Gene 83996.m00224 (T.vaginalis)

83996.m00224

Species: T.vaginalis
Alias: TvagK0890, 83996.m00224
External Links:
Annotation:

Classification

Group: Other
Family: Other-Tvag2

Sequence

Name Sequence Type Origin Length Description Download
83996.m00224.AA Protein None 299 None Fasta, JSON
83996.m00224.kin_dom Protein Kinase Domain None 249 None Fasta, JSON

Protein domain

Protein domains of 83996.m00224.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 83996.m00224.AA Ciliate-E2 13-261 18 6.9e-20 64.93 In-house 7-365 (365) Show / Hide 
Range on Protein: 13-261
Range on HMM: 7-365/365
Sequence Identity: 18% (69 aa)

IGNGSEGSVYRI--DED--------------------------NAIKILKKPDQITLETQKTIYDELS------KE----EIC---YIIPSYDVLY--IN
||.|. ||||.   ...                           |.||.|| . . ..  . |. |.       .|    |.    .||  |.. .   .
IGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDD

DSFGLTMKFFPY-NLETLINEG-------------ISIRDALHIAKHILC---------------GLYQLYSHG-YIWLDCNPRNILMGDNMIPQFTDIG
... | | .. . .|. .|..              .... ...| |.||                .|  | | .  |  |  | |||.     .  .| |
NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFG

NASKVDNSNE---------LQDIDK-------------------NKTICTPLYAAPEVILYYK---------ASYKSDIFSWGVLLYQLLTQKYALLSEE
.. |.|..|.         .    |                   | ...|| | |||.. . |          .||.||.| ||.||..|. |.      
LSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----

FYDSESNDYITEYLKFQVNVDCAE--------------FQCLDELTKSVILG----CLSMNPYERMS-FSDVFGSGIF
         . . .. ... .|.|              .. ... .|  |      .|  .| .|.. .....   .|
---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 83996.m00224.AA ULK 96-261 24 3.3e-19 63.76 In-house 132-329 (329) Show / Hide 
Range on Protein: 96-261
Range on HMM: 132-329/329
Sequence Identity: 24% (48 aa)

ALHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDN------------MIPQFTDIGNASKVDNSNELQDIDKNKTI-----CTPLYAAPEVILYY----K
|... |.|| |.  |..|..|  |  | |||. ..            ..   .| | | .|||.|. |.. .  .      .|||| ||...       .
AIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKP

AS-YKSDIFSWGVLLYQLLTQKYA----LLSEE--FYDSESNDYITEY-----LKFQVNVDCAEFQCLDELTKSVILGCLSMNPYERMSFSDVFGSGIF
 . ||.||.| |...|..|. |.       ..   .. .. |.. . .      ..| . | .. |. .|. |. | ..|  .. .|.|. ..|   .|
YYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPEC-KDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 83996.m00224.AA Ciliate-E2-Unclassified 7-261 18 1.3e-18 61.17 In-house 1-352 (352) Show / Hide 
Range on Protein: 7-261
Range on HMM: 1-352/352
Sequence Identity: 18% (68 aa)

IDDFSFIGNGSEGSVYRIDEDN-----AIKILKKPDQITLETQKTIYDELSKE--EICYI------------------IPSYDVLYINDSFG------LT
      ||.|. |.||.  ...     |.|..||  ..    ...   |.. |  |.. .                  .|.  ...  . |       . 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MKFFPY-NLETLINE-------------------GISIRDAL-----HIAKHILCGL-YQLYSHGYIWLDCNPRNILMGDNM---IPQFTDIGNASKVDN
| .... .|.  |..                    .. . |.     .....||.|| |  .... |  |  | |||. .|.    .  .| |...| ..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

SNELQDI-----------DKNKTIC-TPLYA----APEVILY--YKAS--YKSDIFSWGVLLYQLLTQKYALLSEEFYDSESND----------------
.|. .             .. .|.| || |     ||||.    |  |  ||.||.| ||.||..|...|      |||  ...                
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP-----FYDNNCEQHQQLITQWINNAYRKQ

YITEYLKFQVNVDCAEF----QCLDELTKSVIL----GCLSMNPYERMSFSDVFGSGIF
.. . .. .........    . ...  |  |      .|  || .|..|....   .|
LYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 83996.m00224.AA ULK 96-261 23 5.1e-17 56.99 In-house 128-324 (324) Show / Hide 
Range on Protein: 96-261
Range on HMM: 128-324/324
Sequence Identity: 23% (47 aa)

ALHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDN------------MIPQFTDIGNASKVDNSNELQDIDKNKTI-----CTPLYAAPEVILYY----K
|... |.|. |.  |..|..|  |  | |||. ..             .   .| | | .||| |. |.. .         .|||| ||...       .
AIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKP

AS-YKSDIFSWGVLLYQLLTQKYALLSEEFYDSESN--DYIT-----EYLKFQVNVDCA---EFQCLDELTKSVILGCLSMNPYERMSFSDVFGSGIF
 . ||.||.| |...|..|. ||   |  |.| . .  . |      ...  . ....    . . . . .|. | ..|  .. .|.|. ..|   .|
YYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 83996.m00224.AA S_TKc 7-261 21 5.9e-15 42.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 7-261
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

IDDFSFIGNGSEGSVYRIDEDN-----AIKILKKPDQITLETQKTIYDE---LSKEEICYIIPSYDVLYINDSFGLTMKFFPY---NLETLINEG-----
 .    || |. |.||.  . .     ||||.|          ..|. |   |.|    .|.  ||| .  |.. . | . .    .| ..| .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ISIRDALHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDNMIPQFTDIGNASKVDNSNELQDIDKNKTICTPLYAAPEVILYYKASY-KSDIFSWGV
   ..  .| .... |.|.|  . ||| |  |  | |||. .      .| | | ..           .  . || | ||||.   . .. |.|. | |.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

LLYQLLTQKYALLSEEFYDSESNDYITEYLKFQVNVDCAEFQCLDELTKSVILGCLSMNPYERMSFSDVFG-------SGIF
.|| .|.  | . .            .... |.. .        ..  |. | .|| ..| .|..  ...           |
ILYEMLC-GYPPFP------------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 83996.m00224.AA Ciliate-E1 13-182 20 2.7e-14 43.3 In-house 1-202 (202) Show / Hide 
Range on Protein: 13-182
Range on HMM: 1-202/202
Sequence Identity: 20% (42 aa)

IGNGSEGSVYRI--DEDN----AIKILKKP---DQITLETQKTIYDELSKEEI--CYIIPSYDVLYINDSFGL--TMKFFPYNLETLIN-----------
|||||.. |...  ...|    |.|| .     .|.... ..  |... |  .  ||||  .|...| .. .    . .  ..|.  ..           
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

--EGISIRDA--LHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDNMIPQFTDIGNAS---KVDNSNELQDIDKNKTICTPLYAAPEV--ILYYKASYKS
  . ..  .   ..|..... || .|.... | .| .| |||  .. . ...|.| ..   . .|..  ..  ...  ... |  ||.  .  .| .|||
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS

DIF
||.
DIY
Kinase 83996.m00224.AA AGC 124-193 20 1e-11 25.07 In-house 185-300 (395) Show / Hide 
Range on Protein: 124-193
Range on HMM: 185-300/395
Sequence Identity: 20% (24 aa)

NILMGDNMIPQFTDIGNASKVDNSNELQ---------------------------------------------DIDKNKTIC---TPLYAAPEVILYYKA
|||. ..     || | . .. |..| .                                             . |...|.|   || | |||..     
NILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----Y

SYKSDIFS--WGVLLYQLLT
..  |. |   |.|.|..||
GKACDWWSFGLGCLMYEMLT
Kinase 83996.m00224.AA Pkinase 90-261 22 2e-11 41.48 Pfam 102-293 (293) Show / Hide 
Range on Protein: 90-261
Range on HMM: 102-293/293
Sequence Identity: 22% (45 aa)

GI--SIRDALHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDNMIP----QFTDIGNASKVDNSNELQDIDKNKTIC-TPLYAAPEVIL-YYKASYKSDI
..  | ... .... ||.||. ..|.| |  |  | |||. .|. .      .| | | ..|    .     ..|.| || |.|||||. . . ..|.|.
CFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

FSWGVLLYQLLTQKYALLSE----EFYDSESNDYITEYLKFQVNVDCAEFQCLD-----------------ELTKSVILGCLSMNPYERMSFSDVFGSGI
.| |..||..|. .    ..    . .|     . .  .. ..  |. .  .                   |  |..| .|| ..|..| .. ... .  
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRI--MGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F
Kinase 83996.m00224.AA TKL 121-195 20 3.7e-11 36.45 In-house 167-286 (364) Show / Hide 
Range on Protein: 121-195
Range on HMM: 167-286/364
Sequence Identity: 20% (24 aa)

NPRNILMGDNMI--------------PQFTDIGNASKVDNSNELQDID--------------KNKTIC-TPLYAAPEVILY----------------YKA
...|||  .|.               .  .| | .  ...|.. .|.               .. |.| || . ||||.                  ...
KSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEY

SYKSDIFSWGVLLYQLLTQK
| |.|..|.|..|. .|| .
SEKCDVYSFGIVLWEILTRC
Kinase 83996.m00224.AA Ciliate-E3 119-192 30 5.5e-10 27.62 In-house 128-202 (202) Show / Hide 
Range on Protein: 119-192
Range on HMM: 128-202/202
Sequence Identity: 30% (25 aa)

DCNPRNILMGDNM---IPQFTDIGNASKVDNSNELQDIDK--NKTI---CTPLYAAPEVILYYKASYKSDIFSWGVLLYQLL
| .| ||| . |    | .. | | . .  .       .|  . |    .||.|||||.  . . |  ||. | |. . || 
DIKPDNILVDKNNNQLIIKICDFGESKQLRK-------NKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC
Kinase 83996.m00224.AA SAK 94-193 32 1e-09 29.01 In-house 100-195 (254) Show / Hide 
Range on Protein: 94-193
Range on HMM: 100-195/254
Sequence Identity: 32% (33 aa)

RDALHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDNMIPQFTDIGNASKVDNSNELQDIDKNKTIC-TPLYAAPEVILYYKASYKSDIFSWGVLLYQLL
..| |. ..|. |.  | ||| .  |    |||.  .|  .  | | |...   .|     |  |.| || | .||..       .||..| | .|| ||
EEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHE-----KHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLL

T
.
I
Kinase 83996.m00224.AA DRAK 89-193 29 1.1e-09 25.64 In-house 94-196 (259) Show / Hide 
Range on Protein: 89-193
Range on HMM: 94-196/259
Sequence Identity: 29% (32 aa)

EGISIRDALHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDNMIPQ---FTDIGNASKVDNSNELQDIDKNKTICTPLYAAPEVILYYKASYKSDIFSWG
|... .|. .. . || |.. | .   . ||  | |||.    .       | | . .. |. |. .|       || | |||.  |   .   |. | |
ECFCEKDVQRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREI-----MGTPDYVAPEILNYDPITMATDMWSIG

VLLYQLLT
|| | .||
VLTYVMLT
Kinase 83996.m00224.AA TyrKc 7-261 21 7e-08 -95.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 7-261
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

IDDFSFIGNGSEGSVYR---IDEDNAIKILKKPDQITLETQKTIYDE---LSKE--EICYIIPSYDVLYIN-------DSFGLTMKFFPY-NLETLI--N
|     .|.|  | ||.   . .. |.| ||.        .. ...|   ..|   .   |.  | |           .   . | . |. .|   .  .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

EG-ISIRDALHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDNMIPQFTDIGNASKVDNS----NELQDIDKNKTICTP--L---YAAPEVILYYKASYK
.. .. .| |...  | ||   | |...|  |   ||.| |.| .   .| | . ....      . . ..| .. ..   |     |||.| |.| . |
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDIFSWGVLLYQLLTQKYALLSEEFYDS-----ESNDYITEYLKFQVNVDCAEFQ--------CLDELTKSVILGCLSMNPYERMSFSDVFGSGIF
||..|.||... ..|     . .. |        ||. . ||.| | .               | ||. . ... |   .| .| .||..    .|
SDVWSFGVCMWEIFT-----YGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase 83996.m00224.AA Pkinase 7-23 41 7.479254 0.56 Pfam 1-17 (293) Show / Hide 
Range on Protein: 7-23
Range on HMM: 1-17/293
Sequence Identity: 41% (7 aa)

IDDFSFIGNGSEGSVYR
.   . || || |.||.
YHIGRKIGSGSFGCVYK