Gene 88273.m00404 (T.vaginalis)

88273.m00404

Species: T.vaginalis
Alias: 88273.m00404, TvagK0659
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
88273.m00404.AA Protein None 433 None Fasta, JSON
88273.m00404.kin_dom Protein Kinase Domain None 290 None Fasta, JSON

Protein domain

Protein domains of 88273.m00404.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 88273.m00404.AA DYRK 129-418 35 1.3e-97 330.64 In-house 1-320 (320) Show / Hide 
Range on Protein: 129-418
Range on HMM: 1-320/320
Sequence Identity: 35% (112 aa)

FQMISILGEGSSGFVIKCHDHKLNEDVAIKALRDTRKTHDHVLLEKAYLTTLQQNGGPDKFHIIRYKDSFIFRGYFCIVMELASINIYSLICSQPFKRL-
.. ....| || | |.|| ||| ||.|||| .|   . |.  . |   |  | |..  ||.|.....|.|..|. .||| || |.| | ...   |. . 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

QASTYQMVARQTAEALDFMHKN-NVIHSDIKPENILFTNV-RRTSIKLIDFGCSCTEGNTLYTYIQSRFYRAPEVVLENEYDSKIDIWSYGCLLCEMFTG
  . .. .|.|  ..|.|.||| | || |.|||||.  .   .  ||.|||| || |. ..|||||||||||||| |   |. .||.|| || | |.|||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

KPLFEAFDEEELMCLMISMLGIPPKSILKTA--KRAKYYFDE-NFELLDTMEINET------------------------SLKEKTNISDPYLLQLISGC
.|||   .| ... ... .||.||| .....  .|....||.  .. .|...  ..                        ... . .  |  .. .| .|
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKKC

LRWDPKERFSAEDIIKHNYF
| |||..| ....  .|  |
LQWDPHKRITPSQALQHPWF
Kinase 88273.m00404.AA DYRK2 129-418 34 1.5e-94 307.87 In-house 1-318 (318) Show / Hide 
Range on Protein: 129-418
Range on HMM: 1-318/318
Sequence Identity: 34% (109 aa)

FQMISILGEGSSGFVIKCHDHKLNEDVAIKALRDTRKTHDHVLLEKAYLTTLQQNGGPDKFHIIRYKDSFIFRGYFCIVMELASINIYSLICSQPFKRLQ
. . ...| || | |.|| |||... |||| .|   . |   . |   |  . ..     . ... .|.|.||...||. || |.|.|..|.   |. . 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

ASTYQMVARQTAEALDFMHKNNVIHSDIKPENILFTNVRRTSIKLIDFGCSCTEGN-TLYTYIQSRFYRAPEVVLENEYDSKIDIWSYGCLLCEMFTGKP
 . .   |..  ..|.| ||||.|| | ||||||     | .||.|||| || |    .|||||||||||||| |   |.  ||.|| || . |..||.|
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFEAFDEEELMCLMISMLGIPPKSILKTA-----KRAKYYFD---------------ENFELLDTME------INETSLKEKTN-ISDPYLLQLISGCLR
||   .| . . .|.  ||.|||....|.     .|.||.|.               . .. . .        .. .|.|..     |....  |. |. 
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFE

WDPKERFSAEDIIKHNYF
|||.|| ..... || ..
WDPSERMTPSQALKHPWI
Kinase 88273.m00404.AA S_TKc 129-418 22 4.8e-79 269.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 129-418
Range on HMM: 1-231/231
Sequence Identity: 22% (68 aa)

FQMISILGEGSSGFVIKCHDHKLNEDVAIKALRDTRKTHDHVLLEKAYLTTLQQNGGPDKFHIIRYKDSFIFRGYFCIVMELASI---NIYSLICSQPFK
.... ..|.|. | | ||...| .. |||| ..      .|.. | . |         .  .|....|.|   .....|||...    . ...|.... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

R----LQASTYQMVARQTAEALDFMHKNNVIHSDIKPENILFTNVRRTSIKLIDFGCSCTEGNTLYTYIQSRFYRAPEVVLENEYDS-KIDIWSYGCLLC
.    .   . . ...|...||...|....|| |.||||||...     ||..||| ..      .|.. ...|.||||.    |.  |.|.|| ||.| 
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMFTGKPLFEAFDEEELMCLMISMLGIPPKSILKTAKRAKYYFDENFELLDTMEINETSLKEKTNISDPYLLQLISGCLRWDPKERFSAEDIIK------
||..|.|.|.  ...... ..                                              .| ....|..||..||..| .| .. .      
EMLCGYPPFP--QMQMMFKKIG---------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HNYF
 | .|
CHPWF
Kinase 88273.m00404.AA CMGC 129-418 17 2e-77 253.74 In-house 1-513 (513) Show / Hide 
Range on Protein: 129-418
Range on HMM: 1-513/513
Sequence Identity: 17% (88 aa)

FQMISILGEGSSGFVIKCHD--------------HKLNEDVAIKALR-DTRKTHD------------HVLLEKAYLTTLQQNGGPDK----------FH-
.. |. .|||. | | || |              |. || |||| .. .  ....              | |  .|  |..|. | .           | 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-IIRYKDSFIFRG-----------------YFCIVMELASINIYSLICSQPF-------KRLQAST------------YQMVA------RQTAEALD--F
 |.. .|.| ...                 ....|.|.   . | .| ...|       . |                 .         .|  ..|.  .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

MHKNN--VIHSDIKPENILFTNVRR------------------TSIKLIDFGCSCTEGNT------------------------LYTYIQSRFYRAPEVV
.|...  .|| |.||||||...  .                    .|..||| .. ...                         ...|...|.|||||. 
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LE----------NEYDSKIDIWSYGCLLCEMFTG--------KPLFE-----------AFDEEELMCLMISMLGIPPKSILKTAK-------RAKYYFDE
|           ..|...||.|| || . ||.||        ||||              .. . . ... .|| |. ......|       . . ... 
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

NFELLDTM-----------------------------EINETSLKEKTNI-----------------------------------SDPYLLQLISGCLRW
.  .   .                             ...  ..|..                                       || .. |....|..
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

DPKERFSAEDIIKHNYF
||..| .||.. .| ||
DPDKRITAEQALQHPYF
Kinase 88273.m00404.AA DYRK1 129-364 41 4.8e-72 245.66 In-house 1-238 (321) Show / Hide 
Range on Protein: 129-364
Range on HMM: 1-238/321
Sequence Identity: 41% (98 aa)

FQMISILGEGSSGFVIKCHDHKLNEDVAIKALRDTRKTHDHVLLEKAYLTTLQQNGGPDKFHIIRYKDSFIFRGYFCIVMELASINIYSLICSQPFKRLQ
....| .| || | |.| .||.  | |||| ..  .   .  ..|   |  . ..   .|..|.. |  |.||   |.|.|| | |.| |.    |.   
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

ASTYQMVARQTAEALDFMHKN--NVIHSDIKPENILFTNVRRTSIKLIDFGCSCTEGNTLYTYIQSRFYRAPEVVLENEYDSKIDIWSYGCLLCEMFTGK
    .  |.| . || ||     ..|| |.||||||  | .|  ||.|||| ||  |. .| ||||||||.|||.|. ||| .||.|| ||.| || || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFEAFDEEELMCLMISMLGIPPKSILKTAKRAKYYFD
|||   .| . |  .. .||.||| ..  | .|. ||.
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE
Kinase 88273.m00404.AA Pkinase 129-418 24 5.7e-58 203.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 129-418
Range on HMM: 1-293/293
Sequence Identity: 24% (77 aa)

FQMISILGEGSSGFVIKCHDHKLNEDVAIKALRDTRKTH---DHVLL--EKAYLTTLQQNGGPDKFHIIRYKDSFIFRGYFCIVMELASI-----NIYSL
.. ....|.||.| | |||... .. ||.| ..  .. .    . ..  | ...  |.    |   .|.|..|.|  ... ..|||..         ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HP---NIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IC---SQPFKRLQASTYQMVARQTAEALDFMHKNNVIHSDIKPENILFTNVRRT--SIKLIDFGCSC---TEGNTLYTYIQSRFYRAPEVVL-ENEYDSK
|    . .|  ..  . .....|....|...|....|| |.||||||. |   .  ..|..|||...   .  |...|.  ...|.||||..  ..|..|
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPK

IDIWSYGCLLCEMFTGKPLFEAF----DEEELMCLMISMLGIPPKSILKTAKRAKYYFDENFELLDTMEINETSLKEKTNISDPYLLQLISGCLRWDPKE
.|.||.||.| ||..|.|.|       .  . | ..   .| |...   .  .  |.|  ..          . ....    .. ....|..||..|||.
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------F-HWTF-HNWSEECKDFIKWCLCKDPKK

RFSAEDIIKHNYF
| .||.| .| .|
RPTAEQILQHPWF
Kinase 88273.m00404.AA YAK 129-329 34 1.3e-45 152.7 In-house 1-205 (347) Show / Hide 
Range on Protein: 129-329
Range on HMM: 1-205/347
Sequence Identity: 34% (70 aa)

FQMISILGEGSSGFVIKCHDHKLNEDVAIKALRDTRKTHDHVLLEKAYLTTL-QQNGGPDKF---HIIRYKDSFIFRGYFCIVMELASINIYSLICSQPF
.    .|| |  | |.||     || .|.| .           .|   |  | ||    .|    ||.|  |.|...  ||.| |. |.| | ..    |
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

KRLQASTYQMVARQTAEALDFMHKNNVIHSDIKPENILFTNVRRTSIKLIDFGCSCTEGNTLYTYIQSRFYRAPEVVLENEYDSKIDIWSYGCLLCEMFT
. .  .  .    |  ...      ..|| | |||||.  .. .  ||.|||| || |  ..|||||.|.||.||...   |   || || || . | | 
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GKPLF
| |.|
GLPIF
Kinase 88273.m00404.AA Ciliate-E2-Unclassified 129-418 20 9.9e-39 131.98 In-house 1-352 (352) Show / Hide 
Range on Protein: 129-418
Range on HMM: 1-352/352
Sequence Identity: 20% (74 aa)

FQMISILGEGSSGFVIKCHDHKLNEDVAIKALRDTRKTHDHVLLEK----AYLTTLQQNGGPDKF---------------HIIRYKDSFIF--RGYFCIV
. .| ..|.|. | | || . | ..  |.| . . .. ...  ..|      ....... . . .               |....|. ..|  . ...||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MELA-SINIYSLICSQPF---------------KRLQASTYQ-----MVARQTAEALDFMHKNN-VIHSDIKPENILFTNVRR-TSIKLIDFGCSCTEG-
||..   .    |.....               |...    .       ..|  ..|...|..| .|| |||||||||.|  .   ||.|||| |   . 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

-----------------NTLYTYIQSRFYR----APEVVLENEYD----SKIDIWSYGCLLCEMFTGKPLFEAFDEEELMCLMISMLGIPPKSILKTAKR
                 . ..| ...  |     ||||  ...||     |.|||| |..| || .|.. |.. ..|.  .| .  .      .      
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-N----N------

AKYYFDENFELLDTMEINETSLKEKTN-----ISDPYLLQLIS----GCLRWDPKERFSAEDIIKHNYF
    .  ...|..    .... ..  .     ...|    .|.     .| ..|..| ..|.|..| .|
----A-YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 88273.m00404.AA CDK 241-418 28 1e-38 121.35 In-house 119-284 (284) Show / Hide 
Range on Protein: 241-418
Range on HMM: 119-284/284
Sequence Identity: 28% (55 aa)

EALDFMHKNNVIHSDIKPENILFTNVRRTS---IKLIDFGCSCTEGN--------TLYT-YIQSRFYRAPEVVL-ENEYD--SKIDIWSYGCLLCEMFT-
..|...|.|...| |.|| ||| .|   .    .|. ||| ..  |.          ||  .  . |||||. | . .|.    ||.|| || . |||| 
RGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTD

--GKPLFEAFDEEELMCLMISMLGIPPKSILKTAKRAKYYFDENFELLDTMEINETSLKEKTNISDPYLLQLISGCLRWDPKERFSAEDIIKHNYF
  .||||    | . ... . ..| |  ..    .   .|                              .|....|  ||| |.|||.  .| ||
VTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 88273.m00404.AA STE 190-418 21 1.3e-37 130.46 In-house 91-359 (359) Show / Hide 
Range on Protein: 190-418
Range on HMM: 91-359/359
Sequence Identity: 21% (65 aa)

HIIRYKDSFIFRG-------YFCIVMELAS-INIYSLICS--QPFKRLQ----------ASTYQMVARQTAEA-LDFMHKNNVIHSDIKPENILFTNVRR
.|..| ....  |       . .|.||. .   . ..| .   ..|.|.           |    ..||. .. |.. |....|| |||| |||.     
NIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----

TSIKLIDFGCSC-------------------TEGNTLYTYIQSRFYRAPEVVLE------NEYDSKIDIWSYGCLLCEMFTGKPLFEAFDEEELMCLMIS
  .||.|||..                    | .   .| . .  . ||||..       ..|| | |||| ||...|| |||| .  .   . | ... 
--VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPF

M-----LGIPPKSILKTAKRAKYYFDENFELLDTMEINETSLKEKTNISD------------------PYLLQLISGCLRWDPKERFSAEDIIK--HNYF
.                           ||.|  . .|... . ....|.                  | . . |. ||. ||..| .|.. .|  |  .
NYHMQQQ---------------------FEQL--CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 88273.m00404.AA CLK 129-265 28 4.1e-28 80.8 In-house 1-149 (350) Show / Hide 
Range on Protein: 129-265
Range on HMM: 1-149/350
Sequence Identity: 28% (42 aa)

FQMISILGEGSSGFVIKCHDHKL-NEDVAIKALRDTRKTHDHVLLEKA-YLTTLQQN-GGPDKFH--IIRYKDSFIF-RGYFCIVMELASINIYSLICSQ
.  .. ||||  | | .| |||  .  ||.|  |   |  .   .|    . .....     |.   ...  |.| .  | .|||.||   .||....| 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

P------FKRLQASTYQMVARQTAEALDFMHKNNVIHSDIKPENILFTN
       ..... .. .  |.|  ||. |.|..  .| | |||||.|..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVD
Kinase 88273.m00404.AA PRP4 242-370 36 4.4e-27 96.18 In-house 118-246 (320) Show / Hide 
Range on Protein: 242-370
Range on HMM: 118-246/320
Sequence Identity: 36% (48 aa)

ALDFMHKNNVIHSDIKPENILFTNVRRTSIKLIDFGC-SCTEGNTLYTYIQSRFYRAPEVVLENEYDSKIDIWSYGCLLCEMFTGKPLFEAFDEEELMCL
||  . |.| .| |||| |||    . | .|..|||  |  . | .  | .||||||||...  .||  ||.|| || | |..||| .|      . . |
ALKHLKKCNILHADIKPDNILVNESKNT-LKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNHMLKL

MISMLGIPPKSILKTAKRAKYYFDENFELL
.  . |  |. ...  .    .||.|. ..
FMDYKGKMPNKMIRKGQFKDNHFDQNCNFM
Kinase 88273.m00404.AA CLK 269-418 32 2.3e-22 63.24 In-house 184-350 (350) Show / Hide 
Range on Protein: 269-418
Range on HMM: 184-350/350
Sequence Identity: 32% (55 aa)

TSIKLIDFGCSCT----EGNTLYTYIQSRFYRAPEVVLENEYDSKIDIWSYGCLLCEMFTGKPLFEAFDEEELMCLMISMLG--IPPKSILKTA--KRAK
| |..|||| | |    .    .| ...| ||||||.|.  .  . |.|| || | |  ||  ||   |. | . .|   .|  ||   | .|   |  .
THICVIDFG-SATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQ

YYFDENFELLDTMEINETS-------LKEKTNISDP---YLLQLISGCLRWDPKERFSAEDIIKHNYF
 || .| .. | .   . .       ||.   . ||    |  ||. .|  ||  | .. |. .| .|
KYFYHNRLDWDWHNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 88273.m00404.AA TyrKc 129-418 17 2.7e-11 -40.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 129-418
Range on HMM: 1-280/280
Sequence Identity: 17% (59 aa)

FQMISILGEGSSGFVIKCHDHKLNEDVAIKALRDTRKTHDHVLLEKAYLTTL--QQNGGPDKFHIIRYKDSFIFR-------GYFCIVMELAS-------
 ... .||||  | | |..     ..||.| |..    .   . |   .. |  .        .|.|     .         .  .||||...       
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

--INIYSLICSQPFKRLQASTYQMVARQTAEALDFMHKNNVIHSDIKPENILFTNVRRTSIKLIDFGCSCTEGNT-------LYTYI----QSR-----F
   .            |. ..    . | |.  .. |..|.|| |.   |.| .. .   .|  ||| |   ..         |       ...      
LRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

YRAPEVVLENEYDSKIDIWSYGCLLCEMFT-GKPLFEA-----FDEEELMCLMISM--LGIPPK----SILKTAKRAKYYFDENFELLDTMEINETSLKE
  |||.  .... .| |.||.| .. |.|| |..  .       . .|.. .  .   . .||     |                           .   
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------F---

KTNISDPYLLQLISGCLRWDPKERFSAEDIIKHNYF
   .  . . |... | . ||..| . ..|  | .|
--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 88273.m00404.AA PRP4 129-214 31 1.9e-10 34.57 In-house 1-89 (320) Show / Hide 
Range on Protein: 129-214
Range on HMM: 1-89/320
Sequence Identity: 31% (28 aa)

FQMISILGEGSSGFVIKCH-DHKLNEDVAIKALRDTRKTHDHVLLEKAYLTTLQQN--GGPDKFHIIRYKDSFIFRGYFCIVMELASIN
.. ..  |.|  . |..|    . ||.|||| .|     |.  | |. .|  |  .     ||||..| ...| .|   |.| |  | |
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMN
Kinase 88273.m00404.AA CDK 129-161 28 5e-07 18.36 In-house 1-38 (284) Show / Hide 
Range on Protein: 129-161
Range on HMM: 1-38/284
Sequence Identity: 28% (11 aa)

FQMISILGEGSSGFVIKCHDHK-----LNEDVAIKALR
....  .|||. | | |. |..      .. ||.| .|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIR
Kinase 88273.m00404.AA Pkinase_Tyr 297-324 42 4.1e-05 17.96 Pfam 182-209 (270) Show / Hide 
Range on Protein: 297-324
Range on HMM: 182-209/270
Sequence Identity: 42% (12 aa)

APEVVLENEYDSKIDIWSYGCLLCEMFT
|||.  .... .| |.||.| |. |.||
APECINYGKFTTKSDVWSFGVLMWEIFT
Kinase 88273.m00404.AA STE 129-158 26 7.2e-05 13.27 In-house 1-45 (359) Show / Hide 
Range on Protein: 129-158
Range on HMM: 1-45/359
Sequence Identity: 26% (12 aa)

FQMISILGEGSSGFVIKCHDH------KLNED---------VAIK
.. |...|.|..| | |. .|      | .|          .|||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIK
Kinase 88273.m00404.AA DYRK1 394-418 36 0.002046 7.29 In-house 297-321 (321) Show / Hide 
Range on Protein: 394-418
Range on HMM: 297-321/321
Sequence Identity: 36% (9 aa)

LISGCLRWDPKERFSAEDIIKHNYF
||   |..|||.| .  ....|..|
LIKRMLQYDPKQRITPYYALQHSFF
Kinase 88273.m00404.AA PRP4 394-418 36 0.002831 7.94 In-house 296-320 (320) Show / Hide 
Range on Protein: 394-418
Range on HMM: 296-320/320
Sequence Identity: 36% (9 aa)

LISGCLRWDPKERFSAEDIIKHNYF
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LLDKCLMLDPKKRITCNEALKHPFI
Kinase 88273.m00404.AA Pkinase_Tyr 129-163 28 1.095207 2.95 Pfam 1-39 (270) Show / Hide 
Range on Protein: 129-163
Range on HMM: 1-39/270
Sequence Identity: 28% (11 aa)

FQMISILGEGSSGFVIKCHDH----KLNEDVAIKALRDT
 ...  ||||. | | |.. .    . . .||.| |...
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG