Gene MLKx_f (S.moellendorffii)

MLKx_f

Species: S.moellendorffii
Alias: MLKx_f
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_f.AA Protein None 1143 None Fasta, JSON
MLKx_f.NA RNA None 3432 None Fasta, JSON
MLKx_f.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of MLKx_f.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKx_f.AA TKL 204-456 24 6.1e-75 255.27 In-house 1-364 (364) Show / Hide 
Range on Protein: 204-456
Range on HMM: 1-364/364
Sequence Identity: 24% (91 aa)

IGSGAFGSVYKAEWLG----------APVAVKEFRSGDASF----------------------------DKEVNILKELILEPHPSVLQMIGYYQKDEK-
||||.|| |||..| |           .|||| |.| . ..                            ..|.. .. ..   || ..|..|| .  .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------AYLVMELM-ERD-LTSVIRKAEGSLQLLTSVDIMLQIASGMSYLHQRN--------VVHRDLKPSNVLVKT-LKNHACNTCF------
             ..|||..   . |  ..        .   ....|.||.||.|||..|        ..|||||..|.||.  ..|.  |  .      
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMYNPNADW

DARLTDFGVSKSNFISFAPD------------------LSYQRGTIQYMAPEMLRGQ----------------KYSREVDVYSFGITCFQILTGTLPFQD
.. ..||| |.... |.                     .. |.||...||||.||||                .||  .|||||||  . |||. .|..|
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

DGKQLVA------DKLVEAIEDGNRPDLP------------TGCPLELVVLLNRCWNRNPKDRPTFEQISRML
..   .       . .. ....|.|| .|            . || ..  |. .||. .|..||.|..|   |
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc MLKx_f.AA S_TKc 198-458 24 1.1e-69 238.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 198-458
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

LELKTLIGSGAFGSVYKAEWLG--APVAVKEFRSGDASFDKEVNILKELILEPHPSVLQMIGYYQKDEKAYLVMELMER---DLTSVIRKAEGS-----L
 |.  .||.||||.|||. . .    ||.|. .    .. .|..|||.     || . ......|  .. |.|||...    || ..|.|  .      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

QLLTSVDIMLQIASGMSYLHQRNVVHRDLKPSNVLVKTLKNHACNTCFDARLTDFGVSKSNFISFAPDLSYQRGTIQYMAPEMLRGQKYSR-EVDVYSFG
   .   .| ||.... |.|.....||||||.|.|. .             ..|||...          . . ||  |||||.|   .|.. ..|..|.|
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

ITCFQILTGTLPFQDDGKQLVADKLVEAIEDGNRPDLPTGCPLELVVLLNRCWNRNPKDRPTFEQISR-------MLWS
.. .  |.|  ||.    |.. .|..               . |.  ....|....|..|||  .. .       . | 
CILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase MLKx_f.AA Pkinase 198-456 26 1.2e-66 232.53 Pfam 1-293 (293) Show / Hide 
Range on Protein: 198-456
Range on HMM: 1-293/293
Sequence Identity: 26% (81 aa)

LELKTLIGSGAFGSVYKAEWLGAP--VAVKEFRSGDASFDK--------EVNILKELILEPHPSVLQMIGYYQKDEKAYLVMELMER-----DLTSVIR-
....  ||||.||.|||. . | .  ||||...  ... .|        |. |.|.|    || ......... . . |.|||..|      || ..|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

KAEGSL--QLLTSVDIMLQIASGMSYLHQRNVVHRDLKPSNVLVK-TLKNHACNTCFDARLTDFGVSK--SNFISFAPDLSYQRGTIQYMAPEMLR-GQK
...|..  .  .  ..|.||..|. |.|.....||||||.|.|.. .  . |     . ...|||..|  .  .   . ..   ||. ||||| .| ||.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQY

YSREVDVYSFGITCFQILTGTLPFQDD----GKQLVADKLVEAIEDGNRPDLPTGCP-------------------LELVVLLNRCWNRNPKDRPTFEQI
|...||..|.|..... |.| .||...    .      ....  .  .. | |. |.                    |.  ....|....||.|||.|||
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

SRM--L
     .
LQHPWF
Kinase MLKx_f.AA MLK 198-456 27 6.8e-62 211.93 In-house 1-291 (291) Show / Hide 
Range on Protein: 198-456
Range on HMM: 1-291/291
Sequence Identity: 27% (82 aa)

LELKTLIGSGAFGSVYKAEWLGAP-----VAVKEFR--------SG--DASFDKEVNILKELILEP-HPSVLQMIGYYQKDEK-AYLVMELMER-DLTSV
..... ||||.||.|.|..| .       ||||..|        ..  .  |..|...|. |  .  ||.. |  |  .....  ..||| .|   | .|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IRKAEG---------------SLQLLTSVDIMLQIASGMSYLHQRN---VVHRDLKPSNVLVKT-LKNHACNTCFDARLTDFGVSKSNFISFAPD-LSYQ
.. |..               .....  ....||.|.||.|||.     ..|||||..|.|.    . . ...  ... .|||.|.. . .   .    .
LHGARSKWMDANHNQKNDRVYDHDHA--MNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHG--TLKICDFGTSRD-WHQMC-TNMMSN

RGTIQYMAPEML---RGQKYSREVDVYSFGITCFQILTGTLPFQDDGKQLVADKLVEAIEDGNRPDLPTGCPLELVVLLNRCWNRNPKDRPTFEQISRML
.||  .||||..   |..|||. .||.|.|.   ..||. .|.... ... .  . .... |.|| .| .||  .  |...||| .|..||.| ||   |
AGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAI--AWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLKx_f.AA TK 198-456 19 5.9e-59 195.94 In-house 1-486 (486) Show / Hide 
Range on Protein: 198-456
Range on HMM: 1-486/486
Sequence Identity: 19% (93 aa)

LELKTLIGSGAFG---SVYKAEWLGA---------------------------PVAVKEFRSGDASFDK------------------EVNILKELI--LE
..|   .|.|.||    |||.|| |                            |||||  ..|||. ..                  |....| .   | 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHPSVLQMIGYYQKD------------EKAYLVMELME-RD----LTSVIRKAEG---------------------------------------------
 || .....|.  ..            |  ..|||.|.  |    | .  ||  .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------SLQLLTSVD-------------------IMLQIASGMSYLHQR------NVVHRDLKPSNVLVKTLKNHA---CNTCFDARLTDFGVSKS
          .|..   ..                   ...|||.||.|||..      |.|||||   |.||   .. .    .... ....||| |. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

NF----ISFAPDLSYQRGT-----------------------------IQYMAPEMLRGQK---------YSREVDVYSFGITCFQILT-G-TLPFQDDG
.         .|  | | .                             | .|||| |....         .. . ||.|||.... |.| | . .  .  
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

KQLVAD-----KLVEAIEDG--------------NRPDLPTGCP--------------LELVVLLNRCWNRNPKDRPTFEQISRML
 | |.       ..| ...|              .|.  | .||               |.  |. .||...|.|||||.|. ..|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKx_f.AA TKL-Unique 200-456 30 9.5e-55 188.2 In-house 1-290 (290) Show / Hide 
Range on Protein: 200-456
Range on HMM: 1-290/290
Sequence Identity: 30% (91 aa)

LKTLIGSGAFGSVYKAEWLGAPVAVKEFRS---GDAS----FDKEVNILKELILEPHPSVLQMIGYYQ----KDEKAYLVMELMERD-LTSVIR------
   .||.|..|.|||..| | |||.| |        .    | .|||..|   |..|| ... .||      .  . ..||| ...  | .|.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMK--KLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---KAEGSLQLLTSVDIMLQIASGMSYLHQRN--VVHRDLKPSNVLVKTLKNHACNTCFDARLTDFGVSKSNFISFAPDLS--------YQRGTIQYMAP
   . .  | ..  |.. ..||.|| ||| ..  . |||||.||.||    | |    . ... ||| ||.|  . .  ..           |....|||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIA---EWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAP

EMLRG--QKYSREVDVYSFGITCFQILTGTL------PFQDDGKQLVADKLVEAIEDGNRPDLPTGCPLELVVLLNRCWNRNPKDRPTFEQISRML
|.||.   .||. .|||||||    |.|...      |.|.   . .. .. .  |.. || .|. || |.  |...||...| .||.|..|   |
EVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKx_f.AA STE 198-458 20 4.6e-53 182.61 In-house 1-359 (359) Show / Hide 
Range on Protein: 198-458
Range on HMM: 1-359/359
Sequence Identity: 20% (78 aa)

LELKTLIGSGAFGSVYKAEWL-----------------GAPVAVKEFRSGDASF---------------DKEVNILKEL----ILEP-HPSVLQMIGYYQ
.|.   ||.||||.||||                    |  .|.|. .  . .                ... .||||.     . . || . . .|.| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD-------EKAYLVMELME-RDLTSVIR---KAEGSLQ----------LLTSVDIMLQIASG-MSYLHQRNVVHRDLKPSNVLVKTLKNHACNTCFDAR
|.       .. ...||.|.   |...|.   .  ..|.                |  ||  | ..|||. ...|||.||.|.|.             . 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------------VK

LTDFGVSKSNFISFA---------------PDLSYQRGTIQYMAPEMLRG------QKYSREVDVYSFGITCFQILTGTLPFQD-DGK---QLVADK---
|.||||...   | |                      ||  .||||....      ..|.. .|..|.|.|.   .||  |. |        . ...   
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHM

-----LVEAIEDGNRPDLPT-------------------GCPLELVVLLNRCWNRNPKDRPTFEQISR--MLWS
     .. .| .|. | ||.                    .  |.   .|.| ...|..||| .|  .    . 
QQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MLKx_f.AA TyrKc 198-456 28 7.9e-53 182.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 198-456
Range on HMM: 1-280/280
Sequence Identity: 28% (82 aa)

LELKTLIGSGAFGSVYKAEWLGAPVAVKEFR--SGDASFDKEVNILKEL-ILEPHPSVLQMIGYYQKD-------EKAYLVMELMER-DLTSVIRKAEGS
..|.  .|.|||| |||..|   .||||  .  .  . | .| .|...|     || .....|.  ..       |  ..|||.|.  || . .|| .. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGG--HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LQLLTSVDIMLQIASGMSYLHQRNVVHRDLKPSNVLVKTLKNHACNTCFDARLTDFGVSKSNFIS----FAPDLSY------QR--GTIQYMAPEMLRGQ
|.. . .....|||.||.|||..|..||||   |.||.  .         .. .||| |.          . |          .    |  |||| ..  
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

KYSREVDVYSFGITCFQILTGTLPFQDDGKQ--LVADKLVEAIEDGNRPDLPTG--------CPLELVVLLNRCWNRNPKDRPTFEQISRML
|.. . ||.|||.... |.|   .   .  |  . .. ..| ...|.|.. |          || |.  .  .||...|.|||||..| . .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKx_f.AA Ciliate-E2 198-458 19 3.2e-52 177.57 In-house 1-365 (365) Show / Hide 
Range on Protein: 198-458
Range on HMM: 1-365/365
Sequence Identity: 19% (77 aa)

LELKTLIGSGAFGSVYKAEWLGAP-------------------------VAVKEFR-SGDASFDKEVNILKELILEP--------------HPSVLQMIG
 ..  .||.|.||||||..    .                         .|.| .. ..  .. .| .|..|.                  || ...|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

YYQ--KDEKAYLVMELMER-DLTSVIR-----------KAEGSLQLLTSVDIMLQIAS---------------GMSYLHQRN-VVHRDLKPSNVLVKTLK
..|  .|.. |||||. .  || . |.           |. ... .    .|| ||..               .. |||..| ..|||.||.|.|.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

NHACNTCFDARLTDFGVSKSNFIS-----------FAPDLSY--------------------QRGTIQYMAPEMLRGQK---------YSREVDVYSFGI
           ..||| || . ..             .. ..                    . ||  |||||.|.|.|         |. ..|..|.|.
---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

TCFQILTGTLPFQDDGKQLVADKLVEAIEDGNRPDLP------------------TGCPLELVVLLNR----CWNRNPKDRPT-FEQISRMLWS
. .. |.| .||             . .   .  |.|                    ...|   |...    . ...|. |.| .|||    | 
ILYEMLFGKPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MLKx_f.AA CAMK 203-458 17 2.1e-47 150.38 In-house 1-425 (425) Show / Hide 
Range on Protein: 203-458
Range on HMM: 1-425/425
Sequence Identity: 17% (73 aa)

LIGSGAFGSVYKAEWLGAP--------------VAVKE--------------------------------FRSGDASFDKEVNILKELILEP----HPSV
 .|.|.|| |....    .              ||.|                                   .  ... .|..|.| |        || .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LQMIGYYQK-------------------DEKAYLVM---ELMER-----DLTSVIRKA--------------EGSLQLLTSVDIMLQIASGMSYLHQRNV
.... .|.                    |.. |.||   |...      || . |..               .| ..      .. ||.|.. |.|..|.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPSNVLVKTLKNHACNTC----------FDARLTDFGVSKSNFISF----------------------APDLSYQRGTIQYMA-PEMLRG-----
||||||| |.|. . ... ..            ..  ..||| ..  . .                        . .. . ||  ||| ||.|.|     
VHRDLKPENILLDDNNDDSDP-VEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------QKYSREVDVYSFGITCFQILTGTLPFQDD-GKQLVA--------DKLVEAIEDGNRP-DLPT----------------------GCPLELV
         . |....|. | |. ..  |.|..||..| ... .          .| | |  |.   . |                        .  |  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

VLLNRCWNRNPKDRPTFEQISRMLWS
 |.... ...|..|.| ||. .  | 
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MLKx_f.AA LRRK 267-458 30 2.4e-44 153.64 In-house 132-351 (351) Show / Hide 
Range on Protein: 267-458
Range on HMM: 132-351/351
Sequence Identity: 30% (67 aa)

LVMELMER-DLTSVIRKAEGS--------LQLLTSVDIMLQIASGMSYLHQRN--VVHRDLKPSNVLVKTLKNH----ACNTCFDARLTDFGVSKSNFIS
.|||..   || ..... . .        .   .   |.||||.|| ||| .|  ..|||||. |.|.......    . |.   | . ||| |   | .
MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQC

FAPD-LSYQRGTIQYMAPEMLRGQ---KYSREVDVYSFGITCFQILTGT-LPFQD-DGKQLV--ADKLVEAIEDGNRPDLPTG-CPL-----ELVVLLNR
| .  ..   |....|||| .|.     |. .||.||||.  . .||.. .||.. |..       .. ..| .| || .|   ||      ..  |.. 
FHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQH

CWNRNPKDRPTFEQISRMLWS
||. .||.||.|.||   | .
CWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_f.AA TK-Unique 198-456 27 7.4e-44 149.12 In-house 1-294 (294) Show / Hide 
Range on Protein: 198-456
Range on HMM: 1-294/294
Sequence Identity: 27% (84 aa)

LELKTLIGSGAFGSVYKAEWLG--------APVAVKEFRSGDASFDKEVNILKEL----ILEPHPSVLQMIGYYQKD-EKAYLVMELMERD-LTSVIRKA
||.. .||.|||| |...|  |          ||||  . . |.. .. . |||.     | .|| ..|..|. .|. |  ...|| ...  | . .|. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDN-ATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

EGS-------------------------LQLLTSVDIMLQIASGMSYLHQ--RNVVHRDLKPSNVLVKTLKNHACNTCFDARLTDFGVSK--SNFISFAP
 .                          ... . . .. |||.||.||..  ...|||||  .|||.           . . ..||| ..  ..    . 
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE--------DKVCKICDFGMARDVYTNGVYSM

DLSYQRGTIQYMAPEMLR--GQKY-SREVDVYSFGITCFQILT-GTLPFQDDGKQLVADKLVEAIEDGNRPDLPTGC-PLELVVLLNRCWNRNPKDRPTF
  |..|  | .|||| |.  .. | . . ||.|||.. . |.| |  |.     .. .....|.|.|| |...| .| . |.  |. .||...|..||.|
MCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYP----GMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSF

EQISRML
.||  .|
RQIKHRL
Kinase MLKx_f.AA Pkinase_Tyr 198-316 32 2e-29 100.27 Pfam 1-137 (270) Show / Hide 
Range on Protein: 198-316
Range on HMM: 1-137/270
Sequence Identity: 32% (45 aa)

LELKTLIGSGAFGSVYKAEWL------GAPVAVKEF--RSGDAS-----FDKEVNILKEL-ILEPHPSVLQMIGYYQ-KDEK--AYLVMELMER-DLTSV
...   .|.||||.|||..|       . |||||     . .       | .|..|.|.|     || .....|    ..|    |.|||.|.  || . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGH---HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IRKA---EGSLQLLTSVDIMLQIASGMSYLHQRNVVHRDL
 ||    ...| . . ... .|||.||.||...| .||||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase MLKx_f.AA Dicty4 361-458 36 4.2e-29 94.33 In-house 179-277 (277) Show / Hide 
Range on Protein: 361-458
Range on HMM: 179-277/277
Sequence Identity: 36% (37 aa)

GTIQYMAPEMLRGQKYSREVDVYSFGITCFQILTGTLPFQDDGKQLVADKLVEAIED-GNRPDLPTGCPLELVVLLNRCWNRNPKDRPTFEQISRM--LW
||  .||||....| |   .|||||||  ..|||.  |.|  .. ..  ..|.|. . ..|| .|  ||  .  |...||. .|. ||.||.|.    | 
GTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYM--QFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILE

S
.
H
Kinase MLKx_f.AA Dicty4 198-323 29 2.6e-27 88.28 In-house 1-147 (277) Show / Hide 
Range on Protein: 198-323
Range on HMM: 1-147/277
Sequence Identity: 29% (44 aa)

LELKTLIGSGAFGSVYKAEWLGAPVAVKEF--RSGD------ASFDKEVNILKELILEPHPSVLQMIGYYQ----KDEKAYLVMELM-ERDLTSVIRK--
.    .||.|.||.|||. | |  |||| .  .  .       .| |||.|.. .    || ...  |.      . .|   |.|.|   .| |....  
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIR---HPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKP

----AEGSLQ--LLTS-VDIMLQIASGMSYLHQRN--VVHRDLKPSNVLV
     . .|.  | ..   ... .| || .|| .|  ..|||||..| ||
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV
Kinase MLKx_f.AA Pkinase_Tyr 366-456 37 1.6e-23 80.27 Pfam 181-270 (270) Show / Hide 
Range on Protein: 366-456
Range on HMM: 181-270/270
Sequence Identity: 37% (35 aa)

MAPEMLRGQKYSREVDVYSFGITCFQILT-GTLP-FQDDGKQLVADKLVEAI-EDGNRPDLPTGCPLELVVLLNRCWNRNPKDRPTFEQISRML
|||| ..  |.. . ||.|||.... |.| |  | ...    .    ..|.| |||.| . | .|| |.  |. .||. .|.|||||..| ..|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG----MSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKx_f.AA LRRK 198-227 45 2e-09 29.49 In-house 1-31 (351) Show / Hide 
Range on Protein: 198-227
Range on HMM: 1-31/351
Sequence Identity: 45% (14 aa)

LELKTLIGSGAFG-SVYKAEWLGAPVAVKEF
|.   .||.|.|| .||.|.| |.||.|...
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRM
Kinase MLKx_f.AA TKL 665-769 18 1.7e-11 37.69 In-house 1-152 (364) Show / Hide 
Range on Protein: 665-769
Range on HMM: 1-152/364
Sequence Identity: 18% (28 aa)

VGMSNHGTMFRGRWLD----------VPVMVKALGTGN-------------------------EAEKLLKELDKGHAELRNRPHPNVTQVFGYTRHGEN-
.|    |. ..|.|             .| || . . |                         ||... ... .    .... |||. |  ||   ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LFVVTERVSGGH-FRVTKFPLVLTIEILLQVAQGVAYLHEHN
            |. |.| ..||  . .    . ... . |..|.|..||| .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--WHQRCRWALDIARGMNYLHSMN
Kinase MLKx_f.AA TK 659-770 11 4.3e-07 19.02 In-house 1-255 (486) Show / Hide 
Range on Protein: 659-770
Range on HMM: 1-255/486
Sequence Identity: 11% (30 aa)

IVLLDFVGMSNHG---TMFRGRWLD---------------------------VPVMVKALGTGNEAEKLLKELD--------------KGHAELRN---R
|.|..  |  . |   . ..|.| .                           .|| || |  |.....  ....                 ... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHPNVTQVFGYTRHGEN------------LFVVTERVSGG-----------HFRVTKFPLVLTIE-----------------------------------
 |||. . .|.  .||.            . .|.| ...|             | ....   ...                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------ILLQVAQGVAYLHEHNC
                                      . .|.|.| .|||..||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNC
Kinase MLKx_f.AA Pkinase 708-770 15 2e-06 23.97 Pfam 54-129 (293) Show / Hide 
Range on Protein: 708-770
Range on HMM: 54-129/293
Sequence Identity: 15% (12 aa)

LRNRPHPNVTQVFGYTRHGENLFVVTERVSGG----HFR-------VTKF--PLVLTIEILLQVAQGVAYLHEHNC
...  |||. . ... . . .. .|.| . ||               ..|  .    . ...|...|..|.|....
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGI
Kinase MLKx_f.AA CAMK 713-769 14 5e-06 14.73 In-house 97-199 (425) Show / Hide 
Range on Protein: 713-769
Range on HMM: 97-199/425
Sequence Identity: 14% (15 aa)

HPNVTQVFGYTRHGEN-------------------LFVVT---ERVSGG------HFRVTK------------------FPLVLTIEILLQVAQGVAYLH
|||. . . .   ...                   .. |.   | .|||        ....                  |.   .  .  |....|.|.|
HPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH

EHN
.||
SHN
Kinase MLKx_f.AA TKL-Unique 661-782 19 4.5e-05 14.04 In-house 1-148 (290) Show / Hide 
Range on Protein: 661-782
Range on HMM: 1-148/290
Sequence Identity: 19% (29 aa)

LLDFVGMSNHGTMFRGRWLDVPVMVKALGTGNEAEKLLKELDKGHAEL----RNRPHPNVTQVFGYTR----HGENLFVVTERVSGG------H------
 .  .| .  |. ..| |   || .| .    .... ...... . |.    . ..|||... .||.     .  |.. |.| ..||      |      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---FRVTKFPLVLTIEILLQVAQGVAYLHEHN-----CELSDLNTLLVEF
    . .|... . . . ...|||  |||  .     . |  .|.|....
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNN
Kinase MLKx_f.AA TK-Unique 659-770 18 0.000117 12.13 In-house 1-154 (294) Show / Hide 
Range on Protein: 659-770
Range on HMM: 1-154/294
Sequence Identity: 18% (29 aa)

IVLLDFVGMSNHGTMFRGRWL--------DVPVMVKALG---TGNEAEKLLKELDKGHAELRNRPHPNVTQVFGYTRHG-ENLFVVTERVSGG-------
....| .|. . |. .||           .. | ||.|    |. .  ..|||. . . ||   .|||. | .|..    |. . . | ...|       
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEI-QMMKELG--DHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

-----HFRV-------------TKFPL--VLT----IEILLQVAQGVAYLHE--HNC
     ....             ...|.   ..    . .. |.|.| .||..  ...
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI
Kinase MLKx_f.AA STE 712-769 19 0.000697 9.74 In-house 87-172 (359) Show / Hide 
Range on Protein: 712-769
Range on HMM: 87-172/359
Sequence Identity: 19% (17 aa)

P-HPNVTQVFGYTRHG-------ENLFVVTERVSGGHFR---V----------------TKFPLVLTIEILLQVAQG-VAYLHEHN
. |||. . .|.  ..       ..|... | ..|| ..                    ..||  . . |. |. .|  .|||.|.
HMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH
Kinase MLKx_f.AA LRRK 740-769 43 0.002778 7.45 In-house 155-184 (351) Show / Hide 
Range on Protein: 740-769
Range on HMM: 155-184/351
Sequence Identity: 43% (13 aa)

HFRVTKFPLVLTIEILLQVAQGVAYLHEHN
||  ....  |...| ||.| |..||| ||
HFMKAHISWMLKLKIALQIAKGMEYLHSHN
Kinase MLKx_f.AA MLK 659-739 23 0.004105 6.8 In-house 1-95 (291) Show / Hide 
Range on Protein: 659-739
Range on HMM: 1-95/291
Sequence Identity: 23% (23 aa)

IVLLDFVGMSNHGTMFRGRWLDVP-----VMVKALG--------TGNEAEKLLKELDKGHAELRNRPHPN----VTQVFGY-TRHGENLFVVTERVSGG
| .. ..| .  | ...|||         | ||.          |. |.... .|      .||   |||    . |. |  .... ....|.| ..||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMEC----RHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGG
Kinase MLKx_f.AA MLK 756-768 53 0.008718 5.65 In-house 131-143 (291) Show / Hide 
Range on Protein: 756-768
Range on HMM: 131-143/291
Sequence Identity: 53% (7 aa)

LQVAQGVAYLHEH
||.|.|..|||..
LQCARGMHYLHSM
Kinase MLKx_f.AA Pkinase_Tyr 659-770 22 0.027303 8.38 Pfam 1-132 (270) Show / Hide 
Range on Protein: 659-770
Range on HMM: 1-132/270
Sequence Identity: 22% (30 aa)

IVLLDFVGMSNHGTMFRGRWL------DVPVMVKAL--GTGNEA---EKLLKELDKGHAELRNR-PHPNVTQVFGYTR-HGEN--LFVVTERVSGG----
|...   |  . |. ..|.|       ..|| || |  |.  |.   |....|.      ...   |||. .  |    .||   ...|.| . .|    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKI----MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

--HFR---VTKFPLVLTIEILLQVAQGVAYLHEHNC
  . .     ....   ... .|.|.| .||...||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNC
Kinase MLKx_f.AA Ciliate-E2 713-770 17 0.036656 3.2 In-house 91-182 (365) Show / Hide 
Range on Protein: 713-770
Range on HMM: 91-182/365
Sequence Identity: 17% (16 aa)

HPNVTQVFGYTR--HGENLFVVTERVSGG----------HFRVTKFP------LVLTIEILLQVAQ---------------GVAYLHEHN-C
|||. . . .      .|.. |.| ..||          ..|  ...      .   ..|  |..|               .. |||. | .
HPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNI
Kinase MLKx_f.AA Dicty4 746-770 26 0.09366 1.83 In-house 108-133 (277) Show / Hide 
Range on Protein: 746-770
Range on HMM: 108-133/277
Sequence Identity: 26% (7 aa)

FPLVLT-IEILLQVAQGVAYLHEHNC
.||..  . . . .|.|...||. |.
WPLIKRAMRMAFDAARGMNWLHCCNP
Kinase MLKx_f.AA LRRK 857-899 24 0.000196 11.58 In-house 299-351 (351) Show / Hide 
Range on Protein: 857-899
Range on HMM: 299-351/351
Sequence Identity: 24% (13 aa)

EEILLSGKLPQLSHD-CTG------IKAVIEKCLSSQP---PAFHQIVELLQS
|.. ..|  | .. . |..       .. |..| . .|   | | |||. | .
EDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ