Gene 108748.m00003 (T.vaginalis)

108748.m00003

Species: T.vaginalis
Alias: TvagK0574, 108748.m00003
External Links:
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MAK

Sequence

Name Sequence Type Origin Length Description Download
108748.m00003.AA Protein None 427 None Fasta, JSON
108748.m00003.kin_dom Protein Kinase Domain None 281 None Fasta, JSON

Protein domain

Protein domains of 108748.m00003.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 108748.m00003.AA RCK 4-284 51 3.1e-156 499.44 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-298/298
Sequence Identity: 51% (154 aa)

FEEIQVLGDGAFGVVTKCRDKETGEIVAIKKMKQKFVKDFNECLQLKEVKSLRKIK-HENVVRLLQLFRDNE--YFYMVFECCGESLLKTMSK---RTTR
   |  ||||..|.|.| ..|||||||||||||||| .. .|| .|.|.|||||.. |.|.. |.  .|||.    | |||.. . | . |     |...
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKF-YSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKY

FSESE--IRYIMHQFVTGLAYVHKQGFFHRDIKPDNLLWCG----------KTLKIADFGLAREIRSRPPYTEYISTRWYRAPEIILRHKSYNSPVDIWA
..|..  |. || |   |||. ||.||||||.|| |.. .|           ..|||||||.|||||.||||.|.|||||||||..||   ||||.||||
LPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWA

SACIMAELYMGKPLFQGTSETDQMYKICQIMGNPSVQQWPDCEKLILRLGFRLPQATAVPLKTLMPEASDEAIDLMYKMLMYDPSKRPSAQQVLAHPFF
  |||.|||| .||| |.|| || .|||..|| |. . |||  ||   ..|..||  ..|||.| | .| ..|.||.||| .||.||..|||.| ||.|
VGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 108748.m00003.AA MAK 4-284 42 6.00000000001e-148 474.34 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-352/352
Sequence Identity: 42% (149 aa)

FEEIQVLGDGAFGVVTKCRD------------------------------KETGEIVAIKKMKQKFVKDFNECLQLKEVKSLRKIK-HENVVRLLQLFR-
.  |. ||||..| |.. ..                              ..|||.||||.||.||  ...||..| |||||.|.. | |.|.|.  .| 
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFY-SWEECMNLREVKSLKKLNAHPNIVKLKEVIRD

-DNEYFYMVFECCGESLLKTMSKRTT-RFSESEIRYIMHQFVTGLAYVHKQGFFHRDIKPDNLLWCG------------------KTLKIADFGLAREIR
  |.  |.|||.  | |   |  |..  |.|..|| || |  .|||..|| ||||||.|| |.. .|                    .||||||||||||
SENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIR

SRPPYTEYISTRWYRAPEIILRHKSYNSPVDIWASACIMAELYMGKPLFQGTSETDQMYKICQIMGNPSVQQ----------------WPDCEKLILRLG
|.|||| |.|||||||||. ||  .|.||.|.||  |||||||. .||| |.|| ||..||||..| |  ..                |||  .|   ..
SKPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMN

FRLPQATA---VPLKTLMPEASD-EAIDLMYKMLMYDPSKRPSAQQVLAHPFF
||.||  .   .|||.|.|..|  .||.|| .|| .|| ||| ||| . .|.|
FRFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase 108748.m00003.AA CMGC 4-284 25 7.50000000001e-124 409.17 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-513/513
Sequence Identity: 25% (129 aa)

FEEIQVLGDGAFGVVTKCRD--------------KETGEIVAIKKMKQKFVKDFNECL-----------QLKEVKSLRKIK-----------------HE
.| |...| |..||| ||||              .||.|||||||.|..|  . ....            | |.| |....                 |.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF--YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

NVVRLLQLFRDNE-----------------YFYMVFECCGESLLKTMSK--------RTTRFSESE------------IRYIM------HQFVTGLA--Y
|.|.|.  |....                 ..|.|||... .|.. . .        |   .|| .            |.|.|      .|  .||.  |
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

VHKQG--FFHRDIKPDNLLWCGKT---------------------LKIADFGLAR--EIRSRP--------------------PYTEYISTRWYRAPEII
 |...  ..|||.|| |.| . ..                     |||.||||||  ...|..                    |||.|..|||||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LRHKSYN---------SPVDIWASACIMAELYMG--------KPLFQGTSE-----------TDQMYKICQIMGNPS---------------VQQWPDCE
|. | |.         .|.|.|. .||.||.|.|        ||||.| ||            ||..||....|.|.                ..||.. 
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

K-------------------------LILRLGFRLPQATAVPLKTLMPE-----------------------------------ASDEAIDLMYKMLMYD
|                         . .. ..|.|.    |.| |.|                                    ....||||. ||| ||
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PSKRPSAQQVLAHPFF
|.||..|.| |.||.|
PDKRITAEQALQHPYF
Kinase 108748.m00003.AA CDK 4-284 34 2.7e-103 331.34 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-284/284
Sequence Identity: 34% (110 aa)

FEEIQVLGDGAFGVVTKCRDKETG-----EIVAIKKMK---QKFVKDFNECLQ---LKEVKSLRKIKHENVVRLLQLFRDN-----------EYFYMVFE
.| .. .| |..||| |.|||.||     .|||.|| .   ..  ..  | .    . |.. |... |.|.|.|.  . ..             .|||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEG-REEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

CCGESLLKTMSKRTTRFSESEIRYIMHQFVTGLAYVHKQGFFHRDIKPDNLLWCGKT------LKIADFGLAREIRS-------RPPYTEYISTRWYRAP
 .   | | |.          |. .|.|   ||.| |.... |||.|| |.|   .       ||||||||||.  .       . .||  . |.|||||
YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

EIILRHKSYN--SPVDIWASACIMAELYM---GKPLFQGTSETDQMYKICQIMGNPSVQQWPDCEKLILRLGFRLPQATAVPLKTLMPEASDEAIDLMYK
|. |  | |.   |.|.|.  ||.||...   .||||.|.||.||. ||..|.| |. ..||...|| .                          ||. |
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNK

MLMYDPSKRPSAQQVLAHPFF
||.|||.|| ||.| | ||.|
MLCYDPKKRISAEQALQHPYF
Kinase 108748.m00003.AA S_TKc 4-284 31 4.5e-101 343.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-231/231
Sequence Identity: 31% (95 aa)

FEEIQVLGDGAFGVVTKCRDKETGEIVAIKKMKQKFVKDFNECLQLKEVKSLRKIKHENVVRLLQLFRDNEYFYMVFECCGE---SLLKTMSKRTTR---
.| ....| ||||.| |||.|.||.|||||..|         .  ..|.. |.| .|.|.|.|.  |.| ...|||.|.|.    .|.. . || ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FSESEIRYIMHQFVTGLAYVHKQGFFHRDIKPDNLLWCGKTLKIADFGLAREIRSRPPYTEYISTRWYRAPEIILRHKSYNS-PVDIWASACIMAELY
  |.| ..|..|.| . .|.| |..|. |||.||.|.| .  ..||.||||||..      | .. |.||.|||..    .|.  ..|.|.  ||..|..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

MGKPLFQGTSETDQMYKICQIMGNPSVQQWPDCEKLILRLGFRLPQATAVPLKTLMPEASDEAIDLMYKMLMYDPSKRPSAQQVLA-------HPFF
 |.|.|.      ||... ...|                                    |.||.|.. |.| .||.|||.| ..|.       ||.|
CGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 108748.m00003.AA Pkinase 4-284 35 9.9e-94 322.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-293/293
Sequence Identity: 35% (106 aa)

FEEIQVLGDGAFGVVTKCRDKETGEIVAIKKMKQKFVKDFNECLQLK--EVKSLRKIKHENVVRLLQLFRDNEYFYMVFECCGE-----SLLKTMS-KRT
.. ....| |.||.| ||..| ||.|||.|..| .  |.  .   ..  |.. .....|.|.|||.  |.|. . |||.|.|.      .|   .| .| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TRF--SESEIRYIMHQFVTGLAYVHKQGFFHRDIKPDNLLWC--GKT---LKIADFGLARE--IRSRPPYTEYISTRWYRAPEIILRHKSYNSPVDIWAS
..|  || |.. .| | . ||.| |..|. |||.||.|.|    | .   .||.|||||.   . . . .| .  |.||.|||.|. .. | ..||.|. 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

ACIMAELYMGKPLFQGT----SETDQMYKICQIMGNPSVQQWPDCEKLILRLGFRLPQATAVPLKTLMPEASDEAIDLMYKMLMYDPSKRPSAQQVLAHP
 ||..|.. |.|.|.|     .  |||..||.||| |   .||      ..  ||  . .   ..|. ...|.|..|.....| .||.|||.|.|.| ||
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

FF
.|
WF
Kinase 108748.m00003.AA CDC2 4-284 36 2.8e-92 283.86 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-301/301
Sequence Identity: 36% (112 aa)

FEEIQVLGDGAFGVVTKCRDKETGEIVAIKKMKQKFVKDFNEC-----LQLKEVKSLRKIK-HENVVRLLQLFRDNEYFYMVFECCGESLLKTMS---KR
.. |. .| | .|||.||.|..|..|||.|| .   .. ..|        ..|   | ..| |.|.|.|   .      |||||..   | | |    . 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIR---LEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPK

TTRFSESEIRYIMHQFVTGLAYVHKQGFFHRDIKPDNLLWCGK-TLKIADFGLAREIRS-RPPYT--EYISTRWYRAPEIILRHKSYNSPVDIWASACIM
 . .... .. .|.| . |... | .. .|||.||.|.|   | ..||||||||| .     .||    . |.||||||| |. | |. |||.|.  ||.
NKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIF

AEL---YMGKPLFQGTSETDQMYKICQIMGNPSVQQWPDCEKLI-LRLGFRLPQATAVPLKTLMPE---------ASDEAIDLMYKMLMYDPSKRPSAQQ
||.    . ||||.| || || .|| .|.| |. | ||....|      |  |. ..  |....|          . .|.|||  .|| |||.|| ||..
AEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTF--PRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKE

VLAHPFF
 |.||.|
ALQHPYF
Kinase 108748.m00003.AA CDK7 4-284 35 2.1e-89 238.21 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-288/288
Sequence Identity: 35% (102 aa)

FEEIQVLGDGAFGVVTKCRDKETGEIVAIKKMK----QKFVKDFNECLQLKEVKSLRKIKHENVVRLLQLFRDNEYFYMVFECCGESLLKTMSKRTTRFS
.| |. .| | |..| | .|..||.|||||| |    .   ||  .   . |.| |. ..|.||. |.  |      ..||.     |          . 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

ESEIRYIMHQFVTGLAYVHKQGFFHRDIKPDNLLWCGK-TLKIADFGLAREIRS-RPPYTEYISTRWYRAPEIILRHKSYNSPVDIWASACIMAELYMGK
 ..|  .| .   || | |.    |||.|| |||      |||||||||| . |    ||  . ||||||||     ..| . ||.|.  ||.|||    
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFQGTSETDQMYKICQIMGNPSVQQWPDCEKLILRLGFRLPQA-TAVPLKTLMPEASDEAIDLMYKMLMYDPSKRPSAQQVLAHPFF
| . |.|. ||. .|.|..| |. ..||.  ..   . |.   . . .||. .   |||...||| .|.  .|.|| .. | | .|.|
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 108748.m00003.AA CDKL 4-284 37 9.1e-85 287.93 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-286/286
Sequence Identity: 37% (108 aa)

FEEIQVLGDGAFGVVTKCRDKETGEIVAIKKMKQ-KFVKDFNECLQLKEVKSLRKIKHENVVRLLQLFRDNEYFYMVFECCGESLLKTMSKRTTRFSESE
.| . ..| |. ||| |||.||||.|||||| |  .  .  .    . |.| |.  |||| | |.  || .   ..||| |  ..| .  .. .   |. 
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIA-MREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHV

IRYIMHQFVTGLAYVHKQGFFHRDIKPDNLLWC--GKTLKIADFGLAREIRSRPP--YTEYISTRWYRAPEIILRHKSYNSPVDIWASACIMAELYMGKP
.| .| |   .... ||.   |||||| |.|     ...|. |||.|| . . |   ||.|  ||||||||  .   .| .|||||| .|.|||. .| |
VRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQP

LFQGTSETDQMYKICQIMGNPSVQQWPDCEKLILRLGFRLPQATAV-PLKTLMPEAS-DEAIDLMYKMLMYDPSKRPSAQQVLAHPFF
|. | |. ||.|.| . .|.   ..     |  .  | ..|.   . ||.  .|..|  .|.|.| |.|  ||..|....| . ||.|
LWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 108748.m00003.AA CDK4 4-284 34 8.6e-71 241.5 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-290/290
Sequence Identity: 34% (103 aa)

FEEIQVLGDGAFGVVTKCRDKETGEIVAIKKMKQKFVKDFNE-----CLQLKEV---KSLRKIKHENVVRLLQLFRDNEYFY------MVFECCGESLLK
..... .| ||.| | . || .|| .|| |. .   .   .|        . |.   . | .  | |.|.|.  .   .         |||| | .  |.
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVR---IPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHC-DWDLH

TMSKRTTR--FSESEIRYIMHQFVTGLAYVHKQGFFHRDIKPDNLLWC-GKTLKIADFGLAREIRSRPPYTEYISTRWYRAPEIILRHKSYNSPVDIWAS
|   .  .   ..  |. .|||...|. . |     ||| ||.|.|    ...|.|||||||.  .    |  . | ||||||. |   .||.|||.|. 
TYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLLQ-SYYNTPVDMWSV

ACIMAELYMGKPLFQGTSETDQMYKICQIMGNPSVQQWPDCEKLILRLGFRLPQATAVPLKTLMPEASDEAIDLMYKMLMYDPSKRPSAQQVLAHPFF
.||.||.|  .||| |.|| ||  ||  .|| |  ..||  .  . .  |  ||  . |.| . |. .  ..||. ||| |...||.|| | | ||.|
GCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPR-DVSLPWDHF--PQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase 108748.m00003.AA MAPK 51-284 33 1.7e-65 223.92 In-house 54-328 (328) Show / Hide 
Range on Protein: 51-284
Range on HMM: 54-328/328
Sequence Identity: 33% (93 aa)

EVKSLRKI-KHENVVRLLQLFRD------NEY-----FYMVFECCGESLLKTMSKRTTRFSESEIRYIMHQFVTG--LAYVHKQGFFHRDIKPDNLLWCG
|.| || . .|||...||  |.       |.      .|.|.| ..  | . .  .    |.  |.|.| |   |  | | |  .  |||.|| |.|   
EIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNE

K-TLKIADFGLAREIRSRPPY---------------TEYISTRWYRAPEIILR--HKSYNSPVDIWASACIMAELYM-GKPLFQGTSETDQMYKICQIMG
  .|||.|||||| | .   .               |||..|||||||||.|    . |.  ||.|.  ||.||..  .||||.|..  ||. .| ...|
NCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLG

NPSVQQWPDCE--KLILRLGFRL---PQATAVPLKTLMPE----ASDEAIDLMYKMLMYDPSKRPSAQQVLAHPFF
.|| . .   .  .    .  .|   |. ...|.... |     |...||||. |||  ||.|| .... |.||.|
TPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 108748.m00003.AA PITSLRE 86-284 41 2.2e-59 203.62 In-house 91-295 (295) Show / Hide 
Range on Protein: 86-284
Range on HMM: 91-295/295
Sequence Identity: 41% (85 aa)

SLLKTMSKRTTRFSESEIRYIMHQFVTGLAYVHKQGFFHRDIKPDNLLWCGK-TLKIADFGLAREIRSR-PPYTEYISTRWYRAPEIILRHKSYNSPVDI
||. .|..|  .|...||   | |   | .. |.    ||| |  |||   |  |||.|||||||  |   |||  . | ||||||. |  | |  |||.
SLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDM

WASACIMAELYMGKPLFQGTSETDQMYKICQIMGNPSVQQWPDCEKLILRLGFR-LPQATAVPLKTLMP---EASDEAIDLMYKMLMYDPSKRPSAQQVL
|   ||.||. ..|||||| ||.||. .| . || |. . ||.  .| .   .  .|.     |. . |     || . ||. .|| |.| .| .| . |
WSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDAL

AHPFF
 ||.|
KHPWF
Kinase 108748.m00003.AA TyrKc 4-284 22 2.3e-15 25.79 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

FEEIQVLGDGAFGVVTKCRDKETGEIVAIKKMK-QKFVKDFNECLQLKEVKSLRKI--KHENVVRLLQLFRDN-------EYFYMVFE-CCGESLLKTMS
 . ...|| ||||.| |.. |   . ||.|..|  . ..||     ..| . ..|.  .|.|.|||.   ..        |  ..|.| ... .|..   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDF-----MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KRTTRFSESEIRYIMHQFVTGLAYVHKQGFFHRDIKPDN-LLWCGKTLKIADFGLAREIRSR-------PPYT------EY--ISTRWYRAPEIILRHKS
|.  ... ..  ....|   | .| |.... |||.   | |.  ..| ||.||||.|.| .          |.      .   .  ||. ||| | ... 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGK

YNSPVDIWASACIMAELY-MGKPLFQG-----TSETDQMYKICQIMGNPSVQQ----WPDCEKLILRLGFRLPQATAVPLKTLMPEASDEAIDLMYKMLM
...  |.|.    | |..  |..   |      | .. . .. | .  |  .                                ....||  ..| .  .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQIMKQCWH

YDPSKRPSAQQVLAHPFF
.||..||. ...  | .|
EDPEDRPTFSEI--HECF
Kinase 108748.m00003.AA Pkinase_Tyr 4-185 26 3e-15 52.27 Pfam 1-199 (270) Show / Hide 
Range on Protein: 4-185
Range on HMM: 1-199/270
Sequence Identity: 26% (54 aa)

FEEIQVLGDGAFGVVTKCRDK----ETGEIVAIKKMKQKFVKD---FNECLQLKEVKSLRKI-KHENVVRLLQLFR-DNEY--FYMVFE-CCGESLLKTM
 . ...|| ||||.| |.. |    .|.  ||.|..|..  ..     . ..  |.| .... .|.|.|||.     . |    |.|.| ... .||.  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR--EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

SKR---TTRFSESEIRYIMHQFVTGLAYVHKQGFFHRDIKPDNLLWC-GKTLKIADFGLAREIRSRPPY-----TEYISTRWYRAPEIILRHKSYNSPVD
 |.     ... ...  . .|   |..| . ... |||.   | |   ... ||.|||||| | .   |        .  .|. ||| |   | ...  |
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM-APECINYGK-FTTKSD

IWA
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VWS
Kinase 108748.m00003.AA MAPK 4-39 35 8.8e-12 36.8 In-house 1-42 (328) Show / Hide 
Range on Protein: 4-39
Range on HMM: 1-42/328
Sequence Identity: 35% (15 aa)

FEEIQVLGDGAFGVVTKCRDKE------TGEIVAIKKMKQKF
.. .. .| ||.||| ...||.      .|..|||||. . |
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPF
Kinase 108748.m00003.AA PITSLRE 4-36 42 7.6e-11 35.91 In-house 1-33 (295) Show / Hide 
Range on Protein: 4-36
Range on HMM: 1-33/295
Sequence Identity: 42% (14 aa)

FEEIQVLGDGAFGVVTKCRDKETGEIVAIKKMK
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FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLK