Gene 93204.m00229 (T.vaginalis)

93204.m00229

Species: T.vaginalis
Alias: TvagK0838, 93204.m00229
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK8-like

Sequence

Name Sequence Type Origin Length Description Download
93204.m00229.AA Protein None 339 None Fasta, JSON
93204.m00229.kin_dom Protein Kinase Domain None 304 None Fasta, JSON

Protein domain

Protein domains of 93204.m00229.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93204.m00229.AA CMGC 103-309 20 8.7e-67 218.16 In-house 156-513 (513) Show / Hide 
Range on Protein: 103-309
Range on HMM: 156-513/513
Sequence Identity: 20% (73 aa)

KQRTLEHIT------------AKSIL------FQLLLALN--HLHSHG--IIHCDISPANLIIMPRNYE---------------RPGILKLIDFGLSRTD
... |..               |...      .|.| .|.  ..|||.  |||.|. |.|. | ...                   |.||..||||.|  
RPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWY

EWK---------------------GQDKSTIVVTIWYRSPELLLDD---------KKYTVAVDIWAAGCIFAELLTG--------QVIFHSETRSQNSNE
.                       ..  .. ||| |||.||.|| .         ..|| ..|.|..||||||..||        . .|. ..   |   
HPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPN---

FCS--------KQMIAILSIMGNFK---------------AT-------------------------DLPPYATTYMAE---FNNLNRTHFESQFE----
            |.  |  ..|..                                           .... | .|      | . .. .....|     
--DDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPN

----------------KKFA-----------YIDKDARDLLREMLCINPNNRISAYNALRHPYF
                .||.            .|..|.|||  ||...|..||.|  ||.||||
WDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 93204.m00229.AA CDK 113-309 32 9e-60 189.84 In-house 111-284 (284) Show / Hide 
Range on Protein: 113-309
Range on HMM: 111-284/284
Sequence Identity: 32% (67 aa)

KSILFQLLLALNHLHSHGIIHCDISPANLIIMPRNYERPGILKLIDFGLSRTDEW------KGQDKSTIVVTIWYRSPELLLDDKKYT--VAVDIWAAGC
|....||| .|...||..|.| |. |.|. |. .  . .| ||. ||||.|          . .  .  ||| |||.||||| .|.|.   ..|.|..||
KCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGC

IFAELLT---GQVIFHSETRSQNSNEFCSKQMIAILSIMGNFKATDLPPYATTYMAEFNNLNRTHFESQFEKKFAYIDKDARDLLREMLCINPNNRISAY
||||..|   .. .|. ..           |.  |  |.|     . |    | . ..                        |||  ||| .|..|||| 
IFAEMFTDVTRKPLFPGDSE--------IDQLFKIFRICGTPTEDNWP--GVTKLPDY------------------------DLLNKMLCYDPKKRISAE

NALRHPYF
 || ||||
QALQHPYF
S_TKc 93204.m00229.AA S_TKc 6-309 22 7.7e-58 199.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-309
Range on HMM: 1-231/231
Sequence Identity: 22% (73 aa)

HSKENMIGKGTYGEAYRIVGPL-GEDLCKKTSKNIQSDKHIPVVPIREICLLSEPKYRHIIHAKNVTLEQLYPNIFTLNFHYDYGAIDVYKLCNYFINKQ
  . . ||||..|. |. .    |.    |  |            .||| .|.. .  .|.. . |  .        | .  .|   |.  |  |  ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

R-----TLEHITAKSILFQLLLALNHLHSHGIIHCDISPANLIIMPRNYERPGILKLIDFGLSRTDEWKGQDKSTIVVTIWYRSPELLLDDKKYTV-AVD
|      .   .|.... |...||...|||||||.|. |.|. .          .|..||||.|         .|...| ||..||.|    .|.  ..|
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCD

IWAAGCIFAELLTGQVIFHSETRSQNSNEFCSKQMIAILSIMGNFKATDLPPYATTYMAEFNNLNRTHFESQFEKKFAYIDKDARDLLREMLCINPNNRI
.|. |||..|.|.|.  |.              || ... ..|                                     ...|.|..| .|. .|..|.
WWSCGCILYEMLCGYPPFP--------------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRP

SAYNALR-------HPYF
.|  ||.       ||.|
TA-EALQDEWDIKCHPWF
Kinase 93204.m00229.AA Pkinase 100-309 22 2e-47 168.7 Pfam 94-293 (293) Show / Hide 
Range on Protein: 100-309
Range on HMM: 94-293/293
Sequence Identity: 22% (48 aa)

FIN--KQRTL--EHITAKSILFQLLLALNHLHSHGIIHCDISPANLIIMPRNYERPGILKLIDFGLSRTD-EWKGQDKSTIVVTIWYRSPELLLDDKKYT
.|   .....  .  ..|... |.| .|...||.||||.|. |.|. |  .|.. . ..|..||||..   . ...  .|...|.||..||.......|.
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

VAVDIWAAGCIFAELLTGQVIFHSE--TRSQNSNEFCSKQMIAILSIMGNFKATDLPPYATTYMAEFNNLNRTHFESQFEKKFAYIDKDARDLLREMLCI
 .||.|..|||..|.|.|. .| ..  . . ..  .. ..          ..  . ...  ..  .            ....  .......|... .|| 
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------F-HWTF-HNWSEECKDFIKWCLCK

NPNNRISAYNALRHPYF
.|. |..|  .| ||.|
DPKKRPTAEQILQHPWF
Kinase 93204.m00229.AA MAPK 101-309 28 7.5e-47 159.97 In-house 106-328 (328) Show / Hide 
Range on Protein: 101-309
Range on HMM: 106-328/328
Sequence Identity: 28% (68 aa)

INKQRTLEHITAKSILFQLLLA--LNHLHSHGIIHCDISPANLIIMPRNYERPGILKLIDFGLSR----TDEWKGQ----------DKSTIVVTIWYRSP
|. |..|...  .....|.| .  | ..|| ..||.|. |.|. .   | .  . ||. ||||.|    ... ..|          . .  |.| |||.|
IKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILV---NEN--CDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELLLDD--KKYTVAVDIWAAGCIFAELLT-GQVIFHSETRSQNSNEFCSKQMIAILSIMGNFKATDL-----PPYATTYMAEF---NNLNRTHFESQFEK
|..|    ..|| |||.|..||||||.|| ....|          .    |.  |....|. .  ..     .. | .|   .    . .. ..|. | .
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFP--------GKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPN

-KFAYIDKDARDLLREMLCINPNNRISAYNALRHPYF
  |   . .|.|||  || ..|. ||..  ||.||||
ANF-NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 93204.m00229.AA CDKL 113-216 42 3.1e-36 121.37 In-house 101-200 (286) Show / Hide 
Range on Protein: 113-216
Range on HMM: 101-200/286
Sequence Identity: 42% (44 aa)

KSILFQLLLALNHLHSHGIIHCDISPANLIIMPRNYERPGILKLIDFGLSRTDEWKGQDKSTIVVTIWYRSPELLLDDKKYTVAVDIWAAGCIFAELLTG
.....|.| |.|..|.| .|| || | |. | |.|.    ..|| |||. |. . .|      | | |||.||||..| .|  .|||||.||..||...|
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNG----QVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDG

QVIF
| ..
QPLW
Kinase 93204.m00229.AA CDK8 10-241 30 4.9e-36 110.11 In-house 1-253 (329) Show / Hide 
Range on Protein: 10-241
Range on HMM: 1-253/329
Sequence Identity: 30% (78 aa)

NMIGKGTYGEAYRIVGPLG--EDLCKKTSKNIQSDK------H---IPVVPIREICLLSEPKYRHIIHAKNVTLEQLYPNIFTLNFHYDYGAIDVYKLCN
  || ||||  |  .   .  ..  .   | ....|      .   |     ||| |. | .  ..|    | |..    .. |   .||   | .    
KYIGRGTYGHVYKAKRKKQKKKPNKEYALKQFRTEKDGVEQLEGTGISMSACREIALCRELHHPNVICLQRVFLNHKDKCVWML---FDYAEHDLWHIIK

YFINKQRTLEHIT------AKSILFQLLLALNHLHSHGIIHCDISPANLIIMPRNYE--RPGILKLIDFGLSRTDEWKGQ---DKSTIVVTIWYRSPELL
.    . .    |       |||..|.|     |||  ..| |  ||| ..|    |  . |  |  |.|..|  .   .   |   .|||.|||.||||
FHRHNKAHMKDPTMVPRNMVKSIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMC-GCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELL

LDDKKYTVAVDIWAAGCIFAELLTGQVIFHSETR---SQNSNEFCSKQMIAILSIMG
|  . || |.|||| |||||||.| . ||| .     .  .| .   |.  |...||
LGARHYTKAIDIWAIGCIFAELITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMG
Kinase 93204.m00229.AA CDC2 101-219 36 2.9e-33 99.2 In-house 94-212 (301) Show / Hide 
Range on Protein: 101-219
Range on HMM: 94-212/301
Sequence Identity: 36% (45 aa)

INKQRTLEHITAKSILFQLLLALNHLHSHGIIHCDISPANLIIMPRNYERPGILKLIDFGLSRTDEWKGQDKSTI--VVTIWYRSPELLLDDKKYTVAVD
| |.  .. .. ||...|.| .....|...|.| |. | |. |      . | .|. ||||.|.         |   ||| |||.||.|| .|.|...||
IPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILI-----DKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVD

IWAAGCIFAEL---LTGQVIFHSE
.|. ||||||.    |   .|| .
MWSIGCIFAEMFMDVTKKPLFHGD
Kinase 93204.m00229.AA PITSLRE 113-216 44 4.6e-33 116.18 In-house 109-207 (295) Show / Hide 
Range on Protein: 113-216
Range on HMM: 109-207/295
Sequence Identity: 44% (47 aa)

KSILFQLLLALNHLHSHGIIHCDISPANLIIMPRNYERPGILKLIDFGLSRTDEWKGQ--DKSTIVVTIWYRSPELLLDDKKYTVAVDIWAAGCIFAELL
|. . |||..  |.|.. |.| |   .||      |   ||||. |||| |  |. .     . .||| |||.|||||. |||. .||.|  ||||||..
KCLMQQLLRGVEHMHDNWIMHRDLKTSNLL-----YSHKGILKICDFGLAR--EYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFI

TGQVIF
|....|
TMKPLF
Kinase 93204.m00229.AA CDK5 6-216 33 2.3e-32 99.18 In-house 1-200 (287) Show / Hide 
Range on Protein: 6-216
Range on HMM: 1-200/287
Sequence Identity: 33% (72 aa)

HSKENMIGKGTYGEAYRIVGPLGEDLCKKTSKNIQSDKH---IPVVPIREICLLSEPKYRHIIHAKNVTLEQLYPNIFTLNFHYDYGAIDVYKLCNYFIN
..| . || ||||  |.      . .     | .. |     .|   ||||||| | | . |.    |       .  || | .    .|   |  |. .
YEKMEKIGEGTYGTVYKARNKETHEIV--ALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSE---KKLTLVFEF----CD-QDLKKYMDS

KQRTLEHITAKSILFQLLLALNHLHSHGIIHCDISPANLIIMPRNYERPGILKLIDFGLSRTDEWKGQDKSTIVVTIWYRSPELLLDDKKYTVAVDIWAA
 .  ..  ..||...|||  |   |.| . | |  | || |      . |.||| |||| |      .  |  ||| ||| |  |.  |.|.  .|.| .
CNGEMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLI-----NKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSC

GCIFAELL-TGQVIF
||||||.  .|.  |
GCIFAEMANAGRPLF
Kinase 93204.m00229.AA JNK 107-216 36 1.5e-27 97.83 In-house 103-207 (309) Show / Hide 
Range on Protein: 107-216
Range on HMM: 103-207/309
Sequence Identity: 36% (41 aa)

LEHITAKSILFQLLLALNHLHSHGIIHCDISPANLIIMPRNYERPGILKLIDFGLSRTDEWKGQDKSTIVVTIWYRSPELLLDDK-KYTVAVDIWAAGCI
| | . .....| ...  |||| |||| |  | | ..   |..  ..||. |||..||   .    .  ||| .|| || ..     |.  ||||  |||
LDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVV---NQD--CTLKICDFGHARTEDPT-FMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCI

FAELLTGQVIF
.||.....|.|
MAEMIRHHVLF
Kinase 93204.m00229.AA CDC2 255-309 31 2.6e-18 52.37 In-house 242-301 (301) Show / Hide 
Range on Protein: 255-309
Range on HMM: 242-301/301
Sequence Identity: 31% (19 aa)

YMAEFNNLNRTHFESQFEK-KFAY----IDKDARDLLREMLCINPNNRISAYNALRHPYF
| . | ..... ....... .. .    .|....|||..||...|..||||  ||.||||
YKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase 93204.m00229.AA RCK 180-211 53 1.5e-15 45.57 In-house 178-209 (298) Show / Hide 
Range on Protein: 180-211
Range on HMM: 178-209/298
Sequence Identity: 53% (17 aa)

WYRSPELLLDDKKYTVAVDIWAAGCIFAELLT
|||.||.|| . .|.  .|||| |||..|| .
WYRAPECLLRCTYYNSPMDIWAVGCIMYELYM
Kinase 93204.m00229.AA RCK 102-163 29 1.7e-15 45.36 In-house 92-162 (298) Show / Hide 
Range on Protein: 102-163
Range on HMM: 92-162/298
Sequence Identity: 29% (21 aa)

N---KQRTLEHIT--AKSILFQLLLALNHLHSHGIIHCDISPANLIIMP-RNYER---PGILKLIDFGLSR
.   ... |  ..   |.|..|.|..|.|.|.||. | |..| |. ...  .|     ....|..||||.|
DFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCR
Kinase 93204.m00229.AA RCK 280-309 46 3.1e-14 41.29 In-house 269-298 (298) Show / Hide 
Range on Protein: 280-309
Range on HMM: 269-298/298
Sequence Identity: 46% (14 aa)

KDARDLLREMLCINPNNRISAYNALRHPYF
.|. .|...||...|. ||.|. ||.||||
QDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 93204.m00229.AA CDK5 279-309 61 1.2e-13 39.05 In-house 257-287 (287) Show / Hide 
Range on Protein: 279-309
Range on HMM: 257-287/287
Sequence Identity: 61% (19 aa)

DKDARDLLREMLCINPNNRISAYNALRHPYF
|.  .||| .|| .||| |||| .||.||||
DEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 93204.m00229.AA PITSLRE 259-309 35 2.2e-11 37.91 In-house 240-295 (295) Show / Hide 
Range on Protein: 259-309
Range on HMM: 240-295/295
Sequence Identity: 35% (20 aa)

FNNLN--RTHFESQFEKKFA---YIDKDARDLLREMLCINPNNRISAYNALRHPYF
....|  . . ...  |.|    .|   . |||  ||. || |||.|  || ||.|
WKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 93204.m00229.AA JNK 281-309 62 2e-10 34.98 In-house 281-309 (309) Show / Hide 
Range on Protein: 281-309
Range on HMM: 281-309/309
Sequence Identity: 62% (18 aa)

DARDLLREMLCINPNNRISAYNALRHPYF
.|||||  || |||  |||   ||.||| 
MARDLLFRMLVINPDDRISVDDALQHPYI
Kinase 93204.m00229.AA CDK8 279-309 45 1.1e-09 26.0 In-house 299-329 (329) Show / Hide 
Range on Protein: 279-309
Range on HMM: 299-329/329
Sequence Identity: 45% (14 aa)

DKDARDLLREMLCINPNNRISAYNALRHPYF
|. | .||  || . |. ||.. .|. ||||
DSHAYHLLYKMLTMDPTKRITCEQAMEHPYF
Kinase 93204.m00229.AA CDKL 272-309 30 4.9e-09 27.05 In-house 248-286 (286) Show / Hide 
Range on Protein: 272-309
Range on HMM: 248-286/286
Sequence Identity: 30% (12 aa)

EKKFAYID-KDARDLLREMLCINPNNRISAYNALRHPYF
||..  .  | | |... .| ..|  |...  ...||||
EKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 93204.m00229.AA TyrKc 6-275 16 5.9e-05 -142.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-275
Range on HMM: 1-280/280
Sequence Identity: 16% (49 aa)

HSKENMIGKGTYGEAYRIVGPLGEDLCK---KTSKNIQSDKHIPVVPIREICLLSEP--KYRHIIHAKNVTLEQLY-----PNIFTLNFHYDYGAIDVYK
 ... ..| | .|| |. .        .   |. |.           .||. ....   .  .|.    | ..|       . .. .  . ..|.     
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD-----

LCNYFINKQRTLEHITAKSILFQLLLALNHLHSHGIIHCDISPANLIIMPRNYERPGILKLIDFGLSRTDEWK-------GQDK-----STI-VVTIWYR
| .|  .....| . .  |. .|     ..|||...|| |.   |  .  ..     . |  ||||||  . .          .     ..  .. |   
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

SPELLLDDKKYTVAVDIWAAGCIFAELLTGQVIFHSE---TRSQNSNEFCSKQMIA-ILSIMGN-----FKATDLPPYATTYMAEFNNL---NRTHFESQ
.|| . ...|.| . |.|. |    |..|     ...       .  |   . .    . .. |     |  .  .   .  | .  .    .|  |.  
APECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI

FEKKF
  ..|
-HECF
Kinase 93204.m00229.AA CDK 6-22 47 0.001614 6.94 In-house 1-17 (284) Show / Hide 
Range on Protein: 6-22
Range on HMM: 1-17/284
Sequence Identity: 47% (8 aa)

HSKENMIGKGTYGEAYR
  | . || ||||. |.
YEKLEKIGEGTYGVVYK
Kinase 93204.m00229.AA CDC2 6-22 47 0.00461 4.67 In-house 1-17 (301) Show / Hide 
Range on Protein: 6-22
Range on HMM: 1-17/301
Sequence Identity: 47% (8 aa)

HSKENMIGKGTYGEAYR
  | ..||.||||. |.
YQKIEKIGEGTYGVVYK
Kinase 93204.m00229.AA PITSLRE 6-22 47 0.305152 0.54 In-house 1-17 (295) Show / Hide 
Range on Protein: 6-22
Range on HMM: 1-17/295
Sequence Identity: 47% (8 aa)

HSKENMIGKGTYGEAYR
  . | |. ||||. ||
FQCLNRIHEGTYGVVYR