Gene MLKx_r (S.moellendorffii)
MLKx_r
Species: S.moellendorffii
Alias: MLKx_r
External Links:
Annotation:
Sequence
Protein domains of MLKx_r.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Pkinase | MLKx_r.AA | Pkinase | 137-371 | 23 | 7.8e-38 | 134.85 | Pfam | 1-238 (293) | Show / Hide |
Range on Protein: 137-371 Range on HMM: 1-238/293 Sequence Identity: 23% (62 aa) FQMGIFLAQGAYGAIHKCTWSKQE--FAIKLFSEEEHLQD----------EAVIHFTLDHPHVVKPHGYSISGSGSSSGNHSGAGLIMELMDG-----DL .. | . .|..| ||.. . . .|.| .. . | . |. |. |.||..|. ... . ... ..||...| || YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIY---MVMEYCEGGLYVMDL QTWIKNKVEKDPHHLPL--EEKAAIDVMLQLATALMYMHAFGLIHRDVKPGNFLVRFNQTFPSGLEVKLGDFGTAR---SVDDGKLTARRGTHCYWAPEV ..|. | .. .|. ....|.|.. .| |.|. | ||||.|| |.|. | . .. ||..||| |. .. .| . || | |||| FDYIST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV LQGDEGSKCSYTDKADVYSFGMTFYAVLTGETPLDKY----KELSPEKFLEKIRGGNWIIP .. . |. |.|..|.| ..| .|.|..| . . ... . ...|.|. . . IR----GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFD |
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Kinase | MLKx_r.AA | TKL | 143-357 | 18 | 1.7e-35 | 124.26 | In-house | 1-298 (364) | Show / Hide |
Range on Protein: 143-357 Range on HMM: 1-298/364 Sequence Identity: 18% (56 aa) LAQGAYGAIHKCTWSK----------QEFAIKLFSEE--------------------------------EHLQDEAVIHFTLDHPHVVKPHGYSISGSG- . .|..| ..| .| .. |.| |... ... |.... |.||..|. ||...... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG -SSS---GNHSGAGLIMELM-DGDLQTWIKNKVEKDPHHLPLEEKAAIDVMLQLATALMYMHAFG--------LIHRDVKPGNFLVR-FNQ-------TF . |. . ...||.. |.| . .. .|. | .. |.|. . .|||| |. | || .. CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNP PSGLEVKLGDFGTARSVDDGK---------------------LTARRGTHCYWAPEVLQGDEGSKC-----------SYTDKADVYSFGMTFYAVLTGET .. .|..|||..|... . . ..|| .. |||||.|.. .. .|. |.||||||. .. .||... NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR PLDKYKELSPE | ..|.. ... PYYDYPYMPMI |
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S_TKc | MLKx_r.AA | S_TKc | 137-404 | 25 | 1.2e-34 | 122.37 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 137-404 Range on HMM: 1-231/231 Sequence Identity: 25% (74 aa) FQMGIFLAQGAYGAIHKCTWSK--QEFAIKLFSEEEHLQDEAVIHFTLDHPHVVKPHGYSISGSGSSSGNHSGAGLIMELMDG---DLQTWIKNKVEKDP .... . .||.| .||.. | ...||| . ||.. | |. .||..|| ... . . ..||..|| || . ||.. . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIKKRGRHGL HHLPLEEKAAIDVMLQLATALMYMHAFGLIHRDVKPGNFLVRFNQTFPSGLEVKLGDFGTARSVDDGKLTARRGTHCYWAPEVLQGDEGSKCSYTD-KAD . |. | | .| |.. || |.| | ||||.|| | |. ..|..||| || . | || | ||||| .|. |.| R-FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL-----TTFCGTPWYMAPEVL--------GYGKCKCD VYSFGMTFYAVLTGETPLDKYKELSPEKFLEKIRGGNWIIPGLKRAGKRPRLPSSSEAM-----------ARRQGIAPPVA-------VPAA ..|.| ..| |.|..| . ... ..||. |.|| ..| .. . | WWSCGCILYEMLCGYPPFP-----QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | MLKx_r.AA | CAMK | 142-368 | 17 | 5e-33 | 103.22 | In-house | 1-364 (425) | Show / Hide |
Range on Protein: 142-368 Range on HMM: 1-364/425 Sequence Identity: 17% (64 aa) FLAQGAYGAIHKCTWS-K-------------QEFAIKLFS---------------------------------EEEHLQDEAVIHFT-------LDHPHV | .|..| ..|. |..||| . .. .. | |. . ||||.. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKPHGYSISGSG----SSSG-NHSG--------AGLIM---ELMDG-DLQTWIKNKVEKDPH------------HLPLEEKAAIDVMLQLATALMYMHAF .| . . ... .. . . | ..| |...| .| . ... . .. . ..|. | .. |.. |. |.| IKLYEVYEDPHYFKNTND-YET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH GLIHRDVKPGNFLVRFNQT-FPSGL-----------EVKLGDFGTARSVDDGK-------------------------LTARRGTHCYWA-PEVLQGDEG . .||| || | |. | . ... . .|. ||| |. .|.|. .. . || .| | ||||.| . NIVHRDLKPENILLDDNNDDSDP-VEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH S---------KCSYTDKADVYSFGMTFYAVLTGETPLDKYKEL----------SPEKFLEKIRGGNW . | |. |.|. | | |. |.|. | . .. .... .|||. |.. CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKY |
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Kinase | MLKx_r.AA | STE | 137-337 | 22 | 1.1e-31 | 109.14 | In-house | 1-257 (359) | Show / Hide |
Range on Protein: 137-337 Range on HMM: 1-257/359 Sequence Identity: 22% (60 aa) FQMGIFLAQGAYGAIHKCTWS-----------------KQEFAIKLFS----------------------EEEHLQDEAVIHFTLD--HPHVVKPHGYSI .. .. .||.| .|. .. .||| . |.. .. | |. .. ||..|| .|. . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF SGSGSSSGNHSGAGLIMELMD-GDLQTWIKNKVEK-DPHH------LPLEEKAAIDVMLQLATA-LMYMHAFGLIHRDVKPGNFLVRFNQTFPSGLEVKL .. ..|.. ..||.|| | | ||.| .. .|.. ...|. . . |. . | | | . ||||.||.| |. ||| KEGHN-HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----------VKL GDFGTARSVDD------------------GKLTARRGTHCYWAPEVLQGDEGS-KCSYTDKADVYSFGMT |||.. ...| .| . || . ||||.|..... . |. |.|..|.| | CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCT |
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Kinase | MLKx_r.AA | Ciliate-E2 | 210-371 | 23 | 9.9e-28 | 92.26 | In-house | 111-308 (365) | Show / Hide |
Range on Protein: 210-371 Range on HMM: 111-308/365 Sequence Identity: 23% (52 aa) LIMELMDG-DLQTWIKNKVEKDPHHLP----LEEKAAIDVMLQLAT---------------ALMYMHAFG-LIHRDVKPGNFLVRFNQTFPSGLEVKLGD |.||. .| ||. .|||. | .|... . || ....| |.. || |.| . |||| || | |. .|. | LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----------IKIID FGTARSVDD-----------GKLTARR-----------------------GTHCYWAPEVLQGDEGS----KCSYTDKADVYSFGMTFYAVLTGETPLDK ||... .|| .... . || | |||.|.| . . . |. |.|..|.|...| |.|..| FGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-- YKELSPEKFLEKIRGGNWIIP ...| ... .| ---------QQQIKQCKIDFP |
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Kinase | MLKx_r.AA | TK | 137-347 | 15 | 2.3e-24 | 77.9 | In-house | 1-394 (486) | Show / Hide |
Range on Protein: 137-347 Range on HMM: 1-394/486 Sequence Identity: 15% (61 aa) FQMGIFLAQGAYG---AIHKCTWSK---------------------------QEFAIKLFSEE-EHLQDE--------------------AVIHFT---L ..| | .|..| ..|..| .. |.| |. .. |.| . . . ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG DHPHVVKPHGYSISGSGSSSGN----HSGAGLIMELMD-GD----LQTWIKNKVEK-------------------------------------------- .||..|. .|.. | .... . ..||.|. || |... ... .| HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY -----DPHHLPLEEKAAID-------------------VMLQLATALMYMHAF------GLIHRDVKPGNFLVRFNQTFP-----SGLEVKLGDFG---- ..| .|| .| .. ..|.| .. |.|. ...|||. | || | . .|. .|..||| DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ ----TARSVDDGKLTARRGTHC----------------------------YWAPEVLQGDEGSKC----SYTDKADVYSFGMTFYAVLT-GETP || ..... |.... . |||.|.. . | . .| | ||.||| . . ..| |..| GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP |
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Kinase | MLKx_r.AA | ULK | 210-364 | 28 | 2.3e-23 | 78.46 | In-house | 97-283 (329) | Show / Hide |
Range on Protein: 210-364 Range on HMM: 97-283/329 Sequence Identity: 28% (55 aa) LIMELMDG-DLQTWIKNKVEKDPHHLP--------LEEKAAIDVMLQLATALMYMHAFGLIHRDVKPGNFLVRFNQTF-------PSGLEVKLGDFGTAR .|||. .| ||.. ||.. ..|| |.|. || .. |.. .....| . |||| || | |. .|. | .|..||| |. IIMEYCNGGDLEQYIKKN-----KKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAK SVDDG------KLTAR-----RGTHCYWAPEVLQGDEGSKCSYTDK-ADVYSFGMTFYAVLTGETP----LDKYKELSPEKFLEK-------IR .||.. .|. .|| | ||..||| | .. |.|. .|..|.|. || |.|..| ..... .| ... |. HVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQ-GEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIK |
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Kinase | MLKx_r.AA | Dicty4-Unclassified | 137-347 | 30 | 3.2e-23 | 76.36 | In-house | 1-207 (263) | Show / Hide |
Range on Protein: 137-347 Range on HMM: 1-207/263 Sequence Identity: 30% (67 aa) FQMGIFLAQGAYGAIHKCTWSKQEFAIKLFSE------EEHLQD---EAVIHFTLDHPHVVKPHGYSISG-SGSSSGNHSGAGLIMELM-DGDLQTWIKN | |. .|. .|| | . |.| | | || .|| | | . || || ||.| | | .||.| | | | IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRS-----HKSTMCIVMEFMHKGNLFEVIHS KVEKDPHHLPLEEKAAIDVMLQLATALMYMHAFGLIHRDVKPGNFLVRFNQTFPSGLEVKLGDFGTARSVDDG-KLTARRGTHCYWAPEVLQGDEGSKCS | . |.. | . . | . ..| .||||.| | |. . .| .||| .| .| .|. || .||.| . | KPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKH------FNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHE-----S YTDKADVYSFGMTFYAVLTGETP |. |.||||..| | .||. | YNQKSDVYSYAMMLYELATGDEP |
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Kinase | MLKx_r.AA | ULK | 210-364 | 27 | 8.6e-23 | 77.74 | In-house | 94-278 (324) | Show / Hide |
Range on Protein: 210-364 Range on HMM: 94-278/324 Sequence Identity: 27% (52 aa) LIMELMDG-DLQTWIKNKVEKDPHH---LPLEEKAAIDVMLQLATALMYMHAFGLIHRDVKPGNFLVRFNQTF-------PSGLEVKLGDFGTARSVDDG .|||. .| ||.. ||.. .. . |.|. || .. |.. .....| . |||| || | |. .|. | .|..||| |..||.. IIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNN KLTARR-----------GTHCYWAPEVLQGDEGSKCSYTDK-ADVYSFGMTFYAVLTGETP----LDKYKELSPEKFLEK-------IR . . || | ||..||| | .. |.|. .|..|.|. || |.|..| .... .| ... |. NMEQQMCQTCVNEKRIKGTPLYMAPQILQGQ-GEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIK |
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Kinase | MLKx_r.AA | C8 | 212-338 | 28 | 2e-19 | 64.13 | In-house | 99-226 (226) | Show / Hide |
Range on Protein: 212-338 Range on HMM: 99-226/226 Sequence Identity: 28% (38 aa) MELMDGDLQTWIKNKVEKDPHHLPLEEKAAIDVMLQLATALMYMHAFGLIHRDVKPGNFLVRFNQTFPSGLEVKLGDFGTARSVDDGK--LTARR----G ||| . |. . . .|. ...... . .|. . |.| . .|||.|| ||||...|. .| |.|| ||| | | . | . | MELCEQNLKQLYDERRNKQ---QQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQN--YGFEIKLCDFGFASQVSKNKSHIQSKKMNTCG THCYWAPEVLQGDEGSKCSYTDKADVYSFGMTF | |.|||...... |. . |..| |. TWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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Kinase | MLKx_r.AA | TAK1 | 245-351 | 26 | 1.3e-17 | 56.01 | In-house | 108-228 (284) | Show / Hide |
Range on Protein: 245-351 Range on HMM: 108-228/284 Sequence Identity: 26% (35 aa) MLQLATALMYMHAFG---LIHRDVKPGNFLVRFNQTFPSGLEVKLGDFGTARSVDDGKLTARRGTHCYWAPEV----------------------LQGDE |.|.| .. |.|. .||||.|| | | .. |. ||||. . | ||| . |||| ... MHQCAQGVAYLHSMQPKPQIHRDIKPQNMLL-----CNKHRTLKICDFGTFCDMHQ-MMTCNRGTCRWMAPEVRELFDFKSNRIIINQPTGFQKVFRCEK GSKCSYTDKADVYSFGMTFYAVLTGETPLDKY |. |.|.||.| .. |.. | |.. -----YNMKCDIYSWGIIMWEVISRKHPYDHI |
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Kinase | MLKx_r.AA | TyrKc | 137-389 | 21 | 6.3e-13 | -13.68 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 137-389 Range on HMM: 1-280/280 Sequence Identity: 21% (66 aa) FQMGIFLAQGAYGAIHKCTWSKQEFAIKLFSEE--EHLQDEAVIHFTL--DHPHVVKPHGYSISGSGSSSGNH---SGAGLIMELMD-GDLQTWIKNKVE ..| | ||.| ..|.||. .. |.| |. | . .|| | | .||..|. .|. ..... ..||.|. |||. .... . ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLKDYLRKHRP KDPHHLPLEEKAAIDVMLQLATALMYMHAFGLIHRDVKPGNFLVRFNQTFPSGLEVKLGDFGTARSVDDG-------KLTARRGTHCYW--------APE | | | .. ..| | | | ..|||| | || |. || .||| .| ..|. . ... . ||| K------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE VLQGDEGSKCSYTDKADVYSFGMTFYAVLTGETPLDKYKE-----LSPEKFLEKIRGGNWIIPGLK-----------------------RAGKRPRLPSS .. .. .| | ||.||| . . ..| . | . .|.. .|... |. . . .||. CI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQP--YPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI SEAM | . HECF |
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Kinase | MLKx_r.AA | TAK1 | 138-217 | 25 | 2.5e-07 | 20.68 | In-house | 2-83 (284) | Show / Hide |
Range on Protein: 138-217 Range on HMM: 2-83/284 Sequence Identity: 25% (23 aa) QMGIFLAQGAYGAIHKCTWSKQEFAIKLFS--------EEEHLQDEAVIHFTL-DHPHVVKPHG-YSISGSGSSSGNHSGAGLIMELMDG | |. |.||. | .| ..| |.| | .|. ... . .. ||| ..| .| | . . ...|.|| ||. QNEHFVGKGTYGVVCKAKWRNKEIAVKRFEFIKYSSEECEQKNIEREIMQWSRVDHPNIIKLYGMY--------ACHRQCQCLVMEYMDC |
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Kinase | MLKx_r.AA | Pkinase_Tyr | 137-265 | 24 | 2.7e-07 | 25.33 | Pfam | 1-137 (270) | Show / Hide |
Range on Protein: 137-265 Range on HMM: 1-137/270 Sequence Identity: 24% (35 aa) FQMGIFLAQGAYGAIHKCTWS------KQEFAIKLF-----SEE---EHLQDEAVIHFTL-DHPHVVKPHGYSISGSGSSSGNHSGAGLIMELMDG-DLQ ..| | .||.| ..|.|| |.. |.| .|. | . || | .| .||..|. .| .. .... ..||.| . || ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPHGDLL TWIKNKVEKDPHHLPLEEKAAIDVMLQLATALMYMHAFGLIHRDV . ... |...|.... .. .| | .. | .. ..||||. DYLRKHR-EDKQPLTMKD--LLQMCWQIAKGMEYLESKNCIHRDL |
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Kinase | MLKx_r.AA | Pkinase_Tyr | 280-367 | 30 | 2e-06 | 22.08 | Pfam | 146-233 (270) | Show / Hide |
Range on Protein: 280-367 Range on HMM: 146-233/270 Sequence Identity: 30% (29 aa) SGLEVKLGDFGTARSV-DDGKLTARRGTHCYW-----APEVLQGDEGSKCSYTDKADVYSFGMTFYAVLT-GETPLDKYKELSPEKFLEKI-RGGN ... || .||| || . .|. | .... . |||... . .| | ||.||| . . ..| ||.| |...|.| ..|.| . |. ENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK-----FTTKSDVWSFGVLMWEIFTYGEQP--TYPGMSNEEVYEYIYEDGY |
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Kinase | MLKx_r.AA | Ciliate-E2 | 137-193 | 16 | 0.133036 | 1.25 | In-house | 1-100 (365) | Show / Hide |
Range on Protein: 137-193 Range on HMM: 1-100/365 Sequence Identity: 16% (16 aa) FQMGIFLAQGAYGAIHKC-TWSKQE------------------------FAIKLFSEEEHLQDEAVIHFT------------------LDHPHVVKPHGY . . ||..| . || |..|. .|.| ... . | . .|| |.||...| . . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC |