Gene 87823.m00117 (T.vaginalis)

87823.m00117

Species: T.vaginalis
Alias: 87823.m00117, TvagK0299
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
87823.m00117.AA Protein None 963 None Fasta, JSON
87823.m00117.kin_dom Protein Kinase Domain None 217 None Fasta, JSON

Protein domain

Protein domains of 87823.m00117.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 87823.m00117.AA TKL 1-217 24 5e-63 215.71 In-house 64-364 (364) Show / Hide 
Range on Protein: 1-217
Range on HMM: 64-364/364
Sequence Identity: 24% (76 aa)

MTEALERRFVSEVCALYRCQHPFLLGLIGFSNAPP--------------YIIVTEYISNANLREFIHDKQFQSKRTGTTL-TKIAMGIASGMSFFHAQK-
... .. ... |.  . |..|| .. ..|....||              . ||.||... .|....|            .  ..|..||.||.. |... 
EASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNP

-------LMHRDLKPDNVILDNDFL--------------PKICDFGLTREFDKPS--------------------TPTHKIGTRYYMAPEVIQNG-----
       . |||||..|. .|...               .||||||| |.... .                    |  ...|| ..|||||...      
KWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTE

----------VAYDEKCDVYSYGVILFQMLTQKVPFFDASP----------EDFNVMIIKGKREPIP------------YNCPPNLKRLISDCWSENLFV
            |.|||||||.|..|. .|| ..|..|  .          |.| . . ||.| |||             .||| .|.|. |||...   
KVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEK

RPPFSLIYEMF
|| |. | . .
RPSFQEILKRL
Kinase 87823.m00117.AA MLK 27-217 29 1.6e-52 180.5 In-house 75-291 (291) Show / Hide 
Range on Protein: 27-217
Range on HMM: 75-291/291
Sequence Identity: 29% (65 aa)

LIGFSNAPP-YIIVTEYISNANLREFIHDKQFQSK-----------RTGTTLTKIAMGIASGMSFFHAQK---LMHRDLKPDNVILDN------DFLPKI
. . .. |. . ||.||...  | ...|... ..             .   . ..|. .|.||...|...   . |||||. |. .|.      .   ||
YGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKI

CDFGLTREFDKP-STPTHKIGTRYYMAPEVIQ--NGVAYDEKCDVYSYGVILFQMLTQKVPFF-DAS-PEDFNVMIIKGKREPIPYNCPPNLKRLISDCW
||||. |.. .  .. . ..||  .|||||||   .  |.|||||.|.||.| .||| .||.  . .  . .  .. .|.| |||..||. .|.|...||
CDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCW

SENLFVRPPFSLIYEMF
...   || |. | . .
NQDPHKRPSFRQIVQHL
Kinase 87823.m00117.AA LRRK 12-219 29 4.4e-47 162.75 In-house 107-351 (351) Show / Hide 
Range on Protein: 12-219
Range on HMM: 107-351/351
Sequence Identity: 29% (73 aa)

EVCALYRCQHPFLLGLIGFSNAPPYIIVTEYISNANLREFIHDKQFQS------KRTGTTLTKIAMGIASGMSFFHAQK--LMHRDLKPDNVIL---D--
||  ... .|| .. |.||.   |...|.||... .| .|.|.|.  .      . . ... |||. ||.|| . | ..  . |||||..|..|   .  
EVWIMSHLNHPNIVSLKGFCIH-PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQN

-------NDFLPKICDFGLTR--EFDKPSTPTHKIGTRYYMAPEVIQNG--VAYDEKCDVYSYGVILFQMLTQKVPFFDA-S-------PEDFNVMIIKG
       ..   ||.|||..|    ....    . |.  .||||.....  . |.|| |.||.|.||.  || ....||  .        | .   ||.|
HSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEG

KREPIPYN-CPP-----NLKRLISDCWSENLFVRPPFSLIYEMFAT
 | .|| . |||      .. || .||...   || || | .   .
LRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 87823.m00117.AA Pkinase 11-200 27 2.4e-43 154.35 Pfam 49-274 (293) Show / Hide 
Range on Protein: 11-200
Range on HMM: 49-274/293
Sequence Identity: 27% (63 aa)

SEVCALYRCQHPFLLGLIGFSNAPPYII-VTEYISNA----NLREFIH---DKQF--QSKRTGTTLTKIAMGIASGMSFFHAQKLMHRDLKPDNVILDND
||.. . |..||. . |...   ...|  |.||  .      | ..|.   .. |  . .       ...  |..|. . |... .||||||.|. .||.
SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECK----FYMYQILRGLEYCHSMGIIHRDLKPENILIDNN

FLP----KICDFGLTRE--FDKPSTPTHKIGTRYYMAPEVIQNGVAYDEKCDVYSYGVILFQMLTQKVPFFDA----SPEDFNVMIIKGKREPIPYNCP-
  .    ||||||| .     . | .|.  ||..|||||||. |  |. |.|..|.|.||..||. . || ..    .  | ..|| . .. |.....| 
GHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPW

----------------------PNLKRLISDCW
                      ...| .|..|.
WCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL
Kinase 87823.m00117.AA Dicty4-Unclassified 9-217 32 5e-41 138.23 In-house 45-263 (263) Show / Hide 
Range on Protein: 9-217
Range on HMM: 45-263/263
Sequence Identity: 32% (71 aa)

FVSEVCALYRCQHPFLLGLIGFSNAP-----PYIIVTEYISNANLREFIH----DKQFQSKRTGTTLTKIAMGIASGMSFFHAQKLMHRDLKPDNVILDN
|  ||  |   ||| |. . | . .|      ..||.| .   || | ||    ..|   |   |   |.|. || || . |   . |||.|  |. .| 
FKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDK

DFLPKICDFGLTREFDKPSTPTHKIGTRYYMAPEVIQNGVAYDEKCDVYSYGVILFQMLTQKVPFFDAS-PEDFNVMII-KGKREPIPYNCPPNLKRLIS
.|  || |||. |. |   . |   ||    .||.   . .|  | |||||...|. ..|   |. .   . .    .  |. |  || ||....|.|| 
HFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLM-HESYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIK

DCWSENLFVRPPFSLIYEMF
.||..    || .  | .  
WCWHNDPNKRPTMNQIIQYL
Kinase 87823.m00117.AA TKL-Unique 9-217 28 5.8e-41 142.2 In-house 42-290 (290) Show / Hide 
Range on Protein: 9-217
Range on HMM: 42-290/290
Sequence Identity: 28% (72 aa)

FVSEVCALYRCQ-HPFLLGLIGFSN----APP-YIIVTEYISNANLREFIHD--------KQFQSKRTGTTLTKIAMGIASGMSFFHAQK--LMHRDLKP
| .||  . . . ||... ..|..     .|| ..||.||..  .|.. .|.        ..  .| .     |.|  ||.|| . |  .   .|||||.
FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNN-NCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKS

DNVILDND-----FLPKICDFGLTREFDKPSTPTHK----------IGTRYYMAPEVIQNG-VAYDEKCDVYSYGVILFQMLTQKV------PFFDASPE
 |. .||.     .  ||||||| .  .| .. | .          .|.  .|||||. .    |.||.||||.|..|  ..| |.      |. . ..|
SNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQE

-DFNVMII--KGKREPIPYNCPPNLKRLISDCWSENLFVRPPFSLIYEMF
 .. .     ...|.||| .||.... || .||  .   || |. |..  
QWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 87823.m00117.AA Dicty4 20-219 32 1.4e-39 129.81 In-house 56-277 (277) Show / Hide 
Range on Protein: 20-219
Range on HMM: 56-277/277
Sequence Identity: 32% (72 aa)

QHPFLLGLIGFSN----APPYI-IVTEYISNANLREFIHD---KQFQSKRTG-TTLTK---IAMGIASGMSFFHA--QKLMHRDLKPDNVILDNDFLPKI
.|| .. . | ..    .|. . ||||| .  || . .||    | ||.    .. ..   .|  .| ||   |.      |||||..|   | ..  |.
RHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKV

CDFGLTR----EFDKPS-TPTHKIGTRYYMAPEVIQNGVAYDEKCDVYSYGVILFQMLTQKVPFF--DASPEDFNVMIIK-GKREPIPYNCPPNLKRLIS
||||| .    . |.   . | . ||  .||||| ..  .|.|| ||||.| .|...|| . |..    ... |   .   . | ||| .|||..|.|| 
CDFGLSQYMKKHEDHKDNQMTAC-GTPCWMAPEVMMH-QPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQ

DCWSENLFVRPPFSLIYEM--FAT
.||...  .|| |. | .     .
WCWDHDPQHRPSFEEIIQRRILEH
Kinase 87823.m00117.AA Dicty5 38-221 35 5.5e-39 131.82 In-house 76-260 (260) Show / Hide 
Range on Protein: 38-221
Range on HMM: 76-260/260
Sequence Identity: 35% (66 aa)

IVTEYISNANLREFIHDKQF---QSKRTGTTLTKIAMGIASGMSFFHAQKLMHRDLKPDNVILDNDFLPKICDFGLTREFDKPSTPTHKIGTRYYMAPEV
.||||..|  |..   |.     |    .. |  .|..|| .| . |     |||||  |. .  ..  || |||  |  |     |  .||  .||.| 
HVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQL-HMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACE-

IQNGVAYDEKCDVYSYGVILFQMLTQKVPFFDASPEDFNVMIIKGKREPIPYNCPPNLKRLISDCWSENLFVRPPFSLIYEMFATGK
. ||  |..||||||.|..|. |.|.| |. .    .  ||. || |  ||  ||     ||  || .    || |  | ..|    
LFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase 87823.m00117.AA TK 8-217 15 5.4e-36 117.61 In-house 87-486 (486) Show / Hide 
Range on Protein: 8-217
Range on HMM: 87-486/486
Sequence Identity: 15% (62 aa)

RFVSEVCALY--RCQHPFLLGLIG-FSNA------------PPYIIVTEYISNAN----LREFIHDKQ--------------------------------
....| . .    ..|| .. |.|  .              .|..||.|| .. .    ||.. ...                                 
EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY

-----------------------------------------FQSKRTGTTLTKIAMGIASGMSFFHAQ------KLMHRDLKPDNVILDNDFL-------
                                         .... |  .|  ... ||.||.. |..      .. ||||   |. ....         
SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDG

----PKICDFGLTRE------FDKPSTPTHKIGTRYY-----------------------------MAPEVIQNGV--------AYDEKCDVYSYGVILF
     ||.||||.|.       | .|       . |.                             ||||... .|         . .| ||.|.|| ..
CGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMW

QMLT--QKVPFFDASP---------EDFNVMIIKG--------------KREPIPYNCP--------------PNLKRLISDCWSENLFVRPPFSLIYEM
 ..|  |. .  . |          ...  .. .|               | | | .||              . . .|. .||...   || || ..|.
EIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQ

F
.
L
Kinase 87823.m00117.AA ZAK 36-216 38 4.7e-35 122.29 In-house 67-257 (257) Show / Hide 
Range on Protein: 36-216
Range on HMM: 67-257/257
Sequence Identity: 38% (73 aa)

YIIVTEYISNANLREFIHDKQFQSKR---TGTTLTKI---AMGIASGMSFFH---AQKLMHRDLKPDNVILDNDFLPKICDFGLTREFDKPSTPTHKIGT
| ||||| .   |  .||  . |.      |  .  |   |  ||.|| . |     |  |||||  ||..| .   ||||||  |.|    |     ||
YFIVTEYAEKGSLYDYIHSNRSQEMDSSSGGNSMDHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVIDKNGVCKICDFGTSRDFHHHCTHMSWVGT

RYYMAPEVIQNGVAYDEKCDVYSYGVILFQMLTQKVPFFDASPEDFNVMII-KGKREPIPYNCPPNLKRLISDCWSENLFVRPPFSLIYEM
   ||||.|       | |||.||||.|  |||. ||. | .      ||. |. |  ||  ||  .| |...||      || .  |   
FPWMAPEMILQSEPVTETCDVWSYGVVLWEMLTREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase 87823.m00117.AA RIPK 73-217 30 1.2e-34 115.44 In-house 116-290 (290) Show / Hide 
Range on Protein: 73-217
Range on HMM: 116-290/290
Sequence Identity: 30% (53 aa)

IASGMSFFHAQK--LMHRDLKPDNVILDNDFLPKICDFGLTREFDKPSTPTH--------KI-------GTRYYMAPEVIQ--NGVA---YDEKCDVYSY
|..|| . | ..  . |||||| |. .||.|  || ||||   .   |. .         ..       || .||.|| .   |  .    ..| ||||.
ISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLA-TWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSF

GVILFQMLTQKVPFFDASPEDFNVMIIK-GKR---EPIPYNCPPN-----LKRLISDCWSENLFVRPPFSLIYEMF
...... |||| |. |. ..   .| .| |.|   .|.| ..|       ...|. .||. .  .|| |  . | .
AIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase 87823.m00117.AA Pkinase_Tyr 9-217 29 5.1e-33 112.45 Pfam 50-270 (270) Show / Hide 
Range on Protein: 9-217
Range on HMM: 50-270/270
Sequence Identity: 29% (66 aa)

FVSEVCALYRC-QHPFLLGLIGFSN--APP--YIIVTEYISNANLREFIHDK-QFQSKRTGTTLTKIAMGIASGMSFFHAQKLMHRDLKPDNVILDNDFL
| .|.  .    .|| .. |.|       |  ..||.||  . .|... ...   . . |  .| .... ||.||.. ..... ||||   |. ..... 
FMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNV

PKICDFGLTREF-DKPSTPTHKIGTRY----YMAPEVIQNGVAYDEKCDVYSYGVILFQMLT-QKVP-FFDASPEDFNVMI-IKGKREPIPYNCPPNLKR
 |||||||.|   ..    ..| |        ||||.|..|. . .| ||.|.|| .. ..|  . | . . |.|..  .|  .| | |.| |||. . .
VKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYD

LISDCWSENLFVRPPFSLIYEMF
|. .|| ..   || || |.|..
LMKQCWHYDPEDRPTFSEIHEQL
Kinase 87823.m00117.AA S_TKc 3-219 23 1.5e-27 98.78 SMART 17-231 (231) Show / Hide 
Range on Protein: 3-219
Range on HMM: 17-231/231
Sequence Identity: 23% (58 aa)

EALERR-------------FVSEVCALYRCQHPFLLGLIGFSNAPPYIIVTEYISN--ANLREFIHDKQFQ---SKRTGTTLTKIAMGIASGMSFFHAQK
 . ...             . .|.  | . .||..  |...     . .|.||...   .|...|.... .   .. .  .  ...  |.... . | ..
KCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG

LMHRDLKPDNVILDNDFLPKICDFGLTREFDKPSTPTHKIGTRYYMAPEVIQNGVAYDE-KCDVYSYGVILFQMLTQKVPFFDASPEDFNVMIIKGKREP
 .||||||.|. ||.    ||||||| |..      |. .||..||||||.     |.  |||..| |.||. ||. . ||      . ..|. | .   
IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---

IPYNCPPNLKRLISDCWSENLFVRPPFSLIYE-------MFAT
     .| .| .|. |.  .   ||    . .       .   
-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 87823.m00117.AA TyrKc 1-217 23 6.9e-20 73.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-217
Range on HMM: 1-280/280
Sequence Identity: 23% (66 aa)

MT-----------------------------EALERRFVSEVCALYRC--QHPFLLGLIGFSNA--------PPYIIVTEYISNANLREFIHDKQFQSKR
 |                             .| .. | .|   . .   .|| .. |.|            .|. ||.|| .. .|........ .   
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--L

TGTTLTKIAMGIASGMSFFHAQKLMHRDLKPDNVILDNDFLPKICDFGLTREFDKP-----STPTHKI----GTR-----YYMAPEVIQNGVAYDEKCDV
.  .| ...  ||.||.. | ... ||||   |. .....  ||.||||.|. .       |. . .     |..       ||||.|. |. . .| ||
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK-FTTKSDV

YSYGVILFQMLTQ-KVPFFD-----ASPEDFNVMIIKGKREPIPYN--------CPPNLKRLISDCWSENLFVRPPFSLIYEMF
.|.|| .. ..|  . |  .      |...    . .|.| |.| |        ||. . .....|| |.   || || |.| |
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF