Gene 96732.m00493 (T.vaginalis)
96732.m00493
Species: T.vaginalis
Alias: 96732.m00493, TvagK0888
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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96732.m00493.AA | Protein | None | 300 | None | Fasta, JSON |
96732.m00493.kin_dom | Protein Kinase Domain | None | 242 | None | Fasta, JSON |
Protein domains of 96732.m00493.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 96732.m00493.AA | WEE | 117-291 | 25 | 3.3e-32 | 105.36 | In-house | 84-297 (297) | Show / Hide |
Range on Protein: 117-291 Range on HMM: 84-297/297 Sequence Identity: 25% (56 aa) MELCNNGD--IAAMV---------LEEPYLWLLIHDIGNALNIVHKS-GWMHLDVSPSNILVEGN---------------------LFKLADFGTLIRIG ||.||.| ... . |.|. .| .. || ..|. .| . | .|.|. |.||.. . .|..||| .... MEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMN ----EYESGKEGAGPYCSPETMEFNGTD--GITVEPTTDIFSFGVVLLEASTGYQAPRGGDDRYGQLRNG-------QILLGGDLYNCDCSQELIDLVNA .... || ..|..||. . | . ||||.| ...|. .... |. ||. |.|.| || . ..|||| .|. SNNNNPHQEQEGDSRYMAPEILQ----GYYHYTHLYKADIFSLGITIYELACNMDLPKNGDWWH-QIRQGDLSFDKNQIPF--PEFDNIISQELKQLIKW MISRDPADRPTAADLANHPRA |. .|| |||...| .|| MMHPDPEQRPTCQQLLQHPVL |
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Kinase | 96732.m00493.AA | Ciliate-E2 | 57-289 | 17 | 9.1e-16 | 50.59 | In-house | 11-363 (365) | Show / Hide |
Range on Protein: 57-289 Range on HMM: 11-363/365 Sequence Identity: 17% (66 aa) GNSSVYKATSITTNEEWALK----------------------VSKHKSRIVEEFQKRNYLE------------------NSKYLVKSYEIYD--KPNFAM . .||||.. . .... |.| ...|. | . .|. . . |.....| || . . | NFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIY LKMELCNNGDIAAMVLEE------------PYLWLLIHDI------GN-------------ALNIVHKSG-WMHLDVSPSNILVEGNLFKLADFGTLIRI | ||.|. || . .. . | .| |. ||. |. . .| | |.|||. |..|||. .. LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKY G-------------EYESGKE----------------------GAGPYCSPETMEFNGTD----GITVEPTTDIFSFGVVLLEASTGYQAPRGGDDRYGQ .| | | .| .|| . . | . ||.|.||.| | .|. DDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------- LRNGQILLGGDLY-NCD------------------CSQELIDLVNA----MISRDPADRPT-AADLANHP |. . ... .| .||| .|| . |. .|| |.| . .. ||| ---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHP |
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S_TKc | 96732.m00493.AA | S_TKc | 47-291 | 21 | 1.3e-15 | 51.81 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 47-291 Range on HMM: 1-231/231 Sequence Identity: 21% (57 aa) IDPFSPIRSTGNSSVYKATSITTNEEWALKVSKHKSRIVEEFQKRNYLENSKYLVKSYEIYDKPNFAMLKMELCNN--GDIAA-MV----------LEEP . .| . . ..|||.. . |... |.|. | .| | | . ...|| |.... .. . ||.|.. || .. . | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE- YLWLLIHDIGNALNIVHKSGWMHLDVSPSNILVEGNLFKLADFGTLIRIGEYESGKEGAGPYCSPETMEFNGTDGITVEP-TTDIFSFGVVLLEASTGYQ . ... | .||. |. | .| |. |.|||. |..||| .. . | |..|| . . |. |.|..| | .|| HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYEMLCGYP APRGGDDRYGQLRNGQILLGGDLYNCDCSQELIDLVNAMISRDPADRPTAADLAN-------HPRA . . . ... |.|..|... . .||..|||| .. . || PFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 96732.m00493.AA | Pkinase | 59-289 | 19 | 2.3e-15 | 55.43 | Pfam | 13-291 (293) | Show / Hide |
Range on Protein: 59-289 Range on HMM: 13-291/293 Sequence Identity: 19% (57 aa) SSVYKATSITTNEEWALKVSKHKSRIVEEFQKR---------NYLENSKYLVKSYEIYDKPNFAMLKMELCNNG----DIA-------AMVL--EEPYLW ..|||.. . |....|.|. | ... .. | . . | |... |. |... .. . ||.|..| | . .. .| . GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECK LLIHDIGNALNIVHKSGWMHLDVSPSNILVE--GNL---FKLADFGT-----LIRIGEYESGKEGAGPYCSPETMEFNGTDGITVEPTTDIFSFGVVLLE . | .|. |. | .| |. |.|||. |.. .|..||| . . . . . | .|..|| .| | |..|.|..| | FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF-CGTPWYMAPEVIR----GGQYYGPKVDMWSCGCILYE ASTGYQAPRGG----DDRYGQLRNGQILLGGDLYNCDCS---------------------QELIDLVNAMISRDPADRPTAADLANHP .|. .| . . . . .|. . .... . .|..|... .. .||..||||... .|| MLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP |
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Kinase | 96732.m00493.AA | Ciliate-E2-Unclassified | 57-289 | 16 | 9.8e-13 | 40.52 | In-house | 11-350 (352) | Show / Hide |
Range on Protein: 57-289 Range on HMM: 11-350/352 Sequence Identity: 16% (57 aa) GNSSVYKATSITTNEEWALKVSKHKSRIVEEFQKRNY---------LENSK---------------------YLVKSYEIYDKPNFAMLKMELCNNGDIA |...|||. . .. . . . ..|..|. |..| ..| | ..|| ... . . . ||.|..|| GFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLW AMVL---------------------EEPYLWL------LIHDIGNALNIVHKSG-WMHLDVSPSNILV-EGN---LFKLADFGTLIRIGE---------- . . . . .. | ..|. |... | | |.|||. ... |..||| ..... QYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQ ------YESGKEGAGPYC------SPETMEFNGTDGITVEPTTDIFSFGVVLLEASTGYQAPRGGDDRYG---------------QLRNGQIL--LGGDL .. . .| .. .|| .. .. |. . ||.|.||.| | .|| | .. ... ||.. .. . . KMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPK YN-----CDCSQELIDLVN----AMISRDPADRPTAADLANHP .. .. |.| .|..| |. .| |.|. .. ||| FPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHP |
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Kinase | 96732.m00493.AA | TKL | 156-289 | 15 | 2.6e-12 | 40.67 | In-house | 163-364 (364) | Show / Hide |
Range on Protein: 156-289 Range on HMM: 163-364/364 Sequence Identity: 15% (31 aa) HLDVSPSNILVEGNL---------------FKLADFGTLIRIGEYESGKEG-------------------AG---PYCSPETMEFNGT-----------D | | ..|||| |. |..|||. .. . .. . . . ...|| .. .. HRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCK GITVEPTTDIFSFGVVLLEASTGYQAPRGGDDR------------YGQLRNG-QILLGGDLYN-------CDCSQELIDLVNAMISRDPADRPTAADLAN | . . .|..|||.|| | |. . .. . . .. .| . .. | || .....| . || .||.. .. GFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILK HP . RL |
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Kinase | 96732.m00493.AA | Ciliate-E1 | 53-218 | 14 | 1.6e-10 | 30.92 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 53-218 Range on HMM: 1-202/202 Sequence Identity: 14% (30 aa) IRSTGNSSVYKATSITTN-EEWALKVSKHKSRIV---------EEFQKRNYLENSKYLVKSYEIYD-KPN-FAMLKMELCNNGDIAAMV----------- | . . | |.|| .. .| .. |.|. . . .. |... . ... .|... ..... . | . ....|.|. . . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC ---LEEPYLWL---LIHDIGNALNIVHKSGWMHLDVSPSNILV--EGNLFKLADFGTL---IRIGEYESGKEGAGPYCSPETMEF----NGTDGITVEPT . . . .| .. .|...| . .|.| |.|||. . . ....|||. . .... ..| | .|. . . . ... QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK TDIF .||. SDIY |
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Kinase | 96732.m00493.AA | MOK | 145-177 | 48 | 1.8e-07 | 18.95 | In-house | 112-144 (283) | Show / Hide |
Range on Protein: 145-177 Range on HMM: 112-144/283 Sequence Identity: 48% (16 aa) ALNIVHKSGWMHLDVSPSNILVEGNLFKLADFG .|. .|. | | || | |||. |||||| SLDHMHRNGIFHRDVKPENILIKQDHLKLADFG |
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Kinase | 96732.m00493.AA | KIS | 138-177 | 40 | 4.9e-07 | 16.84 | In-house | 278-319 (473) | Show / Hide |
Range on Protein: 138-177 Range on HMM: 278-319/473 Sequence Identity: 40% (17 aa) LIHDIGNALNIVHKSGWMHLDVSPSNIL--VEGNLFKLADFG .. || .| ||. || | | | ||| . .|. ||| CARDIAECLEFVHHCGWVHADLKPRNILWSAQNECWKIIDFG |
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Kinase | 96732.m00493.AA | TyrKc | 60-292 | 19 | 1e-06 | -115.71 | SMART | 14-280 (280) | Show / Hide |
Range on Protein: 60-292 Range on HMM: 14-280/280 Sequence Identity: 19% (54 aa) SVYKATSITTNEEWALKVSKHKSRIVEEFQKRNYL---E--NSKYLVKSYEIYDKP-------NFAMLKMELCNNGD------IAAMVLEEPYLWLLIHD |||.| . .. | |. |. . .|.| . . . . .|. | . .. |. ||.. .|| | . | .. EVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQ IGNALNIVHKSGWMHLDVSPSNILVEGNL-FKLADFGTLIRIGEY-------ESGKEG---AGP------YCSPETMEFNGTDGITVEPTTDIFSFGVVL | . . |. . | | |.|| |. | .||| |... . . | ..||.. .|. . .|..||||.. IACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGKF-TTKSDVWSFGVCM LEASTGYQAPRGG--------DDRYGQLRNGQILLGGDLYNCD-----CSQELIDLVNAMISRDPADRPTAADLANHPRAI | | | | | .. . ....| . . . |..|. .. .||.|||| ... . . WEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---HECF |
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Kinase | 96732.m00493.AA | CAMK | 260-289 | 43 | 1e-06 | 16.42 | In-house | 394-423 (425) | Show / Hide |
Range on Protein: 260-289 Range on HMM: 394-423/425 Sequence Identity: 43% (13 aa) CSQELIDLVNAMISRDPADRPTAADLANHP .||| .||.. | .|| .|.|... ||| VSQECKDLIRKMLQVDPEKRMTIEQCLNHP |
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Kinase | 96732.m00493.AA | RCK | 258-289 | 40 | 2e-06 | 15.91 | In-house | 265-296 (298) | Show / Hide |
Range on Protein: 258-289 Range on HMM: 265-296/298 Sequence Identity: 40% (13 aa) CDCSQELIDLVNAMISRDPADRPTAADLANHP ..|||..|.|.. | || |.||. . .|| PNCSQDCIELMEKMLQWDPQKRITAQQALQHP |
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Kinase | 96732.m00493.AA | RCK | 145-177 | 34 | 5e-06 | 14.84 | In-house | 117-159 (298) | Show / Hide |
Range on Protein: 145-177 Range on HMM: 117-159/298 Sequence Identity: 34% (15 aa) ALNIVHKSGWMHLDVSPSNILVEG----------NLFKLADFG .|. || | .| |..| ||.. | .. |.|||| GLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFG |
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Kinase | 96732.m00493.AA | STE | 256-291 | 36 | 6e-06 | 17.22 | In-house | 322-359 (359) | Show / Hide |
Range on Protein: 256-291 Range on HMM: 322-359/359 Sequence Identity: 36% (14 aa) YNCDCSQELIDLVNAMISRDPADRPTAADLAN--HPRA | .|.|..| .| .|| .|||| .| . || YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | 96732.m00493.AA | STE | 57-178 | 18 | 0.000174 | 11.9 | In-house | 10-193 (359) | Show / Hide |
Range on Protein: 57-178 Range on HMM: 10-193/359 Sequence Identity: 18% (34 aa) GNSS-VYKATSIT---------------TNEEWALKVSK----------------------HKSRIVEEFQKRNYLEN-SKYLVKSYEIYDKP------- |.. |||| . |.| | |. . . .| .| . . . . ... || | | | GAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKND NFAMLKMELCNNGDIAAMVLE-------------------EPYLWLLIHDIGNA-LNIVHKSGWMHLDVSPSNILVEGNLFKLADFGT . . ||....| . .. . |. . ...| . |. |. . .| |. |.|||. ||.|||. DELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGV |
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Kinase | 96732.m00493.AA | KIS | 264-291 | 35 | 0.002204 | 5.14 | In-house | 446-473 (473) | Show / Hide |
Range on Protein: 264-291 Range on HMM: 446-473/473 Sequence Identity: 35% (10 aa) LIDLVNAMISRDPADRPTAADLANHPRA | ||. | |.| |. |. || LRDLIKSMLHCDIARRIPAEMILCHPFF |
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Kinase | 96732.m00493.AA | CAMK | 52-177 | 13 | 0.002439 | 5.82 | In-house | 1-241 (425) | Show / Hide |
Range on Protein: 52-177 Range on HMM: 1-241/425 Sequence Identity: 13% (33 aa) PIRSTGNSSVYKATSITTN------------EEWALKV---------------------------------SKHKSRIVEEFQKRNYLE------NSKYL . . . . |.... . |. ...| |. | . .. | . . | . . . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKSYEIYDKPNF-------------------AMLKM---ELCNNG----D-------------------IAAMV--LEEPYLWLLIHDIGNALNIVHKSG .| ||.|. |.. . | |.| .| | |. . ..| ... | |.. |. . IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN WMHLDVSPSNILVEGN------------------LFKLADFG .|.| | |||. | |..||| IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFG |
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Kinase | 96732.m00493.AA | MOK | 261-291 | 25 | 0.035549 | 2.04 | In-house | 253-283 (283) | Show / Hide |
Range on Protein: 261-291 Range on HMM: 253-283/283 Sequence Identity: 25% (8 aa) SQELIDLVNAMISRDPADRPTAADLANHPRA .. ......|.. || .| || || TKQCLEIMHKMCTYDPDERITAHQVIQHPYF |