Gene 92815.m00005 (T.vaginalis)

92815.m00005

Species: T.vaginalis
Alias: 92815.m00005, TvagK0976
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
92815.m00005.AA Protein None 521 None Fasta, JSON
92815.m00005.kin_dom Protein Kinase Domain None 225 None Fasta, JSON

Protein domain

Protein domains of 92815.m00005.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 92815.m00005.AA TK 92-267 14 6.1e-29 93.53 In-house 121-486 (486) Show / Hide 
Range on Protein: 92-267
Range on HMM: 121-486/486
Sequence Identity: 14% (52 aa)

FN-----NPIIIASNYIPNGN----LYEAIKSGR------------------------------------------------------------------
|.      |..|   | |.|.    | .  .. |                                                                  
FEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQM

-----------LNPTDKTKIAMGIAYALRRLHKM------HIVHGDLKSRNIMLGDDMR-----------PLVSDFGYGAIA---LALQVP---IQYRIN
           |.. ..  ... || ... ||..      ..||.||  ||...|....             ..|||        ||  ..     || .
AWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKS

DPY----------------------------WCAPEVLTGAV---------PTSASDVYSFGTLISELYN--EQVPAQG------------AAVLARTHQ
...                            |.|||.|.. |          |..|||.||| |. |..   .. .. |            . |. .  .
SYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRR

E--------------FIPS---SAP--------------KILRALVQCCTMENPARRPDFRRIYRLF
.              . .     .|              ...  | |.|  ..|..||.|. ... .
GGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 92815.m00005.AA TKL 94-267 18 4.4e-28 98.23 In-house 105-364 (364) Show / Hide 
Range on Protein: 94-267
Range on HMM: 105-364/364
Sequence Identity: 18% (50 aa)

NP------IIIASNYIPNGNLYEAIKSGRLNPTDKTKIAMGIAYALRRLHKMH--------IVHGDLKSRNIMLGDDMR--------------PLVSDFG
.|      . |   |.|.|.|.. .      .  . ..|..|| ..  || |.        |.| ||||.||.. ....              . ..|||
HPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFG

----------YGAIALA--------LQVPIQYRIN-DPYWCAPEVLTGA----------------VPTSASDVYSFGTLISELYNEQVPAQGAA------
            ... .        ..    ...   |.|.||||| |.                  . ..|||||| .. |..  ..| ..        
LSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIF

--------VLARTHQE--FIP------------SSAPKILRALVQCCTMENPARRPDFRRIYRLF
        ...  ...   ||            ...|. .. | |.|  ..|  || | .|   .
QDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 92815.m00005.AA TKL-Unique 97-267 25 2.3e-15 50.79 In-house 76-290 (290) Show / Hide 
Range on Protein: 97-267
Range on HMM: 76-290/290
Sequence Identity: 25% (55 aa)

IIASNYIPNGNLYEAIK-----------SGRLNPTDKTKIAMGIAYALRRLHKMH--IVHGDLKSRNIMLGDD-----MRPLVSDFGYGAIAL-ALQVPI
.| . |.| |.||. .            .  ||.  . |.|  || .. .||     | |.||||.|. .  .     ..  ..|||   ..   .. ..
CIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTN

Q--------YRINDPYWCAPEVLTG--AVPTSASDVYSFGTLISELYNEQV------PAQGAAVL--A-------RTHQEFIPSSAPKILRALVQCCTME
          |.  . | |||||..  .  .  |||||||.   |... ..      | || .    .       .  .. ||.. ||..| | | |   
NEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHH

NPARRPDFRRIYRLF
.|  || |  |.   
DPSQRPSFDEIIHRL
Kinase 92815.m00005.AA TK-Unique 125-210 32 6.4e-15 48.0 In-house 136-229 (294) Show / Hide 
Range on Protein: 125-210
Range on HMM: 136-229/294
Sequence Identity: 32% (32 aa)

IAMGIAYALRRLHK--MHIVHGDLKSRNIMLGDDMRPLVSDFGYGA--------IALALQVPIQYRINDPYWCAPEVLT--GAVP-TSASDVYSFGTLI
.| .|| ..  |..  ..|||.|| .||..|..| .  ..|||           .    | .|..|     |.|||.|   . .  |. |||.||| |.
FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIR-----WMAPESLKCYHGMYHTTKSDVWSFGVLM
Kinase 92815.m00005.AA UTK 117-214 27 6.7e-15 47.42 In-house 115-234 (296) Show / Hide 
Range on Protein: 117-214
Range on HMM: 115-234/296
Sequence Identity: 27% (33 aa)

LNPTDKTKIAMGIAYALRRLHKMHIVHGDLKSRNIMLGDD-------MRPLVSDFGYGAIALALQVP----------IQYRINDP------YWCAPEVLT
|. ..... |. || ..  || ...||.||  ||. ....       |   ..||| |.  .. .|.           .|   ..       |.|||.||
LTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGG--MSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALT

GA-VPTSASDVYSFGTLISELY
 .  .|..|||.||| .  |..
HHTRFTTKSDVWSFGVVCWEIW
Kinase 92815.m00005.AA RTKE 185-267 25 9.5e-15 46.7 In-house 192-293 (293) Show / Hide 
Range on Protein: 185-267
Range on HMM: 192-293/293
Sequence Identity: 25% (26 aa)

YWCAPEVLTGAVPTSASDVYSFGTLISELY-NEQV-----PAQGAAVLARTHQE-------------FIPSSAPKILRALVQCCTMENPARRPDFRRIYR
.| ||||.   .....|||...| |  |.. |.|      . |  .   ...|                |...|  ...| | |.  ||..||.|. .|.
RWWAPEVWKDQHFSFKSDVWAYGCLCWEVWNNGQMPYAHMDDQQFMQRIVQCQMPSGGHLGDHEPVHAPPVHCPPWADRLMQWCLCINPEHRPNFAQLYQ

LF
  
MW
TyrKc 92815.m00005.AA TyrKc 25-267 19 6.3e-14 2.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-267
Range on HMM: 1-280/280
Sequence Identity: 19% (56 aa)

TIPMQKLETGDYGYSNISKYSITNRNIVIKQIY-YADSDQEKLNKLFSQYILLMRA--TNRYLNPPIGFIFN--------NPIIIASNYIPNGNLYEAIK
    .||  | .|     ...   ..  .| .  .|      .  . .   ....    .  .   .| .           |. |   | |.|.| . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SGR--LNPTDKTKIAMGIAYALRRLHKMHIVHGDLKSRNIMLGDDMRPLVSDFGYGAIALALQVPIQ---------YRI----NDP-----YWCAPEVLT
. |  |.. |. ...  ||   . ||.....| ||  ||...|.. .  .||||     |.  .            ||     .        |.|||.. 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG-----LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GAVPTSASDVYSFG-------TLISELYNE-----QVPAQGAAVLARTHQEFIPSS--------APKILRALVQCCTMENPARRPDFRRIYRLF
  . |..|||.|||       |.  . | .       ...  . . . .   .| .        .|. .  . ..| .|.|. || |. |...|
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
S_TKc 92815.m00005.AA S_TKc 25-267 17 8.9e-14 25.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-267
Range on HMM: 1-231/231
Sequence Identity: 17% (46 aa)

TIPMQKLETGDYGYSNISKYSITNRNIVIKQIYYADSDQEKLNKLFSQYILLMRATNRYLNPPIGFIFN-NPIIIASNYIPN--GNLYEAIKSGR-----
   ..|.  | .|     .   |.|   ||.|           . . . | ...  .      .  .|  . . .   |...  |.|.. ||. .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LNPTDKTKIAMGIAYALRRLHKMHIVHGDLKSRNIMLGDDMRPLVSDFGYGAIALALQVPIQYRINDPYWCAPEVLTGAVPTS-ASDVYSFGTLISEL
  ... .  ...  |. ||  .|...|.| |||  ||.| .  .  ..|||  ..           .  |...|||||     .  ..|..|.| .. |.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

YNEQVPAQGAAVLARTHQEFIPSSAPKILRALVQCCTMENPARRPDFRRIYR---------LF
.  . | .    .... .       .. .. ... |   .|..||    . .          |
LCGYPPFP---QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 92815.m00005.AA Pkinase 102-267 17 1.3e-11 42.16 Pfam 81-293 (293) Show / Hide 
Range on Protein: 102-267
Range on HMM: 81-293/293
Sequence Identity: 17% (38 aa)

YIPNG----NLYEAIK---SGRL--NPTDKTKIAMGIAYALRRLHKMHIVHGDLKSRNIMLGDDMRP----LVSDFGYGAIA-LALQVPIQYRINDPYWC
| ..|     |.. |.   .|..   . .  ...  |. .|  .|.| |.| |||. ||.. ... .     ..|||  . . .  ..  . .   |...
YCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYM

APEVLT-GAVPTSASDVYSFGTLISELYNEQVPAQGA-------------AVLARTHQEFIPSSAP-------------------KILRALVQCCTMENP
||||.  |   ....|..|.| .. |... . | .|.              .. .   . .| . .                   . .. .. .|   .|
APEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP

ARRPDFRRIYRL--F
..|| .. |     |
KKRPTAEQILQHPWF
Kinase 92815.m00005.AA RAF 125-219 30 2.2e-11 32.84 In-house 108-220 (282) Show / Hide 
Range on Protein: 125-219
Range on HMM: 108-220/282
Sequence Identity: 30% (34 aa)

IAMGIAYALRRLHKMHIVHGDLKSRNIMLGDDMRPLVSDFGYGAIALALQVPIQYRINDP----YWCAPEVLT-------------GAVP-TSASDVYSF
|.  .. ..  ||.  |.| ||||.||.| .||.  . |||   .     .  .  .. |     | ||||                  | .  ||||||
ISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSFQSDVYSF

GTLISELYNEQVP
|. . ||  .. |
GIVMYELMTRHMP
Kinase 92815.m00005.AA Fer 186-268 20 1.9e-10 31.94 In-house 184-283 (283) Show / Hide 
Range on Protein: 186-268
Range on HMM: 184-283/283
Sequence Identity: 20% (20 aa)

WCAPEVLTGAVPTSASDVYSFGTLISELYN-------E--------QVPAQGAAVLAR-THQEFIPSSAPKILRALVQ-CCTMENPARRPDFRRIYRLFK
| |||...  . ....||.||| .. | ..       .        .|. |  .. ..  .  ..|...|. .. ..  .|  ..|  || .  |.. .|
WLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase 92815.m00005.AA MLK 186-267 27 2.3e-10 32.3 In-house 199-291 (291) Show / Hide 
Range on Protein: 186-267
Range on HMM: 199-291/291
Sequence Identity: 27% (26 aa)

WCAPEVL---TGAVPTSASDVYSFGTLISEL------YN-EQVPAQGAAVLARTH-QEFIPSSAPKILRALVQCCTMENPARRPDFRRIYRLF
| ||||.    .   . ..||.|.| .. |.      |  .. |.. |.  | ..    |||..|...  | ..|  ..|..||.|| |   .
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 92815.m00005.AA NZAK 96-165 31 4.1e-09 26.21 In-house 77-150 (329) Show / Hide 
Range on Protein: 96-165
Range on HMM: 77-150/329
Sequence Identity: 31% (23 aa)

IIIASNYIPNGNLYEAI----KSGRLNPTDKTKIAMGIAYALRRLHKMHIVHGDLKSRNIMLGDDMRPLVSDFG
. | . ..  ||| . .    | .| ..    |.   ||  .  ||| ||.| |.|| |..|      .  |||
HCIYMEWMEGGNLTQFLMNDKKQLRFKEHRIIKMIADIAETMSYLHKHHIIHRDIKSNNVILDFNKNLKLIDFG
Kinase 92815.m00005.AA NZAK 188-267 23 7.4e-08 21.94 In-house 240-329 (329) Show / Hide 
Range on Protein: 188-267
Range on HMM: 240-329/329
Sequence Identity: 23% (21 aa)

APEVLTGAVPTSASDVYSFGTLISEL--YNEQ----VPAQGAAVLARTHQEF---IPSSAPKILRALVQCCTMENPARR-PDFRRIYRLF
|||.. .   .  |||.||| .. ..  || .     |   |.. .   ..    ||   | ... ... |   .| .|  ||  .  . 
APENKNNHRINEKSDVWSFGCTVWQMFGYNPPNTIYSPKEMASMVSDQKFNYIPQIPFHVPDKMKDFITQCWDIDPKKRPKDFSHMIEKL
Kinase 92815.m00005.AA MLK 102-165 23 1e-06 18.91 In-house 91-178 (291) Show / Hide 
Range on Protein: 102-165
Range on HMM: 91-178/291
Sequence Identity: 23% (21 aa)

YIPNGNLYEAIKSGR---------------LNPTDKTKIAMGIAYALRRLHKMH---IVHGDLKSRNIMLGD------DMRPLVSDFG
|...| ||. ....|                 .  . ..|. .| ..  ||.|    |.| ||||.||.. .      ..   ..|||
YCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFG
Kinase 92815.m00005.AA Pkinase_Tyr 102-165 24 3e-06 21.88 Pfam 88-156 (270) Show / Hide 
Range on Protein: 102-165
Range on HMM: 88-156/270
Sequence Identity: 24% (17 aa)

YIPNGNLYEAIKSG-----RLNPTDKTKIAMGIAYALRRLHKMHIVHGDLKSRNIMLGDDMRPLVSDFG
| |.|.|..  ..      .|.. |. .... || ..  |. ....| ||  ||.......   ..|||
YMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 92815.m00005.AA Pkinase_Tyr 186-214 44 1.4e-05 19.48 Pfam 180-208 (270) Show / Hide 
Range on Protein: 186-214
Range on HMM: 180-208/270
Sequence Identity: 44% (13 aa)

WCAPEVLTGAVPTSASDVYSFGTLISELY
|.|||..   . |..|||.||| |. |..
WMAPECINYGKFTTKSDVWSFGVLMWEIF
Kinase 92815.m00005.AA Fer 136-165 33 0.000738 9.15 In-house 127-159 (283) Show / Hide 
Range on Protein: 136-165
Range on HMM: 127-159/283
Sequence Identity: 33% (11 aa)

LHKMHIVHGDLKSRNIMLGDDMRPL---VSDFG
||.....| |. .||. ...|   .   .||||
LHSKNCIHRDIAARNCLYHKDKVKKKCKISDFG
Kinase 92815.m00005.AA UTK 223-267 21 0.004026 6.53 In-house 251-296 (296) Show / Hide 
Range on Protein: 223-267
Range on HMM: 251-296/296
Sequence Identity: 21% (10 aa)

AAVLART-HQEFIPSSAPKILRALVQCCTMENPARRPDFRRIYRLF
..|...  .. . | . |  .  |.. | . .|..||||....  .
HQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase 92815.m00005.AA RAF 234-269 22 0.005313 5.23 In-house 247-282 (282) Show / Hide 
Range on Protein: 234-269
Range on HMM: 247-282/282
Sequence Identity: 22% (8 aa)

IPSSAPKILRALVQCCTMENPARRPDFRRIYRLFKN
. . .|| .. |.. | . ..  || |. |    . 
VRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase 92815.m00005.AA Pkinase_Tyr 251-267 29 0.045464 7.63 Pfam 254-270 (270) Show / Hide 
Range on Protein: 251-267
Range on HMM: 254-270/270
Sequence Identity: 29% (5 aa)

MENPARRPDFRRIYRLF
...|..|| |. |.. .
HYDPEDRPTFSEIHEQL