Gene LmjF15.0770 (L.major)

LmjF15.0770

Species: L.major
Alias: LmajK104, LmjF15.0770
External Links:
Annotation:

Classification

Group: Other
Family: NAK
Subfamily: NAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
LmjF15.0770.AA Protein None 666 None Fasta, JSON
LmjF15.0770.kin_dom Protein Kinase Domain None 279 None Fasta, JSON

Protein domain

Protein domains of LmjF15.0770.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF15.0770.AA NAK 68-289 33 1.1e-44 147.09 In-house 8-250 (299) Show / Hide 
Range on Protein: 68-289
Range on HMM: 8-250/299
Sequence Identity: 33% (83 aa)

GEGGSSYVYLVENTSHLPEFP------RHLALKRSFFG--VDQVMEAHKEVEIVSRIE-DKNIVCVYHSEISRSE---GRLGVSIAMEYCSN-NLYHRI-
.||| ||||||..   . ..       .. |||| .     ..  .. .|.|.  ..   .||| ...|.|....   |   | . ||||.. .|   . 
AEGGFSYVYLVQDN-YINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYCCHGSLWDLMN

-RSSAGTGIVTRLTEAEICHVMFAVTSAVGYLHAQQP--PITHRDIRPENILINNKHAGPTAYKLTNFGNATTEAYQCETREEANM---AIADIQMHTNP
 | .      |..||.|| . .  |. .| ..|..||  ||.|||| .||||... |.  . |||  || .||. .| |.| ||.    .  .|...| |
KRLM---DKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGN-YKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYTTP

AFRAPEMADPWSKKRICEKTDMWSMGVLLYYMMYMSLPFDP------S
 .||||| | .|.. | ||.| |..|..|| |..  .||..      |
MYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDS
Kinase LmjF15.0770.AA BIKE 59-336 29 6.8e-33 115.17 In-house 1-267 (267) Show / Hide 
Range on Protein: 59-336
Range on HMM: 1-267/267
Sequence Identity: 29% (83 aa)

VTRQRSTKYGEGGSSYVYLVENTSHLPEFPRHLALKRSFFGVDQVMEAHK-EVEIVSRIE-DKNIVCVYHSEI-SRSEGRLGVSIAMEYCSNNLYHRIRS
||   .    ||| . |.|| . .         |||| .    . ... . |..|.. .   ||||    . | . ..|   . | |||| ...   .  
VTVEEQ--LAEGGFAMVFLVRDHKG-----NKCALKRMYVNNEHDLNVCCREHQIMKQCSGHKNIVGYVDCYINCIGNGVWECMILMEYCRHQVVNMMNQ

SAGTGIVTRLTEAEICHVMFAVTSAVGYLHAQQPPITHRDIRPENILINNKHAGPTAYKLTNFGNATTEAYQCETREEANMAIADIQMHTNPAFRAPEMA
   .|    .|| |. ..   |  || .||  | || ||| . ||||...  .||  | |  || ||.   . .. .  |.    |.  |  ..||||| 
RLQQGQY--FTEQEVLQIFCDVCEAVSRLHHCQTPIIHRDLKVENILLHD--HGPPHYVLCDFGSATNKFLNPQK-HGVNYVKDEIEKYTTMCYRAPEMI

DPWSKKRICEKTDMWSMGVLLYYMMYMSLPFDPSTTIVKDWALTFPSEATASYTPSLRVITEHLLDPDPCSRWDVFALINY
| .| | |  | | | .|..|| . . .|||. |.  . |   |.|.     |   ...    .|.||.  | |..     
DLYSGKEITTKADIWALGCMLYKLCFFCLPFGESQLAICDGNFTIPDNSK--YSREMHCLIRYMLEPDMEKRPDIYQVSHV
Kinase LmjF15.0770.AA NAK-Unclassified 62-287 21 2.6e-30 102.87 In-house 1-345 (405) Show / Hide 
Range on Protein: 62-287
Range on HMM: 1-345/405
Sequence Identity: 21% (77 aa)

QRSTKY-GEGGSSYVYLVE---------NTSHLPEFP-RHLALKRSFF-GVDQVMEAHKEVEIVSRIE-DKNIVCVYHSEIS-RSEG--RLGVSIAMEYC
 .  .| .||| |.||||          ||   |     . .||| .   ..   ..  |...  |    .|||    . |. .  .     | . ||||
YTIVRYLAEGGFSFVYLVKFSKYINPPDNTASVPHSNSNMYCLKRMICQDEESLNTMKREIDVMKRFRNHPNIVKYIDHHIMRENHNNQSYEVFMLMEYC

SN-------N----LYHRIRSSAGTGIVTRLTEAEICHVMFAVTSAVGYLHAQQP--------------------------------------------P
|.       |    .| |  ..      ||..|.|.   |  |. .. ..|..||                                            |
SRGSLQDFMNNQRTIYQRLTEQ------TRFHEQECLQIMSDVCQGIQCMHQHQPRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIP

ITHRDIRPENILIN------------------------------------------------------NKHAGPTAYKLTNFGNATTEAYQCETREEANM
. |||| .||.|.                                                          .    |||  || ....    |.| |.. 
LIHRDIKIENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSEHNGIYKLCDFGSCCECIITIENRQEMQY

AIADIQMHTNPAFRAPEMADPWSKKRICEKTDMWSMGVLLYYMMYMSLPFD
.  .| ||| |  ||||| |  .   | || | |. |..|| |..   ||.
LQDWINMHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFE
Kinase LmjF15.0770.AA S_TKc 61-337 20 9e-29 102.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 61-337
Range on HMM: 1-231/231
Sequence Identity: 20% (58 aa)

RQRSTKYGEGGSSYVYLVENTSHLPEFPRHLALKRSFFGVDQVMEAHKEVEIVSRIEDKNIVCVYHSEISRSEGRLGVSIAMEYCSN---NLYHRIRSSA
 .   | |.|. . ||.. ...      |. |.|.          . .|..| ..   .|||  | .  .       . . ||||..   .|...|..  
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRG

GTGIVTRLTEAEICHVMFAVTSAVGYLHAQQPPITHRDIRPENILINNKHAGPTAYKLTNFGNATTEAYQCETREEANMAIADIQMHTNPAFRAPEMADP
. |   ...| .....|  . .|. |.| .   | |||. |||||...        |.. || |.                    .   | ..|||.   
RHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE------HIKICDFGLARQL----------------TTFCGTPWYMAPEVL--

WSKKRICE-KTDMWSMGVLLYYMMYMSLPFDPSTTIVKDWALTFPSEATASYTPSLRVITEHLLDPDPCSRWDVFALIN---------YM
         | |.|| |..|| |..   ||.     . .  .          .|... . ...|. ||  |. .  . .         ..
----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF15.0770.AA Ciliate-E2 140-286 22 9.2e-22 71.46 In-house 111-296 (365) Show / Hide 
Range on Protein: 140-286
Range on HMM: 111-296/365
Sequence Identity: 22% (44 aa)

IAMEYCSN-NLYHRIR--SSAGTGIVT---RLTEAEICHVMFAVTS---------------AVGYLHAQQPPITHRDIRPENILINNKHAGPTAYKLTNF
. ||||.  .|...|.  .   . . .   ..|| ||...|  ...               |. ||| . . | |||| |||||.          |.. |
LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF---------IKIIDF

GNATTEAYQ-CETREEANMAIADIQMH-----------------------TNPAFRAPEMADPWS------KKRICEKTDMWSMGVLLYYMMYMSLPF
|...    . .....  ...   .. .                        .| . |||.    .      .|.  .| |.||.||.||.|..  .||
GLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF
Kinase LmjF15.0770.AA GAK 180-287 41 1.6e-19 61.46 In-house 120-227 (277) Show / Hide 
Range on Protein: 180-287
Range on HMM: 120-227/277
Sequence Identity: 41% (46 aa)

AVGYLHAQQPPITHRDIRPENILINNKHAGPTAYKLTNFGNATTEAYQCET---REEANMAIADIQMHTNPAFRAPEMADPWSKKRICEKTDMWSMGVLL
|| ..| | ||| ||||  || ||.|.       ||  || |||. ..        .  |    .  || |  | ||| | .|   | .| | | || .|
AVQHMHSQKPPIIHRDIKIENFLIGNQK----TIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMFRHTTPMYRSPEMCDLYSNWPIGHKQDIWAMGCML

YYMMYMSLPF-D
| | |   || |
YFMCYRQHPFED
Kinase LmjF15.0770.AA CAMK 108-222 21 2.9e-16 48.24 In-house 80-244 (425) Show / Hide 
Range on Protein: 108-222
Range on HMM: 80-244/425
Sequence Identity: 21% (36 aa)

KEVEIVSR-------IEDKNIVCVYHSEISRSEGRLG----------------VSIAM---EYCSNN-----LYHRIRSSAGTGIV---------TRLTE
.|.|| ..       .  .||.  |.   ... .  .                . . |   ||||.      |. .|..  . |            |.||
REIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFK-NTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTE

AEICHVMFAVTSAVGYLHAQQPPITHRDIRPENILINNKHAGP-------------TAYKLTNFGNAT
.| ....  . ||| |.| .   | |||. |||||..... .                 |.. || |.
REARRYFRQICSAVHYCHSHN--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFAN
Kinase LmjF15.0770.AA TKL 140-277 19 3.1e-15 51.32 In-house 115-280 (364) Show / Hide 
Range on Protein: 140-277
Range on HMM: 115-280/364
Sequence Identity: 19% (34 aa)

IAMEYC-SNNLYHRIRSSAGTGIVTRLTEAEICHVMFAVTSAVGYLHAQQ------PPITHRDIRPENILINN----------KHAGPTAYKLTNFGNAT
| ||||   .|.|..                .|. .  . ... |||...      ||| |||. ..|||...          ... .   |.. || ..
IVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSR

TEAYQCETREEANMAI----------ADIQMHTNPAFRAPEMAD---PWSKK----------RICEKTDMWSMGVLLY
.     .    ...            . .    .|.. |||. .   . ..|             ||.|..|.|..|.
FMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW
Kinase LmjF15.0770.AA STE 108-219 26 3.4e-15 50.23 In-house 77-192 (359) Show / Hide 
Range on Protein: 108-219
Range on HMM: 77-192/359
Sequence Identity: 26% (34 aa)

KEVEIVSRIE--DKNIVCVYHSEISR---SEGRLGVSIAMEYCS-NNLYHRIRSSAGTGIV--------TRLTEAEICHVMFAVTSA-VGYLHAQQPPIT
||..| ..     .|||  | ...     .. .  . |.|||..   |   |..  |.|          .|. | .|... ...  .   ||| ..  | 
KEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--II

HRDIRPENILINNKHAGPTAYKLTNFG
|||| | |||.          ||..||
HRDIKPANILL---------VKLCDFG
Kinase LmjF15.0770.AA CAMKL 101-207 26 9.9e-13 36.8 In-house 41-164 (297) Show / Hide 
Range on Protein: 101-207
Range on HMM: 41-164/297
Sequence Identity: 26% (34 aa)

DQVMEAH-------------KEVEIVSRIE---DKNIVCVYHS-EISRS--EGRLGVSIAMEYCSNN---LYHRIRSSAGTGIVTRLTEAEICHVMFAVT
|..|...             .|..| ...     .||.  |.  | ..   |    . . |||||.    |...|..  . .   |..| | ..    . 
DPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCSGGEMDLFDYIVKHGHRR--GRMPEHEARRYFRQIV

SAVGYLHAQQPPITHRDIRPENILINNKH
||| |.| .   | |||| |||||. ...
SAVNYCHSHG--IVHRDIKPENILLDENG
Kinase LmjF15.0770.AA CAMK-Unique 163-205 35 1.3e-10 31.09 In-house 150-192 (363) Show / Hide 
Range on Protein: 163-205
Range on HMM: 150-192/363
Sequence Identity: 35% (16 aa)

TRLTE--AEICHVMFAVTSAVGYLHAQQPPITHRDIRPENILINN
....|  ...| .|. ..||| |.| |.  | |||. .|||....
GHFSERCWDTCFIMQCLLSAVAYMHSQD--IVHRDLKLENIMVCY
Kinase LmjF15.0770.AA Pkinase 119-206 27 6.5e-10 36.13 Pfam 60-144 (293) Show / Hide 
Range on Protein: 119-206
Range on HMM: 60-144/293
Sequence Identity: 27% (26 aa)

KNIVCVYHSEISRSEGRLGVSIAMEYCSN-----NLYHRIRSSAGTGIVTRLTEAEICHVMFAVTSAVGYLHAQQPPITHRDIRPENILINNK
.|||  |..  .  ....   . |||| .      |...|. ......   ..| |....|  . ... |.|..   | |||. ||||||.|.
PNIVRLYDWFED--KDHIY--MVMEYCEGGLYVMDLFDYISTWRHGCFY--FSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNN
Kinase LmjF15.0770.AA CAMKL 266-287 59 2.1e-07 19.53 In-house 216-237 (297) Show / Hide 
Range on Protein: 266-287
Range on HMM: 216-237/297
Sequence Identity: 59% (13 aa)

KTDMWSMGVLLYYMMYMSLPFD
|.|.||.||.|| |..  ||||
KVDIWSCGVILYAMVCGYLPFD
Kinase LmjF15.0770.AA CAMK 265-287 52 5.8e-07 17.72 In-house 313-335 (425) Show / Hide 
Range on Protein: 265-287
Range on HMM: 313-335/425
Sequence Identity: 52% (12 aa)

EKTDMWSMGVLLYYMMYMSLPFD
.|.||||.||.|| |    .||.
PKCDMWSCGVILYIMLCGYPPFY
Kinase LmjF15.0770.AA TyrKc 61-337 16 1e-06 -116.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 61-337
Range on HMM: 1-280/280
Sequence Identity: 16% (53 aa)

RQRSTKYGEGGSSYVYLVENTSHLPEFPRHLALKRSFFGVDQVMEAHKEVEIVSRI--EDKNIVCVYHSEISRSEGR-----LGVSIAMEYCSN-NLYHR
 .   | |||    ||. . .       .  | |    .   ... ..| .| ...  . .|||. |   . ...||       . | |||... .| ..
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYG--VCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IRSSAGTGIVTRLTEAEICHVMFAVTSAVGYLHAQQPPITHRDIRPENILINNKHAGPTAYKLTNFG---NATTE--------AYQCETREEAN--MAIA
.|.. ..     |. .. .. .. . .   ||| .  .. |||.   |.|....|      | . ||   . . .         |   ... ..  . | 
LRKHRPK-----LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI-

DIQMHTNPAFRAPEMADPWSKKRIC-EKTDMWSMGVLLY--YMMYMSLPFD-----PSTTIVKDWALTF---PSEATAS------YTPSLRVITEHLLDP
           |||      ..... .|.| || ||...  .   .. . .      | . |  .  .    |  . .        .. .  | .   . 
--------RWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE

DPCSRWDVFALINYM
|| .|    ... ..
DPEDRPTFSEIHECF
Kinase LmjF15.0770.AA CAMK-Unique 265-290 36 1.1e-05 14.57 In-house 268-297 (363) Show / Hide 
Range on Protein: 265-290
Range on HMM: 268-297/363
Sequence Identity: 36% (11 aa)

EKT----DMWSMGVLLYYMMYMSLPFDPST
..     | ||.||..|||   ..|||...
QQCSPASDIWSLGVIMYYMLCGCPPFDCEC
Kinase LmjF15.0770.AA Pkinase 266-287 50 0.005289 11.7 Pfam 192-213 (293) Show / Hide 
Range on Protein: 266-287
Range on HMM: 192-213/293
Sequence Identity: 50% (11 aa)

KTDMWSMGVLLYYMMYMSLPFD
| ||||.|..||.|.   .||.
KVDMWSCGCILYEMLCGRPPFP
Kinase LmjF15.0770.AA NAK 318-337 30 0.127319 1.09 In-house 280-299 (299) Show / Hide 
Range on Protein: 318-337
Range on HMM: 280-299/299
Sequence Identity: 30% (6 aa)

HLLDPDPCSRWDVFALINYM
..|.|||  | ... ..|..
YMLTPDPEQRPNIYQVLNQL