Gene MLKx_j (S.moellendorffii)

MLKx_j

Species: S.moellendorffii
Alias: MLKx_j
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_j.AA Protein None 599 None Fasta, JSON
MLKx_j.NA RNA None 1800 None Fasta, JSON
MLKx_j.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of MLKx_j.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKx_j.AA TKL 211-467 23 3.3e-64 219.64 In-house 1-364 (364) Show / Hide 
Range on Protein: 211-467
Range on HMM: 1-364/364
Sequence Identity: 23% (88 aa)

IGEGSYAYVYEATWLG----------RTVATKAYAVQD-------------------------------PSSERELQALFYLRHPNIVKMVGYTQRSK--
||.|... || ..| |          ..|| | . ...                                  |.|.  .  |||||||...|| ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------EGPYVLLMERM-KRD-LHNLIKDIVQIKPGPPFEMDVAVDIVLQIARGMEFLHAND--------VSHLDLKTANILINLPSNEC-------
         .| . . || . . . ||.|.             ... ....|.|||||..||...        . | |||..|||..   . .       
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNP

-SFYTAKLSDFGLSETKLKSA-----------------QTKVPVRRGGTVNFMAPEIWNEEKN--------------ASRKKADVYSFGMTCYEIFTGKV
 . ...|..||||| .. .|                  . |   ...|| ..||||. ... |                 .|.||||||.  .||.|...
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR

PFE-GCSYPAA------GFFLRVKDNNLRPILP------------PGFPRCLSLFLQCCWHGRPEIRPTFKKICNYL
|..   ..|         .|  | |..||| .|            | .|. ..  .|.||.  || ||.|..|  .|
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLKx_j.AA TKL-Unique 207-467 28 1e-46 161.56 In-house 1-290 (290) Show / Hide 
Range on Protein: 207-467
Range on HMM: 1-290/290
Sequence Identity: 28% (84 aa)

QGKLIGEGSYAYVYEATWLGRTVATKAYAV-QDPSSE------RELQALFYLR-HPNIVKMVGYTQ--RSKEGPYVLLMERMKRD-LHNLIKDIVQIK--
 ...||||.|. || ..| |  || |  ..  |.|.|      .|.  .  |. |||||. .||.     ... . . || . .  |.... .       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

--PGPPFEMDVAVDIVLQIARGMEFLHAND--VSHLDLKTANILINLPSNECSFYTAKLSDFGLSETKLKSAQTKVP-------VRRGGTVNFMAPEIWN
  .  .. | . |.....||.||..|| ..  . |.|||. |.|..  ||.   . .|..||||| .. |. ....          | |. . ||||. .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAE-WNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

EEKNASRKKADVYSFGMTCYEIFTGKV------PFEGCSYPAAGFFLRVKDNNLRPILPPGFPRCLSLFLQCCWHGRPEIRPTFKKICNYL
 . .   .|.||||||.  .||.|.|.      |..|..  .    ...   |.|| .|.  |  ..  .| |||  |..||.|  | ..|
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKx_j.AA MLK 205-467 26 2.8e-46 158.53 In-house 1-291 (291) Show / Hide 
Range on Protein: 205-467
Range on HMM: 1-291/291
Sequence Identity: 26% (79 aa)

VIQGKLIGEGSYAYVYEATWLGRT-----VATKAYA---VQDPSS--------ERELQALFYLRHPN----IVKMVGYTQRSKEGPYVLLMERMKR-DLH
    . ||.||.  |. ..| ...     || |...     | |.        |.|   |  |.|||    |.. .|  ...   .....|| .    |.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLY

NLIKDI-VQIK----PGP---PFEMDVAVDIVLQIARGMEFLHAND---VSHLDLKTANILIN-LPSNECSFYTAKLSDFGLSETKLKSAQTKVPVRRGG
|.....  ..     ...      .|.|... ||.||||..||...   . | |||  ||||    . .    |.| .|||.|  . .. ...    . |
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRDWHQMCTNM--MSNAG

TVNFMAPEIWNE-EKNASRKKADVYSFGMTCYEIFTGKVPFEGCSYPAAGFFLRVKDNNLRPILPPGFPRCLSLFLQCCWHGRPEIRPTFKKICNYL
|. .||||.    . .   .|.||.|.|.  .|..|..||...  .|.| ..  .  |.||| .|...|. .. ....||.  |. ||.|. |  .|
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAY-NGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLKx_j.AA Pkinase 205-467 22 7.8e-43 152.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 205-467
Range on HMM: 1-293/293
Sequence Identity: 22% (71 aa)

VIQGKLIGEGSYAYVYEATWLGRT--VATKAYAVQDPSSER--------ELQALFYLRHPNIVKMVGYTQRSKEGPYVLLMERMKR-----DLHNLIKDI
   |. ||.||.. ||.... |    || |   ... .|.         |.| .  |.|||||.. .. ..  .. . . || .       ||. .|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

VQIKPGPPF--EMDVAVDIVLQIARGMEFLHANDVSHLDLKTANILINLPSNECSFYTAKLSDFGLSET--KLKSAQTKVPVRRGGTVNFMAPEIWNEEK
   . . .|  ..... ....||.||.|..|.. . | ||| .||||.   . ..  . |..||||..     ..  .....   || ..||||. .. .
---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNS-MTTFC---GTPWYMAPEVIRGGQ

NASRKKADVYSFGMTCYEIFTGKVPFEGC----SYPAAGFFLRVKDNNLRPILPPGFP-----------------------RCLSLFLQCCWHGRPEIRP
  .. |.|..|.| ..|| ..|. || |.    .     . ..   ....|.|.  .|                       . .  |. .|..  |. ||
YYGP-KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMIC---RIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP

TFKKICNY--L
|.. |..   .
TAEQILQHPWF
Kinase MLKx_j.AA TK 205-467 17 5.9e-41 134.52 In-house 1-486 (486) Show / Hide 
Range on Protein: 205-467
Range on HMM: 1-486/486
Sequence Identity: 17% (85 aa)

VIQGKLIGEGSYA---YVYEATWLGR---------------------------TVATKAYAVQDPSSER------------------ELQALFYLR----
.. || .||| .     ||...| ||                           .|| |     |..|..                  |....  ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVKMVGYTQRSKE----------GPYVLLMERMK-RD----LHNLIKDIVQIKPG-----------------------------------------
 |||||...|.  ....          .|. ..|| |.  |    |..  ..    .                                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------PPFEMDVAVD-------------------IVLQIARGMEFLHANDV------SHLDLKTANILINLPSN-----ECSFYTAKLSDFGLS--
         ||. .   ..                   . .|||.|||.||.. .       | || . |.|..   .     . . ...|..|||||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----ETKLKSA--------------------------------QTKVPVRRGGTVNFMAPEIWNEE-------KNASRKKADVYSFGMTCYEIFT-GKVP
     ..                                    ..|.|.|       |||| .|.        ..    | ||.||| ...|||| |..|
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIR------WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP

FEGCSYP--------AAGFFLRVKDN-------------NLRPILPPGFP--------------RCLSLFLQCCWHGRPEIRPTFKKICNYL
. |             . .. ....               .|.  ||. |                . ...|.|||  || ||||. . ..|
YYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKx_j.AA LRRK 306-469 31 2.3e-36 126.18 In-house 169-351 (351) Show / Hide 
Range on Protein: 306-469
Range on HMM: 169-351/351
Sequence Identity: 31% (58 aa)

IVLQIARGMEFLHAND--VSHLDLKTANILI-NLPSNEC-----SFYTAKLSDFGLSETKLKSAQTKVPVRRGGTVNFMAPEIWNEE--KNASRKKADVY
|.||||.|||.|| ..  . | |||. |||.  .| |        ...||..|||.|    .. ...|  . .|.  .||||| ...  .. .  |.|.|
IALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYT-EKVDCY

SFGMTCYEIFTGK-VPFEGCSYPAAG-FFLRVKD---NNLRPILPPG-FPR-----CLSLFLQCCWHGRPEIRPTFKKICNYLIA
||||  .|. |..  ||.. . .. . .  ...|   . ||| .|.   |.     ...  .| ||.. |. ||.| .|   |  
SFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_j.AA S_TKc 205-467 24 3.2e-36 127.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 205-467
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

VIQGKLIGEGSYAYVYEATWLG--RTVATKAYAVQDPSSERELQALFYLRHPNIVKMVGYTQRSKEGPYVLLMERMKR---DLHNLIKDIVQIKPGPPFE
   ...||.|... || ... .  | || |       . .||.| |   .||||||. .. |    . . . || .     ||. .||.    ... || 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

MDVAVDIVLQIARGMEFLHANDVSHLDLKTANILINLPSNECSFYTAKLSDFGLSETKLKSAQTKVPVRRGGTVNFMAPEIWNEEKNASRKKADVYSFGM
  .|  .. ||....|..| . . | ||| .|||..         . |..||||.                || ..||||.       ...|.|..|.| 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

TCYEIFTGKVPFEGCSYPAAGFFLRVKDNNLRPILPPGFPRCLSLFLQCCWHGRPEIRPTFKKICN---------YL
. || ..|. ||.      .  | ...            | ... |.. |..  || |||  .. .         ..
ILYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKx_j.AA Dicty4 206-469 29 1.2e-35 116.51 In-house 1-277 (277) Show / Hide 
Range on Protein: 206-469
Range on HMM: 1-277/277
Sequence Identity: 29% (85 aa)

IQ-GKLIGEGSYAYVYEATWLGRTVATKAY-AVQDPSSERELQA-------LFYLRHPNIVKMVGYTQ--RSKEGPYVLLMERM-KRDLHNLIKD---IV
|. ...||.||.. || .|| |  || |   . .. ..| .|..       .  .|||||..  |.    ||. |  .  .| | | .|..|. |     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

QIKPGPPFEMDVA-VDIVLQIARGMEFLHA-N-DVSHLDLKTANILINLPSNECSFYTAKLSDFGLSE----TKLKSAQTKVPVRRGGTVNFMAPEIWNE
| .  ....   .   . . .||||  ||. | .. |.|||..|.|.         ...| .|||||      . ... .. ..   ||.  ||||.  .
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVD------KNWRVKVCDFGLSQYMKKHEDHKDNQMTAC---GTPCWMAPEVMMH

EKNASRKKADVYSFGMTCYEIFTGKVPFE--GCSYPAAGFFLRVKDNNLRPILPPGFPRCLSLFLQCCWHGRPEIRPTFKKICNY--LIA
.   .  ||||||||.  .||.|.. |.   . .|.   |.  | .  |||..|. .|  ..  .| ||.  |. ||.|. | ..  | .
QPYNE--KADVYSFGIVLWEILTRQEPYQKHHMPYMQ--FVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLKx_j.AA Pkinase_Tyr 205-467 28 5.2e-33 112.42 Pfam 1-270 (270) Show / Hide 
Range on Protein: 205-467
Range on HMM: 1-270/270
Sequence Identity: 28% (83 aa)

VIQGKLIGEGSYAYVYEATWL------GRTVATKAYAVQDPSSE-------RELQALFYL-RHPNIVKMVGYTQRSKEGP--YVLLMERMKR-DLHNLIK
.. || .|||..  ||..||       . .|| |    .  ...       ||.. .  | .|||||...|    ....|  . . || |.  ||..  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT-DQGEPNQIYIVMEYMPHGDLLDYLR

DIVQIKPGPPFEMDVAVDIVLQIARGMEFLHANDVSHLDLKTANILINLPSNECSFYTAKLSDFGLSETK-------LKSAQTKVPVRRGGTVNFMAPEI
.     ...|. |   ... .|||.|||.|...   | || . |.|..         ..| .||||. .         |.  .|.|..       |||| 
KHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIK------WMAPEC

WNEEKNASRKKADVYSFGMTCYEIFT-GKVP-FEGCSYPAAGFFLRV-KDNNLRPILPPGFPRCLSLFLQCCWHGRPEIRPTFKKICNYL
.|. |     | ||.||| ...|||| |. | ..|.  . . .. .. .|..  |. |.. |  .   .. |||  || ||||. | . |
INYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGM--SNEEVYEYIYEDGYRMPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKx_j.AA Dicty4-Unclassified 206-467 29 7.4e-32 106.36 In-house 1-263 (263) Show / Hide 
Range on Protein: 206-467
Range on HMM: 1-263/263
Sequence Identity: 29% (81 aa)

IQ-GKLIGEGSYAYVYEATWLGRTVATKAYAVQDPSSE--------RELQALFYLRHPNIVKMVGYTQ--RSKEGPYVLLMERMKR-DLHNLIK--DIVQ
||  . ||.|  . |.   | |. || |       .          .|   |  . ||| ||. ||    ||    ..  || | .  |  .|      |
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

IKPGPPFEMDV--AVDIVLQIARGMEFLHANDVSHLDLKTANILINLPSNECSFYTAKLSDFGLS-ETKLKSAQTKVPVRRGGTVNFMAPEIWNEEKNAS
 .   |  .|    . . . ||.|| .||  .. | |.| .|||.    |      .|  |||.| ..      | .    .||.   .||.   |  . 
QQ---PIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFN------IKIADFGISRVIDFNFNMTTI----AGTPKWESPECLMHE--SY

RKKADVYSFGMTCYEIFTGKVPFEGCSYPAAGFFLRVKDNNLRPILPPGFPRCLSLFLQCCWHGRPEIRPTFKKICNYL
  |.||||..|  ||  ||  |. .   .     . | |  ||| .|   .  ..     |||  |  |||. .| .||
NQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARS-VCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLKx_j.AA RIPK 306-467 26 4.1e-30 99.78 In-house 112-290 (290) Show / Hide 
Range on Protein: 306-467
Range on HMM: 112-290/290
Sequence Identity: 26% (49 aa)

IVLQIARGMEFLHAND--VSHLDLKTANILINLPSNECSFYTAKLSDFGLSETKLKSAQTK-------VPV----RRGGTVNFMAPEIWNEEKNAS----
.. .|..|| .|| ..  . |.|||..|||.       . . .|..||||.  .  | ...       |       |.||  .|.||  ..   ..    
MIHEISCGMCYLHSMNPPIIHRDLKPENILVD------NNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVV

RKKADVYSFGMTCYEIFTGKVPFEGCSYPAAGFFLRVKDNNLRPILPP---GFPRC-----LSLFLQCCWHGRPEIRPTFKKICNYL
 .| |||||... .|..|.| |.|.   .   . ...|  . || |.|    .|.      .   .| ||.  |. ||.|  .    
TPKYDVYSFAIVMWEVLTQKHPYEDRKCMMM-IMMCCKQGH-RPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase MLKx_j.AA STE 206-462 19 1.3e-27 94.63 In-house 1-350 (359) Show / Hide 
Range on Protein: 206-462
Range on HMM: 1-350/359
Sequence Identity: 19% (72 aa)

IQG-KLIGEGSYAYVYEATWL-----------------GRTVATKAYAVQDPSS---------------------ERELQALFYLR--HPNIVKMVGYTQ
 .| . ||.|..  || |                    |. .| |   ... ..                     ..|.. .  ..  ||||||  |.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

RSK-----EGPYVLLMERMK-RDLHNLIK---DIVQIKP-----GPPFEMDVAVDIVLQIARG-MEFLHANDVSHLDLKTANILINLPSNECSFYTAKLS
.       ..   . || |    |  .||    . .  .     . .|. ..   |. || .| ...|| . . | |.| ||||.           .||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----------VKLC

DFGLSETKLKS--------------AQTKVPVRRGGTVNFMAPEIWNEEKNASR-----KKADVYSFGMTCYEIFTGKVPFEGCSYPAAGFFLR--VKDN
|||..    .|               . .      ||  .||||. . .... |      |.|..|.| |. |  |||.|.   ... | |      .  
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ

N----------LRPILPP-------------------GFPRCLSLFLQCCWHGRPEIRPTFKK
.            | ||.                    .  ..  |.. |    |. ||| ..
QQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase MLKx_j.AA TyrKc 205-467 27 2.4e-26 94.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 205-467
Range on HMM: 1-280/280
Sequence Identity: 27% (80 aa)

VIQGKLIGEGSYAYVYEATWLGRTVATKAYAVQDPSSE--RELQALFYL--RHPNIVKMVGYTQRSKE-----GPYVLLMERMKR-DLHNLIKDIVQIKP
.  || .||| .  ||..||  ..|| |         .  ||.. .  |  .|||||...|.   ...     .|. ..|| |.  ||.. ...      
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

GPPFEMDVAVDIVLQIARGMEFLHANDVSHLDLKTANILINLPSNECSFYTAKLSDFGLSETKLKS------AQTKVP----VRRG-GTVNFMAPEIWNE
   . |.  ... .|||.|||.|| . . | || . |.|.. .       |.| ||||||             .....     ...   .  |||| .  
---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

EKNASRKKADVYSFGMTCYEIFT-GKVPFEG-CS--YPAAGFFLRVKDNNLRPILPP--------GFPRCLSLFLQCCWHGRPEIRPTFKKICNYL
 ..    | ||.||| ...|||| |. | .|      ...  . .||. . .|. |           .   .   ..|||  || ||||. |. ..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase MLKx_j.AA Gdt 306-411 40 2.4e-21 69.87 In-house 135-234 (289) Show / Hide 
Range on Protein: 306-411
Range on HMM: 135-234/289
Sequence Identity: 40% (44 aa)

IVLQIARGMEFLHANDVSHLDLKTANILINLPS-NECSFYTAKLSDFG-LSETKLKSAQTKVPVRRGGTVNFMAPEIWNEEKNASRKKADVYSFGMTCYE
| . ||.| .|||.|.  | |||  ||||   | || |   || .|||   |.. .. . .   ..| |.| | .||   |.    | .||||||...||
IMIDIAKGCQFLHQNGIIHRDLKPDNILIF--STNENSEVCAKICDFGTSKEINEFHCKNT---NCG-TMNYMSNEIFEGENYQ--KSTDVYSFGILFYE

IFTGKVPF
.. ...||
MMIERIPF
Kinase MLKx_j.AA LRRK 205-232 31 4e-06 17.51 In-house 1-29 (351) Show / Hide 
Range on Protein: 205-232
Range on HMM: 1-29/351
Sequence Identity: 31% (9 aa)

VIQGKLIGEGSYA-YVYEATWLGRTVATK
.. ...||.|...  || |.| | .|. .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVC
Kinase MLKx_j.AA Gdt 205-261 22 4e-06 17.1 In-house 1-68 (289) Show / Hide 
Range on Protein: 205-261
Range on HMM: 1-68/289
Sequence Identity: 22% (15 aa)

VIQGKLIGEGSYAYVYEATWLGRTVATKAYAVQDPS-----------SERELQALFYLRHPNIVKMVG
..  .....|..  || . | .  || |  .. .              .||.. |  ..|.|||  .|
IDFKEYCSQGTFGMVYKGIWRSSQVAVKMFKHHYVNYTKTYSQSCDEIYREMDILSKIKHQNIVSFIG
Kinase MLKx_j.AA Gdt 443-467 40 0.002187 7.47 In-house 265-289 (289) Show / Hide 
Range on Protein: 443-467
Range on HMM: 265-289/289
Sequence Identity: 40% (10 aa)

SLFLQCCWHGRPEIRPTFKKICNYL
.. . |||   |  ||||  |   |
RNIIECCWNKNPHKRPTFDEISKHL
Kinase MLKx_j.AA LRRK 243-265 34 0.008113 5.78 In-house 106-128 (351) Show / Hide 
Range on Protein: 243-265
Range on HMM: 106-128/351
Sequence Identity: 34% (8 aa)

RELQALFYLRHPNIVKMVGYTQR
.|.  .  |.|||||...|.. .
HEVWIMSHLNHPNIVSLKGFCIH