Gene MLKx_k (S.moellendorffii)

MLKx_k

Species: S.moellendorffii
Alias: MLKx_k
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_k.AA Protein None 646 None Fasta, JSON
MLKx_k.NA RNA None 1941 None Fasta, JSON
MLKx_k.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of MLKx_k.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKx_k.AA TKL 266-520 23 6.4e-76 258.53 In-house 1-364 (364) Show / Hide 
Range on Protein: 266-520
Range on HMM: 1-364/364
Sequence Identity: 23% (88 aa)

IGSGTFGLVYEAGWLH----------QIVAVKIFRPGD-----------------------------YSFEKEFTALVTLQQ-HPNVVSIIGFTRDVEG-
||||.|| || . |            . ||||.|.  .                             . |..|. ... ..  |||.|...|.  . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

----------KQCSIIMERM-SMD-LEKFIGENKGAAGVPLVTAVSIMLQIAEGMAFLHS--------KNVIHRDLKPRNILVKY-LE----------VG
          .|. |.|| .   . |. ..          .   ....|.|| ||..|||        ...||||||..||||.  ..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

ILTKISDFGTAKTNFST-----------------SQAASATVGVGTKIYRAPEVFRSENTDGKA----------KYSKKADVYSFAIICCYLVTGRLPFE
.  ||.|||...... .                 ...      .||. . ||||.| .. . ..          .||.|.|||||.|. . ..|...|..
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

DIIER--I------DFAILVCAENKRPQLP------------VDCPEELTTLIRSCWNRNAEERPTFGEICDRL
|. ..  |      .....|| ...|| .|             |||...  |.  ||. ..|.||.| || .||
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc MLKx_k.AA S_TKc 260-527 26 7.5e-59 202.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 260-527
Range on HMM: 1-231/231
Sequence Identity: 26% (74 aa)

LVLGKLIGSGTFGLVYEAGWLH--QIVAVKIFRPGDYSFEKEFTALVTLQQHPNVVSIIGFTRDVEGKQCSIIMERMSM---DLEKFIGENKGAAG---V
  ....||.|.|| || . . .  .|||.|| .    ....|   |    .|||.| .... .|   .   ..|| ..    || ..| ....  .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PLVTAVSIMLQIAEGMAFLHSKNVIHRDLKPRNILVKYLEVGILTKISDFGTAKTNFSTSQAASATVGVGTKIYRAPEVFRSENTDGKAKYSK-KADVYS
|  .| ..| ||.......||...||||||| |||.         ||.||| |.           |  .||  |.||||.         .|.| |.|..|
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---------GYGKCKCDWWS

FAIICCYLVTGRLPFEDIIERIDFAILVCAENKRPQLPVDCPEELTTLIRSCWNRNAEERPTFGEICD--RLKRLRSLV
. .|   ...|. ||.   .   | ...             ..|.  .|| |.... |.|||  |.    .. ..   .
CGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase MLKx_k.AA Pkinase 260-520 26 1.9e-56 198.64 Pfam 1-293 (293) Show / Hide 
Range on Protein: 260-520
Range on HMM: 1-293/293
Sequence Identity: 26% (83 aa)

LVLGKLIGSGTFGLVYEAGWLHQ--IVAVKIFRPGDYSFEK--------EFTALVTLQQHPNVVSIIGFTRDVEGKQCSIIMERMSM-----DLEKFIG-
...|. ||||.|| ||.. .     ||||||..  . . .|        |   .  | .|||.| .... .|  .. . ..|| . .     ||  .|  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

-ENKGAAGVPLVTAVSIMLQIAEGMAFLHSKNVIHRDLKPRNILVKYLEVGIL---TKISDFGTAKT-NFSTSQAASATVGVGTKIYRAPEVFRSENTDG
 ....    .  .. ..|.||..|....||...||||||| |||..  . | .    ||.||| ||  .  .     .|. .||  |.|||| |     |
WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIR-----G

KAKYSKKADVYSFAIICCYLVTGRLPFEDI----IERIDFAILVCAENKRPQLPVDCP-----------------------EELTTLIRSCWNRNAEERP
  .|..|.|..|. .|. ....||.|| .       . . ....  ....|.|. |.|                       ||.  .|..|.... ..||
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMIC--RIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP

TFGEICDR--L
|. .|.    .
TAEQILQHPWF
Kinase MLKx_k.AA MLK 260-520 29 9.3e-55 188.24 In-house 1-291 (291) Show / Hide 
Range on Protein: 260-520
Range on HMM: 1-291/291
Sequence Identity: 29% (88 aa)

LVLGKLIGSGTFGLVYEAGWLHQI-----VAVKIFR-----PGD-----YSFEKEFTALVTLQQHPN----VVSIIGFTRDVEGKQCSIIMERMSM-DLE
. . . ||||.|| |. . |  ..     ||||..|      .|       ||.|.  |  | .|||    .. . |   . . ..  |.|| ..   | 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRIL-SHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLY

KFI--GENKGA---------AGVPLVTAVSIMLQIAEGMAFLHSKN---VIHRDLKPRNILVKY----LEVGILTKISDFGTAKTNFSTSQAASATVGVG
 ..  ...|..         . ...  |....||.|.||..|||.    .||||||..|||.      .. |.| ||.||||. . ..... .  .   |
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTL-KICDFGTS-RDWHQMC-TNMMSNAG

TKIYRAPEVF---RSENTDGKAKYSKKADVYSFAIICCYLVTGRLPFEDIIERIDFAILVCAENKRPQLPVDCPEELTTLIRSCWNRNAEERPTFGEICD
| ...||||.   |.|      |||.|.||.|....   ..|...|...... .  |. | ....|| .| .||| .  |.  ||| ....||.| .|  
TYAWMAPEVIQQFRCE------KYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQ

RL
 |
HL
Kinase MLKx_k.AA TK 260-520 18 1.8e-52 173.81 In-house 1-486 (486) Show / Hide 
Range on Protein: 260-520
Range on HMM: 1-486/486
Sequence Identity: 18% (88 aa)

LVLGKLIGSGTFG---LVYEA------GWLH---------------------QIVAVKIFRPG-DYSFEKEFT-----------------ALVTLQQ---
..||| .|.| ||    ||..      .|                       . ||||. ..| . | | .|                  ..  ...   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVVSIIG-FTRD---------VEGKQCSIIMERMS-MD----LEKFIGENKGAAG------------------------------------------
 |||.|...|  |..         |... . |.|| |.  |    | ..  .... .                                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VPLVTAVSIMLQIAEGMAFLHSK------NVIHRDLKPRNILVKYLEV--------GILTKISDFG---
                               ... . . ...|||.||..||||      |..||||  ||.||    |        |   ||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----TAKTNFSTSQAASAT-VGVGTKIYR------------------------APEVFRSENTDGK---AKYSKKADVYSFAIICCYLVT-GRLPFEDI
      |.   | .   ...  |.|. . .                        |||....     .    |.. | ||.|| . .  ..| |. |.   
QGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

IERID-------FAILVCAEN---------------KRPQLPVDCP--------------EELTTLIRSCWNRNAEERPTFGEICDRL
.   |         .. . ..                |.  |..||              ||.  |...||....|.|||| .. ..|
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKx_k.AA LRRK 308-522 30 1e-46 161.55 In-house 115-351 (351) Show / Hide 
Range on Protein: 308-522
Range on HMM: 115-351/351
Sequence Identity: 30% (74 aa)

QHPNVVSIIGFTRDVEGKQCSIIMERMSM-DLEKFIGENKGAA------GVPLVTAVSIMLQIAEGMAFLHSKN--VIHRDLKPRNILVKYLE-------
.|||.||..||. .     . ..|| ..  || .|. ..|  .        .  .   |.||||.||..|||.|  .||||||. |||.. .        
NHPNIVSLKGFCIH----PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNY

--VGILTKISDFGTAKTNFSTSQAASATVGVGTKIYRAPEVFRSENTDGKAKYSKKADVYSFAIICCYLVTGR-LPFEDII--ERIDFAILVCA---ENK
    .  ||.|||.    |.. . . |   ||.....|||. | .   |.  |. |.|.|||..|   |.|.. .||...     . . ...     |  
PNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMRYN---GEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGL

RPQLPVD-CPE-----ELTTLIRSCWNRNAEERPTFGEICDRLKR
|| .| . ||.     .. .|| .||. . ..||.| .| .||. 
RPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_k.AA TKL-Unique 357-520 32 1.1e-46 161.36 In-house 113-290 (290) Show / Hide 
Range on Protein: 357-520
Range on HMM: 113-290/290
Sequence Identity: 32% (60 aa)

VSIMLQIAEGMAFLHSKN--VIHRDLKPRNILVKYL--EVGILTKISDFGTAKTNFSTSQAASA-------TVGVGTKIYRAPEVFRSENTDGKAKYSKK
|.. ..|| || .||...  .||||||..|.||     .  .  ||.|||..|.| . ..  .        .. .|. ...||||.|...    ..||.|
VKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF----CQYSEK

ADVYSFAIICCYLVTGRL------PFEDIIERIDFAILVCA--ENKRPQLPVDCPEELTTLIRSCWNRNAEERPTFGEICDRL
.|||||.|.   ..|. .      |... ....  . .|    ||.|| .| .||.|.. ||. ||... ..||.| ||  ||
SDVYSFGIVLWEIATRKITKTYKKPYQG-MDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKx_k.AA STE 260-512 20 1.3e-41 144.52 In-house 1-347 (359) Show / Hide 
Range on Protein: 260-512
Range on HMM: 1-347/359
Sequence Identity: 20% (74 aa)

LVLGKLIGSGTFGLVYEA-----------------GWLHQIVAVKIFRPGDY---------------------SFEKEFTALVTLQQ-HPNVVSIIGFTR
. . . ||.|.|| || |                 |  ..|.|.|. .  .                      ...||   .  ... |||.|  .|   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----DVEGKQCSIIMERMS-MDLEKFIGENKGAAG-----------VPLVTAVSIMLQIAEG-MAFLHSKNVIHRDLKPRNILVKYLEVGILTKISDFG
     . .. .. |.|| |.   |...| ...|  .           .|      |  || .| ...|||...||||.|| |||.         |..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFG

TAKTNFST--------------SQAASATVGVGTKIYRAPEVFRSENTDGK-AKYSKKADVYSFAIICCYLVTGRLPFED-IIERIDFAIL---VCAE--
...   ..              ...   .  |||  . |||| . .... .  .|. |.|..|. . .. ..||. |. |    |  |.|.   ....  
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQF

-------NKRPQLPV-------------------DCPEELTTLIRSCWNRNAEERPT
       .. |.||                     . .|.   |. | ... ..|||
EQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT
Kinase MLKx_k.AA TyrKc 260-520 28 2.6e-40 141.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 260-520
Range on HMM: 1-280/280
Sequence Identity: 28% (84 aa)

LVLGKLIGSGTFGLVYEAGWLHQIVAVKIFRPGD-YSFEKEFTALVTL-QQHPNVVSIIGFTRDVEG-----KQCSIIMERMSM-DLEKFIGENKGAAGV
..||| .|.| || ||.. |  . ||||  ...    | .|   .  |  .|||.| ..|  .. ..     ..  |.|| |.  || ... ....   .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--L

PLVTAVSIMLQIAEGMAFLHSKNVIHRDLKPRNILVKYLEVGILTKISDFGTAKTNFST---SQAASATVGV----GTK---IYR--APEVFRSENTDGK
.. . .|...|||.||..|||||.|||||  ||.||.        |||||| ..   .      ... .  .    |.|    .|  |||..       .
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECI------NY

AKYSKKADVYSFAIICCY--LVTGRLPFEDIIE--RIDFAILVCAENK-RPQLPVD--------CPEELTTLIRSCWNRNAEERPTFGEICDRL
 |.. | ||.|| . |..  .  |  | ...|.    .. .. . ..  |.  | .        ||.|. .....||....|.|||| ||....
GKFTTKSDVWSFGV-CMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKx_k.AA Dicty4 352-522 32 6.9e-36 117.28 In-house 109-277 (277) Show / Hide 
Range on Protein: 352-522
Range on HMM: 109-277/277
Sequence Identity: 32% (59 aa)

PLVTA-VSIMLQIAEGMAFLHSKN--VIHRDLKPRNILV-KYLEVGILTKISDFGTAK-TNFSTSQAASATVGVGTKIYRAPEVFRSENTDGKAKYSKKA
||...   ... .| ||. ||. |  .||||||. |.|| | . |    |..||| ..     ... . ..  .||  . |||| ...       |  ||
PLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRV----KVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQ------PYNEKA

DVYSFAIICCYLVTGRLPFE-DIIERIDFAILVCAENKRPQLPVDCPEELTTLIRSCWNRNAEERPTFGEICDR--LKR
|||||.|.   ..|.  |.   ...   |...|| .  || .| .||  ...||  ||. . . ||.| ||  |  |  
DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLKx_k.AA TAK1 356-519 28 2.8e-35 116.57 In-house 104-284 (284) Show / Hide 
Range on Protein: 356-519
Range on HMM: 104-284/284
Sequence Identity: 28% (56 aa)

AVSIMLQIAEGMAFLHSKN---VIHRDLKPRNILVKYLEVGILTKISDFGTAKTNFSTSQAASATVGVGTKIYRAPEV----------------------
|.| |.|.|.| |.|||.    .||||.|| | |    . .   || ||||.     ..   . |   || .. ||||                      
AMSWMHQCAQGVAYLHSMQPKPQIHRDIKPQNMLL--CNKHRTLKICDFGTF-----CDMHQMMTCNRGTCRWMAPEVRELFDFKSNRIIINQPTGFQKV

FRSENTDGKAKYSKKADVYSFAIICCYLVTGRLPFEDIIE---RIDFAILVCAENKRPQLPV--DCPEELTTLIRSCWNRNAEERPTFGEICDR
|| |      ||. |.|.||..||   . . ..|...|        .   .   |..|.. .  |||. .  .   ||. |.|.||.  |.   
FRCE------KYNMKCDIYSWGIIMWEVISRKHPYDHIMNPNSAYRIMWAIHNGNRPPMETNRSDCPKRIEQFMKCCWDDNPEKRPSMQECVKY
Kinase MLKx_k.AA Dicty4-Unclassified 359-520 33 1e-33 112.85 In-house 114-263 (263) Show / Hide 
Range on Protein: 359-520
Range on HMM: 114-263/263
Sequence Identity: 33% (55 aa)

IMLQIAEGMAFLHSKNVIHRDLKPRNILV-KYLEVGILTKISDFGTAKTNFSTSQAASATVGVGTKIYRAPEVFRSENTDGKAKYSKKADVYSFAIICCY
. . || ||..||..|.||||.|  |||. |   .    || ||| .     ..     |   ||    .||. . |       |  |.||||.|..   
YAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNI----KIADFGISRV---IDFNFNMTTIAGTPKWESPECLMHES------YNQKSDVYSYAMMLYE

LVTGRLPFEDIIERIDFAILVCAENKRPQLPVDCPEELTTLIRSCWNRNAEERPTFGEICDRL
|.||  |. .|   .. |..||    ||..|  |.  .  ||  ||      |||. .| ..|
LATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLKx_k.AA Pkinase_Tyr 260-402 33 7.8e-27 91.51 Pfam 1-156 (270) Show / Hide 
Range on Protein: 260-402
Range on HMM: 1-156/270
Sequence Identity: 33% (53 aa)

LVLGKLIGSGTFGLVYEAGWL------HQIVAVKIFRPGDYS-------FEKEFTALVTLQQHPNVVSIIGFTRDVEGK-QCSIIMERMSM-DLEKFIGE
...|| .|.| || ||.. |       .. ||||. ..|  .       | .|   . .| .|||.|. .|   | ..  |  |.|| |   || ..  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N-KGAAGVPLVTAVSIMLQIAEGMAFLHSKNVIHRDLKPRNILVKYLEVGILTKISDFG
.  .   ... . ... .|||.||..|.||| |||||  ||.||.    .   ||.|||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFG
Kinase MLKx_k.AA TK-Unique 260-454 26 3.6e-24 80.3 In-house 1-228 (294) Show / Hide 
Range on Protein: 260-454
Range on HMM: 1-228/294
Sequence Identity: 26% (63 aa)

LVLGKLIGSGTFGLVYEAGWL--------HQIVAVKIFR--PGDYS---FEKEFTALVTLQQHPNVVSIIGFTRDVEGKQCSIIMERMSMD-LEKFIGEN
|..|..||.| || |. ..          ...||||  .    | .   | ||.  .  | .|||.|...| . . .  .  |||| ...  |.... ..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

KGA-----------------AGVPLVTAVS------IMLQIAEGMAFLHS--KNVIHRDLKPRNILVKYLEVGILTKISDFGTAK---TNFSTSQAASAT
..|                    |. ...|      .. ||| ||..|.|  |...||||  ||.|.     .   ||.||| |.   |     .. | .
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE---DKVCKICDFGMARDVYT----NGVYSMM

VGVGTKIYR--APEVFRSENTDGKAKYSKKADVYSFAII
 . |. ..|  |||...     ..  .. | ||.||...
CSQGRIPIRWMAPESLKCY---HGMYHTTKSDVWSFGVL
Kinase MLKx_k.AA Pkinase_Tyr 441-520 30 8.5e-14 47.35 Pfam 190-270 (270) Show / Hide 
Range on Protein: 441-520
Range on HMM: 190-270/270
Sequence Identity: 30% (25 aa)

KYSKKADVYSFAIICCYLVT-GRLP-FEDIIERIDFAILVCAENKRPQLPVDCPEELTTLIRSCWNRNAEERPTFGEICDRL
|.. | ||.|| . .  ..| |. | ....    ..  ..  .. |   | .||.|. .|...||. ..|.|||| ||  .|
KFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKx_k.AA TKL-Unique 262-332 35 7.6e-13 41.79 In-house 1-80 (290) Show / Hide 
Range on Protein: 262-332
Range on HMM: 1-80/290
Sequence Identity: 35% (28 aa)

LGKLIGSGTFGLVYEAGWLHQIVAVKIFRP-GDYS------FEKEFTALVTLQQHPNVVSIIGFTRD--VEGKQCSIIME
 ...||.|..| || . |   .||.|.| |  | |      ||.| . . .|. |||.| ..|.. |  |  ....|.||
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVME
Kinase MLKx_k.AA TK-Unique 483-520 41 9.2e-12 36.95 In-house 256-294 (294) Show / Hide 
Range on Protein: 483-520
Range on HMM: 256-294/294
Sequence Identity: 41% (16 aa)

KRPQLPVDC-PEELTTLIRSCWNRNAEERPTFGEICDRL
.|...|  | ..|.. |..|||....||||.| .| .||
YRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase MLKx_k.AA TAK1 262-332 26 4.2e-10 30.22 In-house 3-79 (284) Show / Hide 
Range on Protein: 262-332
Range on HMM: 3-79/284
Sequence Identity: 26% (21 aa)

LGKLIGSGTFGLVYEAGWLHQIVAVKIFR--------PGDYSFEKEFTALVTLQQHPNVVSIIGFTRDVEGKQCSIIME
. ...| ||.|.|. | |  . .|||.|.          .  .|.| . . ..  |||.. ..|     ...||  .||
NEHFVGKGTYGVVCKAKWRNKEIAVKRFEFIKYSSEECEQKNIEREIMQW-SRVDHPNIIKLYGMYACHRQCQC-LVME
Kinase MLKx_k.AA LRRK 260-289 23 2e-06 18.62 In-house 1-59 (351) Show / Hide 
Range on Protein: 260-289
Range on HMM: 1-59/351
Sequence Identity: 23% (14 aa)

LVLGKLIGSGTFG-LVYEAGWLH----------------------------QIVAVKIF
|. ...||.|.|| .|| | |                              | ||.|..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKW
Kinase MLKx_k.AA Dicty4 260-289 40 2e-06 17.5 In-house 1-30 (277) Show / Hide 
Range on Protein: 260-289
Range on HMM: 1-30/277
Sequence Identity: 40% (12 aa)

LVLGKLIGSGTFGLVYEAGWLHQIVAVKIF
.. ...||.| || || . |  ..||||..
INIEQRIGKGSFGEVYKGTWRGKEVAVKKL
Kinase MLKx_k.AA Dicty4-Unclassified 260-317 30 0.000242 10.74 In-house 1-65 (263) Show / Hide 
Range on Protein: 260-317
Range on HMM: 1-65/263
Sequence Identity: 30% (20 aa)

LVLGKLIGSGTFGLVYEAGWLHQIVAVKIFRPGDYSFE----KEFTALVTL---QQHPNVVSIIG
.   . || | |  |.   |    ||||.|  . ..|     ..| . | .    |||| | . |
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYG
Kinase MLKx_k.AA TKL 570-638 20 4e-09 29.03 In-house 7-130 (364) Show / Hide 
Range on Protein: 570-638
Range on HMM: 7-130/364
Sequence Identity: 20% (26 aa)

GSAYRGILVT---------GEEVAVEVLPS---------------------------------GIVEAELNFFCRVSHPNILKLIGYCNEGGR-------
|  |.|..           |..||| ...|                                    | |..   | .||||....|||....        
GEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHP

------FSTVSEYITQGSLIEHLH
      .  | ||.  ||| ..||
VGPWGQLCIVMEYCPGGSLLHYLH
Kinase MLKx_k.AA Dicty4 601-638 35 2.4e-07 20.73 In-house 53-94 (277) Show / Hide 
Range on Protein: 601-638
Range on HMM: 53-94/277
Sequence Identity: 35% (15 aa)

CRVSHPNILKLIGYCN----EGGRFSTVSEYITQGSLIEHLH
|  .||||... |.|.    . |... |.||  .|.| . ||
CKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLH
Kinase MLKx_k.AA TKL-Unique 605-638 39 5.5e-07 20.88 In-house 55-92 (290) Show / Hide 
Range on Protein: 605-638
Range on HMM: 55-92/290
Sequence Identity: 39% (15 aa)

HPNILKLIGYCN----EGGRFSTVSEYITQGSLIEHLH
||||....|||       .... |.||.  ||| ..||
HPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLH
Kinase MLKx_k.AA MLK 570-638 25 7e-06 16.48 In-house 13-102 (291) Show / Hide 
Range on Protein: 570-638
Range on HMM: 13-102/291
Sequence Identity: 25% (23 aa)

GSAYRGILVTGEE-----VAVEVLP------------SGIVEAELNFFCRVSHPN----ILKLIGYCNEGGR-FSTVSEYITQGSLIEHLH
|. ..|    ...     |||                .  .| | . . ..||||    | .. | |.. .  |  |.||.  ||| . ||
GKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLH
Kinase MLKx_k.AA TK-Unique 605-639 30 1.2e-05 15.63 In-house 63-98 (294) Show / Hide 
Range on Protein: 605-639
Range on HMM: 63-98/294
Sequence Identity: 30% (11 aa)

HPNILKLIGYCNEGG-RFSTVSEYITQGSLIEHLHF
||||....|.| . . ..  . ||. .|.|  .|..
HPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT
Kinase MLKx_k.AA Pkinase_Tyr 596-638 31 0.000182 15.75 Pfam 53-99 (270) Show / Hide 
Range on Protein: 596-638
Range on HMM: 53-99/270
Sequence Identity: 31% (15 aa)

ELNFFCRV-SHPNILKLIGYCN-EGGR--FSTVSEYITQGSLIEHLH
|..  .   .||||..|.| |  .|.      | ||   |.| ..|.
EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR
Kinase MLKx_k.AA TK 573-638 17 0.00034 9.12 In-house 19-151 (486) Show / Hide 
Range on Protein: 573-638
Range on HMM: 19-151/486
Sequence Identity: 17% (23 aa)

YRGILVTG--------------------------EEVAVEVLP---SGIVEA--------------------ELNFFC--RVSHPNILKLIGYCNEG---
|.|.. ..                          ..||| .|    .   |.                    |.  .|     ||||..|.|.| .|   
YKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPK

---------GRFSTVSEYITQGS----LIEHLH
         . .  | ||   |.    | ..|.
PCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLR
Kinase MLKx_k.AA TAK1 593-638 41 0.000491 9.41 In-house 45-91 (284) Show / Hide 
Range on Protein: 593-638
Range on HMM: 45-91/284
Sequence Identity: 41% (20 aa)

VEAELNFFCRVSHPNILKLIG--YCNEGGRFSTVSEYITQGSLIEHLH
.| |.    ||.|||| ||.|   |....    | ||.  |||   ||
IEREIMQWSRVDHPNIIKLYGMYACHRQCQC-LVMEYMDCGSLHNFLH
Kinase MLKx_k.AA Dicty4-Unclassified 595-638 29 0.00559 6.0 In-house 47-94 (263) Show / Hide 
Range on Protein: 595-638
Range on HMM: 47-94/263
Sequence Identity: 29% (14 aa)

AELNFFCRVSHPNILKLIGYCNEG----GRFSTVSEYITQGSLIEHLH
.|      ..||| .|. |||         .  | | . .| |.|  |
KEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIH
Kinase MLKx_k.AA Pkinase 602-643 25 0.025574 9.28 Pfam 56-103 (293) Show / Hide 
Range on Protein: 602-643
Range on HMM: 56-103/293
Sequence Identity: 25% (12 aa)

RVSHPNILKLIGYCNEGGRFSTVSEYITQG----SLIEHLH--FGKSF
|..||||..|.... ....   | ||   |    .| ....   ...|
RLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCF
Kinase MLKx_k.AA LRRK 605-638 41 0.026425 3.94 In-house 116-147 (351) Show / Hide 
Range on Protein: 605-638
Range on HMM: 116-147/351
Sequence Identity: 41% (14 aa)

HPNILKLIGYCNEGGRFSTVSEYITQGSLIEHLH
||||..|.|.| .  ..  | ||...|.| ..||
HPNIVSLKGFCIHPLCM--VMEYAPHGDLYHFLH
Kinase MLKx_k.AA STE 570-633 16 0.029337 3.93 In-house 13-124 (359) Show / Hide 
Range on Protein: 570-633
Range on HMM: 13-124/359
Sequence Identity: 16% (19 aa)

GSAYRGILV----------------TGEEVAVEVLP-----------------------SGIVEAELNFFCRVS--HPNILKLIGYCNEGG-------RF
|. |... .                ||| .|. ...                          .. |...  . .  |||| | .|..  .|         
GTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDEL

STVSEYITQGSL
  . ||.  |||
WICMEYMDGGSL