IGSGGAGKVYKATLKSNN------ECSHLAIKKLWSCD-----------------------KAEIRNDYGFKTEVN-ILGRIRHFNIVRLLCCCSNGET-
||||| |.|||.... ..       .   |.||. | .                         |..    |. |.  .. |.|| |||... .| ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------NLLVYEYVPNGSLGDALHHPSTKISGVLDWPARYRIALGAAQGLSYLHHDCV-----PAILHRDIKSNNILLSDEYD-----------
              .|.||.|.||| . ||           |. | |.||..|.|..||| .       |.|.|||.||.|||. . .            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---ALLADFGIAKLVGSNSSTEFS----------------MSVLAGSHGYIAPEYAHRM----------------KVNEKSDVYSFGVVLLELVTGKKPV
   . ..|||... .  ... . .                 .   |. .. |||    .                . .||.||||||.|| |..|...  
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--

GSPEFGDNGVDIVTWACNSIQSKQGV-------DAVIDPRLSPAI-----------CRQRDLLLVLKIALRCTNALASSRPSMRDVVQML
              ....   . ..          |.| .| | |           .    .  . |.. .| .. ...|||. .... |
-------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8_p-2.AA IRAK 716-926 33 1.3e-43 151.23 In-house 2-224 (317) Show / Hide 
Range on Protein: 716-926
Range on HMM: 2-224/317
Sequence Identity: 33% (76 aa)

DEDNVIGSGGAGKVYKATLKSNN-ECSHLAIKKLWSCDKAEIRN-DYGFKT---EVNILGRIRHFNIVRLLCCCSNGETNLLVYEYVPNGSLGDALHHPS
..||.||.|| | ||.. .| .   .   |.||| .  . ..   .  | .   |. .. |.|| ||| |.  |. ..   |||.| ||||| | |.   
HKDNRIGEGGFGCVYRGQWKNTTGIY---AVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLW--C

TKISGV---LDWPARYRIALGAAQGLSYLHHDC-VPAILHRDIKSNNILLSDEYDALLADFGIAKLV---GSNSSTEF---SMSVLAGSHGYIAPEYAH-
.. ..    | |. |  |..|.| |. .|| .    .| |.|||| |||| .   . ..||| .      ... ...      |.. |.  | .||.   
QDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRD

-RMKVNEKSDVYSFGVVLLELVTGKKPV
   .   |.||||||.||||..|| ..|
PQGQLTKKTDVYSFGIVLLEVLTGCRAV
Kinase LRR8_p-2.AA MLK 715-925 27 5.8e-40 136.34 In-house 1-235 (291) Show / Hide 
Range on Protein: 715-925
Range on HMM: 1-235/291
Sequence Identity: 27% (67 aa)

LDEDNVIGSGGAGKVYKATLKSNN-ECSHLAIKKLWSCDKAEIRNDY----GFKTEVNILGRIRHFN----IVRLLCCCSNGETN-LLVYEYVPNGSLGD
...  .||||. |||.|.. . ..     .|.|.  .    ..   |     |..|...| ...| |    |.... .|.. . . ..| ||...||| .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ALHHPSTKIS---------GVLDWPARYRIALGAAQGLSYLHHDCVPAILHRDIKSNNILLSD------EYDALLADFGIAKLVGSNSSTEFS-MSVLAG
 ||  ..|..         .| |     ..||  |.|..||| . ...| |||.|| |||...      . ..  .|||... .   .... . |   ||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDW---HQMC-TNMMSNAG

SHGYIAPEY---AHRMKVNEKSDVYSFGVVLLELVTGKKP
.  . |||    .   |..||.||.|.|||| |..|.. |
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase LRR8_p-2.AA TKL-Unique 719-925 31 1.5e-39 137.14 In-house 3-233 (290) Show / Hide 
Range on Protein: 719-925
Range on HMM: 3-233/290
Sequence Identity: 31% (75 aa)

NVIGSGGAGKVYKATLKSNNECSHLAIKKLWSCDKAEIRND--YGFKTEVNILGRIR-HFNIVRLLCCCS----NGETNLLVYEYVPNGSLGDALH--HP
|.||.||.|.|||.. ..    .  |||..    .....|.    |. |||.. ... | |||..   |           .| ||.| ||| | ||   .
NKIGEGGYGQVYKGKWRG----YPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNN

ST---KISGVLDWPARYRIALGAAQGLSYLHHDCVPAILHRDIKSNNILLSDE-----YDALLADFGIAKLVGSNSSTEFSMS------VLAGSHGYIAP
     . .  |..  |...|. .|||. ||||   | |.|||.|| |.|.. .     . . ..|||..|.  ... . ....      .  ||  ..||
NNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAP

EYAHR--MKVNEKSDVYSFGVVLLELVTGKK------P
|   .   . .|||||||||.|| |..|.|       |
EVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase LRR8_p-2.AA Pkinase 715-923 25 3.1e-38 136.26 Pfam 1-209 (293) Show / Hide 
Range on Protein: 715-923
Range on HMM: 1-209/293
Sequence Identity: 25% (56 aa)

LDEDNVIGSGGAGKVYKATLKSNNECSHLAIKKLWSCDKAEIRNDYGFK-TEVNILGRIRHFNIVRLLCCCSNGETNLLVYEYVPNG----SLGDALH-H
.    .||||. |.|||.. |....    |.|... ... .  . . .. .|. |. |..| |||||.... ..    .| ||...|    .| | .. .
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

PSTKISGVLDWPARYRIALGAAQGLSYLHHDCVPAILHRDIKSNNILLSDEYDA----LLADFGIAKLVGSNSSTEFSMSVLAGSHGYIAPEYAH-RMKV
 .....  ...    ....  ..|| |.|      |.|||.|. |||......      ..|||.||..  . . .  |....|. .|.|||    . . 
RHGCFY--FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS--MTTFCGTPWYMAPEVIRGGQYY

NEKSDVYSFGVVLLELVTGK
  |.|..|.|..| |...|.
GPKVDMWSCGCILYEMLCGR
Kinase LRR8_p-2.AA Dicty4 715-925 33 2.6e-37 122.11 In-house 1-216 (277) Show / Hide 
Range on Protein: 715-925
Range on HMM: 1-216/277
Sequence Identity: 33% (75 aa)

LDEDNVIGSGGAGKVYKATLKSNNECSHLAIKKL---WSCDKAEIRNDYGFKTEVNILGRIRHFNIVRLLCCCS----NGETNLLVYEYVPNGSLGDALH
.. .. ||.|. |.|||.| .     .  |.|||      . ... |.  |. ||.|.. ||| ||. ..  |     . .. . | ||.| |.|   ||
INIEQRIGKGSFGEVYKGTWR----GKEVAVKKLNNHNQNFDENMLNE--FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLH

H------PSTKISGVLDWPARYR---IALGAAQGLSYLHHDCVPAILHRDIKSNNILLSDEYDALLADFGIAKLVGSNSSTEFSMSVLAGSHGYIAPEYA
       .|.|    |||| . |   .|. ||.|. .||  | | |.|||.|| |.| .. . .  .|||....    ..  . ..  .|. .. |||  
DKPSEQQQSIK----LDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM

HRMKVNEKSDVYSFGVVLLELVTGKKP
     |||.|||||| || |..|.. |
MHQPYNEKADVYSFGIVLWEILTRQEP
Kinase LRR8_p-2.AA LISK 720-925 28 9.6e-34 106.87 In-house 1-238 (296) Show / Hide 
Range on Protein: 720-925
Range on HMM: 1-238/296
Sequence Identity: 28% (70 aa)

VIGSGGAGKVYKATLK-SNNECSHLAIKKLWS-----CDKAEIRNDYGFKTEVNILGRIRHFNIVRLLCCCSN-GETNLLVYEYVPNGSLGDALHHPST-
.||.|. ||||| |.. ....    |||.. .     .|.. ...   .. || .. ..|| |||.    | .      .| ||.  | | . |. ..  
EIGKGFFGKVYKGTHRQTGQV---MAIKMIHRQPNDPNDPEYQKF---MLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKH

KISGVLDWPARYRIALGAAQGLSYLHHDCVPAILHRDIKSNNILLSDE----YDALLADFGIAKLVGSNS------------------------------
||  .| || | .|||. |.|.||||  .   |.||| ||.|.|...     . . ..||| |...   .                              
KI--PLPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKC

--STEFSMSVLAGSHGYIAPEYAHRMKVNEKSDVYSFGVVLLELVTGKKP
  .   .|..  |.    |||    .. .|..||.|||.||.|..|..|.
MNQRKRRMTIC-GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKA
Kinase LRR8_p-2.AA STE 715-923 22 1.2e-30 105.55 In-house 1-265 (359) Show / Hide 
Range on Protein: 715-923
Range on HMM: 1-265/359
Sequence Identity: 22% (61 aa)

LDEDNVIGSGGAGKVYKATLK------SNNECSH-------LAIKKLW--SCDKAEIR------------NDY-GFKTEVNILGRIR--HFNIVRLLCCC
..   .||.|. |.||||  .      ...| .         |||..   .|.. .              ..   .. |..|. . .  | |||. ..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

SNG-------ETNLLVYEYVPNGSLGDALHHP-STKIS--------GVLDWPARYRIALGAAQG-LSYLHHDCVPAILHRDIKSNNILLSDEYDALLADF
 ..       ..  .. ||...||| | ..|  ... .        .... .   .|.    .| |.|||      | |||||. ||||     . |.||
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDF

GIAK-LVGSNS------------STEFSMSVLAGSHGYIAPEYAHRMKVN------EKSDVYSFGVVLLELVTGK
|... |. |..            ..      ..|.  . |||   ... .      .|.|..|.| ...|..|||
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase LRR8_p-2.AA DRK 762-921 36 1.3e-30 100.89 In-house 44-197 (258) Show / Hide 
Range on Protein: 762-921
Range on HMM: 44-197/258
Sequence Identity: 36% (58 aa)

FKTEVNILGRIRHFNIVRLLCCCSNGETNLLVYEYVPNGSLGDALHHPSTKISGVLDWPARYRIALGAAQGLSYLHHDCVPAILHRDIKSNNILLSDEYD
|. |.|.. . || ||.  .  | |    . . || | |||   || .| .    .||| . .... .| |. |||  | | |.||| || | |  . . 
FHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIE----MDWPLMKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQ

ALLADFGIAKLVGSNSSTEFSMSVLAGSHGYIAPEYAHRMKVNEKSDVYSFGVVLLELVT
   |||| .       .  | |    |  . .|||        || |||||..|| |.||
VKVADFGLSTRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT
Kinase LRR8_p-2.AA S_TKc 715-1005 20 5.1e-30 106.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 715-1005
Range on HMM: 1-231/231
Sequence Identity: 20% (62 aa)

LDEDNVIGSGGAGKVYKATLKSNNECSHLAIKKLWSCDKAEIRNDYGFKTEVNILGRIRHFNIVRLLCCCSNGETNLLVYEYVPN--GSLGDALHHPST-
 .  ..||.|. |||||.. |.     . |||..             .. |..|| . .| |||.|. .. . .   .| ||...  |.| | ...  . 
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

KISGVLDWPARYRIALGAAQGLSYLHHDCVPAILHRDIKSNNILLSDEYDALLADFGIAKLVGSNSSTEFSMSVLAGSHGYIAPEYAHRMKVNE-KSDVY
.   ...     ...   ...| |.|      |.|||.|  ||||..     ..|||.|...          . . |.  |.|||     . .  |.|..
GLRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWW

SFGVVLLELVTGKKPVGSPEFGDNGVDIVTWACNSIQSKQGVDAVIDPRLSPAICRQRDLLLVLKIALRCTNALASSRPSMRDVVQ--MLLDAHPGS
|.|..| |...|. |             .    . |                          .. .  .| .   . ||.  .. |  ..  .||  
SCGCILYEMLCGYPPFP----------QMQMMFKKIG----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_p-2.AA LRRK 715-925 26 7.9e-30 102.69 In-house 1-282 (351) Show / Hide 
Range on Protein: 715-925
Range on HMM: 1-282/351
Sequence Identity: 26% (77 aa)

LDEDNVIGSGGAG-KVYKATLKSN------------------------NECSHLAIKKLWSC-------------------------------DKAEIRN
| . . ||.|| | .||.|.....                        . |.  ||||.  .                               .   .|.
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

DYGFKTEVNILGRIRHFNIVRLLCCCSNGETNLLVYEYVPNGSLGDALHHPS-TK---ISGVLDWPARYRIALGAAQGLSYLHHDCVPAILHRDIKSNNI
   |  || |. . .| ||| |.  | .  .  .| ||.|.|.| . ||... ..   .  ...|  ...|||  | |. || |.. | |.||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLC--MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI

LL-SD-----------EYDALLADFGIAKLVGSNSSTEFS-MSVLAGSHGYIAPEYAHRM---KVNEKSDVYSFGVVLLELVTGK-KP
|| |            .. | .|||||   .   ...  .  . . |  |. |||    .     .||.|.||||..| ||.|..  |
LLWSSPQNHSPNYPNAHVCAKIADFGISR-MF--QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase LRR8_p-2.AA TK 715-925 15 1.4e-27 88.95 In-house 1-394 (486) Show / Hide 
Range on Protein: 715-925
Range on HMM: 1-394/486
Sequence Identity: 15% (63 aa)

LDEDNVIGSGGAG---KVYKATLKS-----------------------NNECSHLAIKKLWSCDKAEIRNDYG--------------FKTEVNILG--RI
.   ...|.|  |   .|||.....                       ....   |.| | . | .. .                  .  |  ..     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHFNIVRLLCCCSNGET------------NLLVYEYVPNGS----LGDALHHPSTKISG-----------------------------------------
.| |||||. .|. ||.             ..| ||.|.|.    | | |.  . | .                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------VLDWPARYRIALGAAQGLSYLHHD----CVPAILHRDIKSNNILLSDEYD-----------ALLADFGIA
                               |. . .  ... .|.|..|||        . . |||.   |.|.....            . .|||| .
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

K-----LVGSNSSTEFSMSVLAGSHGY--------------------------IAPEYAH---------RMKVNEKSDVYSFGVVLLELVT-GKKP
.     |     | .   ..  ...|                            |||              |  .||||.||||.. |..| |..|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase LRR8_p-2.AA Pkinase_Tyr 715-873 28 1.2e-18 63.73 Pfam 1-161 (270) Show / Hide 
Range on Protein: 715-873
Range on HMM: 1-161/270
Sequence Identity: 28% (47 aa)

LDEDNVIGSGGAGKVYKATLK--SNNECSHLAIKKLWSCDKAEIRN--DYGFKTEVNILGRI-RHFNIVRLLCCCS-NGET--NLLVYEYVPNGSLGDAL
.  . ..|.|  |.|||.|.|    |.. . |.|.|    .|  ..     |  |..|.  . .| |||||. .|.  ||    ..| ||.|.|.| | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HHPSTKISGVLDWPARYRIALGAAQGLSYLHHDCVPAILHRDIKSNNILLSDEYDALLADFGIAKLV
. ..    . |. .    ...  |.|..||.      . |||.   |.|....  .  .||| |...
RKHR-EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase LRR8_p-2.AA TyrKc 715-998 22 9.1e-17 48.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 715-998
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

LDEDNVIGSGGAGKVYKATLKSNNECSHLAIKKLWSCDKAEIRNDYGFKTEVNILGRI--RHFNIVRLLCCCSNG-------ETNLLVYEYVPNGSLGDA
.  . ..|.|  |.|||.|.|        |.|.| ..          |  | .|. ..  .| |||||. .|. .       |  ..| ||.|.|.| | 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LHHPSTKISGVLDWPARYRIALGAAQGLSYLHHDCVPAILHRDIKSNNILLSDEYDALLADFGIAKLVGSN-----SSTEFSMSVLAGSHG-----YIAP
|. .  |    | ..    ... .|.| .|||.     . |||.   |.|..... .  .||| .. ...      |.   ...   |...       ||
LRKHRPK----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EYAHRMKVNEKSDVYSFGVVLLELVTGKKPVGSPEFG-----DNGVDIVTWACNSIQSKQGVDAVIDPRLSPAI----CRQRDLLLVLKIALRCTNALAS
|     | ..||||.||||.. |. |     ..|  |      .  ... .  .    .|  ..       | .    | .     . .| ..| .. ..
ECINYGKFTTKSDVWSFGVCMWEIFTY---GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY------P-MSFVCCPDE----MYQIMKQCWHEDPE

SRPSMRDVVQML
.||....... .
DRPTFSEIHECF
Kinase LRR8_p-2.AA Pkinase_Tyr 894-925 48 1.5e-05 19.38 Pfam 182-214 (270) Show / Hide 
Range on Protein: 894-925
Range on HMM: 182-214/270
Sequence Identity: 48% (16 aa)

APEYAHRMKVNEKSDVYSFGVVLLELVT-GKKP
|||  . .| ..||||.||||.. |..| |..|
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQP
Kinase LRR8_p-2.AA TK 976-998 17 0.000482 8.6 In-house 464-486 (486) Show / Hide 
Range on Protein: 976-998
Range on HMM: 464-486/486
Sequence Identity: 17% (4 aa)

IALRCTNALASSRPSMRDVVQML
. ..| .. .. ||........|
LMQQCWHYDPEDRPTFSQLHEQL
Kinase LRR8_p-2.AA IRAK 977-998 36 0.003864 7.17 In-house 296-317 (317) Show / Hide 
Range on Protein: 977-998
Range on HMM: 296-317/317
Sequence Identity: 36% (8 aa)

ALRCTNALASSRPSMRDVVQML
|..|. . |  |..|. |.| |
ACCCGHHRANRRCDMAWVMQQL
Kinase LRR8_p-2.AA MLK 979-998 45 0.02725 3.91 In-house 272-291 (291) Show / Hide 
Range on Protein: 979-998
Range on HMM: 272-291/291
Sequence Identity: 45% (9 aa)

RCTNALASSRPSMRDVVQML
.| |. ...|||.| .|| |
QCWNQDPHKRPSFRQIVQHL
Kinase LRR8_p-2.AA LISK 974-998 32 0.038316 2.53 In-house 272-296 (296) Show / Hide 
Range on Protein: 974-998
Range on HMM: 272-296/296
Sequence Identity: 32% (8 aa)

LKIALRCTNALASSRPSMRDVVQML
|.....|..   ..|||  ..|| |
LDLCFDCCKYDPKNRPSFKEIVQWL
Kinase LRR8_p-2.AA LRRK 980-1000 23 0.06573 2.52 In-house 331-351 (351) Show / Hide 
Range on Protein: 980-1000
Range on HMM: 331-351/351
Sequence Identity: 23% (5 aa)

CTNALASSRPSMRDVVQMLLD
| ..   .||.. ..|. | .
CWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_p-2.AA Dicty4 986-1001 29 0.188799 0.8 In-house 261-277 (277) Show / Hide 
Range on Protein: 986-1001
Range on HMM: 261-277/277
Sequence Identity: 29% (5 aa)

SSRPSMRDVVQM-LLDA
..|||.  ..|  .|..
QHRPSFEEIIQRRILEH
Kinase LRR8_p-2.AA Pkinase_Tyr 978-998 19 0.614508 3.8 Pfam 250-270 (270) Show / Hide 
Range on Protein: 978-998
Range on HMM: 250-270/270
Sequence Identity: 19% (4 aa)

LRCTNALASSRPSMRDVVQML
..| .. .. ||........|
KQCWHYDPEDRPTFSEIHEQL