Gene LZK_b-2 (S.moellendorffii)

LZK_b-2

Species: S.moellendorffii
Alias: LZK_b-2
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: LZK

Sequence

Name Sequence Type Origin Length Description Download
LZK_b-2.AA Protein None 1038 None Fasta, JSON
LZK_b-2.NA RNA None 3117 None Fasta, JSON
LZK_b-2.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of LZK_b-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PB1 LZK_b-2.AA PB1 57-144 40 4.2e-29 103.94 SMART 1-95 (95) Show / Hide 
Range on Protein: 57-144
Range on HMM: 1-95/95
Sequence Identity: 40% (39 aa)

PSDGRLRYAGGDTRMIAVTRDTSYLNLMLKMVEIQPQ----TVAIKYQLPDEDLDALVSVSSEEDLENMMEEFDKLEAGD----GHARLRVFLFTS
| |...|| ||||| ..| ||.|.  || |. .. ..    .. .||||||||.||.|.....|||..|||. |.||.      . ..||...| .
PVDVKCRYVGGDTRRFSVPRDWSFDDLMSKVAQRCGHDNDQPFTLKYQLPDEDGDAWVTITCDEDLQEMMEMYDSLES-QNKSSCWKTLRLHVFPF
PB1 LZK_b-2.AA PB1 57-144 35 1.3e-22 82.86 Pfam 1-86 (86) Show / Hide 
Range on Protein: 57-144
Range on HMM: 1-86/86
Sequence Identity: 35% (32 aa)

PSDGRLRYAGGDTR-MIAVTRDTSYLNLMLKMVEIQPQTVAIKYQLPDEDLDALVSVSSEEDLENMMEEFDKLEAGDGHARLRVFLFTS
. ....|| |...|  | | |..|.  || |. .. .. . .|||.||||.|..|.....|||..|||| ...|   ....||...| |
TVRIKCRYGGDIRRFIIHVRRNISFEDLMHKVEQRCKCDHTFKYQYPDEDGDDWVTITCDEDLQEMMEEYRSSE---KSMTLRLHVFPS
Kinase LZK_b-2.AA TKL 736-994 28 4.9e-79 268.87 In-house 1-364 (364) Show / Hide 
Range on Protein: 736-994
Range on HMM: 1-364/364
Sequence Identity: 28% (105 aa)

LGSGTFGTVYHGKWRG----------TDVAIKRIKASCFFGPPS-------------------EQDRLKDDFWSEACILAHLHHPNVVAFYGVVPDSPGG
.|||.||.||.|||||          .|||.|..|        .                   |. .... .  |. ..  |.|||.| |.|.. ..|.|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

T-----------LATVTEFMVNGSLKQVLHKKERILDRRRRLLVAMDAAFGMEYLHD--------KKIIHFDLKGENLLVN--MR-------DSQKPV-C
.           |. |.|.. .|||  .||         .|.  |.|.| ||.|||         ..||| ||| .|.||.  ..       . .... |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KVGDLGLSKIKHKTM--------------------VTGGVRGTLPWMAPELLNGR--------------SISVSEKVVDVFSFGIVMWELLTGEEPYADL
|..|.|||. .....                     |. ..||. |||||.|.|               . . ||| .||.|||||.||.||...||.|.
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEK-CDVYSFGIVLWEILTRCRPYYDY

HYG---------AIIGGIVSNQLRPQVP------------SSCDPEWQSLMERCWADDPAVRPTFPAIVGEL
.|          ... ......||| .|            ..|.|.. .||..||. ||  ||.|  |. .|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LZK_b-2.AA MLK 730-994 35 3.5e-78 266.03 In-house 1-291 (291) Show / Hide 
Range on Protein: 730-994
Range on HMM: 1-291/291
Sequence Identity: 35% (107 aa)

LEEIRELGSGTFGTVYHGKWRGTD-----VAIKRIKASCFFGPPSEQDRLKDDFWSEACILAHLHHPN----VVAFYGVVPDSPGGTLATVTEFMVNGSL
... . .|||.|| |. |.||..|     ||.||..|. |    |. .  ..||  |. .|..| |||    ...||||  ..|   .. |.|.. .|||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF--DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSL

KQVLHKKE-------------RILDRRRRLLVAMDAAFGMEYLHDKK---IIHFDLKGENLLVN---MRDSQKPVCKVGDLGLSKIKHKT---MVTGGVR
  ||| ..             |. |    .  |.. | ||.||| ..   |||.|||  |.|.      | .. ..|. | |.|. .|..   |   . .
YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRDWHQMCTNMM--SNA

GTLPWMAPELLNG-RSISVSEKVVDVFSFGIVMWELLTGEEPYA-DLHYGAIIGGIVSNQLRPQVPSSCDPEWQSLMERCWADDPAVRPTFPAIVGEL
||. ||||| .   |.  .||| .||.|.|.|.||.||.|.||. ..   ||. ... | ||| .||.|.. | .||..|| .||. ||.|  || .|
GTYAWMAPEVIQQFRCEKYSEK-CDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase LZK_b-2.AA Dicty4 730-996 34 5.7e-67 222.43 In-house 1-277 (277) Show / Hide 
Range on Protein: 730-996
Range on HMM: 1-277/277
Sequence Identity: 34% (101 aa)

LEEIRELGSGTFGTVYHGKWRGTDVAIKRI---KASCFFGPPSEQDRLKDDFWSEACILAHLHHPNVVAFYG--VVPDSPGGTLATVTEFMVNGSLKQVL
.    ..|.| ||.|| |.|||..||.|     .        .....|. .|  |. |.. . |||.. |.|    | |  |..  |||.|  |.|  .|
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQN------FDENMLN-EFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLL

HK------KERILD--RRRR-LLVAMDAAFGMEYLHD--KKIIHFDLKGENLLVNMRDSQKPVCKVGDLGLSK----IKHKTMVTGGVRGTLPWMAPELL
|.      ..  ||  ...| .. | ||| || .||     ||| |||  ||||    ..  . ||.|.|||.    .. ..  . .. ||  ||||| .
HDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV----DKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM

NGRSISVSEKVVDVFSFGIVMWELLTGEEPYA--DLHYGAIIGGIVSNQLRPQVPSSCDPEWQSLMERCWADDPAVRPTFPAIVGE--LRS
  .. .  || .||.||||| ||.||..|||.     |  .. .... .||| .|..|.| | .|...||  || .||.|. |. .  | .
--MHQPYNEK-ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase LZK_b-2.AA Pkinase_Tyr 730-994 34 8.9e-67 226.78 Pfam 1-270 (270) Show / Hide 
Range on Protein: 730-994
Range on HMM: 1-270/270
Sequence Identity: 34% (98 aa)

LEEIRELGSGTFGTVYHGKWR------GTDVAIKRIKASCFFGPPSEQDRLKDDFWSEACILAHL-HHPNVVAFYGVVP--DSPGGTLATVTEFMVNGSL
.. ...||.| ||.||.|.|.      ...||.| .|     |  .||  ...|| .|| |. .| ||||.| .|||.   . |.  .  |.|.| .|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE----GAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDL

KQVLHKK---ERILDRRRRLLVAMDAAFGMEYLHDKKIIHFDLKGENLLVNMRDSQKPVCKVGDLGLSKIK-----HKTMVTGGVRGTLPWMAPELLNGR
.  |.|.   .. |.  . |  ... | |||||..|..|| ||   | ||.     . |.|..| ||..         . ..|| .   .||||| .| .
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYG

SISVSEKVVDVFSFGIVMWELLT-GEEP-YADLHYGAIIGGIVSNQLRPQVPSSCDPEWQSLMERCWADDPAVRPTFPAIVGEL
    ..|  || |||..|||..| ||.| |...    ..  |  .  |   |  | .|  .|| .||. ||. |||| .|. .|
K--FTTK-SDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase LZK_b-2.AA TyrKc 730-994 30 3.4e-65 223.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 730-994
Range on HMM: 1-280/280
Sequence Identity: 30% (92 aa)

LEEIRELGSGTFGTVYHGKWRGTDVAIKRIKASCFFGPPSEQDRLKDDFWSEACILAHL--HHPNVVAFYGVVPDSPG-----GTLATVTEFMVNGSLKQ
.. ...||.| ||.||.|.|. ..||.| .|...           . || .|| |. .|  ||||.|..|||. .. .     . |  |.|.| .|.||.
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

VLHKKERILDRRRRLLVAMDAAFGMEYLHDKKIIHFDLKGENLLVNMRDSQKPVCKVGDLGLSKIKHKT--------MVTG----GVR--GTLPWMAPEL
 |.|... |  .  |  . ..| ||||||.|..|| ||   | ||. .     ..|..| |||.  .          . .     | .    . ||||| 
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LNGRSISVSEKVVDVFSFGIVMWELLT-GEEPYAD-----LHYGAIIGGIVSNQLRPQVPS-------SCDPEWQSLMERCWADDPAVRPTFPAIVGEL
.     ..     ||.|||..|||..| |..|| .     .    .|  . .   .|| |.        | .|  ..|..||. ||. |||| .|. ..
I---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LZK_b-2.AA TKL-Unique 733-994 31 8.2e-64 218.31 In-house 2-290 (290) Show / Hide 
Range on Protein: 733-994
Range on HMM: 2-290/290
Sequence Identity: 31% (95 aa)

IRELGSGTFGTVYHGKWRGTDVAIKRIKASCFFGPP-SEQD-RLKDDFWSEACILAHLH-HPNVVAFYGVVPD---SPGGTLATVTEFMVNGSLKQVLH-
.  .|.|..|.||.|||||..||||...       | ...  .....| .|  ..  || |||.| ..|.  |   .|.  .  |.|..  |||  ||| 
WNKIGEGGYGQVYKGKWRGYPVAIKQFH-------PNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPP-NMCIVMEYCPGGSLYDVLHQ

--------KKERILDRRRRLLVAMDAAFGMEYLHDKK--IIHFDLKGENLLVNMR-DSQKPVCKVGDLGLSKIKH--KTMVTG--------GVRGTLPWM
        ...  |.  .|.  | |.| ||.||| ..  |||.|||  |.||. .  . .   |. | ||||..    .| ..        .. |.. ||
NNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWM

APELLNG--RSISVSEKVVDVFSFGIVMWELLTGEE------PYADLHYGAIIGGIVS--NQLRPQVPSSCDPEWQSLMERCWADDPAVRPTFPAIVGEL
|||.|..    .| .   .||.|||||.||..|..       || ..   ...  . .    .|| .|..| .| . |...||..||  ||.|  |. .|
APEVLRMNFCQYSEK---SDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase LZK_b-2.AA TK 730-994 19 3.4e-62 206.99 In-house 1-486 (486) Show / Hide 
Range on Protein: 730-994
Range on HMM: 1-486/486
Sequence Identity: 19% (98 aa)

LEEIRELGSGTFG---TVYHGKWRG---------------------------TDVAIKRIKASCFFGPPSEQDRLKDD---------FWSEACILAH--L
.. ...||.| ||   .|| |.|||                           |.||.| .|. .   .  ..|.  .|         ...|.... |  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPNVVAFYGVVPDSPG----------GTLATVTEFMVNGS----LKQVLHKKER---------------------------------------------
||||.| .|||. .. .          . .  |.|.| .|.    |.. |.|. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------ILDRRRRLLVAMDAAFGMEYLHDK------KIIHFDLKGENLLVNMRDSQK-------PVCKVGDLG---
                              .|. ...|  ....| ||||||.|      ...| ||   | ||. ..  |       ||||..| |   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSKIKHK--TMVTGGVRGT-------------------------LPWMAPELLNGR--------------SISVSEKVVDVFSFGIVMWELLT-G
     |..  ..    .. . .||                         . ||||| ||.|              |        ||.|||..|||..| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKS--------DVWSFGVLMWEIFTYG

EEPYADLHYG---------AIIGGIVSNQ--------------LRPQVPSSCD--------------PEWQSLMERCWADDPAVRPTFPAIVGEL
.|||.  .           . .   . .               .|.  |  |               .|.. || .||. ||. |||| ... .|
QEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LZK_b-2.AA S_TKc 730-1002 25 1.8e-58 201.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 730-1002
Range on HMM: 1-231/231
Sequence Identity: 25% (72 aa)

LEEIRELGSGTFGTVYHGKWRG--TDVAIKRIKASCFFGPPSEQDRLKDDFWSEACILAHLHHPNVVAFYGVVPDSPGGTLATVTEFMVN--GSLKQVLH
 | .|..|.|.||.|| .....    ||||.||               .....|  || . ||||.| .|.|  |   . |  |.|.. .  |.|.....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIK

KKERI-----LDRRRRLLVAMDAAFGMEYLHDKKIIHFDLKGENLLVNMRDSQKPVCKVGDLGLSKIKHKTMVTGGVRGTLPWMAPELLNGRSISVSEKV
|. |      ..  .   ..   . ..||.|...||| ||| ||.|..       . |..| ||...         . ||. .||||.|     . . . 
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL-----GYGKCK

VDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVSNQLRPQVPSSCDPEWQSLMERCWADDPAVRPTFPAIVG-ELRSMMMSLA
.|. |.|....|.|.|. |.   .. ...  |.            .||  .....|.  ||. |||   .   |.  ...   
CDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LZK_b-2.AA HH498 730-994 32 1.4e-55 174.44 In-house 1-284 (284) Show / Hide 
Range on Protein: 730-994
Range on HMM: 1-284/284
Sequence Identity: 32% (95 aa)

LEEIRELGSGTFGTVYHGKWRGTDVAIKRIKASCFFGPPSE-QDRLKDDFWSEACILAHLHHPNVVAFYGVVPDSPGGTLATVTEFMVNGSLKQVL----
.|  .  ||| || || |.||.  ||.|| .|.  |.  |.    . | |  |. |.  | ||.||.| .   | |   .| ||..  ||||  .|    
IEFHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMA-FCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDP-SQFAIVTQYCDNGSLFSILNTIP

----------HKKE---RILDRRRRLLVAMDAAFGMEYLHD---KKIIHFDLKGENLLVNMRDSQKPVCKVGDLGLS----KIKHKTMVT--GGVRGTLP
          |      ||.|   .. ...| | ||.|||.   . ||| ||   | |.     .    .| | | |     .  ..|    |  |    
IGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH----EDGHAVVADFGESRFVCDMHDDNMTKQPGNLR----

WMAPELLNGRSISVSEKVVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVSNQLRPQVPSS----CDPEWQSLMERCWADDPAVRPTFPAIVGEL
|||||     .   |.| |||||.....||..|.| |....   |    .   . || .| .     .  | .|. .||   |  ||.|  ||  |
WMAPEVFS-QCQKYSIK-VDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase LZK_b-2.AA Pkinase 730-994 25 1.2e-54 192.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 730-994
Range on HMM: 1-293/293
Sequence Identity: 25% (76 aa)

LEEIRELGSGTFGTVYHGKWRGTD--VAIKRIKASCFFGPPSEQDRLKDDFWSEACILAHLHHPNVVAFYGVVPDSPGGTLATVTEFMVNG----SLKQV
.. .| .|||.||.||.....||   ||.|.|| .       ...|.     ||..|...|.|||.| .|... |  .. .  |.|.. .|    .|. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDY

LH-KKERIL--DRRRRLLVAMDAAFGMEYLHDKKIIHFDLKGENLLVNMRDSQKPVCKVGDLGLSKI--KHKTMVTGGVRGTLPWMAPELLN-GRSISVS
.. .... .  . .    ..   . |.||.|...||| ||| ||.|.. ..  ..  |..| ||.|     .   . .. ||...||||... |. .. .
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

EKVVDVFSFGIVMWELLTGEEPYADL------HYGAIIGGIVSNQLRPQVPSSCD-------------------PEWQSLMERCWADDPAVRPTFPAIVG
   ||..|.|....|.|.|. |. .          ..|  | . .|. . | .|.                   .| ......|.. ||. |||.. |. 
---VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

E--L
   .
HPWF
Kinase LZK_b-2.AA Dicty4-Unclassified 730-994 32 1.9e-54 184.91 In-house 1-263 (263) Show / Hide 
Range on Protein: 730-994
Range on HMM: 1-263/263
Sequence Identity: 32% (88 aa)

LEEIRELGSGTFGTVYHGKWRGTDVAIKRIKASCFFGPPSEQDRLKDDFWSEACILAHLHHPNVVAFYG--VVPDSPGGTLATVTEFMVNGSLKQVLH--
.   ...| | |  |. | |.| |||.| .    |    .  . . .||  |  ||  . ||| |  ||  . | |   |.  |.|||  | |  | |  
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKF----KFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSK

---KKERI-LDRRRRLLVAMDAAFGMEYLHDKKIIHFDLKGENLLVNMRDSQKPVCKVGDLGLSKIKHKTMVTGGVRGTLPWMAPELLNGRSISVSEKVV
   ..  | ||    . .|.| | || .|| . .|| |.|  |.|.          |..|.|.|     .     . ||  | .|| | . |        
PSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFN----IKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESY---NQKS

DVFSFGIVMWELLTGEEPYADLH-YGAIIGGIVSNQLRPQVPSSCDPEWQSLMERCWADDPAVRPTFPAIVGEL
||.|......||.||.||| .      .   . .  |||..|..||. |..|   || .||  |||.  |.  |
DVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase LZK_b-2.AA DRK 737-996 32 9.5e-51 170.11 In-house 8-258 (258) Show / Hide 
Range on Protein: 737-996
Range on HMM: 8-258/258
Sequence Identity: 32% (88 aa)

GSGTFGTVYHGKWRGTDVAIKRIKASCFFGPPSEQ-DRLKDDFWSEACILAHLHHPNVVAFYGVVPDSPGGTLATVTEFMVNGSLKQVLHKKERILDRRR
| | .| |. | |||| ||.|. ..        .    .  .|  |. ..  | |||.. | |    .|      ..|.|  ||| ..||     .|  .
GRGNYGEVFRGTWRGTQVAVKMLFNHN------INDENFLNEFHREINLMCQLRHPNICQFMGTCNNPP--DICICMEYMPRGSLYNILHDESIEMDWPL

RLLVAMDAAFGMEYLHDKK--IIHFDLKGENLLVNMRDSQKPVCKVGDLGLSK----IKHKTMVTGGVRGTLPWMAPELLNGRSISVSEKVVDVFSFGIV
..  ..|.| || |||     ||| |||  ||||   .. .   || | |||     .| ..     . ||  | ||| |  |.    ||  ||.||.||
MKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVD--EHWQ--VKVADFGLSTRFKKHKQHKFAMTMC-GTPCWTAPEVL--RNQRYTEK-ADVYSFAIV

MWELLTGEEPYADLHYGAIIGGIVSNQLRPQVPSSCDPEWQSLMERCWADDPAVRPTFPAIVGELRS
 ||..| . ||.      ..  .    .|| .|  | | .  || .||  ||  ||... ..  | .
LWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase LZK_b-2.AA LRRK 781-996 31 1.1e-48 168.12 In-house 107-351 (351) Show / Hide 
Range on Protein: 781-996
Range on HMM: 107-351/351
Sequence Identity: 31% (79 aa)

EACILAHLHHPNVVAFYGVVPDSPGGTLATVTEFMVNGSLKQVLHKKER--I------LDRRRRLLVAMDAAFGMEYLHDKK--IIHFDLKGENLLV-NM
|. |. ||.|||.|  .|.  . |   |. |.|.. .|.| ..||.|..  .      ...  .| .|.. | ||||||...  ||| ||| .| |.  .
EVWIMSHLNHPNIVSLKGFCIH-P---LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSS

R-DS------QKPVCKVGDLGLSK--IKHKTMVTGGVRGTLPWMAPELLNGR-SISVSEKVVDVFSFGIVMWELLTGE-EPYADLH----Y--GAIIGGI
  ..      .  ..|..| |.|      .. |. |. |.  ||||| ...   .. .|| ||..|||...|||||..  |. ..     .    .|  .
PQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEK-VDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDK

VSNQLRPQVPSS-CDP-----EWQSLMERCWADDPAVRPTFPAIVGELRS
....||| .|.. | |     . |.|.. ||. ||  ||.|  ||  | .
IIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase LZK_b-2.AA LZK 785-994 38 3.4e-47 157.11 In-house 41-241 (241) Show / Hide 
Range on Protein: 785-994
Range on HMM: 41-241/241
Sequence Identity: 38% (83 aa)

LAHLHHPNVVAFYGVVPDSPGGTLATVTEFMVNGSLKQVLHKKERILDRRRRLLV--AMDAAFGMEYLHDKKIIHFDLKGENLLVNMRDSQKPVCKVGDL
| .|.|||...| ||   ||      . |.   | | .|| ..  |.   ..|.|   .. | ||.|||  |||| |||  |.|.   |    | |. | 
LRKLKHPNIIEFKGVCTQSP--CYCIIMEYCPHGQLYEVLRERRTIT---PQLMVDWSKQIAQGMHYLHQHKIIHRDLKSPNILISHND----VVKICDF

GLSKIKHKT-MVTGGVRGTLPWMAPELLNGRSISVSEKVVDVFSFGIVMWELLTGEEPYADLHYGAIIGGIVSNQLRPQVPSSCDPEWQSLMERCWADDP
| |.   .         ||  |||||.   |   .||| ||..|||.|.||.||.| ||.|    ||| |. || |.  .||.|      ||  ||   |
GTSHMWNEMDSTKMSFCGTVAWMAPEVI--RNEPCSEK-VDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVGSNSLHLPMPSTCPEGFKLLMKQCWSQKP

AVRPTFPAIVGEL
  || |  |   .
RNRPSFRQILMHW
Kinase LZK_b-2.AA LRRK 730-757 26 8.1e-10 30.9 In-house 1-57 (351) Show / Hide 
Range on Protein: 730-757
Range on HMM: 1-57/351
Sequence Identity: 26% (15 aa)

LEEIRELGSGTFG-TVYHGKWRG----------------------------TDVAIK
|.. ...|.|.|| .|| .||||                            ..||||
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIK
Kinase LZK_b-2.AA LZK 730-760 38 5e-06 16.27 In-house 1-31 (241) Show / Hide 
Range on Protein: 730-760
Range on HMM: 1-31/241
Sequence Identity: 38% (12 aa)

LEEIRELGSGTFGTVYHGKWRGTDVAIKRIK
  |   ||||  | |. |..|.  ||.|...
ISELQWLGSGAQGAVFRGWFRNETVAVKKVR