Gene LRR8-2_b (S.moellendorffii)

LRR8-2_b

Species: S.moellendorffii
Alias: LRR8-2_b
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8-2

Sequence

Name Sequence Type Origin Length Description Download
LRR8-2_b.AA Protein None 1066 None Fasta, JSON
LRR8-2_b.NA RNA None 3201 None Fasta, JSON
LRR8-2_b.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of LRR8-2_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 LRR8-2_b.AA LRR_1 160-184 36 0.020662 12.72 Pfam 1-26 (26) Show / Hide 
Range on Protein: 160-184
Range on HMM: 1-26/26
Sequence Identity: 36% (11 aa)

QLRHLDLSE-N--GLH-LGGPIPGQ-LASL
.|.|||||  |   |      ||   . .|
NLQHLDLSGCNCCNLTGH---IPPSCF-NL
LRR_1 LRR8-2_b.AA LRR_1 186-208 40 0.00262 15.9 Pfam 1-26 (26) Show / Hide 
Range on Protein: 186-208
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

KLRHLGLAG-N--QLTGSIPEE-LCTI
.|.|| | | |  .|||.||.. .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8-2_b.AA LRR_1 210-232 37 0.000657 18.03 Pfam 1-26 (26) Show / Hide 
Range on Protein: 210-232
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLKYLDLSR-N--QLQGPVPAC-LGNS
.|..||||. |  .|.| .|   . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8-2_b.AA LRR_1 234-256 32 0.00467 15.01 Pfam 1-26 (26) Show / Hide 
Range on Protein: 234-256
Range on HMM: 1-26/26
Sequence Identity: 32% (9 aa)

SLRVLDLGS-N--RL-RSRIPAE-LGQL
.|..|||.. |  .| .. || . . .|
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
LRR_1 LRR8-2_b.AA LRR_1 258-280 33 0.000309 19.19 Pfam 1-26 (26) Show / Hide 
Range on Protein: 258-280
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLLYLNLEN-N--RLQGEVPES-LGSL
.| .|.| . |  .|.|..|.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8-2_b.AA LRR_1 282-304 25 0.469574 7.91 Pfam 1-26 (26) Show / Hide 
Range on Protein: 282-304
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLQTLRCGR-N--MLEGVLPRQ-LGQA
.||.|  .. |   |.| .|   . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8-2_b.AA LRR_1 306-329 40 0.010654 13.74 Pfam 1-26 (26) Show / Hide 
Range on Protein: 306-329
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLQVLDFSL-N-SDIAGSIPAS-LGSL
.||.||.|  | . . |.|| | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8-2_b.AA LRR_1 331-353 25 6.598427 3.84 Pfam 1-26 (26) Show / Hide 
Range on Protein: 331-353
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

DIVELSLFS-M--GLNGTIPSE-LGKL
 . .|.| .     | |.||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8-2_b.AA LRR_1 355-377 40 0.004887 14.94 Pfam 1-26 (26) Show / Hide 
Range on Protein: 355-377
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLSALRLHS-N--SISGSIPGS-FSEL
||  | | . |  ...|.|| | |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8-2_b.AA LRR_1 379-402 37 0.000404 18.78 Pfam 1-26 (26) Show / Hide 
Range on Protein: 379-402
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLKVLQVQG-N--QLSGSLPSSVFKQL
.|..| ..| |  .|.|..|.| | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8-2_b.AA LRR_1 404-426 29 0.997345 6.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 404-426
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

GLQGLYLQI-N--SFTGVLPVE-ITRM
 || |.|.  |  ..|| .| . .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8-2_b.AA LRR_1 428-450 29 0.012695 13.47 Pfam 1-26 (26) Show / Hide 
Range on Protein: 428-450
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLSVLNLGF-N--QLDGELPET-LGSM
|| .|.|.  |  .| |..|.  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8-2_b.AA LRR_1 452-464 25 69.509902 0.21 Pfam 1-16 (26) Show / Hide 
Range on Protein: 452-464
Range on HMM: 1-16/26
Sequence Identity: 25% (4 aa)

SLEWLLLGS-N--RFS
.|. | |.. |  ...
NLQHLDLSGCNCCNLT
Malectin LRR8-2_b.AA Malectin 505-628 33 2.1e-21 82.23 Pfam 69-202 (202) Show / Hide 
Range on Protein: 505-628
Range on HMM: 69-202/202
Sequence Identity: 33% (46 aa)

DSRFVEATQ---ELYTTARVGGDSIAYYGRCLKPGSYAVELHFIELENYT----VDSPGRRVFDVFLQEQRVHEKLDVFRVAGGPFVPLVLKF-QARVGE
.|.|   ..   |||.|.| . .| .||. ||. |.| |.||| |... .     .||||||||| .| ..| . .|..  ||| . . . .|  . |  
SSIFYTTDDVDPELYQTERWSPSSFRYYIPCLENGNYTVILHFAEIYFQDTDQTWNSPGRRVFDVYIQGKLVLKDFDIWKEAGGKGKAAHKEFINVTV--

ESSTLK--LELRGTGSWNTSGAAG-SYHG-PTISAI
 ..||.  . .  .|   ..     .|.| |.||||
TNGTLEYVIHFYWAGKGTCCIPFRKGYYGNPKISAI
Kinase LRR8-2_b.AA IRAK 701-907 37 3.2e-64 219.65 In-house 1-226 (317) Show / Hide 
Range on Protein: 701-907
Range on HMM: 1-226/317
Sequence Identity: 37% (85 aa)

FSSDNLLGQGAYGRVYKGFLPDGK-IVAIK---QLVHRTPT-CQRWFYH---ELQVISSVRHRNLVPLIGCCIDRGFPLLVCEFMPNGSLQGALFGRD-S
|. ||..|.|..| ||.| .     |.|.|   . .  ...   . |     ||.| .. || |.||| | |..|... || ..||||||.  | ..| .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

GIF--LDWERRLQIALDVARGLQYLHEDCAKVRIIHRDVKPGNILLDEDMRAHISDFGLAKLI--AHHEEAEVV----VSSVMGTRGYLAPEYVI--NGQ
.    | | .|. |..  |.|.|.||..  .. |||.|.|. |||||... . |.||||.     | | |. ..    .| | ||  |..||.     ||
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LSEKVDVYSYGIVLLELVSGRRGMQS
|. |.|||| ||||||...|.| . .
LTKKTDVYSFGIVLLEVLTGCRAVYD
Kinase LRR8-2_b.AA TKL 707-977 21 1.2e-62 214.42 In-house 1-364 (364) Show / Hide 
Range on Protein: 707-977
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

LGQGAYGRVYKGFLPD---------GKIVAIKQLVHRTPTCQRW---------------------------FYHELQVISSVRHRNLVPLIGCCIDRGF-
.|.|..| |||| .           || ||.|..  .   .  .                           .  |. ..|. || |.|...|.|.. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PLLVCEFMPNGSLQGALFGRDSGIFLDWERRLQIALDVARGLQYLHEDCA----KVRIIHRDVKPGNILLDEDMR-------------
            . .| |..|.|||   |          |..|...|||.|||..||| .      |  ||||| |. |||.||...             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-AHISDFGLAKLIAHHEE----------------AEVVVSSVMGTRGYLAPEYVING----------------QLSEKVDVYSYGIVLLELVSGRRGMQS
 . |.||||.. . ....                 .   ... || ...|||   .                 . |||.||||.|||| |.....|    
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----

SVNVGAPEPVS-IDEW---------AWEALGSNKIEA---------MADPRFGRKYSMDAMVRIVQIAMWCTQGLPEQRPSMGQVVAML
        | . ...          .. .. ..| .          .   . .     |.. .. .....| .  ||.|||. ...  |
--------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8-2_b.AA Pkinase 701-902 29 2.3e-52 185.08 Pfam 1-209 (293) Show / Hide 
Range on Protein: 701-902
Range on HMM: 1-209/293
Sequence Identity: 29% (64 aa)

FSSDNLLGQGAYGRVYKGFLPDG-KIVAIKQLVHRTPTCQRWFYH----ELQVISSVRHRNLVPLIGCCIDRGFPLLVCEFMPNG----SLQGALFGRDS
.     .|.|..|.|||.   .  ||||.|..  |.  .. . .|    |.|.  ...| | | |.... |.. . .| |....|    .|   . ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GIF-LDWERRLQIALDVARGLQYLHEDCAKVRIIHRDVKPGNILLDEDMRA----HISDFGLAKLIAHHEEAEVVVSSVMGTRGYLAPEYVI-NGQLSEK
| | ....    ... ..|||.|.|.     .|||||.|| |||.|...      .|.||||||..   .   .  ... ||..|.||| .  .   . |
GCFYFSEWECKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

VDVYSYGIVLLELVSGR
||..|.|..| |...||
VDMWSCGCILYEMLCGR
Kinase LRR8-2_b.AA Dicty4 701-899 33 7.2e-43 140.9 In-house 1-211 (277) Show / Hide 
Range on Protein: 701-899
Range on HMM: 1-211/277
Sequence Identity: 33% (73 aa)

FSSDNLLGQGAYGRVYKGFLPDGKIVAIKQL-VHRTPTCQRW---FYHELQVISSVRHRNLVPLIGCCI----DRGFPLLVCEFMPNGSLQGALFGRD--
   ....|.|..| ||||    ||.||.| |  | .   .     | .|    .. || |.. . | |.      | .. | |.|| |.|   |  .|  
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLL--HDKP

----SGIFLDWERRLQ---IALDVARGLQYLHE-DCAKVRIIHRDVKPGNILLDEDMRAHISDFGLAKLIAHHEEAEVVVSSVMGTRGYLAPEYVINGQL
    . | |||.....   .|.|.|||...||. ..   .||||| |. |.| |...|. ..||||....  ||.     ... || .. |||   .   
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNP---VIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPY

SEKVDVYSYGIVLLELV
 ||.||||.|||| |..
NEKADVYSFGIVLWEIL
Kinase LRR8-2_b.AA MLK 701-902 28 6.6e-42 143.18 In-house 1-233 (291) Show / Hide 
Range on Protein: 701-902
Range on HMM: 1-233/291
Sequence Identity: 28% (69 aa)

FSSDNLLGQGAYGRVYKGFLPDGKI-----VAIKQLVHRT------PTCQRWFYHELQVISSVRHRN----LVPLIGCCIDRGF-PLLVCEFMPNGSLQG
.     .| |..| |.||    .|.     ||.|.  .|.       . |. |  |    . ..|.|     ... |.|.. .   ..| |....|||  
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ALFGRDSGIF-----------LDWERRLQIALDVARGLQYLHEDCAKVRIIHRDVKPGNILLDE------DMRAHISDFGLAKLIAHHEEAEVVVSSVMG
 | |..|...            | .  ...||..|||..|||.. |.. ||||| |. |||.||      .. . |.|||... . ....      | .|
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSM-APKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTN---MMSNAG

TRGYLAPEYVI----NGQLSEKVDVYSYGIVLLELVSGR
|  . ||| ||    ... |||.||.|.|.|| |.....
TYAWMAPE-VIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase LRR8-2_b.AA TKL-Unique 705-901 31 6.8e-42 145.49 In-house 3-224 (290) Show / Hide 
Range on Protein: 705-901
Range on HMM: 3-224/290
Sequence Identity: 31% (71 aa)

NLLGQGAYGRVYKGFLPDGKIVAIKQLVH---RTPTCQRWFYHELQVISSVR-HRNLVPLIGCCI----DRGFPLLVCEFMPNGSLQGALF-------GR
|..|.|.||.||||  . |..|||||.       ..  . |. |. ...  . | |.| ..| |.    . .   .|.|..| |||   |          
NKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

DSGIFLDWERRLQIALDVARGLQYLHEDCAKVRIIHRDVKPGNILLDED-----MRAHISDFGLAKLIAHHEEAEVVVS------SVMGTRGYLAPEYVI
 . . |....|...|.|.|.|. |||   ..  ||||| |. |.|.|..     ... |.||||.|. .   .  .  .      ...|.  ..||| |.
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP--IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE-VL

NG---QLSEKVDVYSYGIVLLELVSG
..   | |||.||||.|||| |....
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase LRR8-2_b.AA TK 701-977 14 4.6e-41 134.9 In-house 1-486 (486) Show / Hide 
Range on Protein: 701-977
Range on HMM: 1-486/486
Sequence Identity: 14% (76 aa)

FSSDNLLGQGAYG---RVYKGFLPDGK--------------------------IVAIKQLVHRTPTCQRWFYH--------------ELQVISSVR----
    . ||.|..|   .|||| . ...                           ||.|.|   ... |. |                |.....  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLVPLIGCCIDR------------GFPLLVCEFMPNGS----LQGALFGRDSGIF------------------------------------------
 | |.| |.|.| .             . ...| |.||.|.    |.  |  .. . .                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWERRLQIALDVARGLQYLHED-CAKV--RIIHRDVKPGNILLDEDMR-----------AHISDFGLA
                               |. ...| .....|.|..|||.  |     ...|||.   |.|..|...           . |.||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------KLIAHHEEAEVVVSSVMGTRG-------------------------YLAPEYVI---------NGQLSEKVDVYSYGIVLLELVS-GR---RGM
         ..... . ...|  ||..                         ..||| .          .|  ..| ||.|.|... |... |.    |.
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

QSS---------------VNVG----------------APEPVSIDEWAWEALGSNKIEAMADPRFGRKYSMDAMV-----RIVQI-AMWCTQGLPEQRP
 |.               .  |                 | |.   .|.                    | | .        ....  . | .  ||.||
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWM-R------------------YRM-H-PPHCPPEEYYDLMQQCWHYDPEDRP

SMGQVVAML
.. |.. .|
TFSQLHEQL
Kinase LRR8-2_b.AA LRRK 701-903 24 3.5e-39 136.27 In-house 1-281 (351) Show / Hide 
Range on Protein: 701-903
Range on HMM: 1-281/351
Sequence Identity: 24% (72 aa)

FSSDNLLGQGAYG-RVYKGFLPD---------------------------GKIVAIKQLVHR----------------------------------TPTC
. . ...|.|..| .||.. . .                           .. ||||..                                     ... 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

QRWFYHELQVISSVRHRNLVPLIGCCIDRGFPL-LVCEFMPNGSLQGALFGRD-SG-----IFLDWERRLQIALDVARGLQYLHEDCAKVR--IIHRDVK
 | | ||. ..|. .| |.|.|.| ||.   || .| |..|.|.|.  |. .  .|     . ..|  .|.|||..|.|..|||    . .  ||||| |
FREFRHEVWIMSHLNHPNIVSLKGFCIH---PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH----SHNPPIIHRDLK

PGNILL---D---------EDMRAHISDFGLAK--LIAHHEEAEVVVSSVMGTRGYLAPEYVING----QLSEKVDVYSYGIVLLELVSGR-R
. ||||   .         ... |.|.|||.     . |..    |.. . |. |..||| ....    . .||||.||.|..| ||.... .
SPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMG----VAKGCVGNPGWMAPE-IMRYNGEEEYTEKVDCYSFGMILWELLTRQHH
Kinase LRR8-2_b.AA Pkinase_Tyr 701-900 27 1.5e-34 117.66 Pfam 1-209 (270) Show / Hide 
Range on Protein: 701-900
Range on HMM: 1-209/270
Sequence Identity: 27% (59 aa)

FSSDNLLGQGAYGRVYKGFLP-----DGKIVAIKQLVHRTPTCQ----RWFYHELQVISSV-RHRNLVPLIGCCI-DRGF--PLLVCEFMPNGSLQGALF
 . .  ||.||.|.|||| .      ..  ||.| |   . . .    . | .|... ..  .| |.| |.|.|. ...   ...| |.||.|.|   | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

GR-DSGIFLDWERRLQIALDVARGLQYLHEDCAKVRIIHRDVKPGNILLDEDMRAHISDFGLAKLIAHHEEA-EVVVSSVMGTRGYLAPEYVINGQLSEK
 . ...  |. .. ||.....|.|..||..      .||||.   |.|..|.. . |.|||||..| . ..   .  .. .  . . |||   .|  ..|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN----CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM-APECINYGKFTTK

VDVYSYGIVLLELVS
 ||.|.|... |...
SDVWSFGVLMWEIFT
Kinase LRR8-2_b.AA STE 701-902 21 1.9e-34 119.12 In-house 1-265 (359) Show / Hide 
Range on Protein: 701-902
Range on HMM: 1-265/359
Sequence Identity: 21% (58 aa)

FSSDNLLGQGAYGRVYKGFLPD----------------GKIVAIKQLVHRTP-----------------TCQRWFYHELQVISSVR--HRNLVPLIGCCI
.     .|.||.| |||.   .                |.|.||||. ...                  . .  . .|... .  .  | | |  .||..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DRG-------FPLLVCEFMPNGSLQGALFGRDSGIFLDW----------ERRL-QIALDVARG-LQYLHEDCAKVRIIHRDVKPGNILLDEDMRAHISDF
. |          .. |.|..|||   .  . .  . .           |  .  |. .. .| |.|||.      |||||.||.||||     . ..||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH----IIHRDIKPANILL-----VKLCDF

GLAKLIAHH-------------EEAEVVVSSVMGTRGYLAPEYVIN------GQLSEKVDVYSYGIVLLELVSGR
|... ....             |       .. ||  . ||| . .      .. ..|.|..| |....|.. |.
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase LRR8-2_b.AA TK-Unique 701-900 24 8.2e-33 110.52 In-house 1-234 (294) Show / Hide 
Range on Protein: 701-900
Range on HMM: 1-234/294
Sequence Identity: 24% (59 aa)

FSSDNLLGQGAYGRVYKGFLPD-------GKIVAIKQLV-HRTPTCQRWFYHELQVISSVR-HRNLVPLIGCCIDRG-FPLLVCEFMPNGSLQGALFGRD
.  ....|.||.| |..| .          |.||.|.|  . |.| .. |  |.|. ...  | |.| ..|||.. .  .... |..|.|.||. |  . 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

SG-----------------------IFLDWERRLQIALDVARGLQYLHEDCAK--VRIIHRDVKPGNILLDEDMRAHISDFGLAKLIAHHEEAEVVVSSV
 .                        ... .. ...| ..|.|..||    |.   .|.|||.   |.|| || .. |.|||.|. . .... .   |. 
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYL----ASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG

MGTRGYLAPEYVI--NGQL-SEKVDVYSYGIVLLELVS
.    ..|||.     |.  ..| ||.|.|... |...
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase LRR8-2_b.AA DRK 704-899 35 8.3e-33 108.46 In-house 4-196 (258) Show / Hide 
Range on Protein: 704-899
Range on HMM: 4-196/258
Sequence Identity: 35% (70 aa)

DNLLGQGAYGRVYKGFLPDGKIVAIKQLVHRTPT---CQRWFYHELQVISSVRHRNLVPLIGCCIDRGFPLLVCEFMPNGSLQGALFGRDSGIFLDWERR
 |  | | || |. |    | .||.| |             |  |  ...  || | .  .| |     .. . |.|| |||   |   |  | .|| ..
GNRIGRGNYGEVFRGTW-RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILH--DESIEMDWPLM

LQIALDVARGLQYLHEDCAKVRIIHRDVKPGNILLDEDMRAHISDFGLAKLIAHHEEAEVVVSSVMGTRGYLAPEYVINGQLSEKVDVYSYGIVLLELV
.|...|.|.|. |||  |    ||||| |  | | ||  .  ..||||.     |..       . || .  |||   |    || ||||..||| |.|
KQMMFDCAKGMIYLH--CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV
Kinase LRR8-2_b.AA S_TKc 701-977 22 1.3e-32 115.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 701-977
Range on HMM: 1-231/231
Sequence Identity: 22% (67 aa)

FSSDNLLGQGAYGRVYKGFLPD-GKIVAIKQLVHRTPTCQRWFYHELQVISSVRHRNLVPLIGCCIDRGFPLLVCEFMPN--GSLQGALFGRDSGIF---
.   ...|.||.|.|||.   . |.|||||..        . .. |.|. .. .| |.| |.... | ..  .| |....  |.|   .  | ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDWERRLQIALDVARGLQYLHEDCAKVRIIHRDVKPGNILLDEDMRAHISDFGLAKLIAHHEEAEVVVSSVMGTRGYLAPEYVINGQLSE-KVDVYSYGI
..  .   ..  ....|.|.|.     .|||||.|| ||||||  .  |.|||||...          ... ||. |.||| .   . .  |.|..| |.
FPE-HARFYMYQICCALEYCHS----HGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VLLELVSGRRGMQSSVNVGAPEPVSIDEWAWEALGSNKIEAMADPRFGRKYSMDAMVRIVQIAMWCTQGLPEQRPSMGQVVA---------ML
.| |...|.   .             ..  .. .|                         .. . | |  ||.||.  .. .          .
ILYEMLCGYPPFP------------QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8-2_b.AA TyrKc 701-977 24 2.2e-32 114.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 701-977
Range on HMM: 1-280/280
Sequence Identity: 24% (75 aa)

FSSDNLLGQGAYGRVYKGFLPDGKIVAIKQLVHRTPTCQRWFYHELQVISSV--RHRNLVPLIGCCIDR-------GFPLLVCEFMPNGSLQGAL-FGRD
 . .  || ||.|.|||| .     ||.| | . .   .. |..|... ...  .| |.| |.|.|..        . ...| |.||.|.|.  |   |.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

SGIFLDWERRLQIALDVARGLQYLHEDCAKVRIIHRDVKPGNILLDEDMRAHISDFGLAKLIAHH----EEAEVVVSSV-MGTRG-----YLAPEYVING
    | ..  |......|.| .|||.     ..||||    |.|..|. .. ||||||.. | ..    |. .. ...   |...      .|||    |
K---LCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

QLSEKVDVYSYGIVLLELVSGRRGMQSSVNVGAPEPVSIDEWAWEALGSNKIEAMADP----RFGRKYSMDAMVRIVQIAMWCTQGLPEQRPSMGQVVAM
  ..| ||.|.|... |. .  .|.|   ..    ..| .| . | . . .     .      |       .   . ||  .| .  ||.||.. ...  
KFTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQ-MMSNQE-VIEYVKQGYRMPQPPNDYPMSF-----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase LRR8-2_b.AA LRRK 957-979 34 0.007512 5.9 In-house 329-351 (351) Show / Hide 
Range on Protein: 957-979
Range on HMM: 329-351/351
Sequence Identity: 34% (8 aa)

MWCTQGLPEQRPSMGQVVAMLVG
..| |. |..||.. |.|  |  
QHCWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8-2_b.AA TK-Unique 959-977 47 0.008783 5.57 In-house 276-294 (294) Show / Hide 
Range on Protein: 959-977
Range on HMM: 276-294/294
Sequence Identity: 47% (9 aa)

CTQGLPEQRPSMGQVVAML
|.|  ||.|||  |.. .|
CWQWEPEERPSFRQIKHRL
Kinase LRR8-2_b.AA MLK 964-977 50 0.011181 5.27 In-house 278-291 (291) Show / Hide 
Range on Protein: 964-977
Range on HMM: 278-291/291
Sequence Identity: 50% (7 aa)

PEQRPSMGQVVAML
|..|||. |.|  |
PHKRPSFRQIVQHL
Kinase LRR8-2_b.AA DRK 964-979 37 0.017712 4.25 In-house 243-258 (258) Show / Hide 
Range on Protein: 964-979
Range on HMM: 243-258/258
Sequence Identity: 37% (6 aa)

PEQRPSMGQVVAMLVG
| .|||| ...  |  
PQHRPSMQECLERLEA
Kinase LRR8-2_b.AA IRAK 952-977 26 0.122651 1.78 In-house 292-317 (317) Show / Hide 
Range on Protein: 952-977
Range on HMM: 292-317/317
Sequence Identity: 26% (7 aa)

IVQIAMWCTQGLPEQRPSMGQVVAML
. | |  |. .    |..| .|.. |
MCQCACCCGHHRANRRCDMAWVMQQL
Kinase LRR8-2_b.AA Pkinase_Tyr 964-977 35 0.255646 5.09 Pfam 257-270 (270) Show / Hide 
Range on Protein: 964-977
Range on HMM: 257-270/270
Sequence Identity: 35% (5 aa)

PEQRPSMGQVVAML
||.||.. ... .|
PEDRPTFSEIHEQL