Gene 84178.m00086 (T.vaginalis)

84178.m00086

Species: T.vaginalis
Alias: TvagK0731, 84178.m00086
External Links:
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: PAKA

Sequence

Name Sequence Type Origin Length Description Download
84178.m00086.AA Protein None 449 None Fasta, JSON
84178.m00086.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of 84178.m00086.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD 84178.m00086.AA PBD 11-46 21 0.151581 0.35 SMART 1-38 (38) Show / Hide 
Range on Protein: 11-46
Range on HMM: 1-38/38
Sequence Identity: 21% (8 aa)

ISNPY-DVRDGIHLT-IDEATGRYLNVPRCLLNAIPQD
||.|  ...  .|   .| .|| . . |  . . ..  
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
PBD 84178.m00086.AA PBD 10-37 27 2.857762 3.97 Pfam 1-29 (60) Show / Hide 
Range on Protein: 10-37
Range on HMM: 1-29/60
Sequence Identity: 27% (8 aa)

NISNP-YDVRDGIHLTIDEATGRYLNVPR
 ||.| ....  .| ..|  || . . |.
MISTPLTNFKHTMHVGWDGQTGFFTGMPP
PBD 84178.m00086.AA PBD 81-138 46 2.2e-19 70.22 Pfam 1-60 (60) Show / Hide 
Range on Protein: 81-138
Range on HMM: 1-60/60
Sequence Identity: 46% (28 aa)

NISAP-YELEHLTHVTFDPQKG-FVGLPPEWDKILKKSGFQKEEIEENPKGVLDVMKFMQ
 ||.| .  .| .||..|.| | |.|.|||| |.|. || .|.| ..||. |.||..| |
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD 84178.m00086.AA PBD 82-116 36 3.1e-09 37.94 SMART 1-38 (38) Show / Hide 
Range on Protein: 82-116
Range on HMM: 1-38/38
Sequence Identity: 36% (14 aa)

ISAPY-ELEHLTHVT-FDP-QKGFVGLPPEWDKILKKS
||.|    .| .||  .|. . .|.|||..| ..|| .
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase 84178.m00086.AA PAKA 172-421 45 1.4e-128 433.44 In-house 2-260 (260) Show / Hide 
Range on Protein: 172-421
Range on HMM: 2-260/260
Sequence Identity: 45% (119 aa)

KNMESIDEGSTCKIYRADNPQTGEA--VAVKEMTLTDKNRQ-TLFDETRLMATMSHPNIIKFYSAHLIENTLWILMELMDGGSLTNVATYCD------VQ
|.|| | .|.... |.| | .|..   ||.| | . . ..  ..  | ..| .  |.||.......|..  ||. || |.||.|| | | |.       .
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD

EPHIAYFAREVLQALDYMHKHNKIHRDIKTDNVLLKSDGEVRLADFGYTAQLESRDQTRKSIVGTPYWMAPELIKYQPYSYGVDIWSLGIMCRELAEGEP
| .|||  ||.||.|...|... |||||| ||.|| .||.| ..|||. |||.  .| |...||||||||||.|. . |.. |||||||||..|..||||
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEP

PYVDSPPMRALFLISTKGIPPISDRENRSTEFLDFLDLCLSMDPHARPSAETLLQHPFI
|| . || ||..||.|.|.|.| |... | || ||||.|| .|.  |.||..||.|||.
PYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase 84178.m00086.AA STE20 171-421 44 5.3e-121 408.3 In-house 1-288 (288) Show / Hide 
Range on Protein: 171-421
Range on HMM: 1-288/288
Sequence Identity: 44% (127 aa)

LKNMESIDEGSTCKIYRADNPQTGEA----VAVKEMTLTDKN-----RQTLFDETRLMATMSHPNIIKFYSAHLIE----NTLWILMELMDGGSLTNVAT
 ...| | .||..|.|.| . .|||     ||.| | | ...     ..... | . |.   ||||.|.| ..| .    . |||.||...||||| . .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

YCD----------VQEPHIAYFAREVLQALDYMHKHNKIHRDIKTDNVLLKSDGEVRLADFGYTAQLES-----RDQTRKSIVGTPYWMAPELIKY----
 |            .|..|||  |||||.||| |....|||||| ||.|| .|||| |||||. |||..     ....|...||||||||||.|.     
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-QPYSYGVDIWSLGIMCRELAEGEPPYVDSPPMRALFLIS--TKGIPPISD--RENRSTEFLDFLDLCLSMDPHARPSAETLLQHPFI
 ..| | .|||||||.. |.||||||| | .||||.|.|   ... |. .|   .. |.|| ||.|.|| .||. ||.|. ||.||||
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 84178.m00086.AA STE 171-421 30 2.3e-106 359.68 In-house 1-359 (359) Show / Hide 
Range on Protein: 171-421
Range on HMM: 1-359/359
Sequence Identity: 30% (111 aa)

LKNMESIDEGSTCKIYRA---------DNPQT------GEAVAVKEMTLTDKN------------------RQTLFDETRLMATMS--HPNIIKFYSAHL
....| | .|.. . |.|         .. ..      || .|.|.| | ..|                  .| .  | ..|  ..  ||||.|.| ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE-------NTLWILMELMDGGSLTNVAT-YCDVQ--------------EPHIAYFAREVLQA-LDYMHKHNKIHRDIKTDNVLLKSDGEVRLADFGYTA
 |       ..||| ||.||||||. .   .. ..              |. |||..|..|.. |.| |.|..|||||| .|.||     | |.|||  .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLES----------------RDQTRKSIVGTPYWMAPELIKY------QPYSYGVDIWSLGIMCRELAEGEPPYVDSPPMRALFLISTK-----------
||..                ..| |...|||| ||||| |.       ..|.. .||||||... |.|.|.||. | .||||.|.| ..           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----GIPPISDR-----------------ENRSTEFLDFLDLCLSMDPHARPSAETLLQ--HPFI
    ..||. |.                 .. | || ||...|| .||. ||.|. ||.  ||||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 84178.m00086.AA PAKB 171-421 46 2.3e-90 306.54 In-house 1-252 (252) Show / Hide 
Range on Protein: 171-421
Range on HMM: 1-252/252
Sequence Identity: 46% (117 aa)

LKNMESIDEGSTCKIYRADNPQTGEAVAVKEMTLTDKNRQT-LFDETRLMATMSHPNIIKFYSAHLIENTLWILMELMDGGSLTNVATYCDVQEPHIAYF
|.|   | ||||  .  | .  ||  |||| | |    |   || |   |    ||||...|| .|... ||..|| |.||.|| . |    .|. ||. 
LDNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATV

AREVLQALDYMHKHNKIHRDIKTDNVLLKSDGEVRLADFGYTAQLESRDQTRKSIVGTPYWMAPELIKYQPYSYGVDIWSLGIMCRELAEGEPPYVDSPP
 | |||||.|.|    |||||| | .||..|| |.| |||. ||. .    ||| ||||||||||.|  .||   |||||||||  |. .|||||   ||
CRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPP

MRALFLISTKGIPPISDRENRSTEFLDFLDLCLSMDPHARPSAETLLQHPFI
..|.  |  .  | ...    | .  .||| .|  ||  | .|. ||.|||.
LQAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase 84178.m00086.AA YSK 172-421 40 4.6e-87 262.13 In-house 2-257 (257) Show / Hide 
Range on Protein: 172-421
Range on HMM: 2-257/257
Sequence Identity: 40% (105 aa)

KNMESIDEGSTCKIYRADNPQTGEAVAVKEMTLTDKNRQ--TLFDETRLMATMSHPNIIKFYSAHLIENTLWILMELMDGGSLTNVATY---CDVQEPHI
.  | |  ||   .| . . .|.. ||.|   | .       .  |    .    |.| |.| . |    ||| ||   |||.            .|..|
TKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYI

AYFAREVLQALDYMHKHNKIHRDIKTDNVLLKSDGEVRLADFGYTAQLESRDQTRKSIVGTPYWMAPELIKY--QPYSYGVDIWSLGIMCRELAEGEPPY
|   ||.|..|||.|. .|||||||  ||||  .|.| |.|||  .|.    . |   ||||||||||.|.     | . .|||||||   |.| |||||
AIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPY

VDSPPMRALFLISTKGIPPISDRENRSTEFLDFLDLCLSMDPHARPSAETLLQHPFI
 |  |||..|||  |  ||    .. |. | .| ..||  ||  ||||..|| | ||
CDYHPMRVMFLI-PKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase 84178.m00086.AA S_TKc 171-421 27 7.6e-78 265.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 171-421
Range on HMM: 1-231/231
Sequence Identity: 27% (75 aa)

LKNMESIDEGSTCKIYRADNPQTGEAVAVKEMTLTDKNRQTLFDETRLMATMSHPNIIKFYSAHLIENTLWILMELMDG--GSLTNVATYCD-------V
 . .. | .|.  | |.. .  ||. ||.|..       ...  | ...    ||||.|.| .    . |.. ||..||  |.|  .   .         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

QEPHIAYFAREVLQALDYMHKHNKIHRDIKTDNVLLKSDGEVRLADFGYTAQLESRDQTRKSIVGTPYWMAPELIKYQPYSY-GVDIWSLGIMCRELAEG
 | |..........||.|.|.|. ||||.| .|.|| .  .. ..|||  .||       ....|||..||||..   .|..  .|.||.|..  |.. |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

EPPYVDSPPMRALFLISTKGIPPISDRENRSTEFLDFLDLCLSMDPHARPSAETLLQ-------HPFI
.||.    ... . .|              | |..||.. || .||  ||.|  .||       ||..
YPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 84178.m00086.AA MST 174-421 42 8.6e-77 243.6 In-house 4-254 (254) Show / Hide 
Range on Protein: 174-421
Range on HMM: 4-254/254
Sequence Identity: 42% (107 aa)

MESIDEGSTCKIYRADNPQTGEAVAVKEMTLTDKNRQTLFDETRLMATMSHPNIIKFYSAHL--IENTLWILMELMDGGSLTNV--ATYCDVQEPHIAYF
.| . .||  . |.| . |||. ||.| .   .   | .  | . |  .  ..| |.|   .   .|..|| ||  ..||.  .  .|     |  ||  
VEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV-NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIACI

AREVLQALDYMHKHNKIHRDIKTDNVLLKSDGEVRLADFGYTAQLESRDQTRKSIVGTPYWMAPELIKYQPYSYGVDIWSLGIMCRELAEGEPPYVDSPP
 . .|| |.| |.  |||||||  | ||  .||  |||||  .||  .   | . .||||||||| |  . | . .||||||| . |.|||.||| |  |
LYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDIHP

MRALFLISTKGIPPISDRENRSTEFLDFLDLCLSMDPHARPSAETLLQHPFI
|||.|.| .| .|  .| |  |.|| ||.  ||  .|  |..|| |||||||
MRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase 84178.m00086.AA MKC 205-421 39 2.2e-73 250.1 In-house 41-260 (260) Show / Hide 
Range on Protein: 205-421
Range on HMM: 41-260/260
Sequence Identity: 39% (88 aa)

TDKNRQTLFDETRLMATMSHPNIIKFYSAHLIEN-TLWILMELMDGGSLTNVATY-CDVQEPHIAYFAREVLQALDYMHKHNKIHRDIKTDNVLLKSDGE
| | ... . | .  .   ||||.|.. .|.  . ..|. || |.|| |.. .      .|  ||| ..|.||.|.| |.|| .|||.|  |.   .|||
TKKHQRNNLNEIGFLNYCNHPNIVKYHCSHMKHDDEIWMVMEFMQGGTLEEASQNSHKFCESCIAYVCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGE

VRLADFGYTAQLES-RDQTRKSIVGTPYWMAPELIKYQPYSYGVDIWSLGIMCRELAEGEPPYVDSPPMRALFLISTKGIPP---ISDRENRSTEFLDFL
. | |||  . ..  . . .   .| |.||.|| |.  ..|| .||||.||   |.| |.||. .| .| | |.  | |.       | .  | .| |||
IKLIDFGLCIDVSHEKEEIH--MCGSPFWMSPEMIQQKQHSYPCDIWSFGICLLEMANGRPPHHKS-RMKAMFMVATNGCKFPKEFDDPCHWSDCFHDFL

DLCLSMDPHARPSAETLLQHPFI
 .|| |||| ||.|| ||.||||
WQCLQMDPHKRPTAEQLLKHPFI
Kinase 84178.m00086.AA Pkinase 171-421 26 2.3e-71 248.2 Pfam 1-293 (293) Show / Hide 
Range on Protein: 171-421
Range on HMM: 1-293/293
Sequence Identity: 26% (78 aa)

LKNMESIDEGSTCKIYRADNPQTGEAVAVKEMTLTDKNR---QTLFD--ETRLMATMSHPNIIKFYSAHLIENTLWILMELMDGG----SLTNVAT---Y
..  . | .||  . |.. .  ||. ||||.. . ...    ||..   | ..|. ..||||...| .   .. ... ||...||    .|  . .   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

CDV--QEPHIAYFAREVLQALDYMHKHNKIHRDIKTDNVLLKSDGEV----RLADFGYTAQL-ESRDQTRKSIVGTPYWMAPELIK-YQPYSYGVDIWSL
. .  .| ..  .....|..|.|.|... ||||.| .|.|....|..    ...|||  .|. . ...  ....|||..||||.|. .|.|.. ||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMCRELAEGEPPYVDS----PPMRALFLISTKGIPPISDRENRS---------------------TEFLDFLDLCLSMDPHARPSAETLLQHPFI
|... |.. |.||. ..    . .. ...|  .. ||..  .  .                      |..||.. || .||. ||.|| .||||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 84178.m00086.AA SLK 172-421 36 3.6e-70 235.88 In-house 2-259 (259) Show / Hide 
Range on Protein: 172-421
Range on HMM: 2-259/259
Sequence Identity: 36% (94 aa)

KNMESIDEGSTCKIYRADNPQTGEAVAVKEMTLTDK-NRQTLFDETRLMATMSHPNIIKFYSAHLIENTLWILMELMDGGSLTNVATYCD--VQEPHIAY
. .  . .|   |.|.| . ...   | | . . |. . .  . |  ..... ||||.| |.|. ..| ||...|  ||| . |.    .  ..|. |.|
EIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQY

FAREVLQALDYMHKHNKIHRDIKTDNVLLKSDGEVRLADFGYTAQLESRDQTRKSIVGTPYWMAPELI-----KYQPYSYGVDIWSLGIMCRELAEGEPP
 ......||...|... ||||.|  |.|.  ||.|||||||  |....  | | . .|||||||||..     | ||| | .|||||||   |.|..|||
VCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPP

YVDSPPMRALFLISTKGIPPISDRENRSTEFLDFLDLCLSMDPHARPSAETLLQHPFI
. .  ||| |. |     | .      | || |||  ||  ||..|.... |.||...
HHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase 84178.m00086.AA KHS 172-421 39 1.5e-69 233.11 In-house 2-258 (258) Show / Hide 
Range on Protein: 172-421
Range on HMM: 2-258/258
Sequence Identity: 39% (102 aa)

KNMESIDEGSTCKIYRADNPQTGEAVAVKEMTL-TDKNRQTLFDETRLMATMSHPNIIKFYSAHLIENTLWILMELMDGGSLTNVATYC-DVQEPHIAYF
  .  .  |    .|.| . |..| .||| . .  . . ...  |  .| . .||||. .. . | .. ||| ||   |||| ..      ..|  ||| 
ELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAYV

AREVLQALDYMHKHNKIHRDIKTDNVLLKSDGEVRLADFGYTAQLESRDQTRKSIVGTPYWMAPELI---KYQPYSYGVDIWSLGIMCRELAEGEPPYVD
.||.||.|.|.| . |.|||||  |.|| ..|.|.||||| .||.      ||| .|||||||||     .   |    |||..||   ||||  ||  |
CRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMFD

SPPMRALFLISTKGIPP--ISDRENRSTEFLDFLDLCLSMDPHARPSAETLLQHPFI
  |||||||..  .  |  . |..  |  | .|. ..|  .|  ||.|| ||||||.
LHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase 84178.m00086.AA MSN 171-421 37 5.5e-65 213.44 In-house 1-265 (265) Show / Hide 
Range on Protein: 171-421
Range on HMM: 1-265/265
Sequence Identity: 37% (100 aa)

LKNMESIDEGSTCKIYRADNPQTGEAVAVKEMTLTDKNRQTLFDETRLMATMS-HPNIIKFYSAHL------IENTLWILMELMDGGSLTNVATYCDVQ-
 . .| .  |   ..|.    .||. .|.| | ... . . .  |  ..   | | ||. .| | .       .. ||. ||.   ||.|..      | 
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQS

--EPHIAYFAREVLQALDYMHKHNKIHRDIKTDNVLLKSDGEVRLADFGYTAQLESRDQTRKSIVGTPYWMAPELIK-----YQPYSYGVDIWSLGIMCR
  |  ||| .||.|. | ..|.|  ||||||  ||||. . ||.| |||  |||.     | . .||||||||| |.        | |  |.||.||   
LKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITAI

ELAEGEPPYVDSPPMRALFLISTKGIPPISDRENRSTEFLDFLDLCLSMDPHARPSAETLLQHPFI
|.|||.||  |  ||||||||  .  | .   .  |  | .|.. ||  . | ||..| .|.||||
EMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase 84178.m00086.AA TyrKc 171-421 22 7e-27 96.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 171-421
Range on HMM: 1-280/280
Sequence Identity: 22% (64 aa)

LKNMESIDEGSTCKIYRADNPQTGEAVAVKEMTLTDKNRQTLFDETRLMATM--SHPNIIKFYSAHLIE-------NTLWILMELMDGGSLTNVATYCD-
..  . . ||  ...|..      . |||| .      |. . .| |.|     .||||...| . . .         |.|.||.|..|.| .   ..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-VQEPHIAYFAREVLQALDYMHKHNKIHRDIKTDNVLLKSDGEVRLADFGYTAQLESR-------DQTRKSI-VGTP-----YWMAPELIKYQPYSYGVD
 .. ..  .|.  . .  .| |..| ||||. . |.|..... |. .||| .  ...        |  ||.   |.       ||||| |.|  ..   |
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

IWSLGIMCRELAE-GEPPYVD-----SPPMRALFLISTKGIPPISDREN------RSTEFLDFLDLCLSMDPHARPSAETLLQHPFI
.|| |... |.   |..|| .      .. ... .. . . .|. .          ..|  .    |   ||. ||. ...  | ..
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 84178.m00086.AA Pkinase_Tyr 185-309 23 9.1e-18 60.8 Pfam 19-156 (270) Show / Hide 
Range on Protein: 185-309
Range on HMM: 19-156/270
Sequence Identity: 23% (32 aa)

IYRADNPQTGEAVAVKEM--TLTDKN--RQTLFDETRLMATM-SHPNIIKFYSAHL-IENT--LWILMELMDGGSLTNVATYC-----DVQEPHIAYFAR
... |  .|.  |||| .  . ....  |. .. | ..| .. .||||...| . .  .    ..| ||.| .|.| .           .  ...  ...
TWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCW

EVLQALDYMHKHNKIHRDIKTDNVLLKSDGEVRLADFG
.. ....| . .| ||||. . |.|..... |. .|||
QIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 84178.m00086.AA Pkinase_Tyr 330-384 31 2.3e-05 18.81 Pfam 180-237 (270) Show / Hide 
Range on Protein: 330-384
Range on HMM: 180-237/270
Sequence Identity: 31% (18 aa)

WMAPELIKYQPYSYGVDIWSLGIMCRELAE-GEPP-YVDSPPMRALFLI-STKGIPPI
||||| |.|  ..   |.|| |. . |.   || | | . .. . . .|    .  |.
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC