Gene 93904.m00291 (T.vaginalis)

93904.m00291

Species: T.vaginalis
Alias: TvagK0886, 93904.m00291
External Links:
Annotation:

Classification

Group: Other
Family: WEE
Subfamily: WEE-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
93904.m00291.AA Protein None 352 None Fasta, JSON
93904.m00291.kin_dom Protein Kinase Domain None 220 None Fasta, JSON

Protein domain

Protein domains of 93904.m00291.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93904.m00291.AA WEE 65-292 22 1.9e-37 123.18 In-house 16-297 (297) Show / Hide 
Range on Protein: 65-292
Range on HMM: 16-297/297
Sequence Identity: 22% (65 aa)

YVAQSAAKSRLYALKSSK-----YI--KRIRHEAEMYKTIG------HCKTVMKYYDTWVQGGKGFIQMELATNGS-------LKNE-YKD-LNVKQIWQ
| ....  ...|| | ||     |   ||. .|.. .  .|      | . . .||  | .... .||||.  .||         .. ... |  ..|||
YKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEEDDHMYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQ

IIAHISSALSFVHSK-GYMHLDVSPSNILHTESS-----------------KFGTIYKLSDFGTIRALG----TFQEDDEGAGPYVSPEALAFPHTEYEV
|. .|. .|...||. | .|.|. |.||. .. .                 .   ..|. ||| .  .      .... || ..| .|| |      |. 
ILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFN-MMCKIGDFGHVTDMNSNNNNPHQEQEGDSRYMAPEILQG---YYHY

GTK--TDIFSFGVVLYELITRKPAPREYPDYENLRNG-------TFKFPKIPPEF-----SFVTKMLNVNPNVRPTAEWISSLDKC
..    ||||.| ..||| .... |.  .. ...|.|        ..|| .. ..     ...  |.. .|  |||.. . . ...
THLYKADIFSLGITIYELACNMDLPKNGDWWHQIRQGDLSFDKNQIPFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase 93904.m00291.AA Ciliate-E2 65-284 18 1.5e-31 105.51 In-house 35-357 (365) Show / Hide 
Range on Protein: 65-284
Range on HMM: 35-357/365
Sequence Identity: 18% (62 aa)

YVAQSA-----AKSRLYALKSS--KYIKRIRHEAEMYKTIGH---------------CKTVMKYYDTWV--QGGKGFIQMELATNGSLKN----------
.. |.      .|. .||.|.   . |. |  |  ....| .               .. ..|.|...   .  . .. ||..  |.|.           
KQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRN

-----EYKDLNVKQIWQIIAHISS---------------ALSFVHSKG-YMHLDVSPSNILHTESSKFGTIYKLSDFGTIRALGTFQEDDE---------
     . | .. |.| .|...| .               || . |||.  .| |  |.|||           |..|||. . . .....           
HEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYM

-------------------------GAGPYVSPEALAFPH-----TEYEVGTKTDIFSFGVVLYELITRKPAPREYPDYENLRNGTFKFP----------
                         |  .|..|| |         .. . ..| ||.|.||.|||... ||       ...  .. ..||          
FKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQC

---------KIPPE-FSFVTK----MLNVNPNVRPT-AE
         |...|   .  |    ||...|. |.| .|
IQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWE
S_TKc 93904.m00291.AA S_TKc 55-296 24 1e-21 79.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 55-296
Range on HMM: 1-231/231
Sequence Identity: 24% (64 aa)

YSTPNE-----SCTIYVAQSAAKSRLYALKSSKYIKRIRHEAEMYKTIGHCKTVMKYYDTWVQGGKGFIQMELATN--GSLKNEYKD---------LNVK
|   ..       . | ..     |..|.|  |  ..|| | .. |   |.. . |.||...  .. .. ||.. .  |.|.   |.         ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

QIWQIIAHISSALSFVHSKGYMHLDVSPSNILHTESSKFGTIYKLSDFGTIRALGTFQEDDEGAGPYVSPEALAFPHTEYEVGT-KTDIFSFGVVLYELI
... ... | .|| . ||.| .| |. |.||| .|        |..|||  | |        |   |..|| |         |. | |. |.|..|||..
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCILYEML

TRKPAPREYPDYENLRNGTFKFPKIPPEFS-FVTKMLNVNPNVRPTAEWISS---LDKCKEIL
...|  .   ... ...        .||.  |. |.|...|. ||||  .     . || . .
CGYPPFP--QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 93904.m00291.AA TKL 120-284 18 1e-17 60.4 In-house 117-358 (364) Show / Hide 
Range on Protein: 120-284
Range on HMM: 117-358/364
Sequence Identity: 18% (45 aa)

MELATNGSLKNEYKDLNVKQIWQIIAHISSALSFVHS--------KGYMHLDVSPSNILHTESSK----------FGTIYKLSDFGTIR-ALGTFQEDDE
||.. .||| . .      |. ...  |...... ||        ..  | |  ..|||  |  .               |..|||. |   ....  | 
MEYCPGGSLLHYLH---WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDT

G------------------AG---PYVSPEALA----FPH--------TEYEVGTKTDIFSFGVVLYELITRKPAPREYPDYENL---------RNGTFK
.                   .    . .||.|     ...         ..|  .|.|..|||.||.|..||..  ..|| .. .              |
MTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDK

F--PKIP------------PEF-----SFVTKMLNVNPNVRPTAE
.  | ||            | .     .  ..  . .|. ||...
GLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQ
Kinase 93904.m00291.AA Ciliate-E2-Unclassified 117-284 21 2.3e-16 53.29 In-house 97-344 (352) Show / Hide 
Range on Protein: 117-284
Range on HMM: 97-344/352
Sequence Identity: 21% (53 aa)

FIQMELATNGSLKNEYKD--------------------LNVKQIW-----QIIAHISSALSFVHSKG-YMHLDVSPSNILHTESSKFGTIYKLSDFGTIR
.| ||.. .|.|..  |.                    .  .|.      ...|.| ..|.. |.|.   | |  |.||| ... |     |..||| ..
YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISK

ALGTFQEDDEGAG-------------------PYV----SPEALAF-PHTEYEVGTKTDIFSFGVVLYELITRKPAPREYPD------------------
 .......| . .                    |     .|| |    . .     | ||.|.||.|||... .  | ....                  
KYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRK

-YENLR-NGTFKFPKIPP-----EFS-----FVT----KMLNVNPNVRPTAE
 ...   .. ..||| |.       |     |..    |||..||| |.|.|
QLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFE
Kinase 93904.m00291.AA TK 120-290 13 1.3e-14 44.65 In-house 134-486 (486) Show / Hide 
Range on Protein: 120-290
Range on HMM: 134-486/486
Sequence Identity: 13% (46 aa)

MELATNGS----LKNEYK-----------------------------------------------------------DLNVKQIWQ--------------
||.. .|.    |..  .                                                           .|  |. .|              
MEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLT

-----IIAHISSALSFVHSK------GYMHLDVSPSNILHTESSK-------FGTIYKLSDFG--------TIRALGTFQEDDEGAGPY-----------
     . . |...... |||      .. | |.   |.| .|. .       .| . |..|||          |...  ..     ...           
MHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDD

------------------VSPEALAFPHT-----EYEVGTKTDIFSFGVVLYELIT--RKPAPREYPD------------YENLRNG-------------
                   .||.|.  .      .    ||.|..||||...|. |  ..| . . ..            .|.||.|             
PWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGY

TFKFP---KIP--------------PEFSF-VTKMLNVNPNVRPTAEWISSLD
 .  |     |              .|.    ..  . .|. ||| . . .  
RMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 93904.m00291.AA Ciliate-E1 127-227 22 1.3e-13 41.06 In-house 98-202 (202) Show / Hide 
Range on Protein: 127-227
Range on HMM: 98-202/202
Sequence Identity: 22% (24 aa)

SLKNEYKDLNVKQIWQIIAHISSALSFVHSKGYMHLDVSPSNILHTESSKFGTIYKLSDFGTIRALGTFQEDDE---GAGPYVSPEALAF-----PHTEY
.......... .|. ||| ..  .|. .|... .|.|  |.|||    ...  .|...|||. . |   |...    |   |..|.   .     .  ..
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILI---NNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQ

EVGTKTDIF
... |.||.
KINYKSDIY
Kinase 93904.m00291.AA CAMK 76-284 15 1.8e-10 29.18 In-house 34-417 (425) Show / Hide 
Range on Protein: 76-284
Range on HMM: 34-417/425
Sequence Identity: 15% (60 aa)

YALKS---------------------------------SKYIKRIRHEAEMYKTIG------HCKTVMKYYDTWV------------QGGK--------G
.| |                                   |  |..|.| |. |..       . . . | |...                |         
VAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHM

FIQM---ELATNGSL----------KNEY------------KDLNVKQIWQIIAHISSALSFVHSKGYMHLDVSPSNILHTESSKFG-------------
.. |   |....| |          .  |            . .. ..  ...  | ||. . ||.. .|.|  | ||| .....               
YMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNN

TIYKLSDFGTIRAL--------------------------GTFQEDDEGAGPYVS-PEALAFPHT----------EYEVGTKTDIFSFGVVLYELITRKP
   |..|||  . .                          |   ..  |  .|.. || |   ..          .  .| |.|. | ||.|| . . .|
NNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYP

APREYPD----------------YENLRNGTFKFPKIP-------------------------PEF-SFVTKMLNVNPNVRPTAE
  ..  |                .|. ..| . ||  .                         .|  ... |||.|.|. |.|.|
PFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIE
Kinase 93904.m00291.AA TyrKc 72-289 19 1.9e-09 -69.99 SMART 17-280 (280) Show / Hide 
Range on Protein: 72-289
Range on HMM: 17-280/280
Sequence Identity: 19% (54 aa)

KSRLY------ALKSSKYIKRIRHEAEMYKTIG-HCKTVMKYYDTWVQG-------GKGFIQMELATNGSLKN---EYKD-LNVKQIWQIIAHISSALSF
| ...       ||... .. ...||.. . .| | . . . |   .|.       .  .| ||.. .|.||.   .... |..|.  ..   |..  ..
KGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEY

VHSKGYMHLDVSPSNILHTESSKFGTIYKLSDFGTIRALGTF-------QEDDEG---AGP------YVSPEALAFPHTEYEVGTKTDIFSFGVVLYELI
 |||.. | |    |.| .|      . | ||||  |...         .  .      |         .||..     ...  ||.|..||||...|. 
LHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGKFTTKSDVWSFGVCMWEIF

TR--KPAPRE----YPDYENLRN-GTFKFPKIPPE-------------FSFVTKMLNVNPNVRPT-AEWISSL
|.  .| | .     ...| ...  . . ...||.             ..  ..  . .|. ||| .| .. .
TYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 93904.m00291.AA Pkinase 204-299 17 6.9e-09 32.5 Pfam 176-293 (293) Show / Hide 
Range on Protein: 204-299
Range on HMM: 176-293/293
Sequence Identity: 17% (23 aa)

PYVSPEALAFPHTEYEVGTKTDIFSFGVVLYELITRKPAPREY-------PDYENLRNGT----FKFPKI---------------------PPEFSFVTK
.|..|| .    .  . |.| |..|.|..|||.....|  ..        ...   |..     | .|.                      ..  .|...
WYMAPEVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

MLNVNPNVRPTAEWISSLDKCKEILNK--I
.|...|. |||         ...||.   .
CLCKDPKKRPT---------AEQILQHPWF
Kinase 93904.m00291.AA ULK 223-278 22 9.6e-08 23.21 In-house 236-315 (329) Show / Hide 
Range on Protein: 223-278
Range on HMM: 236-315/329
Sequence Identity: 22% (18 aa)

KTDIFSFGVVLYELITRKPAPREY-PDYE-----NLRNGTFKFP----KIPPEFS--------------FVTKMLNVNPN
|.||.|.|...||... || ....  |.      .|.| ... |    |.|..|               .  .|| ....
KCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK
Kinase 93904.m00291.AA STE 76-188 25 2.7e-07 21.95 In-house 64-193 (359) Show / Hide 
Range on Protein: 76-188
Range on HMM: 64-193/359
Sequence Identity: 25% (36 aa)

YALKSSKYIKRIRHEAEMYKTIGH-CKTVMKYYDTWVQGG-------KGFIQMELATNGSLKNEYK-------DLN----------VKQIWQIIAHISSA
.  | .. ...| .| .. |   | .. . |||.. ...|       . .| ||.  .|||   .|       .||           .||  |.  |  .
LENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKG

-LSFVHSKGYMHLDVSPSNILHTESSKFGTIYKLSDFGT
 |.. ||....| |. |.|||           ||.|||.
LLYYLHSHHIIHRDIKPANILL---------VKLCDFGV
Kinase 93904.m00291.AA ULK 223-264 22 4.3e-07 21.28 In-house 232-292 (324) Show / Hide 
Range on Protein: 223-264
Range on HMM: 232-292/324
Sequence Identity: 22% (14 aa)

KTDIFSFGVVLYELITRKPA---PREYPDY----ENLRN----------GTFKFP---KIPP
|.||.|.|...||... |.    .  ...|    . ..|            ..||   |.|.
KCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPK
Kinase 93904.m00291.AA Pkinase 79-187 21 9.6e-07 24.93 Pfam 37-157 (293) Show / Hide 
Range on Protein: 79-187
Range on HMM: 37-157/293
Sequence Identity: 21% (26 aa)

KSSKYIKRIRH--EAEMYKTIGHCKTVMKYYDTWVQGGKGFIQMELATNG----SLK-----NEYKDL--NVKQIWQIIAHISSALSFVHSKGYMHLDVS
..|.  .. |.  |... | ..|.  . ..||..  ...  . ||.. .|    .|.      ... .    ...  ..  | ..| . ||.| .| |. 
EKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLK

PSNILHTESSKFGTIYKLSDFG
|.|||  .    ... |..|||
PENILIDNNGHIDACVKICDFG
Kinase 93904.m00291.AA STE 221-284 22 8e-06 16.69 In-house 246-349 (359) Show / Hide 
Range on Protein: 221-284
Range on HMM: 246-349/359
Sequence Identity: 22% (24 aa)

GTKTDIFSFGVVLYELITRKPAPREYPDYENLR--------NGTF-----------KFPKIPPEFS------------------------FVTKMLNVNP
.|| || |.| .. |..| ||   .. |. ..|        .. .           . |..|...|                        |. | |. .|
DTKCDIWSLGCTIIEMATGKP---PWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDP

NVRPTAE
| ||||.
NKRPTAS
Kinase 93904.m00291.AA ULK 120-187 23 5.2e-05 13.53 In-house 99-187 (329) Show / Hide 
Range on Protein: 120-187
Range on HMM: 99-187/329
Sequence Identity: 23% (21 aa)

MELATNGSLK---NEYKDLNVKQ----------IWQIIAHISSALSFVHSKGYMHLDVSPSNIL-HTESSKF-------GTIYKLSDFG
||.   | |.   ...| |. ..          . |.. .| ... . |.....| |  |.||| |    |.         ..|..|||
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG
Kinase 93904.m00291.AA ULK 120-187 23 0.000119 12.49 In-house 96-183 (324) Show / Hide 
Range on Protein: 120-187
Range on HMM: 96-183/324
Sequence Identity: 23% (21 aa)

MELATNGSLK---NEYKDLNVKQ----------IWQIIAHISSALSFVHSKGYMHLDVSPSNIL-HTESSKF-------GTIYKLSDFG
||.   | |.   ...| |.. .          . |.. .| ... . |.....| |  |.||| |    |.         ..|..|||
MEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG
Kinase 93904.m00291.AA Pkinase_Tyr 222-251 40 0.000956 13.31 Pfam 193-221 (270) Show / Hide 
Range on Protein: 222-251
Range on HMM: 193-221/270
Sequence Identity: 40% (13 aa)

TKTDIFSFGVVLYELIT--RKPAPREYPDYEN
||.|. ||||...|..|  ..|   .||.  |
TKSDVWSFGVLMWEIFTYGEQP---TYPGMSN