Gene 93878.m00245 (T.vaginalis)
93878.m00245
Species: T.vaginalis
Alias: TvagK0848, 93878.m00245
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 93878.m00245.AA | Protein | None | 1142 | None | Fasta, JSON |
| 93878.m00245.kin_dom | Protein Kinase Domain | None | 306 | None | Fasta, JSON |
Protein domains of 93878.m00245.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3Ka | 93878.m00245.AA | PI3Ka | 611-798 | 31 | 7.3e-53 | 182.85 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 611-798 Range on HMM: 1-232/232 Sequence Identity: 31% (73 aa) QKAPHL-LKHEDQFRLKELEAYDPLMELTDDDRKLIWLNRNRFV-DNPKMLP-----LVLQSVDYTNTTQINEIPYVLAMW--KPLDPTGALTLLDAKFA . . . |.. .|... .|.|. |||.....||| |. .. ..|| || .|..|. .. .. .. . .. | .|.|| || |||.||. DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFP D---ENVRKYAVDLLDQLNDSELLLYILQLTQALKYE--------------------------VYEDSALVRFLIRRGLNEPKFVGHHLFWLLMSEA--- | ..||.||| | |..| |||.|.||| |||||| |.||.|.|||..| | | .||...|.| || DYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNP-RIGHFFYWYLKSEMYDH ---HISAIRERFSAVVVNFIYGI-GHYRDELIT | . . .|| . ...|. ||. .|. CQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK |
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| PI3Ka | 93878.m00245.AA | PI3Ka | 624-798 | 34 | 4.8e-50 | 173.74 | Pfam | 13-211 (211) | Show / Hide |
Range on Protein: 624-798 Range on HMM: 13-211/211 Sequence Identity: 34% (69 aa) RLKELEAYDPLMELTDDDRKLIWLNRNRFV-DNPKMLP------LVLQ-SVDYTNTTQINEIPYVLAM--WKPLDPTGALTLLDAKFAD--ENVRKYAVD .|... .|||| .|| ....||| | .. ||| || || .| .. .| .. .. | |.|| || |||..|.| ..|| ||| QLEQIIKYDPLSQLTAEEKCLIWKFRHYCCMNNPKALPLMCVGPKFLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNFPDNCPMVRQYAVK LLDQ-LNDSELLLYILQLTQALKYE----VYEDSALVRFLIRRGLNEPKFVGHHLFWLLMSEA------HISAI-RERFSAVVVNFIYGIGHYRDELIT |.. . | |||.|.|||.|||||| .. ||.|.|||..|.. . ||..|| . || |.... .||. . . ...| .. .|.. CLESYMSDDELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFWYMKSEMYKDDEGHDKDYICQRFGVLLESYCRECGTHMQHLNK |
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| PI3Kc | 93878.m00245.AA | PI3Kc | 882-1142 | 28 | 6e-79 | 269.51 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 882-1142
Range on HMM: 1-336/336
Sequence Identity: 28% (97 aa)
QTMFKVGDDLRQDHLTLQVMKVMDYIWRQN----NLDLRMSNYSVLPTGLNQGFIEVVPNSVTEQKLQQEKGKMGS------------------------
. .||.||||||| ...|. ..|. ||... ..||.| |...||| . |.||.|||..| ..| .. |. .
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
--------------------------------FDENTFIDYLKLMNTTEQ-TLQMAKENFMLSSAGYAVATCILGVADRHPGNIMLQ-QDGHFFHIDFGH
| .... |... ..... . |..|| .| ||| ..| |||. |||..|||| ..|| |||||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
FLGNFKKKLGYK---RENAPFHFLPACVVVLD--GQNGKLYKEFEQTSIKAYNVMREKANLIMSLMLLMLGTGI-PELQKP-SDLQYMKDMLHLN-VNER
..|...||.|.| || .|| . . | | |.. .....| .. .||..||. .||||.|. .|....| |.... |..| .. ..|. ....
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE
EDADIFKN-----LIKISTESTKTAVNNWIHNLVCK
| | |.. ||. | || |.... .||.
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| PI3_PI4_kinase | 93878.m00245.AA | PI3_PI4_kinase | 880-1093 | 24 | 5.4e-62 | 217.06 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 880-1093 Range on HMM: 1-300/300 Sequence Identity: 24% (72 aa) PIQTMFKVGDDLR--QDHLTLQVM-----------------------KVMDYIWRQNNLDLR----MSNYSVLPTGLNQGFIEVVPNSVTEQKLQQEKGK .. .||.||||| || ...| ..|. .|.....|.| | |...||| . |.||.|||..| .... .... WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV MGSFDE------------------------------------NTFIDYLKLMNTTE-QTLQMAKENFMLSSAGYAVATCILGVADRHPGNIML---QQDG .... . . .... .|... ... |..|| .| ||..|.. |||..|||..|||. .| KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG HFFHIDFGHFLGNFKKKLGYKRENAPFHFLP------ACVVVLDG----QNGKLYKEFEQTSIKAYNVMREKANLIMSLM-------LLMLGTGIPELQK | |||||||.....| | . |.| ||.... | .. | . . | .|... .||...|. .||.|.|. ..|. .|.|.. . HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | 93878.m00245.AA | FRAP | 979-1018 | 53 | 8.8e-08 | 24.81 | In-house | 139-179 (251) | Show / Hide |
Range on Protein: 979-1018 Range on HMM: 139-179/251 Sequence Identity: 53% (22 aa) NFMLSSAGYAVATCILGVADRHPGNIMLQ-QDGHFFHIDFG |. | | .| ||| |||| ||||| . | ||||| NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | 93878.m00245.AA | PIKK | 976-1019 | 44 | 0.000131 | 13.13 | In-house | 185-229 (290) | Show / Hide |
Range on Protein: 976-1019 Range on HMM: 185-229/290 Sequence Identity: 44% (20 aa) AKENFMLSSAGYAVATCILGVADRHPGNIMLQQD-GHFFHIDFGH ..||. | | .. ||| |||| |||.... | |||||. RRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC |
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| Kinase | 93878.m00245.AA | ATR | 976-1017 | 32 | 0.000226 | 10.33 | In-house | 163-205 (267) | Show / Hide |
Range on Protein: 976-1017 Range on HMM: 163-205/267 Sequence Identity: 32% (14 aa) AKENFMLSSAGYAVATCILGVADRHPGNIMLQQ-DGHFFHIDF ..||.. | | ... |.| ||| ||.... | |.|. SRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDY |
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| Kinase | 93878.m00245.AA | PIKK | 884-940 | 32 | 0.000575 | 10.76 | In-house | 34-94 (290) | Show / Hide |
Range on Protein: 884-940 Range on HMM: 34-94/290 Sequence Identity: 32% (20 aa) MFKVGDDLRQDHLTLQVMKVMDYIWRQN----NLDLRMSNYSVLPTGLNQGFIEVVPNSVT ..| ..||||| ..|. .| . ... .| .. ||| | . . | || |.|.|| LCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVT |
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