Gene 88246.m00062 (T.vaginalis)
88246.m00062
Species: T.vaginalis
Alias: TvagK0959, 88246.m00062
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 88246.m00062.AA | Protein | None | 1396 | None | Fasta, JSON |
| 88246.m00062.kin_dom | Protein Kinase Domain | None | 256 | None | Fasta, JSON |
Protein domains of 88246.m00062.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3Ka | 88246.m00062.AA | PI3Ka | 932-1014 | 25 | 2e-06 | 23.72 | Pfam | 83-174 (211) | Show / Hide |
Range on Protein: 932-1014 Range on HMM: 83-174/211 Sequence Identity: 25% (23 aa) WSPLKPVQALSLLVPEIMN-DKRSASYVARCFEQ-FTRDESLMFIPQLVQSLRFD------THGVMQKFLMKFSESEE-VFSHYLLWNILAE | |..|..||.|| .. . ..| .| |. .. || | ...|||| |... .. || . . . ...| . |. .| WPPIDPCDALELLDCNFPDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFWYMKSE |
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| PI3Ka | 88246.m00062.AA | PI3Ka | 888-1045 | 14 | 8.7e-05 | -39.5 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 888-1045 Range on HMM: 1-232/232 Sequence Identity: 14% (33 aa) QIENLM--SPILLKIIKNTM---------------------FHAATVPEMS------LFL-------AKQQAFDKSNFLFW--SPLKPVQALSLLVPEIM . .... . ...| .. ..|. || | . . . . | |..|..|| || |. DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFP ND--KRSASYVARCFEQFTRDESLMFIPQLVQSLRFD----------------------------THGVMQKFLMKFSESEEVFSHYLLWNILAEK---- . .| .| ||.. || |....|||| |... . . || . . . ..|.. |. .| DYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNPRIGHFFYWYLKSEMYDHC --NNHVTENDNLPQILTQLETKI-IDHMTPQQR ... . . .| .. .. || . .. QLHDPHY-CQRFGMLLEMYCRGCCGHHMRHLFK |
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| PI3Kc | 88246.m00062.AA | PI3Kc | 1139-1393 | 25 | 6.7e-80 | 272.68 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1139-1393
Range on HMM: 1-336/336
Sequence Identity: 25% (86 aa)
ACIFKIHDDVRQDAMMYQFIEVFKGIFRDA----GIDCFVYPYRVFATGENRGVIELIPKSKSRHDIGS-------------------------------
| ||| .|| |||..| |...... | . . |. ..||.. .||.. |.||..| ....| | .
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
--------------------------------ATNEDLLHYFISKYGQIGTAAFNKAQENFVRSMAPNSLICYLFQVKDRHNANIMID-EDGHVIHIDFG
. ..|...|...... . ....|..||.||.| . ..|.....|||| |||.| ..||..|||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN-EDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG
FIFEISPGGNMKF-----ERAPFKLSKEMIDLMGG-SKEAAPFKLFRKLLIQCMFAARARHEEIEAITNLMRSAGF-PCFRAD--SIKKLRERFCFG-MT
.||. . ....| ||.||.| ..|...||| |.. |..||.. . . |.| ...| .. ..| ... ||.|.. .||.||.||. ..
HIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLS
PKEVVQTVDS-----LIAGSYEAITTTGYDAFQASQNK
.|. | .. || | |. ||. |. |. ..
DEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| PI3_PI4_kinase | 88246.m00062.AA | PI3_PI4_kinase | 1137-1345 | 21 | 3.4e-43 | 154.6 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1137-1345
Range on HMM: 1-300/300
Sequence Identity: 21% (66 aa)
PFACIFKIHDDVR--QDAMMYQFI-----------------------EVFKGIFRDAGIDCF----VYPYRVFATGENRGVIELIPKSKSRHDIGSATN-
. ||| .|| | ||. | |.| ...... . | |. . |||. .||...|.||..| . . | | . .
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV
------------------------------------------EDLLHYFISKYGQIGTAAFNKAQENFVRSMAPNSLICYLFQVKDRHNANIMI---DED
..|...|...... . .. .| .|||||.| . . |.... |||| |||. ...
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDA-YEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTT
GHVIHIDFGFIFE-ISPGGNMKFERAPFKLSK------EMIDLMGGS---KEAAPFKLFRKLLIQCMFAARARHEEIEAIT-------NLMRSAGFPCFR
||..|||||..|. . .|.|| ||.. . .|...||| .. . .||... . . | | .. . . ..| .| |..|
GHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWR
A
S
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| Kinase | 88246.m00062.AA | ATR | 1228-1335 | 30 | 2.4e-14 | 44.89 | In-house | 163-267 (267) | Show / Hide |
Range on Protein: 1228-1335 Range on HMM: 163-267/267 Sequence Identity: 30% (33 aa) AQENFVRSMAPNSLICYLFQVKDRHNANIMIDE-DGHVIHIDFGFIFEISPGGNMKF-ERAPFKLSKEMIDLMGGSKEAAPFKLFRKLLIQCMFAARARH ..||..||.| ... |. ||| ||.||. | ..|.|. || | .. | ||.| . |. || | |||. .. | | . SRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNS--GEQFEVPEIVPFRLTHNMVFGMGPMKTYG---LFRRACEVIMMCMRDHR EEIEAITNLM ..| .. . DDIMSVWDCF |
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| Kinase | 88246.m00062.AA | FRAP | 1231-1275 | 43 | 2.7e-08 | 26.7 | In-house | 139-184 (251) | Show / Hide |
Range on Protein: 1231-1275 Range on HMM: 139-184/251 Sequence Identity: 43% (20 aa) NFVRSMAPNSLICYLFQVKDRHNANIMID-EDGHVIHIDFGFIFEI |. ||.| |.. |. ||| |||.. | ..||||| ||. NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEV |
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| Kinase | 88246.m00062.AA | ATM | 1232-1299 | 37 | 3.4e-07 | 18.61 | In-house | 140-207 (304) | Show / Hide |
Range on Protein: 1232-1299 Range on HMM: 140-207/304 Sequence Identity: 37% (27 aa) FVRSMAPNSLICYLFQVKDRHNANIMIDEDG-HVIHIDFGFIFE---ISPGGNMKFERAPFKLSKEMIDLMG . ||.| |.. |. . ||| ||.| | ..||| | || | | | ||.| ....| || YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILP----TPETVPFRLTRDIVDGMG |
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| Kinase | 88246.m00062.AA | PIKK | 1230-1299 | 41 | 4.6e-07 | 22.17 | In-house | 187-257 (290) | Show / Hide |
Range on Protein: 1230-1299 Range on HMM: 187-257/290 Sequence Identity: 41% (30 aa) ENFVRSMAPNSLICYLFQVKDRHNANIMIDED-GHVIHIDFGFIFEISPGGNMKF-ERAPFKLSKEMIDLMG ||. || | . | ||| |||||.. | ..|||||..|| | .. .. | || | . |...|| ENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFE-SAMQRLPVPEKVPFRLTRNMVNAMG |
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| Kinase | 88246.m00062.AA | ATM | 1141-1156 | 56 | 0.014778 | 3.53 | In-house | 3-18 (304) | Show / Hide |
Range on Protein: 1141-1156 Range on HMM: 3-18/304 Sequence Identity: 56% (9 aa) IFKIHDDVRQDAMMYQ . | ||.||||.| | LVKGRDDLRQDAVMQQ |
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