Gene TVAG_166980 (T.vaginalis)

TVAG_166980

Species: T.vaginalis
Alias: TVAG_166980, TvagK1052
External Links:
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
TVAG_166980.AA Protein None 850 None Fasta, JSON
TVAG_166980.kin_dom Protein Kinase Domain None 282 None Fasta, JSON

Protein domain

Protein domains of TVAG_166980.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TVAG_166980.AA GCN2 362-446 36 2.3e-11 35.63 In-house 281-367 (511) Show / Hide 
Range on Protein: 362-446
Range on HMM: 281-367/511
Sequence Identity: 36% (32 aa)

YFFIQTEYCHNRSLTDILQDM-SYPDIN-KSEITRQILEILHYIHSNGIVHNNLSTDCIYVDDNYIIKLGGFGLNTIVNPDSAVNTK
| .|| ||| ...| ... .   ..|   . ...||||| | ||||.|..|  |.   |..| .  .| | ||| |   . | .|.|
YLYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRK
Kinase TVAG_166980.AA Ciliate-E6 362-439 25 4.6e-11 31.78 In-house 24-105 (154) Show / Hide 
Range on Protein: 362-439
Range on HMM: 24-105/154
Sequence Identity: 25% (21 aa)

YFFIQTEYCHNRSLTDILQDMSYPDINKSE-----ITRQILEILHYIHSNGIVHNNLSTDCIYVDDNYIIKLGGFGLNTIVNP
|.||. | |  ..| | ..  .. .. ..      .. |..... |.||...|. |..   |..| |. ||.  ||.   ..|
YYFIVMERC-EMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQQCIIP
Kinase TVAG_166980.AA PEK 348-433 23 1.7e-10 32.01 In-house 331-478 (655) Show / Hide 
Range on Protein: 348-433
Range on HMM: 331-478/655
Sequence Identity: 23% (35 aa)

EEEEENPENPELT------------TYFFIQTEYCHNRSLTDILQD---------------------------------------------MSYPDINKS
||.|.| .| . .             |..||.|||.  .| |....                                             |. .     
EEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCW

EITRQILEILHYIHSNGIVHNNLSTDCIYVDDNYI-----IKLGGFGL
.|.||||| | ||||.|..|  |    |..|..       .| | |||
RIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGL
Kinase TVAG_166980.AA PEK-Unclassified 391-435 42 1.4e-09 28.58 In-house 617-663 (835) Show / Hide 
Range on Protein: 391-435
Range on HMM: 617-663/835
Sequence Identity: 42% (20 aa)

EITRQILEILHYIHSNG-IVHNNLSTDCIYVDDN-YIIKLGGFGLNT
||||||.  | .||. . .||  .  . |.| .| . || | ||| .
EITRQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVK
Kinase TVAG_166980.AA Ciliate-E2 360-440 20 3.5e-09 27.64 In-house 106-209 (365) Show / Hide 
Range on Protein: 360-440
Range on HMM: 106-209/365
Sequence Identity: 20% (22 aa)

TTYFFIQTEYCHNRSLTDILQDM------------SYPDINKSEITRQILE---------------ILHYIHSNG-IVHNNLSTDCIYVDDNYIIKLGGF
...... .|||   .| |.....            .. .   ..|..|||.                |.|.||.. |.| ..  . | .     ||.  |
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDF

GLNTIVNPD
|| .....|
GLSKKYDDD
Kinase TVAG_166980.AA STE 271-410 17 5.5e-09 28.0 In-house 66-175 (359) Show / Hide 
Range on Protein: 271-410
Range on HMM: 66-175/359
Sequence Identity: 17% (28 aa)

IKKPEEEKKIKEVVKALTSLQ--HRNLVRYYNSWVETCDGALAKLINDDFKLVKKNQKRSLTREEAIDFSTITQDYGELEEEEENPENPELTTYFFIQTE
.| .||...|.. .| .  ..  | | |.|| . .  ..                                                  .  .. .|  |
NKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHN------------------------------------------------HKNDDELWICME

YCHNRSLTDILQ-DMSYPDINK--------------SEITRQILEI-LHYIHSNGIVH
|. . ||.||..  .. .. ..              . |.||||.  |.|.||..|.|
YMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIH
S_TKc TVAG_166980.AA S_TKc 242-513 15 9.1e-09 -48.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 242-513
Range on HMM: 1-231/231
Sequence Identity: 15% (48 aa)

FSIIYPFGVGY----IKASNIVDNRVYTVQCMIIKKPEEEKKIKEVVKALTSLQHRNLVRYYNSWVETCDGALAKLINDDFKLVKKNQKRSLTREEAIDF
. |. . | |      |. .. ..|.. . ..                                                    .  . ... ..   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------------------------------------------EHIRREIQILKK---HH

STITQDYGELEEEEENPENPELTTYFFIQTEYCHN--RSLTDILQDMS-------YPDINKSEITRQILEILHYIHSNGIVHNNLSTDCIYVDDNYIIKL
  | . |.  ..           ..... .||| .   .| |.....        .|      ...||.. | |.||.||.|  |  . | .|.   ||.
PNIVKLYDVFQD-----------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKI

GGFGLNTIVNPDSAV-------------NT-KSDMESF---AYILFK---LFYTRSTETTLEDIRLGKLPTDWSFAFPIEAK--IVSLLV-QPNKRPSAL
. ||| ...  .. .             .. |.|. |.    |...    .|.    ..... |.            . |||  |  .|.  |.|||.| 
CDFGLARQL--TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-

DLLQ-------WKII
..||          .
EALQDEWDIKCHPWF
Kinase TVAG_166980.AA Ciliate-E2-Unclassified 360-433 19 9.6e-09 26.48 In-house 93-193 (352) Show / Hide 
Range on Protein: 360-433
Range on HMM: 93-193/352
Sequence Identity: 19% (20 aa)

TTYFFIQTEYCHNRSLTDILQDMS------------------YPDINKS-----EITRQILEILHYIHSNG-IVHNNLSTDCIYVDDNY---IIKLGGFG
. ...| .||| . .| .......                   .. . .      ...|||. | |.|... |.| ..  . | .|.|     ||. .||
KQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFG

L
.
I
Kinase TVAG_166980.AA HRI 446-513 37 1.6e-08 25.3 In-house 540-613 (613) Show / Hide 
Range on Protein: 446-513
Range on HMM: 540-613/613
Sequence Identity: 37% (28 aa)

KSDMESFAYILFKLFYTRSTE----TTLEDIRLGKLPTDWSFAFPIEAKIVSLLVQPN--KRPSALDLLQWKII
|||| |   ||| ||    ||    . |  .| |..|   .   |. || . .| . |  .||||. |||  . 
KSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQIPESLRKRCPVQAKYIQHLTRRNASQRPSAIQLLQSELF
Kinase TVAG_166980.AA GCN2 253-307 36 3.1e-08 24.51 In-house 16-75 (511) Show / Hide 
Range on Protein: 253-307
Range on HMM: 16-75/511
Sequence Identity: 36% (22 aa)

IK-ASNIVDNRVYTVQCMII--KKPEEEKK--IKEVVKALTSLQHRNLVRYYNSWVETCD
.| . | .|.| |..    |  |. . ..|  |.. || | .|.|.. ||||..|.| ||
VKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCD
Kinase TVAG_166980.AA PEK 284-307 50 4.8e-08 23.32 In-house 65-88 (655) Show / Hide 
Range on Protein: 284-307
Range on HMM: 65-88/655
Sequence Identity: 50% (12 aa)

VKALTSLQHRNLVRYYNSWVETCD
||.| .|.|.| |||.|.| |...
VKTLARLNHPNIVRYHNAWIEKPE
Kinase TVAG_166980.AA PEK 284-305 54 6.8e-07 17.74 In-house 56-77 (758) Show / Hide 
Range on Protein: 284-305
Range on HMM: 56-77/758
Sequence Identity: 54% (12 aa)

VKALTSLQHRNLVRYYNSWVET
|..| .| |.| |||.|.| ||
VRTLAMLDHHNIVRYFNAWLET
Kinase TVAG_166980.AA WEE 364-411 34 2e-06 17.42 In-house 81-136 (297) Show / Hide 
Range on Protein: 364-411
Range on HMM: 81-136/297
Sequence Identity: 34% (20 aa)

FIQTEYCHNRS--LTDILQD-------MSYPDINKSEITRQILEILHYIHSN-GIVHN
.||.||| . |  | ...|.       .... | .  | ..|.. ||.|||| |.||.
YIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQ--ILVDICQGLHHIHSNCGMVHM
Kinase TVAG_166980.AA PEK 455-513 26 1.7e-05 14.3 In-house 583-655 (655) Show / Hide 
Range on Protein: 455-513
Range on HMM: 583-655/655
Sequence Identity: 26% (19 aa)

ILFKLFY-TRSTE----TTLEDIRL------GKLP-TDWSFAFPIEAKIVSLLVQ--PNKRPSALDLLQWKII
|.| ..| . .|.    .|| |.|       |..|  ..   .| .|........  | .|||| ..|| . .
IFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase TVAG_166980.AA PEK 467-513 22 2.4e-05 12.48 In-house 710-758 (758) Show / Hide 
Range on Protein: 467-513
Range on HMM: 710-758/758
Sequence Identity: 22% (11 aa)

TTLEDIRLGKLPTDWSFAFPIEAKIVSLL--VQPNKRPSALDLLQWKII
.|. |.| |..| ..    | |.. ....   .|  ||.| ...   . 
RTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNPDERPTADQISMHDFF
Kinase TVAG_166980.AA Pkinase 254-410 14 8.1e-05 18.11 Pfam 17-131 (293) Show / Hide 
Range on Protein: 254-410
Range on HMM: 17-131/293
Sequence Identity: 14% (24 aa)

KASNIVDNRVYTVQCMIIKKPEEEKKIKEV----VKALTSLQHRNLVRYYNSWVETCDGALAKLINDDFKLVKKNQKRSLTREEAIDFSTITQDYGELEE
|. .. ..... | ..  .. ...|..  .    .. . .|.| | ||.| .. .                                             
KCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---------------------------------------------

EEENPENPELTTYFFIQTEYCHNR----SLTDILQ---DMSY--PDINKSEITRQILEILHYIHSNGIVH
           ..  . .||| .     .| |...   . ..  ..     . .|||. | |.||.||.|
----------KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH
Kinase TVAG_166980.AA PEK-Unclassified 277-304 46 0.000158 10.4 In-house 48-74 (835) Show / Hide 
Range on Protein: 277-304
Range on HMM: 48-74/835
Sequence Identity: 46% (13 aa)

EKKIKEVVKALTSLQHRNLVRYYNSWVE
|| |.| | ..  . | | .||| ||.|
EKEIME-VRYMAQVNHPNIIRYYHSWIE
Kinase TVAG_166980.AA TyrKc 274-512 14 0.000159 -149.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 274-512
Range on HMM: 1-280/280
Sequence Identity: 14% (47 aa)

PEEEKKI-----KEVVKALTSLQHRNLVRYYNSWVETCDGALAKLINDDFKLVKKNQKRSLTRE----EAI--DFSTITQDYGELEEEEENPENPELT--
 . .||.      ||.|.  .                      | ...|        .. . ||      .  .   | . ||   ....|         
ITLGKKLGEGAFGEVYKGTWK-----------------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN------FMY

-TYFFIQTEYCHNRSLTDILQDMS--YPDINKSEITRQILEILHYIHSNGIVHNNLSTDCIYVDDNYIIKLGGFGLNTIVNPD------SAVNTK----S
    .| .||. . .| | |..     .   . ..  || .   |.||....|  | .  . |..|...| . |||   .  |      . . .|    .
IEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

DM----------ESFAYILF---------------------KLFYT-----RSTETTLEDIRLG----KLPTDWSFAFP-----IEAKIVSLLVQ-----
            |.. |  |                     .  .       | .  .|... |    . | |     |       ... ..  |     
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY----PMSFVCCPDEMYQIMKQCWHED

PNKRPSALDLLQWKI
|..||.  ..   ..
PEDRPTFSEI-HECF
Kinase TVAG_166980.AA HRI 284-304 57 0.000164 10.81 In-house 49-69 (613) Show / Hide 
Range on Protein: 284-304
Range on HMM: 49-69/613
Sequence Identity: 57% (12 aa)

VKALTSLQHRNLVRYYNSWVE
|| |  ||| | |||  .|.|
VKVLACLQHHNIVRYHQAWIE
Kinase TVAG_166980.AA PEK 362-410 28 0.001531 6.33 In-house 413-465 (758) Show / Hide 
Range on Protein: 362-410
Range on HMM: 413-465/758
Sequence Identity: 28% (15 aa)

YFFIQTEYCHNRSLTDILQDM-SYPDINKSEIT---RQILEILHYIHSNGIVH
| .||...|   .| | . .  .  . .....     ||.| . |||| |. |
YMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIH
Kinase TVAG_166980.AA Ciliate-E2 494-513 23 0.001922 7.66 In-house 345-365 (365) Show / Hide 
Range on Protein: 494-513
Range on HMM: 345-365/365
Sequence Identity: 23% (5 aa)

LLVQPNKRPS-ALDLLQWKII
| ..|.||.. . ..|.....
LQKDPEKRITGWEQILNHPWF
Kinase TVAG_166980.AA WEE 275-305 31 0.004971 6.09 In-house 41-77 (297) Show / Hide 
Range on Protein: 275-305
Range on HMM: 41-77/297
Sequence Identity: 31% (12 aa)

EEEKKIKEVVKALTSLQ-------HRNLVRYYNSWVET
|.. ...| |.|. .|        | . ||||..| |.
ERKRALRE-VYAHMVLGQIMDCDHHPHIVRYYSAWEED
Kinase TVAG_166980.AA STE 498-513 50 0.020198 4.51 In-house 342-359 (359) Show / Hide 
Range on Protein: 498-513
Range on HMM: 342-359/359
Sequence Identity: 50% (9 aa)

PNKRPSALDLLQ--WKII
|||||.| .||.   . |
PNKRPTASQLLKSEHPFI
Kinase TVAG_166980.AA HRI 395-433 37 0.036229 2.36 In-house 441-483 (613) Show / Hide 
Range on Protein: 395-433
Range on HMM: 441-483/613
Sequence Identity: 37% (16 aa)

QILEILHYIHSNGIVHNNLSTDCIYVDDNYI----IKLGGFGL
||.| . |||  .|||  .    |.  |       .| | |||
QIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGL
Kinase TVAG_166980.AA GCN2 498-513 56 0.042481 2.64 In-house 496-511 (511) Show / Hide 
Range on Protein: 498-513
Range on HMM: 496-511/511
Sequence Identity: 56% (9 aa)

PNKRPSALDLLQWKII
|.||||| .||| . .
PQKRPSAQQLLQHEFL
Kinase TVAG_166980.AA WEE 498-513 37 0.057178 2.48 In-house 282-297 (297) Show / Hide 
Range on Protein: 498-513
Range on HMM: 282-297/297
Sequence Identity: 37% (6 aa)

PNKRPSALDLLQWKII
| .||.. .|||  ..
PEQRPTCQQLLQHPVL
Kinase TVAG_166980.AA Ciliate-E2-Unclassified 494-513 30 0.231428 0.51 In-house 333-352 (352) Show / Hide 
Range on Protein: 494-513
Range on HMM: 333-352/352
Sequence Identity: 30% (6 aa)

LLVQPNKRPSALDLLQWKII
| ..||||... ..|.  ..
LKKNPNKRITFEQILNHPWF