Gene LRR8_f-1 (S.moellendorffii)

LRR8_f-1

Species: S.moellendorffii
Alias: LRR8_f-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_f-1.AA Protein None 927 None Fasta, JSON
LRR8_f-1.NA RNA None 2784 None Fasta, JSON
LRR8_f-1.kin_dom Protein Kinase Domain None 194 None Fasta, JSON

Protein domain

Protein domains of LRR8_f-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_f-1.AA LRRNT_2 45-84 34 8e-06 21.85 Pfam 1-46 (46) Show / Hide 
Range on Protein: 45-84
Range on HMM: 1-46/46
Sequence Identity: 34% (16 aa)

RSSDLQILHSFSQQLV--DS-NASLTSWKLES----PCSSWEGVLCR
 ..|.| | .| . |.  |. . .| ||.  |    .|| |.|| | 
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCS-WTGVTCD
LRR_1 LRR8_f-1.AA LRR_1 113-135 44 0.000251 19.51 Pfam 1-26 (26) Show / Hide 
Range on Protein: 113-135
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

FLQRLDLSQ-N--GLSGDIPVE-LLKL
 ||.||||  |   |.|.|| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_f-1.AA LRR_TYP 111-135 36 0.139613 6.86 SMART 1-24 (24) Show / Hide 
Range on Protein: 111-135
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LKFLQRLDLSQNGLSGDIPVELLKL
|  |..|||| | |   .| ...  
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_f-1.AA LRR_1 96-111 42 48.049006 0.78 Pfam 9-26 (26) Show / Hide 
Range on Protein: 96-111
Range on HMM: 9-26/26
Sequence Identity: 42% (8 aa)

Y-N-KFLTGQISPS-LGHL
. |   |||.|.|| . .|
GCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-1.AA LRR_1 161-183 44 3e-06 26.3 Pfam 1-26 (26) Show / Hide 
Range on Protein: 161-183
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

NLEYLYLSR-N--NLSGSIPRS-LGSC
||..|.||. |  ||.|.|| | . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_f-1.AA LRR_TYP 159-183 36 0.00367 17.75 SMART 1-24 (24) Show / Hide 
Range on Protein: 159-183
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LENLEYLYLSRNNLSGSIPRSLGSC
| ||. |.||.|.|  ..|. . ..
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_f-1.AA LRR_1 137-159 37 0.100765 10.28 Pfam 1-26 (26) Show / Hide 
Range on Protein: 137-159
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ELTMLSLSS-N--QLSGQIPRH-MEML
 |. |.||. |  .|.|.||      |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-1.AA LRR_1 185-207 37 0.000334 19.07 Pfam 1-26 (26) Show / Hide 
Range on Protein: 185-207
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLKELDVSG-N--YLEGNVPVE-LGQL
.|..||.|| |   |.|..| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-1.AA LRR_1 209-230 37 0.099464 10.3 Pfam 1-26 (26) Show / Hide 
Range on Protein: 209-230
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLEKLGVAM-N--NLSGGIPD--FTNC
.|..| .   |  ||.| ||.  | |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-1.AA LRR_1 280-302 37 0.002346 16.07 Pfam 1-26 (26) Show / Hide 
Range on Protein: 280-302
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLLILYLSS-N--RFTGTIPEN-LCVN
|| .|.||. |  ..||.||.. .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-1.AA LRR_1 256-278 29 0.0132 13.41 Pfam 1-26 (26) Show / Hide 
Range on Protein: 256-278
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RLQNLWLND-N--QLSGDLPVE-LGRH
.|| | |.. |  .|.|..| . .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_f-1.AA LRR_TYP 254-278 40 0.029679 12.37 SMART 1-24 (24) Show / Hide 
Range on Protein: 254-278
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

LPRLQNLWLNDNQLSGDLPVELGRH
|| |. | |..|||   || .. ..
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_f-1.AA LRR_1 232-254 48 0.039044 11.74 Pfam 1-26 (26) Show / Hide 
Range on Protein: 232-254
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

NLTDLALSF-N--NLTGNVHPS-VATL
||. | ||  |  ||||...||    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_f-1.AA LRR_TYP 279-302 33 0.69453 1.15 SMART 2-24 (24) Show / Hide 
Range on Protein: 279-302
Range on HMM: 2-24/24
Sequence Identity: 33% (8 aa)

SNLLILYLSSNRFTGTIPENLCVN
.||  |.||.|..| ..|.... .
PNLRELDLSNNQLT-HLPPGAFQG
LRR_1 LRR8_f-1.AA LRR_1 328-350 33 0.019237 12.83 Pfam 1-26 (26) Show / Hide 
Range on Protein: 328-350
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

RLERLLLQN-N--MLTGQIPEE-VGQN
.|..| |.. |   |||.||..   . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-1.AA LRR_1 304-326 29 0.031512 12.07 Pfam 1-26 (26) Show / Hide 
Range on Protein: 304-326
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

FLERVYLHD-N--NLQGEIPRK-LVTC
 |.. .| . |  ||.|.||   .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_f-1.AA LRR_TYP 326-350 40 0.450606 2.69 SMART 1-24 (24) Show / Hide 
Range on Protein: 326-350
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

CPRLERLLLQNNMLTGQIPEEVGQN
 | |..| |.|| || ..|... |.
LPNLRELDLSNNQLT-HLPPGAFQG
LRR_1 LRR8_f-1.AA LRR_1 352-374 37 0.001931 16.37 Pfam 1-26 (26) Show / Hide 
Range on Protein: 352-374
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

VLNYLDLSN-N--RLNGSLPAS-LNDC
 | .||||. |  .| |..| | .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-1.AA LRR_1 376-391 31 1.397951 6.23 Pfam 1-19 (26) Show / Hide 
Range on Protein: 376-391
Range on HMM: 1-19/26
Sequence Identity: 31% (6 aa)

NLTTLFLAC-N--RISGDL
||..| | . |  ...|..
NLQHLDLSGCNCCNLTGHI
LRR_1 LRR8_f-1.AA LRR_1 397-419 40 0.000463 18.57 Pfam 1-26 (26) Show / Hide 
Range on Protein: 397-419
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

QLRQLNLSH-N--RLTGLIPRH-FGGS
.|. |.||. |  .||| ||   | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-1.AA LRR_1 444-465 37 0.020662 12.72 Pfam 1-26 (26) Show / Hide 
Range on Protein: 444-465
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLEKLFLDG-N--QLEGTIPR--FIGT
.|..| |.| |  .|.|.||   | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_f-1.AA LRR_TYP 395-418 50 0.023904 13.14 SMART 1-24 (24) Show / Hide 
Range on Protein: 395-418
Range on HMM: 1-24/24
Sequence Identity: 50% (12 aa)

FEQLRQLNLSHNRLTGLIPRHFGG
  .|| |.||.|.|| | |. |.|
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP LRR8_f-1.AA LRR_TYP 442-466 32 0.12442 7.27 SMART 1-24 (24) Show / Hide 
Range on Protein: 442-466
Range on HMM: 1-24/24
Sequence Identity: 32% (8 aa)

LQRLEKLFLDGNQLEGTIPRFIGTF
|  |..| |..|||  ..|. .   
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_f-1.AA LRR_1 420-442 40 0.223975 9.05 Pfam 1-26 (26) Show / Hide 
Range on Protein: 420-442
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

DVFTLDLSH-N--SLHGDIPPD-MQIL
   .||||. |  .| |.|||.    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-1.AA LRR_1 492-514 40 2.6e-05 22.98 Pfam 1-26 (26) Show / Hide 
Range on Protein: 492-514
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLRRIDLSS-N--RLSGTIPAR-LENL
.|...|||. |  .|.|.|| . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-1.AA LRR_1 516-538 44 0.00174 16.53 Pfam 1-26 (26) Show / Hide 
Range on Protein: 516-538
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

MLEDLDLSA-N--NLEGNIPSQ-LERL
 |. ||||  |  ||.|.||.  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_f-1.AA LRR_1 468-490 33 0.008999 14.0 Pfam 1-26 (26) Show / Hide 
Range on Protein: 468-490
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

KLLALVLNN-N--KFTGSIPGD-LGGL
.|  | |.. |  ..||.|| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_f-1.AA LRR_TYP 514-538 36 0.109026 7.74 SMART 1-24 (24) Show / Hide 
Range on Protein: 514-538
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LRMLEDLDLSANNLEGNIPSQLERL
|. |. |||| |.|   .|... . 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_TYP LRR8_f-1.AA LRR_TYP 490-513 36 0.132727 7.04 SMART 1-24 (24) Show / Hide 
Range on Protein: 490-513
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LHSLRRIDLSSNRLSGTIPARL-EN
|..||. |||.|.|  ..|... ..
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_f-1.AA LRR_1 540-571 25 0.223975 9.05 Pfam 1-26 (26) Show / Hide 
Range on Protein: 540-571
Range on HMM: 1-26/26
Sequence Identity: 25% (9 aa)

SLEHLNVSY-N-NHLL-APIPSASSKFNSSSFLGL
.|.||..|. |  .|           . .|.| .|
NLQHLDLSGCNCCNLTGH--------IPPSCF-NL
Kinase LRR8_f-1.AA TKL 653-920 20 1.6e-62 214.02 In-house 1-364 (364) Show / Hide 
Range on Protein: 653-920
Range on HMM: 1-364/364
Sequence Identity: 20% (76 aa)

IGQGGYGTVYRAEMES---------GKVLAIKKLTIAA-----------------------EDSLMHEWE-------TAGKVRHRNILKVLG---HYRHG
||.||.|.||...            ||. |.||. .                         .. .... .          . || ||.. .|     ..|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

G----------SALLVSNFMTNGSLGSLLHGRCSNEKIPWQLRYEIALGIAHGLSYLHHDCV-----PKIIHRDIKANNILLDKDMV-------------
.             .|  .. .||| ..||         |..|  .||.|| |..||| .       |.|||||.| .|||.|...              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PKIADFGLAKLIEKEAETKSMSY-----------------IAGSYGYIAPEYAFTL----------------KVNEKSDIYSFGVILLELLLRKTPLD-
 .||.||||.. .... . . ...                 . |.... |||                     . .||.|.||||..| |.| |..| . 
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

PLFSETDGNMTVWVRNETRGSSTGLESVADPEMWRE---ASRIEKKEMERVFRIALLCTEGNPADRPTMQQIVEML
. ... ...  . .  .  . .   .    |. |..   .   ..  .... ...  | . .| .||..|.|.. |
YPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKM-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8_f-1.AA IRAK 648-840 32 6.6e-45 155.5 In-house 2-218 (317) Show / Hide 
Range on Protein: 648-840
Range on HMM: 2-218/317
Sequence Identity: 32% (71 aa)

NQEFIIGQGGYGTVYRAEMESGK-VLAIKKL-------TIAAEDSLMH---EWETAGKVRHRNILKVLGHYRHGGSALLVSNFMTNGSLGSLLHGRCSNE
.... ||.||.|.|||...     . |.|||       ..  . ..     | ..  . || ||. ..|    ..   ||  .|.||||   |...    
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

K---IPWQLRYEIALGIAHGLSYLHHDC--VPKIIHRDIKANNILLDKDMVPKIADFGLAKLI----EKEAETK---SMSYIAGSYGYIAPEYAF--TLK
     .|. | .|..|.| |. .|| .   .| |||.|||  |||||....|||.||||.       .||. |      | . |.  | .||.    . .
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTP-IIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

VNEKSDIYSFGVILLELL
   |.|.||||. |||.|
LTKKTDVYSFGIVLLEVL
Kinase LRR8_f-1.AA MLK 647-845 25 3.9e-44 151.02 In-house 1-235 (291) Show / Hide 
Range on Protein: 647-845
Range on HMM: 1-235/291
Sequence Identity: 25% (61 aa)

LNQEFIIGQGGYGTVYRAEMESGK----VLAIKKLTIAA---------EDSLMHEWETAGKVRHRN----ILKVLGH-YRHGGSALLVSNFMTNGSLGSL
.. . .|| |..| |.....        ..|.|. .. .          . .  | . . ...|.|    | ...|   ...   ..|. .. .||| ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHGRCSNEK-----------IPWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLD------KDMVPKIADFGLAKLIEKEAETKSMSYIAGSYG
|||. |..            .. ..   .|| .|.|..||| . ...|||||.|  |||.|      .... ||.|||... . .    . |   ||.| 
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGTYA

YIAPEYAF----TLKVNEKSDIYSFGVILLELLLRKTP
. ||| ..      |..||.|..|.||.| |.| |..|
WMAPE-VIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase LRR8_f-1.AA Pkinase 647-845 25 1.4e-38 137.52 Pfam 1-211 (293) Show / Hide 
Range on Protein: 647-845
Range on HMM: 1-211/293
Sequence Identity: 25% (56 aa)

LNQEFIIGQGGYGTVYRAEMESG-KVLAIKKLTIAAEDSLMH-------EWETAGKVRHRNILKVLGHYRHGGSALLVSNFMTNG----SLGSLLHGRCS
.  . .||.|..|.||..   .  |. |.|..    |.| ..       | .   ...| ||.. .. .. ...  .|  .. .|    .| .....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

NEKI--PWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKDMVP----KIADFGLAKLIEKEAETKSMSYIAGSYGYIAPEYAF-TLKVNEKS
. ..  ...    ... |. || |.|     .|||||.|  |||.|.....    ||.||||||... .     |. ..|...|.|||      .   |.
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIYSFGVILLELLLRKTP
|..|.|.|| |.|....|
DMWSCGCILYEMLCGRPP
Kinase LRR8_f-1.AA LISK 652-845 26 1.9e-35 112.46 In-house 1-238 (296) Show / Hide 
Range on Protein: 652-845
Range on HMM: 1-238/296
Sequence Identity: 26% (64 aa)

IIGQGGYGTVYRAEME-SGKVLAIKKLTI--------AAEDSLMHEWETAGKVRHRNILKVLGHYRH-GGSALLVSNFMTNGSLGSLLHGRCS-NEKIPW
.||.|..| ||. .   .|.| |||....        ...  .  | ..  . ||.||..  | ..|  |.  .|  ..  | |  .|. . .    .||
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

QLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLD----KDMVPKIADFGLAKLIEKEAET---------------------------------KSM
..|  |||.|| |.||||  .   ||||| |..|.|..     .   |..|||.|.....|                                    ..|
PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

SYIAGSYGYIAPEYAFTLKVNEKSDIYSFGVILLELLLRKTP
. | |.    |||     . .|..|..|||..|.|.  |...
T-ICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKA
Kinase LRR8_f-1.AA Dicty4 647-840 34 3.3e-34 111.62 In-house 1-211 (277) Show / Hide 
Range on Protein: 647-840
Range on HMM: 1-211/277
Sequence Identity: 34% (73 aa)

LNQEFIIGQGGYGTVYRAEMESGKVLAIKKLTIAAED-------SLMHEWETAGKVRHRNILKVLGHYR----HGGSALLVSNFMTNGSLGSLLHG----
.| | .||.|..|.||..    ||  |.|||    ..       .. .| .  .| || ||.. .|       | |. . |. .|  |.| ||||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

RCSNEKIPWQLRYE---IALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKDMVPKIADFGLAKLIEKEAETKS-MSYIAGSYGYIAPEYAFTLKVNEKS
  .. |..| |.     .|. .| |. .||  | | |||||.|. |.| ||... |..||||.... |. . |  ..  .|. .. |||       |||.
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DIYSFGVILLELL
| |||| .| |.|
DVYSFGIVLWEIL
Kinase LRR8_f-1.AA RIPK 653-845 28 1.5e-33 111.64 In-house 1-227 (290) Show / Hide 
Range on Protein: 653-845
Range on HMM: 1-227/290
Sequence Identity: 28% (64 aa)

IGQGGYGTVYRAEMESGKVLAIKKL-----TIAA-----EDSLMHEWETAGKVRHRNILKVLGHYRHG-----GS-ALLVSNFMTNGSLGSLLHGRC--S
.| || |.|..|   . .. ..||       ...     .  .  | .   | |...|....|  .       .    .|  .| ||||  .|| ..   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

NEKIPWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKDMVPKIADFGLAKLIEKEAETK----------SMSYIA-GSYGYIAPEYAF--TL
.  .|| ||  .   |. |  || |.  | ||||| |  |||.| ..  ||||||||.  .    ..          . |    |   |..||  .    
HHPDPWPLRCRMIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

KV----NEKSDIYSFGVILLELLLRKTP
|     ..|.|.|||.... |.| .| |
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase LRR8_f-1.AA S_TKc 647-922 21 8.2e-33 116.25 SMART 1-231 (231) Show / Hide 
Range on Protein: 647-922
Range on HMM: 1-231/231
Sequence Identity: 21% (63 aa)

LNQEFIIGQGGYGTVYRAEMES-GKVLAIKKLTIAAEDSLMHEWETAGKVRHRNILKVLGHYRHGGSALLVSNFMTN--GSLGSLLHGRCSNEK---IPW
     .||.|..|.||..   . |.. |||..     .... | .   | .| || | ...... ..  .|  .. .  |.| .... | .. .   .| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

QLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKDMVPKIADFGLAKLIEKEAETKSMSYIAGSYGYIAPEYAFTLKVNE-KSDIYSFGVILLEL
     ..  |. .| |.|     .|||||.|  |||||.  . ||.|||||...         . . |.  |.|||     . .  |.|..|.|.|| |.
-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LLRKTPLDPLFSETDGNMTVWVRNETRGSSTGLESVADPEMWREASRIEKKEMERVFRIALLCTEGNPADRPTMQQIVE-------MLRT
| ...| .        .| .  ..                             . .  .   | . .|..|||  .. .       .   
LCGYPPFP--------QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_f-1.AA TK 647-840 14 2.5e-31 101.68 In-house 1-388 (486) Show / Hide 
Range on Protein: 647-840
Range on HMM: 1-388/486
Sequence Identity: 14% (58 aa)

LNQEFIIGQGGYG---TVYRAEMESGK--------------------------VLAIKKLTIAAEDSLMH-----------------EWETAGKVR----
.  .  .|.| .|   .||..|.....                            |.| |.  ...| .                  |.| . . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNILKVLGHYRHG------------GSALLVSNFMTNGS----LGSLLHGRCS---------------------------------------------
 | ||.. .|.  .|            .  ..|  .| .|.    | . |. .                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------NEKIPWQLRYEIALGIAHGLSYLHHD----CVPKIIHRDIKANNILLDKDMV-----------PKIADFGLA
                            ..... . .  ... || |..|||        ....|||. | |.|.....|            |||||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

KLIE----KEAETKSMSYIAGSYG----------------------------YIAPEYAF---------TLKVNEKSDIYSFGVILLELL
.  .    .. . ..  | ..|||                            . |||  .         . |  .|||..|||| . |..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF
Kinase LRR8_f-1.AA TKL-Unique 652-845 32 6e-31 106.45 In-house 4-233 (290) Show / Hide 
Range on Protein: 652-845
Range on HMM: 4-233/290
Sequence Identity: 32% (76 aa)

IIGQGGYGTVYRAEMESGKVLAIKKLTIAAEDSLMH-------EWETAGKVR-HRNILKVLGHYR----HGGSALLVSNFMTNGSLGSLLH-------GR
 ||.||||.||...  . .| |||.. .  |||          |  .  | . | ||..  |       . .   .|. ..  ||| ..||         
KIGEGGYGQVYKGKWRGYPV-AIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

CSNEKIPWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKD-----MVPKIADFGLAKLIEKE-AETKSMS------YIAGSYGYIAPEYAFT
 .| |...|.|. .|. || |. ||||   | |||||.|  |.|.| .     .  ||.||||.|.  |. ..|....         ||. ..|||    
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--LKVNEKSDIYSFGVILLELLLRKT------P
   . .||||.||||..| |.. ||       |
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase LRR8_f-1.AA STE 649-849 22 1.1e-29 102.01 In-house 1-274 (359) Show / Hide 
Range on Protein: 649-849
Range on HMM: 1-274/359
Sequence Identity: 22% (63 aa)

QEF--IIGQGGYGTVYRAEME----------------SGKVLAIKKLTI--------------------AAEDSLMHEWETAGKVR--HRNILKVLGHYR
.|.  .||.|..||||.|                   .|.. |||.. .                      ......| ..  | .  | || | .|.| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HGG-------SALLVSNFMTNGSLGSLLH---GRCSNEK--------IPWQLRYEIALGIAHG-LSYLHHDCVPKIIHRDIKANNILLDKDMVPKIADFG
..|       .  ..  .| .||| ....   |.  . .        .| ..   |.  | .| |.|||      |||||||. ||||      |..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKLIEKE--------------AETKSMSYIAGSYGYIAPEYAFT------LKVNEKSDIYSFGVILLELLLRKTPL---DPL
... ....                 .    ..|.  . |||           . ..|.||.|.|  ..|..  | |.    |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPM
Kinase LRR8_f-1.AA LRRK 719-847 35 1.4e-25 87.48 In-house 136-284 (351) Show / Hide 
Range on Protein: 719-847
Range on HMM: 136-284/351
Sequence Identity: 35% (53 aa)

FMTNGSLGSLLHGRCSNE------KIPWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILL---D---------KDMVPKIADFGLAKLIEKEAET
....|.| ..|| . ...      .|.|.|...||| || |. || |.. |.||||| |  ||||   .          ... ||||||.  .  .   .
YAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHM

KSMSYIAGSYGYIAPEYAF---TLKVNEKSDIYSFGVILLELLLRK-TPLD
.  .   |  |. |||      .   .||.|.||||.|| ||| |.  | |
GVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase LRR8_f-1.AA Pkinase_Tyr 647-834 25 1.1e-24 84.22 Pfam 1-202 (270) Show / Hide 
Range on Protein: 647-834
Range on HMM: 1-202/270
Sequence Identity: 25% (53 aa)

LNQEFIIGQGGYGTVYRAEME-----SGKVLAIKKL--TIAAE----DSLMHEWETAGKV-RHRNILKVLGHYR-HGGS--ALLVSNFMTNGSLGSLLHG
.     .|.| .|.||....       .   |.|.|  .   |    ...|.| ..  .  .| ||.. .|    .|..   ..|  .| .|.| . |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R-CSNEKIPWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKDMVPKIADFGLAKLIEKEAET-KSMSYIAGSYGYIAPEYAFTLKVNEKSDI
.  ...... .   .... || |..||.      .||||. | |.|.....| ||.|||||..|... .  .. .         |||  .. | ..|||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGV
.||||
WSFGV
Kinase LRR8_f-1.AA TyrKc 647-920 21 1.6e-19 72.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 647-920
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

LNQEFIIGQGGYGTVYRAEMESGKVLAIKKLTIAAEDSLMHEWETAGKV--RHRNILKVLGHYRHG-------GSALLVSNFMTNGSLGSLLHGRCSNEK
.  . ..| | .|.||....      |.|.|   |.  .|.| .   |.  .| ||.. .|  ...       .  ..|  .| .|.| . |. .  .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

IPWQLRYEIALGIAHGLSYLHHDCVPKIIHRDIKANNILLDKDMVPKIADFGLAKLIEKE------AETKSMSY--IA---GSYGYIAPEYAFTLKVNEK
....   .... || | .|||.    ..||||. | |.|.... . ||.||||.. |. .       ......    .     .   |||  .. | ..|
LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDIYSFGVILLELLLRKTPLDPLFSETDGNMTVWVRNETRGSSTGLES----VADPEMW---REASRIEKKEM----------ERVFRIALLCTEGNPAD
||..|||| . |..                        |.| .   .     . . |.    ..  | .. .           . ...| . | . .|.|
SDVWSFGVCMWEIF------------------------TYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED

RPTMQQIVEML
|||...|.| .
RPTFSEIHECF
Kinase LRR8_f-1.AA TK 892-920 27 2e-06 16.41 In-house 447-486 (486) Show / Hide 
Range on Protein: 892-920
Range on HMM: 447-486/486
Sequence Identity: 27% (11 aa)

M-----------ERVFRIALLCTEGNPADRPTMQQIVEML
|           | .... . | . .|.||||..|..|.|
MRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LRR8_f-1.AA LRRK 647-679 24 5e-06 17.19 In-house 1-61 (351) Show / Hide 
Range on Protein: 647-679
Range on HMM: 1-61/351
Sequence Identity: 24% (15 aa)

LNQEFIIGQGGYG-TVYRAEMES---------------------------GKVLAIKKLTI
|  |  ||.||.| .||||....                           ..  ||||...
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNR
Kinase LRR8_f-1.AA LRRK 901-922 36 1e-05 16.15 In-house 330-351 (351) Show / Hide 
Range on Protein: 901-922
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

LCTEGNPADRPTMQQIVEMLRT
.| ...| .||...|||. | .
HCWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_f-1.AA MLK 906-920 46 0.000215 11.3 In-house 277-291 (291) Show / Hide 
Range on Protein: 906-920
Range on HMM: 277-291/291
Sequence Identity: 46% (7 aa)

NPADRPTMQQIVEML
.|..||...|||. |
DPHKRPSFRQIVQHL
Kinase LRR8_f-1.AA Pkinase_Tyr 893-920 32 0.000369 14.71 Pfam 243-270 (270) Show / Hide 
Range on Protein: 893-920
Range on HMM: 243-270/270
Sequence Identity: 32% (9 aa)

ERVFRIALLCTEGNPADRPTMQQIVEML
. . .. ..| . .|.||||...|.|.|
DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase LRR8_f-1.AA Dicty4 906-922 26 0.001988 7.49 In-house 259-277 (277) Show / Hide 
Range on Protein: 906-922
Range on HMM: 259-277/277
Sequence Identity: 26% (5 aa)

NPADRPTMQQIVEM--LRT
.|  ||....|..   | .
DPQHRPSFEEIIQRRILEH
Kinase LRR8_f-1.AA TKL-Unique 906-920 33 0.004076 7.05 In-house 276-290 (290) Show / Hide 
Range on Protein: 906-920
Range on HMM: 276-290/290
Sequence Identity: 33% (5 aa)

NPADRPTMQQIVEML
.| .||. ..|.. |
DPSQRPSFDEIIHRL
Kinase LRR8_f-1.AA LISK 896-920 28 0.040798 2.44 In-house 272-296 (296) Show / Hide 
Range on Protein: 896-920
Range on HMM: 272-296/296
Sequence Identity: 28% (7 aa)

FRIALLCTEGNPADRPTMQQIVEML
..... |.. .| .||.   ||. |
LDLCFDCCKYDPKNRPSFKEIVQWL
Kinase LRR8_f-1.AA Pkinase 906-920 35 2.726302 2.11 Pfam 277-293 (293) Show / Hide 
Range on Protein: 906-920
Range on HMM: 277-293/293
Sequence Identity: 35% (6 aa)

NPADRPTMQQIVEM--L
.|..||| .||..   .
DPKKRPTAEQILQHPWF