Gene 81869.m00190 (T.vaginalis)
81869.m00190
Species: T.vaginalis
Alias: TvagK0814, 81869.m00190
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 81869.m00190.AA | Protein | None | 734 | None | Fasta, JSON |
| 81869.m00190.kin_dom | Protein Kinase Domain | None | 285 | None | Fasta, JSON |
Protein domains of 81869.m00190.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3_PI4_kinase | 81869.m00190.AA | PI3_PI4_kinase | 489-682 | 19 | 2e-45 | 162.05 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 489-682
Range on HMM: 1-300/300
Sequence Identity: 19% (59 aa)
VYSAILKYGDDMR--QDALALNTI-----------------------KFIDDHLKGYGLDLC----MSPYKVLPISKVFGMMEFIVGAKAVSKVLEQN--
|..|.|.|||.| ||.. .. | ..... .|. |.|.. | ||...| .. ||.|.. . ....
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV
------------------------------------------NDSISEFWDKSEGD---M--PRQRFIKSSAAYSVVSYVLGVGDRHLDNLLV---SKKG
... .||.... . .|..|..| | ..||.|.||.||||.||..| ..|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG
NFLHVDFGYMFG-----IDPKFVPVTVRVVE------QMTNAM------GPDGTNEFLRLCSV-VFVAVRHIADELCCSL-------AMMMKADLPHLPK
. |.|||..|. ..|. .|. | .| .|| .|.| ...| . . .. |.|. .. . . | ..|... || ...
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
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| PI3Kc | 81869.m00190.AA | PI3Kc | 491-733 | 20 | 3.1e-36 | 127.64 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 491-733
Range on HMM: 1-336/336
Sequence Identity: 20% (70 aa)
SAILKYGDDMRQDALALNTIKFIDDHLKGY----GLDLCMSPYKVLPISKVFGMMEFIVGAKAVSKVL--------------------------------
. |.| |||.|||.... .. ... .. ..||.| |||..|... ||.|.. .. . ...
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
-------------------------------EQNNDSISE-FWDKSEGDM-----PRQRFIKSSAAYSVVSYVLGVGDRHLDNLLVS-KKGNFLHVDFGY
.. ... . ||... ... | .|..| |.|..|.|.||.||||.||... | |. .|.|||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
MFGIDPKFVPVT--------VRVVEQMTNAMG----PDGT-NEFLRLCSVVFVAVRHIADELCCSLAMMMKADL-PHLPKSAAVLSKTMLQKLALD-MSD
.|| .||... . | .| ..|| | | .| ..| .. |.|. .... . ..||... . |.. .. | |.. || .||
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKYLRQRFRLDHLSD
EGAGDLIRQ----EVIDAI-TALRPMFAEYIHRFVQK
| | . | ..| . .. . . . .|.. |
EEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | 81869.m00190.AA | ATR | 574-672 | 33 | 9.8e-15 | 46.22 | In-house | 164-267 (267) | Show / Hide |
Range on Protein: 574-672 Range on HMM: 164-267/267 Sequence Identity: 33% (35 aa) RQRFIKSSAAYSVVSYVLGVGDRHLDNLLVSK-KGNFLHVDFGYMFGIDPKF-VPVTV--RVVEQMTNAMGPDGTNE-FLRLCSVVFVAVRHIADELCCS |. ...| |....| |..| |||| ||.|. | | |||. .|. .| || .| |. . | ..||| .|. | | | |. .|. |.. RENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSV LAMM . WDCF |
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| Kinase | 81869.m00190.AA | PIKK | 574-619 | 38 | 8.1e-12 | 39.64 | In-house | 186-232 (290) | Show / Hide |
Range on Protein: 574-619 Range on HMM: 186-232/290 Sequence Identity: 38% (18 aa) RQRFIKSSAAYSVVSYVLGVGDRHLDNLLVSKK-GNFLHVDFGYMFG |.... | | ..| |.|| ||||..|... . | .|.|||. |. RENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFE |
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| Kinase | 81869.m00190.AA | DNAPK | 574-627 | 40 | 1e-09 | 31.35 | In-house | 187-241 (301) | Show / Hide |
Range on Protein: 574-627 Range on HMM: 187-241/301 Sequence Identity: 40% (22 aa) RQRFIKSSAAYSVVSYVLGVGDRHLDNLLVS-KKGNFLHVDFGYMFGIDPKFVPV | .|| . | . ..||.|||||.| .| | .|||. || | || REHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPV |
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| Kinase | 81869.m00190.AA | FRAP | 574-615 | 39 | 1.2e-07 | 24.38 | In-house | 137-179 (251) | Show / Hide |
Range on Protein: 574-615 Range on HMM: 137-179/251 Sequence Identity: 39% (17 aa) RQRFIKSSAAYSVVSYVLGVGDRHLDNLLVSKK-GNFLHVDFG | . .| | |.. |.|| ||||. |.. . | .|.||| RTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | 81869.m00190.AA | SMG1 | 575-603 | 51 | 1.9e-07 | 20.59 | In-house | 188-216 (242) | Show / Hide |
Range on Protein: 575-603 Range on HMM: 188-216/242 Sequence Identity: 51% (15 aa) QRFIKSSAAYSVVSYVLGVGDRHLDNLLV | . .| | |.| |..|.||||||| |. QSYARSTAVMSMVGYIIGLGDRHLDNVLI |
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| Kinase | 81869.m00190.AA | ATM | 574-618 | 39 | 6e-07 | 17.8 | In-house | 137-182 (304) | Show / Hide |
Range on Protein: 574-618 Range on HMM: 137-182/304 Sequence Identity: 39% (18 aa) RQRFIKSSAAYSVVSYVLGVGDRHLDNLLVSKKG-NFLHVDFGYMF | . .| | |.| |.||.|||| |.|. . |.| | | RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAF |
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