Gene MLK-Un_j-2 (S.moellendorffii)

MLK-Un_j-2

Species: S.moellendorffii
Alias: MLK-Un_j-2
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MLK-Un_j-2.AA Protein None 641 None Fasta, JSON
MLK-Un_j-2.NA RNA None 1926 None Fasta, JSON
MLK-Un_j-2.kin_dom Protein Kinase Domain None 275 None Fasta, JSON

Protein domain

Protein domains of MLK-Un_j-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-Un_j-2.AA TKL 40-315 19 7.8e-62 211.74 In-house 1-364 (364) Show / Hide 
Range on Protein: 40-315
Range on HMM: 1-364/364
Sequence Identity: 19% (77 aa)

IARGAESVVYDARLNG----------KIVAAKKPRLSTAD---------------------------DLDRFHTELQLLTKLNHPRISTLLAAHAHPPD-
| .|. ..|| ....|          | || || .    |                             ...  |. .. .|.|| |  ....   ||. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YLFLFKFYEHGNLFHALHAREVNFTTQQMLKITIQLASALEYLHCHG--------IVHRDVKPANILLDNNWD--------------A
            . .   ....|.|.| ||        .|.... .. |....||| ..        |.||| |..|||.|.||               .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

HLSDFGLACYVDDLKRQDST--------NWKSQGKPTGGFHKKNMVGTLLYMAPEVLNKE----------------TQTTKSDVYAFAITVNELFTGVVP
 ..||||.  ..  . .  |        .     . ... .. . .||. .||||||...                . ..|.|||.|.|   |..|. . 
KICDFGLSRFMSQSGNMNDTMTTMMESAE----HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-

YTDRKTEAQAHTVLEMNYTEQQLS-------AAITSEGLRPVLA---------SEANGCPVALSSLIEQSWHRDPSRRPSFEIIVGKL
              ...| .....       . . ..|||| .          .  . ||  ...|... |. ||. ||||. |. .|
-----------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase MLK-Un_j-2.AA Pkinase 34-252 25 4.2e-51 180.88 Pfam 1-223 (293) Show / Hide 
Range on Protein: 34-252
Range on HMM: 1-223/293
Sequence Identity: 25% (61 aa)

IRLNEEIARGAESVVYDARLNGK--IVAAKKPRLSTADDLD---RFH-TELQLLTKLNHPRISTLLAAHAHPPDYLFLFKFYEHG----NLFHALH-ARE
... . | .|. ..|| ..  |   ||| |. .......     ... .|.|.. .|||| | .|. .   .... . . . |.|     ||. ..  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VNF--TTQQMLKITIQLASALEYLHCHGIVHRDVKPANILLDNNWDA----HLSDFGLACYVDDLKRQDSTNWKSQGKPTGGFHKKNMVGTLLYMAPEVL
 .|  . ..  ..  |....|||.| .||.|||.||.|||.||| .     ...|||||. .|                 ..   .  .||. ||||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------------Y-NNS--MTTFCGTPWYMAPEVI

N-KETQTTKSDVYAFAITVNELFTGVVPYTDR----KTEAQ
.  .  ..|.|.... ... |...|  |. ..    .   |
RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQ
S_TKc MLK-Un_j-2.AA S_TKc 34-319 22 3.3e-49 170.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 34-319
Range on HMM: 1-231/231
Sequence Identity: 22% (67 aa)

IRLNEEIARGAESVVYDARLNG--KIVAAKKPRLSTADDLDRFHTELQLLTKLNHPRISTLLAAHAHPPDYLFLFKFYEH--GNLFHALHAREVN-----
 .. ..| .|| ..|| .| ..  .||| |. .       ...  |.|.| | .|| | .|. .  .  .. . . . ..  |.||. .. |  .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FTTQQMLKITIQLASALEYLHCHGIVHRDVKPANILLDNNWDAHLSDFGLACYVDDLKRQDSTNWKSQGKPTGGFHKKNMVGTLLYMAPEVLNKETQTT-
|.  .  ... |...||||.| |||.|||.||.|||||.     ..|||||. .                       . ..||. |||||||     .. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------------TTFCGTPWYMAPEVL---GYGKC

KSDVYAFAITVNELFTGVVPYTDRKTEAQAHTVLEMNYTEQQLSAAITSEGLRPVLASEANGCPVALSSLIEQSWHRDPSRRPSFEIIVG-----KLQQM
|.|.... ... |...|  |.    ....   ..                             .  . ..|.. ...||..||.   .       |. . 
KCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

L
.
F
Kinase MLK-Un_j-2.AA TKL-Unique 36-315 26 8e-47 161.87 In-house 1-290 (290) Show / Hide 
Range on Protein: 36-315
Range on HMM: 1-290/290
Sequence Identity: 26% (84 aa)

LNEEIARGAESVVYDARLNGKIVAAKKPRL---STADDLDRFHTELQLLTKLN-HPRISTLLAAHA----HPPDYLFLFKFYEHGNLFHALH--------
  . | .|. ..|| .  .|..|| |.  .   |  . .. |. |. .. ||. || | .. .. .    .||.. .   ....|.|   ||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-AREVNFTTQQMLKITIQLASALEYLHCHG--IVHRDVKPANILLDNN-----WDAHLSDFGLACYVD-----DLKRQDSTNWKSQGKPTGGFHKKNMVG
 ... ... ||..|. |. |....|||  .  | ||| |. |.|.|||     | . ..||||.   .      ...   |.            .   .|
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR------------NQTRCG

TLLYMAPEVLNK--ETQTTKSDVYAFAITVNELFTGVV------PYTDRKTEAQAHTVLEMNYTEQQLSAAITS--EGLRPVLASEANGCPVALSSLIEQ
....||||||.   .. ..|||||.|.| . |..|. .      ||               ... .|. .....  |..|| . ..   ||  .. ||.|
SFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPY--------------QGMDQEQWCEMVHYMEENYRPPIPNH---CPKEYRDLIQQ

SWHRDPSRRPSFEIIVGKL
 ||.||| ||||. |. .|
CWHHDPSQRPSFDEIIHRL
Kinase MLK-Un_j-2.AA TK 34-315 15 2.7e-39 128.88 In-house 1-486 (486) Show / Hide 
Range on Protein: 34-315
Range on HMM: 1-486/486
Sequence Identity: 15% (78 aa)

IRLNEEIARGAES---VVYDARLNGK---------------------------IVAAKKPRLSTADDLDRFHT--------------ELQLLTKLN----
|.| ... .|.     .|| ....|.                            || |  .. .|.. ..|.               |.. . ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPRISTLLA-AHAHPPD-----------YLFLFKFYEHGN----LFHALHAREVN--------------------------------------------
 || |  |..  . . |            .. .  . .||.    | . |...  .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FTTQQMLKITIQLASALEYLHCH------GIVHRDVKPANILLDNNWD-----------AHLSDFGLA-
                               .|..|.| .  |.|...|||| .      ..||||.   |.|...|             . ..||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----CYVDDLKRQDSTNWKSQGKPT---------GGFHKKNMVGTLL---YMAPEVLNKET---------QTTKSDVYAFAITVNELFT-G-VVPYTDR
        |. ...| .  .|.|...         .   ..   |. |   .||||.||. .          ||||||..| ... |.|| | . .| . 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

KTEAQAHTVLEMNYTEQQLSAAITSE-----------GLRPVLASEANGCP-------------VALSSLIEQSWHRDPSRRPSFEIIVGKL
  .  ..     . . |..   ....           | |  ..  .. ..              ..  |. | ||.||..||.|. .. .|
SNQDVWKD----G-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK-Un_j-2.AA STE 34-246 22 2e-38 133.3 In-house 1-270 (359) Show / Hide 
Range on Protein: 34-246
Range on HMM: 1-270/359
Sequence Identity: 22% (63 aa)

IRLNEEIARGAESVVYDARLN-----------------GKIVAAKKPRLSTA-----------------DDLDRFHTELQLLTKLN--HPRISTLLAAHA
 .. |.| .||  .|| |. .                 |.|.| |. .|..                  ......  |.... |.|  || | . . .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HP-------PDYLFLFKFYEHGNLFHALH-AREVNFT------------TQQMLKITIQLASA-LEYLHCHGIVHRDVKPANILLDNNWDAHLSDFGLAC
.         .      . . | |   ..   .....             .|  .|. |.  . |.||| |.|.|||.|||||||     . |.|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

YVDD-LKRQDSTNWKSQGKP-----TGGFHKKNMVGTLLYMAPEVLNKETQT------TKSDVYAFAITVNELFTGVVPYTD
 ..| . .. . .    .       |.. . . .|||  .|||||.....|.      ||.|.. . .|. |. || .|. |
QLTDSMANI-Q-S---NN-IIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHD
Kinase MLK-Un_j-2.AA RIPK 136-315 29 2e-33 111.24 In-house 115-290 (290) Show / Hide 
Range on Protein: 136-315
Range on HMM: 115-290/290
Sequence Identity: 29% (57 aa)

QLASALEYLHCHG--IVHRDVKPANILLDNNWDAHLSDFGLACYVDDLKRQD-STNWKSQGKPTGGFHKKNMVGTLLYMAPEVLN--KETQ----TTKSD
. ...  |||. .  | ||| ||.|||.|||  . ..|||||      ....   | .  ..   .  .||  ||| ||.|| ..          |.|.|
EISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCN-QREVY---SMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYD

VYAFAITVNELFTGVVPYTDRKTEAQAHTVLEMNYTEQQLSAAITSEGLRPVLASEANGCPVA-----LSSLIEQSWHRDPSRRPSFEIIVGKL
|| |||.. |..|.  || |||.. .  ...              . | || |. .   .| .     . .|....|. ||  ||.|  .  . 
VYSFAIVMWEVLTQKHPYEDRKCMMMIMMCC--------------KQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase MLK-Un_j-2.AA TyrKc 34-315 25 6.9e-31 109.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 34-315
Range on HMM: 1-280/280
Sequence Identity: 25% (76 aa)

IRLNEEIARGAESVVYDARLNGKIVAAKKPRLSTADDLDRFHTELQLLTKL--NHPRISTLLAAHAHP-------PDYLFLFKFYEHGNLFHALHAREVN
|.|.... .||  .|| ....   || |. . ..   .  |. |.....||  .|| |  |...  ..       . .. .. . .||.| . |.... .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FTTQQMLKITIQLASALEYLHCHGIVHRDVKPANILLDNNWDAHLSDFGLACYVDDL----KRQDSTNWKS--QGKPTGGFHKKNMVGTLLYMAPEVLNK
......|.. .| |.  |||| ....|||    |.|...|  .  |||||. ...|      ..|    |.  .||         ..  .  ||||..|.
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK---------TMLPIRWMAPECINY

ETQTTKSDVYAFAITVNELFT-GVVPYTDR----KTEAQAHTVLEMNYTEQQLSAAITSEGLRPVLASEANGCPVALSSLIEQSWHRDPSRRPSFEIIVG
 . ||||||..| ..  |.|| |  || .     .. ....  ..  |   |   .       | ...   .|| .. ....| ||.||. ||.|. |. 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY------P-MSF--VCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

KL
..
CF
Kinase MLK-Un_j-2.AA MLK 34-176 23 2.7e-29 98.85 In-house 1-181 (291) Show / Hide 
Range on Protein: 34-176
Range on HMM: 1-181/291
Sequence Identity: 23% (42 aa)

IRLNEEIARGAESVVYDARLNGKI-----VAAKKPRLSTADDLDR-------FHTELQLLTKLNHPR----ISTLLAA-HAHPPDYLFLFKFYEHGNLFH
|.. | |  |.  .|. .|  .|.     || |. | ..  |  .       | .|  .| .|.||     |  .... . .|.... .  . |.| |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ALHARE-------------VNFTTQQMLKITIQLASALEYLHCHG---IVHRDVKPANILLDN------NWDAHLSDFGLAC
 ||...             .. . ......  | |....|||..    |.||| |. |||.|.      . ..  .|||...
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase MLK-Un_j-2.AA ULK 108-244 23 3e-27 92.25 In-house 101-256 (329) Show / Hide 
Range on Protein: 108-244
Range on HMM: 101-256/329
Sequence Identity: 23% (39 aa)

FYEHGNLFHALHAREV---------NFTTQQMLKITIQLASALEYLHCHGIVHRDVKPANILLDNNWDAH-------------LSDFGLACYVD-DLKRQ
. ..|.|.. .. .           ... |. ... .|..... .|| |.|.||| ||.|||..|. ...             ..|||.|  || |.. |
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNG-QPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ

DSTNWKS-QGKPTGGFHKKNMVGTLLYMAPEVLN----KETQT-TKSDVYAFAITVNELFTGVVPY
. .   . .         |   || |||||..|.    .. ..  |.|.. . .   |. .| .|.
QMMMTCVNE---------KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPF
Kinase MLK-Un_j-2.AA MLK 199-315 29 8.3e-22 72.52 In-house 183-291 (291) Show / Hide 
Range on Protein: 199-315
Range on HMM: 183-291/291
Sequence Identity: 29% (37 aa)

FHKK-----NMVGTLLYMAPEVL---NKETQTTKSDVYAFAITVNELFTGVVPYTDRKTEAQAHTVLEMNYTEQQLSAAITSEGLRPVLASEANGCPVAL
.|..     .. ||. .|||||.     |. . |.||. ...   |..|. |||                | . .  . .. .|||| . |.   ||  .
WHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYK-------------QHYDPMAIAWWVAYNGLRPPIPST---CPEHW

SSLIEQSWHRDPSRRPSFEIIVGKL
..|..| |. ||..||||  || .|
KKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK-Un_j-2.AA LRRK 202-317 29 1.5e-18 62.25 In-house 237-351 (351) Show / Hide 
Range on Protein: 202-317
Range on HMM: 237-351/351
Sequence Identity: 29% (38 aa)

KNMVGTLLYMAPEVLNKE---TQTTKSDVYAFAITVNELFTGV-VPYTDRKTEAQAHT---VLEMNYTEQQLSAAITSEGLRPVLASEANGCPV-----A
| .||. ..||||.....   . |.|.|.|.|..   || |.   |.       . |.   ......   |.. .|. |||||.. ..   ||       
KGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPF-------DEHDFFDHMQWME---QIEDKII-EGLRPTIPQH-Y-CPPCQPWHM

LSSLIEQSWHRDPSRRPSFEIIVGKLQQ
...||.. |. || .||.|. || .| |
YQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK-Un_j-2.AA Pkinase_Tyr 34-175 24 5.4e-18 61.56 Pfam 1-158 (270) Show / Hide 
Range on Protein: 34-175
Range on HMM: 1-158/270
Sequence Identity: 24% (38 aa)

IRLNEEIARGAESVVYDARLN------GKIVAAKKPRLSTADD---LDRFHTELQLLTKL-NHPRISTLLAAHA--HPP-DYLFLFKFYEHGNLFHALHA
|...... .||  .|| ....      .  || |. . .. ..   .. |  |......| .|| |  |...      |  ..  . . .||.| . |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---EVNFTTQQMLKITIQLASALEYLHCHGIVHRDVKPANILLDNNWDAHLSDFGLA
.   . ..|....|.. .| |...|||. ....|||.   |.|...|  .  .|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase MLK-Un_j-2.AA Dicty4-Unclassified 206-315 29 9.3e-16 50.41 In-house 170-263 (263) Show / Hide 
Range on Protein: 206-315
Range on HMM: 170-263/263
Sequence Identity: 29% (33 aa)

GTLLYMAPEVLNKETQTTKSDVYAFAITVNELFTGVVPYTDRKTEAQAHTVLEMN-YTEQQLSAAITSEGLRPVLASEANGCPVALSSLIEQSWHRDPSR
||    .||.|  |  . ||||| .|.   || ||  ||            .|     .  .   . . .||| . .    |.  ...||   || || .
GTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEPY------------QEIQSIMN--AARSVCDKKLRPKIPDN---CDNFWKKLIKWCWHNDPNK

RPSFEIIVGKL
||... |. .|
RPTMNQIIQYL
Kinase MLK-Un_j-2.AA Dicty4-Unclassified 34-175 24 1.5e-15 49.65 In-house 1-156 (263) Show / Hide 
Range on Protein: 34-175
Range on HMM: 1-156/263
Sequence Identity: 24% (39 aa)

IRLNEEIARGAESVVYDARLNGKIVAAKKPRLSTADDLDR------FHTELQLLTKLNHPRISTLLAAHAHP----PDYLFLFKFYEHGNLFHALH----
|.   .| .|. | |.     || || ||  .    .  |      |  |  .|  . ||   ..  .   |      .     |   ||||   |    
IQIDQFIGKGHFSKVHKGNWKGKDVAVKK--FNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS

--AREVNFTTQQMLKITIQLASALEYLHCHGIVHRDVKPANILLDNNWDAHLSDFGLA
   . .       .|. .  |  . .||   ..|||.| .|||.| .  .   |||..
EQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGIS
Kinase MLK-Un_j-2.AA Dicty4 34-175 27 1.7e-13 41.55 In-house 1-161 (277) Show / Hide 
Range on Protein: 34-175
Range on HMM: 1-161/277
Sequence Identity: 27% (44 aa)

IRLNEEIARGAESVVYDARLNGKIVAAKKP--RLST--ADDLDRFHTELQLLTKLNHPRISTLLAAHA----HPPDYLFLFKFYEHGNLFHALHA-----
|   ..| .|. . || ..  ||.|| ||.  .  .  .. |  |. |  .. |. || | ... |      ||.. .    .   |||.  ||.     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-REVNFTTQQMLK---ITIQLASALEYLHC--HGIVHRDVKPANILLDNNWDAHLSDFGLA
  ..      ...   . .  |  . .|||    |.||| |..|.| | || .  .||||.
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLS
Kinase MLK-Un_j-2.AA LRRK 34-174 22 4.6e-13 42.54 In-house 1-224 (351) Show / Hide 
Range on Protein: 34-174
Range on HMM: 1-224/351
Sequence Identity: 22% (51 aa)

IRLNEEIARGAES-VVYDARLNG----------------------------KIVAAKKPRLS----------------------------------TADD
.. .|.| ||.   .|| |...|                            . ||.||  .                                   ..  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LDRFHTELQLLTKLNHPRISTLLAAHAHPPDYLFLFKFYEHGNLFHALHARE--------VNFTTQQMLKITIQLASALEYLHCHG--IVHRDVKPANIL
.  |. |. .. .|||| |  |.    ||  . .   .  ||.| | ||...         ... .  ||| .| |...|||| |   |.||| |. |||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

L---D---------NNWDAHLSDFGL
|   .         ..  |...|||.
LWSSPQNHSPNYPNAHVCAKIADFGI
Kinase MLK-Un_j-2.AA Dicty4 204-244 41 1e-09 28.77 In-house 177-217 (277) Show / Hide 
Range on Protein: 204-244
Range on HMM: 177-217/277
Sequence Identity: 41% (17 aa)

MVGTLLYMAPEVLNKETQTTKSDVYAFAITVNELFTGVVPY
..|| ..|||||. ..  . |.||| |.|   |..|.  ||
ACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPY
Kinase MLK-Un_j-2.AA Dicty4 265-317 34 3.1e-09 27.12 In-house 226-277 (277) Show / Hide 
Range on Protein: 265-317
Range on HMM: 226-277/277
Sequence Identity: 34% (19 aa)

QLSAAITSEGLRPVLASEANGCPVALSSLIEQSWHRDPSRRPSFEIIVGK--LQQ
|. .|. ...||| . .    ||  ...||.  |. ||..||||| |. .  |  
QFVRAVCNKKLRPPIPDW---CPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK-Un_j-2.AA Pkinase_Tyr 285-315 41 2.8e-08 28.66 Pfam 240-270 (270) Show / Hide 
Range on Protein: 285-315
Range on HMM: 240-270/270
Sequence Identity: 41% (13 aa)

GCPVALSSLIEQSWHRDPSRRPSFEIIVGKL
.||  . .|. | || ||..||.|. |. .|
NCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK-Un_j-2.AA Pkinase_Tyr 211-244 50 2e-06 22.26 Pfam 181-216 (270) Show / Hide 
Range on Protein: 211-244
Range on HMM: 181-216/270
Sequence Identity: 50% (18 aa)

MAPEVLNKETQTTKSDVYAFAITVNELFT-GVVP-Y
||||..|    ||||||..| ..  |.|| |  | |
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY
Kinase MLK-Un_j-2.AA ULK 34-87 17 0.003115 7.24 In-house 1-78 (329) Show / Hide 
Range on Protein: 34-87
Range on HMM: 1-78/329
Sequence Identity: 17% (14 aa)

IRLNEEIARGAESVVYDAR---LN---GKIVAAKK-PRLSTADDLDR---------FHTELQLLTKLN--------HP
. ||...  |.  .|| .|    .   ...||.|. .. .   ...          .  | ... ||.        ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHP
Kinase MLK-Un_j-2.AA Pkinase 292-315 26 6.87231 0.69 Pfam 268-293 (293) Show / Hide 
Range on Protein: 292-315
Range on HMM: 268-293/293
Sequence Identity: 26% (7 aa)

SLIEQSWHRDPSRRPSFEIIVGK--L
..|.  ...||..||..| |.    .
DFIKWCLCKDPKKRPTAEQILQHPWF
PP2C MLK-Un_j-2.AA PP2C 379-624 35 1e-83 289.21 Pfam 1-284 (284) Show / Hide 
Range on Protein: 379-624
Range on HMM: 1-284/284
Sequence Identity: 35% (100 aa)

LSWGIFRTRGGRETMEDRHFLLPNF----SGSKDIHAFGVFDGHRGYEAAEFASRAVP-----------SFLRGSSSKPEEALSLAFTR--TDSAFQ-FE
.  |. |..| |..|||.|...||.    ||  ..| |.||||| |..||....  ..           ||. |  ...|.||. .| .  ||..|   .
WDYGFCRMQGWRHFMEDAHHCYPNMNCSSSGKDSWHFFAVFDGHGGHQAAKYCRKHLHKAMNTILKERKSFPEGNPKDVEQALRKSFLECDTDMMFYSAP

VESER-GSRENWNPGCTALTALFINDR--VFVANAGDCRALLCRDGQSF----PLSKDHLASDPIERTRVVNSGGSVQWQVDTWRVGSAGLQVTRSIGDS
 ....  ..| |. ||||..|...|..   .|||.||.||.|||.|...    .|..|| .|.. || |....||.| |  . |||   .|.|.|..|| 
WHEQNVMHWECWHSGCTAVCAYIRNQKNILYVANCGDSRAVLCRNGNAHNWVHQLTYDHKPSNEDERRRIRQAGGWVMWW-GFWRVNGVWLAVSRAFGDF

DLKP---------AVTAEPDIT-VSSLSAD-DEFLVMATDGLWDTVSNELAISLISDTVKD---PAMCAKRLATAAVERGSRDNI
..||         .|||||||| .  .. | ||||..|.||||| .|.. ..... ....|   | .....|.. ....||.|||
HYKPNHTCFPKEQPVTAEPDITPEHKITPDHDEFLILACDGLWDVMSDQEVCDIVRQCRSDWNDPMEACEKLVDYCIAYGSEDNI
PP2Cc MLK-Un_j-2.AA PP2Cc 370-629 25 4.1e-79 270.05 SMART 1-338 (338) Show / Hide 
Range on Protein: 370-629
Range on HMM: 1-338/338
Sequence Identity: 25% (95 aa)

SRDLVYTPTLSWGI--FRTRGGRETMEDRHFLLPNFSGSKDIHAFGVFDGHRGYEAAEFASRAVPSFLRGSSS---------------------------
   . | . ...|   ..  | |..|||.|.  |          ||||||| | |.|.....  ...|  . .                           
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP---------FFGVFDGHGGHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWRMWHDK

---KPEEALSLAFTRTDSAFQFEVESERGSRENWNPGCTALTALFINDRVFVANAGDCRALLCRDGQ----------SFPLSKDHLASDPIERTRVVNSG
   ..|.||  || |.|...                 |||..||. .....|||.||.|| |||.|.            .|..|| .... || |. ..|
WFEDWEDALRKAFLRMDEEI-----------------CTAVVALIRGNKLYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQAG

GSV---------QWQVDTWRVGSAG--LQVTRSIGDSDLK------------------------PAVTAEPDITVSSL------SADDEFLVMATDGLWD
| |         .|..| |||   .  |.|.|..|| ..|                        |.|.||||.|.  |      . ||.||....|||||
GRVMPMHRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWD

TVSNELAISLISDTV--------------------------KDPAMCAKRLATAAVERGSRDNITVIVI
 .||. ..... ..                           .|| ..||||. .|     .||.||||.
VMSNQEVVDIVRKCLRKWHHKPVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI----CDNMTVIVV
PP2C_SIG MLK-Un_j-2.AA PP2C_SIG 378-631 13 6.8e-09 36.8 SMART 1-250 (250) Show / Hide 
Range on Protein: 378-631
Range on HMM: 1-250/250
Sequence Identity: 13% (38 aa)

TLSWGIFRTRGGRETMEDRHF-------LLPNFSGSKDIHAFGVFDGHR---GYEAAEFASRAVPSFLRGSSSKPEEALSLAFTRTDSAFQFEVESERGS
. .| |.       ..|| .        .  .  | .| ..| . |..    |..||.....|.. .   ...     .. .  |.....  .      .
DDHWDIYQ------YYEDATQVCGDWYDFWKIPEG-QDRYFFVIGDVMGWAHGLPAALMMGMARTMMRTFWHE----SPPQILERCNRWIYQN------N

RENWNPGCTALTAL----FINDRVFVANAGDCRALLCR---DGQSFPLSKDHLASDPIERTRVVNSGGSVQWQVDTWRVGSAGLQVTRSIGDSDLKPAVT
 |.   ..|.. ..    | .... ....|... .| |   .|  ....  |        .|       .  .. .|..   |.... .           
HEECGMFTTMCCCVYMPDFATHTLWYCHCGHSPPYLYRAMDGGRVEHTHD-HYLVQHYV-MRIIDEEDAKHHPWHNWTGPPLGMEPDYM-----------

AEPDITVSSLSADDEFLVMATDGLWDTVSN-----------ELAISLISDTVKDPAM-CAKRLATAAVERGSRDNITVIVIFL
  .|..  .. . .. .||.|||... ..            |. ... ...... |   . .| . . ...  |..||||. .
--YDVQEFQYEP-GDRFVMCTDGVTEARNPQGEFFGEEWLQEILEEHQCCCPQEIAQRIMQELMEHMGDHNGHDDMTVIVVKV