96732.m00493

Species: T.vaginalis
Alias: 96732.m00493, TvagK0888
External Links:
Annotation:

Classification

Group: Other
Family: WEE
Subfamily: WEE-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
96732.m00493.AA Protein None 300 None Fasta, JSON
96732.m00493.kin_dom Protein Kinase Domain None 242 None Fasta, JSON

Protein domain

Protein domains of 96732.m00493.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 96732.m00493.AA WEE 117-291 25 3.3e-32 105.36 In-house 84-297 (297) Show / Hide
Range on Protein: 117-291
Range on HMM: 84-297/297
Sequence Identity: 25% (56 aa)

MELCNNGD--IAAMV---------LEEPYLWLLIHDIGNALNIVHKS-GWMHLDVSPSNILVEGN---------------------LFKLADFGTLIRIG
||.||.|   ... .         |.|. .| .. || ..|. .| . | .|.|. |.||..  .                      .|..||| .... 
MEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMN

----EYESGKEGAGPYCSPETMEFNGTD--GITVEPTTDIFSFGVVLLEASTGYQAPRGGDDRYGQLRNG-------QILLGGDLYNCDCSQELIDLVNA
    ....  || ..|..||.      .    |  .  ||||.| ...|. .... |. ||.   |.|.|       ||    .    ..|||| .|.  
SNNNNPHQEQEGDSRYMAPEILQ----GYYHYTHLYKADIFSLGITIYELACNMDLPKNGDWWH-QIRQGDLSFDKNQIPF--PEFDNIISQELKQLIKW

MISRDPADRPTAADLANHPRA
|. .||  |||...| .||  
MMHPDPEQRPTCQQLLQHPVL

Kinase 96732.m00493.AA Ciliate-E2 57-289 17 9.1e-16 50.59 In-house 11-363 (365) Show / Hide
Range on Protein: 57-289
Range on HMM: 11-363/365
Sequence Identity: 17% (66 aa)

GNSSVYKATSITTNEEWALK----------------------VSKHKSRIVEEFQKRNYLE------------------NSKYLVKSYEIYD--KPNFAM
. .||||.. . .... |.|                       ...|. | . .|. . .                   |.....| || .   . |   
NFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIY

LKMELCNNGDIAAMVLEE------------PYLWLLIHDI------GN-------------ALNIVHKSG-WMHLDVSPSNILVEGNLFKLADFGTLIRI
| ||.|. ||      .             .. .  | .|      |.             ||.  |. .  .| |  |.|||.     |..|||.  ..
LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKY

G-------------EYESGKE----------------------GAGPYCSPETMEFNGTD----GITVEPTTDIFSFGVVLLEASTGYQAPRGGDDRYGQ
              .|   |                       |  .| .||  .  . |    .       ||.|.||.| |  .|.            
DDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------

LRNGQILLGGDLY-NCD------------------CSQELIDLVNA----MISRDPADRPT-AADLANHP
    |. . ...  .|                   .||| .|| .     |. .||  |.| . .. |||
---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHP

S_TKc 96732.m00493.AA S_TKc 47-291 21 1.3e-15 51.81 SMART 1-231 (231) Show / Hide
Range on Protein: 47-291
Range on HMM: 1-231/231
Sequence Identity: 21% (57 aa)

IDPFSPIRSTGNSSVYKATSITTNEEWALKVSKHKSRIVEEFQKRNYLENSKYLVKSYEIYDKPNFAMLKMELCNN--GDIAA-MV----------LEEP
 .   .| . . ..|||.. . |... |.|. |   .|  | |      . ...|| |....  ..  . ||.|..  ||    ..          . | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

YLWLLIHDIGNALNIVHKSGWMHLDVSPSNILVEGNLFKLADFGTLIRIGEYESGKEGAGPYCSPETMEFNGTDGITVEP-TTDIFSFGVVLLEASTGYQ
  . ... | .||.  |. | .| |. |.|||.     |..|||   ..    .   |   |..|| .           .   |. |.|..| |  .|| 
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYEMLCGYP

APRGGDDRYGQLRNGQILLGGDLYNCDCSQELIDLVNAMISRDPADRPTAADLAN-------HPRA
  .   . .  ...              |.|..|... .  .||..|||| .. .       ||  
PFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 96732.m00493.AA Pkinase 59-289 19 2.3e-15 55.43 Pfam 13-291 (293) Show / Hide
Range on Protein: 59-289
Range on HMM: 13-291/293
Sequence Identity: 19% (57 aa)

SSVYKATSITTNEEWALKVSKHKSRIVEEFQKR---------NYLENSKYLVKSYEIYDKPNFAMLKMELCNNG----DIA-------AMVL--EEPYLW
..|||.. . |....|.|. | ...  .. | .         . | |... |. |...  ..   . ||.|..|    | .         ..  .|  . 
GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECK

LLIHDIGNALNIVHKSGWMHLDVSPSNILVE--GNL---FKLADFGT-----LIRIGEYESGKEGAGPYCSPETMEFNGTDGITVEPTTDIFSFGVVLLE
  .  |  .|.  |. | .| |. |.|||.   |..   .|..|||      . . . . .   |  .|..||       .|    |  |..|.|..| |
FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF-CGTPWYMAPEVIR----GGQYYGPKVDMWSCGCILYE

ASTGYQAPRGG----DDRYGQLRNGQILLGGDLYNCDCS---------------------QELIDLVNAMISRDPADRPTAADLANHP
  .|.   .|     . .  . .  .|. .   .... .                     .|..|... .. .||..||||... .||
MLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

Kinase 96732.m00493.AA Ciliate-E2-Unclassified 57-289 16 9.8e-13 40.52 In-house 11-350 (352) Show / Hide
Range on Protein: 57-289
Range on HMM: 11-350/352
Sequence Identity: 16% (57 aa)

GNSSVYKATSITTNEEWALKVSKHKSRIVEEFQKRNY---------LENSK---------------------YLVKSYEIYDKPNFAMLKMELCNNGDIA
|...|||.  . .. . . .  ..|..|.   |..|          ..| |                     ..|| ...  . .   . ||.|..||  
GFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLW

AMVL---------------------EEPYLWL------LIHDIGNALNIVHKSG-WMHLDVSPSNILV-EGN---LFKLADFGTLIRIGE----------
 .                        . .  .      ..  | ..|.  |...   | |  |.|||. ...     |..|||  .....          
QYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQ

------YESGKEGAGPYC------SPETMEFNGTDGITVEPTTDIFSFGVVLLEASTGYQAPRGGDDRYG---------------QLRNGQIL--LGGDL
      ..  .  .| ..      .|| .. .. |. .     ||.|.||.| |  .||  | .. ...                ||.. ..   .  . 
KMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPK

YN-----CDCSQELIDLVN----AMISRDPADRPTAADLANHP
..     .. |.| .|..|     |.  .|  |.|. .. |||
FPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHP

Kinase 96732.m00493.AA TKL 156-289 15 2.6e-12 40.67 In-house 163-364 (364) Show / Hide
Range on Protein: 156-289
Range on HMM: 163-364/364
Sequence Identity: 15% (31 aa)

HLDVSPSNILVEGNL---------------FKLADFGTLIRIGEYESGKEG-------------------AG---PYCSPETMEFNGT-----------D
| |  ..||||  |.                |..|||.  .. . .. . .                    .    ...|| .. ..             
HRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCK

GITVEPTTDIFSFGVVLLEASTGYQAPRGGDDR------------YGQLRNG-QILLGGDLYN-------CDCSQELIDLVNAMISRDPADRPTAADLAN
| .  . .|..|||.|| |  |. .  .. . .            ..   .| . ..     |        || .....|     . || .||.. ..  
GFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILK

HP
. 
RL

Kinase 96732.m00493.AA Ciliate-E1 53-218 14 1.6e-10 30.92 In-house 1-202 (202) Show / Hide
Range on Protein: 53-218
Range on HMM: 1-202/202
Sequence Identity: 14% (30 aa)

IRSTGNSSVYKATSITTN-EEWALKVSKHKSRIV---------EEFQKRNYLENSKYLVKSYEIYD-KPN-FAMLKMELCNNGDIAAMV-----------
| . . | |.|| .. .| .. |.|. . .  ..         |...  . ... .|... ..... . | . ....|.|.  .   .            
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

---LEEPYLWL---LIHDIGNALNIVHKSGWMHLDVSPSNILV--EGNLFKLADFGTL---IRIGEYESGKEGAGPYCSPETMEF----NGTDGITVEPT
     . . .    .| ..  .|...|  . .|.|  |.|||.  . . ....|||.    .   .... ..|   | .|.   .    .  .  ...  
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK

TDIF
.||.
SDIY

Kinase 96732.m00493.AA MOK 145-177 48 1.8e-07 18.95 In-house 112-144 (283) Show / Hide
Range on Protein: 145-177
Range on HMM: 112-144/283
Sequence Identity: 48% (16 aa)

ALNIVHKSGWMHLDVSPSNILVEGNLFKLADFG
.|. .|. |  | || | |||.     ||||||
SLDHMHRNGIFHRDVKPENILIKQDHLKLADFG

Kinase 96732.m00493.AA KIS 138-177 40 4.9e-07 16.84 In-house 278-319 (473) Show / Hide
Range on Protein: 138-177
Range on HMM: 278-319/473
Sequence Identity: 40% (17 aa)

LIHDIGNALNIVHKSGWMHLDVSPSNIL--VEGNLFKLADFG
.. ||  .|  ||. || | |  | |||   .   .|. |||
CARDIAECLEFVHHCGWVHADLKPRNILWSAQNECWKIIDFG

Kinase 96732.m00493.AA TyrKc 60-292 19 1e-06 -115.71 SMART 14-280 (280) Show / Hide
Range on Protein: 60-292
Range on HMM: 14-280/280
Sequence Identity: 19% (54 aa)

SVYKATSITTNEEWALKVSKHKSRIVEEFQKRNYL---E--NSKYLVKSYEIYDKP-------NFAMLKMELCNNGD------IAAMVLEEPYLWLLIHD
 |||.| .   .. | |. |. .  .|.| .   .      . . .|. | .  ..          |. ||.. .||           |  . |    ..
EVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQ

IGNALNIVHKSGWMHLDVSPSNILVEGNL-FKLADFGTLIRIGEY-------ESGKEG---AGP------YCSPETMEFNGTDGITVEPTTDIFSFGVVL
| .  .  |. .  | |    |.||  |.  | .|||    |...       .  .      |        ..||..     .|.   . .|..||||..
IACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGKF-TTKSDVWSFGVCM

LEASTGYQAPRGG--------DDRYGQLRNGQILLGGDLYNCD-----CSQELIDLVNAMISRDPADRPTAADLANHPRAI
 |  |  | |  |        .. . ....|  .   . .        |..|. ..      .||.|||| ...    . .
WEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---HECF

Kinase 96732.m00493.AA CAMK 260-289 43 1e-06 16.42 In-house 394-423 (425) Show / Hide
Range on Protein: 260-289
Range on HMM: 394-423/425
Sequence Identity: 43% (13 aa)

CSQELIDLVNAMISRDPADRPTAADLANHP
.||| .||.. |  .|| .|.|...  |||
VSQECKDLIRKMLQVDPEKRMTIEQCLNHP

Kinase 96732.m00493.AA RCK 258-289 40 2e-06 15.91 In-house 265-296 (298) Show / Hide
Range on Protein: 258-289
Range on HMM: 265-296/298
Sequence Identity: 40% (13 aa)

CDCSQELIDLVNAMISRDPADRPTAADLANHP
..|||..|.|.. |   ||  |.||. . .||
PNCSQDCIELMEKMLQWDPQKRITAQQALQHP

Kinase 96732.m00493.AA RCK 145-177 34 5e-06 14.84 In-house 117-159 (298) Show / Hide
Range on Protein: 145-177
Range on HMM: 117-159/298
Sequence Identity: 34% (15 aa)

ALNIVHKSGWMHLDVSPSNILVEG----------NLFKLADFG
.|.  || | .| |..| ||.. |          .. |.||||
GLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFG

Kinase 96732.m00493.AA STE 256-291 36 6e-06 17.22 In-house 322-359 (359) Show / Hide
Range on Protein: 256-291
Range on HMM: 322-359/359
Sequence Identity: 36% (14 aa)

YNCDCSQELIDLVNAMISRDPADRPTAADLAN--HPRA
|   .|.|..| .|    .|| .|||| .| .  ||  
YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase 96732.m00493.AA STE 57-178 18 0.000174 11.9 In-house 10-193 (359) Show / Hide
Range on Protein: 57-178
Range on HMM: 10-193/359
Sequence Identity: 18% (34 aa)

GNSS-VYKATSIT---------------TNEEWALKVSK----------------------HKSRIVEEFQKRNYLEN-SKYLVKSYEIYDKP-------
|..  ||||  .                |.|  | |. .                       . .| .| .  . . . ... || |  | |        
GAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKND

NFAMLKMELCNNGDIAAMVLE-------------------EPYLWLLIHDIGNA-LNIVHKSGWMHLDVSPSNILVEGNLFKLADFGT
.   . ||....| .  .. .                   |. .   ...|  . |.  |. . .| |. |.|||.     ||.|||.
DELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGV

Kinase 96732.m00493.AA KIS 264-291 35 0.002204 5.14 In-house 446-473 (473) Show / Hide
Range on Protein: 264-291
Range on HMM: 446-473/473
Sequence Identity: 35% (10 aa)

LIDLVNAMISRDPADRPTAADLANHPRA
| ||.  |   |.| |. |.    ||  
LRDLIKSMLHCDIARRIPAEMILCHPFF

Kinase 96732.m00493.AA CAMK 52-177 13 0.002439 5.82 In-house 1-241 (425) Show / Hide
Range on Protein: 52-177
Range on HMM: 1-241/425
Sequence Identity: 13% (33 aa)

PIRSTGNSSVYKATSITTN------------EEWALKV---------------------------------SKHKSRIVEEFQKRNYLE------NSKYL
 . . . . |.... . |.            ...| |.                                  | . ..  | .  . |       . . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKSYEIYDKPNF-------------------AMLKM---ELCNNG----D-------------------IAAMV--LEEPYLWLLIHDIGNALNIVHKSG
.| ||.|. |..                     . |   |.| .|    |                   |. .   ..|     ... |  |..  |. .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

WMHLDVSPSNILVEGN------------------LFKLADFG
 .|.|  | |||.  |                    |..|||
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFG

Kinase 96732.m00493.AA MOK 261-291 25 0.035549 2.04 In-house 253-283 (283) Show / Hide
Range on Protein: 261-291
Range on HMM: 253-283/283
Sequence Identity: 25% (8 aa)

SQELIDLVNAMISRDPADRPTAADLANHPRA
..  ......|.. || .| ||     ||  
TKQCLEIMHKMCTYDPDERITAHQVIQHPYF