Gene 91186.m00078 (T.vaginalis)

91186.m00078

Species: T.vaginalis
Alias: 91186.m00078, TvagK0630
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
91186.m00078.AA Protein None 2206 None Fasta, JSON
91186.m00078.kin_dom Protein Kinase Domain None 207 None Fasta, JSON

Protein domain

Protein domains of 91186.m00078.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT 91186.m00078.AA FAT 1260-1424 20 1.2e-09 32.57 Pfam 52-255 (408) Show / Hide 
Range on Protein: 1260-1424
Range on HMM: 52-255/408
Sequence Identity: 20% (42 aa)

FFQAVFYT--RTQKLD--LAEQSINKGLINLAQDNAA-YSSGDAYRVHENIAYAHAFVELQEVIDTKRNSKKIT-------AEIADSI---WSKRLTGF-
||||.     . .. |   |.. |.|.   | .  .|  ..   .| .  .   .. .||.|.|  |.     .       .|  ...   | ||| |  
FFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCK

KRDSDGWIKLIRVRSLVSL--------------QEQYTPVYLKLISVLRK----ERCWKLIDTYFD---------RFFSGSILPEVEFAQSKILWARGRR
 |. . |  ....|..|                  . .   .|  .. ||    ..| | .    .         .     ..|....|..|..||.|..
QRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHP----RAPPQWTYAYLKYMWATGQQ

QEAIDNLR
|||.  ||
QEAFQHLR
FAT 91186.m00078.AA FAT 1542-1604 14 0.001218 12.42 Pfam 315-390 (408) Show / Hide 
Range on Protein: 1542-1604
Range on HMM: 315-390/408
Sequence Identity: 14% (11 aa)

FN-DDLSFESMKEVLLLFEISKEESNSDYR-TWLGWAYTNSRLININPEEKD-----------KYSYNAVTGFLKA
.. ... .|. .|.|  .    .  .. |.  |  ||. | .... .. ...            .  .||..|...
EQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHS
Rapamycin_bind 91186.m00078.AA Rapamycin_bind 1729-1764 40 2.6e-05 18.37 Pfam 2-38 (100) Show / Hide 
Range on Protein: 1729-1764
Range on HMM: 2-38/100
Sequence Identity: 40% (15 aa)

LLRSASSWFEEWLMSIDLASRAD-HEHNKAKMESILQ
| | | .|.| |   .. |||.  ..||. || .||.
LIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILE
Rapamycin_bind 91186.m00078.AA Rapamycin_bind 1808-1821 28 0.044372 8.16 Pfam 87-100 (100) Show / Hide 
Range on Protein: 1808-1821
Range on HMM: 87-100/100
Sequence Identity: 28% (4 aa)

WDIFKHIFKQLTER
|||....|..... 
WDIYYQVFRRIRKQ
Kinase 91186.m00078.AA FRAP 1888-2139 44 5.5e-87 295.29 In-house 1-251 (251) Show / Hide 
Range on Protein: 1888-2139
Range on HMM: 1-251/251
Sequence Identity: 44% (113 aa)

KVKFLLKGNEDLRLDQRVMQFFVLINSLLNNSRQKREIPAQIAQYAIIPLAPTAGLISWVTGADTLHQMICDMRVTKGIELSAEMEVISKTVGSVYQYLN
   ||||| ||.| | |||| | ||| ||.|  . .     |  |.||||   .||| ||   |||| .| | |  . | . .| ... . . . |. | 
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMC-NDYDHLP

KVQLLEQFYEISKYCPATEVRDCLWMRSPNAAAWLGRNRNFTITNALMSMVGYIIGLGDRHPSNIMVQRDTGRVIHIDFGDSFETAVTRPNFPEKVPFRL
 ..  | |  | .     . .  ||..|||   |. |  |.|   | |||.|||.||||||||||| || ||...|||||| || | .|  ||||.||||
LMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRL

TRMIVCAFDNGSVEGMFRSACEDVMWMLRDNMSPIVAQLEIFIHEPLDEENF
|||.| | .   .|| .| .|| ||  .|..   ..| || |.  ||     
TRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 91186.m00078.AA PIKK 1859-2129 34 5.5e-79 268.73 In-house 1-290 (290) Show / Hide 
Range on Protein: 1859-2129
Range on HMM: 1-290/290
Sequence Identity: 34% (99 aa)

LLKRIEPALQVLSTQQHPRCVLMVDEKGDKVKFLLKGNEDLRLDQRVMQFFVLINSLLNNSRQKREIPAQIAQYAIIPLAPTAGLISWVTGADTLHQMIC
  . . . ..|. . | |.  ..    |    .|.|| ||||.||||||.| |.| .| .  . .    .|  |..||. .  ||| ||....||.  . 
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

DMRVTKGIELSAE-------------------MEVISKTVGSVYQYLNKVQLLEQFYEISKYCPATEVRDCLWMRSPNAAAWLGRNRNFTITNALMSMVG
. .  |.|.   |                   .  . .     || .. .. .| | |..   |.   .. .| ..|....|. |  |.|.. |.|.|||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YIIGLGDRHPSNIMVQRDTGRVIHIDFGDSFETAVTRPNFPEKVPFRLTRMIVCAFDNGSVEGMFRSACEDVMWMLRDNMSPIVAQLEIF
||.|||||||.|||....|| ..|||||..|| | .| ..||||||||||..| |     ||| ||..||.||  .|..  .. . .| |
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 91186.m00078.AA PI3_PI4_kinase 1888-2139 24 1.6e-62 218.79 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1888-2139
Range on HMM: 1-300/300
Sequence Identity: 24% (78 aa)

KVKFLLKGNEDLR--LDQRVMQFF-----------------------VLINSLLNNSRQKREIPAQIAQYAIIPLAPTAGLISWVTGADTLHQMICDMRV
 ..|..||..|||   |.|.||..                        |.| .. . .  |.   |.. | .||..|  |.| ||  ..|.|. ..  .|
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

TKGIEL-------------SAEMEVISKTVGSVYQYLNKVQLLEQFYEISKYCPATEVRDCLWMRSPNA-AAWLGRNRNFTITNALMSMVGYIIGLGDRH
.....              .... .             ..| .|.|.. ..  |    .. .|. .|.|  .|. . .||.   | |..|.||.|.||||
KCKHKHFNKEHKMWMKMWPDWWHLM-------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRH

PSNIMV--QRDTGRVIHIDFGDSFE-TAVTRPNFPEKVPFRLTR------MIVCAF------DNGSVEGMFRSACEDVMWMLRDNMSPIVAQL-------
..||||   ..|| ..|||||..|. ..  ....||.||||.|.      ..| |.      |. . .|.||. |....  || .|  ... |       
NDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRG

EIFIHEPLDEENF
|...| .| . . 
ECMVHDGLPMWRS
Kinase 91186.m00078.AA PI3Kc 1890-2199 20 7.1e-51 176.25 SMART 1-336 (336) Show / Hide 
Range on Protein: 1890-2199
Range on HMM: 1-336/336
Sequence Identity: 20% (76 aa)

KFLLKGNEDLRLDQRVMQFFVLINSLLNNSRQKREIPAQIAQYAIIPLAPTAGLISWVTGADTLHQMICDMRVTKGI-----------------------
 ...|...||| |.|.||.| |.| .. . ...|  . .. .|..||. |  |.| ||. ..||||. .  .  |..                       
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

---------------------ELSAEMEVIS-KTVGSVYQYLNKVQLLEQFYEISKYCPATEVRDCLWMRSPNAAAWLGRNRNFTITNALMSMVGYIIGL
                     .|  ...... ... . |... .    .                          .|  . .|||   | ..||.|| |.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN------------------------EDWWEARDNFTRSCAGYCMVTYILGI

GDRHPSNIMVQRDTGRVIHIDFGDSFETAVTRPNFP----EKVPFRLTRMIVCAFD----NGSVEGMFRSACEDVMWMLRDNMSPIVAQLEIFIHEPL-D
||||..|||. ..|| ..|||||. |. . ..| |.    |.||||||...| .      .  ..| ||. |. .. ..| ..  |.. .|.... |. .
GDRHNDNIMLDMKTGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMP

EENFSSSNKANSRQIIDRVISKLNGRDSLYEDAAIDG----EPELSVEEHVDSLIRIAADPARYITHY
. ...          |. . ....  . | .. |.      .. .  |....|..  . . . ....|
CWRMM-------EKDIKYLRQRFRLDH-LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 91186.m00078.AA ATR 1859-2129 27 1.9e-41 138.73 In-house 2-267 (267) Show / Hide 
Range on Protein: 1859-2129
Range on HMM: 2-267/267
Sequence Identity: 27% (74 aa)

LLKRIEPALQVLSTQQHPRCVLMVDEKGDKVKFLLKGNEDLRLDQRVMQFFVLINSLLNNSRQKREIPAQIAQYAIIPLAPTAGLISWVTGADTLHQMIC
 .  ..  ...|.. |.|. . .    |     . |  .||| | | |.|  ||| ..    ..|    ... ||.|||   ...| ||    ||. .. 
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

DMRVTKGIELSAEMEVISKTVGSVYQYLNKVQLLEQFYEISKYCPATEVRDCLWMRSPNAAAWLGRNRNFTITNALMSMVGYIIGLGDRHPSNIMVQRDT
 .   |..  .   ..         .  .| . . .|  . .. |    .|    | | .  |     |.  . | ..||||||||||||  ||.... .
KLWKEKKQY-MQFYQLRQCMDKKSREEWEKQKVFREFL-LPRHPPI--FHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKIN

GRVIHIDFGDSFETAVTRPNFPEKVPFRLTRMIVCAFDNGSVEGMFRSACEDVMWMLRDNMSPIVAQLEIF
| ..|.|.   |    .  . || ||||||. .| ..     .|.|| |||..| ..||.. .|.. .. |
GECVHVDYNCIFNSGEQF-EVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 91186.m00078.AA ATM 2019-2134 40 1.2e-25 78.6 In-house 131-245 (304) Show / Hide 
Range on Protein: 2019-2134
Range on HMM: 131-245/304
Sequence Identity: 40% (47 aa)

AAWLGRNRNFTITNALMSMVGYIIGLGDRHPSNIMVQRDTGRVIHIDFGDSFETAVTRPNFPEKVPFRLTRMIVCAFDNGSVEGMFRSACEDVMWMLRDN
| |  .   .|   |  |.||||.||||||  ||..      ..||| |  ||     |  || ||||||| ||       |||.||  ||  | ..|  
AIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNS

MSPIVAQLEIFIHEPL
   ..   |. . .||
QETLLTIVEVLLYDPL
Kinase 91186.m00078.AA DNAPK 2039-2138 33 1.1e-14 49.72 In-house 201-301 (301) Show / Hide 
Range on Protein: 2039-2138
Range on HMM: 201-301/301
Sequence Identity: 33% (34 aa)

GYIIGLGDRHPSNIMVQRDTGRVIHIDFGDSFETAVTRPNFPEKVPFRLTRMIVCAFDNGSVEGMFRSACEDVMWMLRDNMSPIVAQLEIFIHEPL-DEE
..| | ||||  | ||  ..| .| |||| ||  |      ||  ||||||  .       . |....     |  .|      .   ..|| .|. |  
HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK

N
|
N
Kinase 91186.m00078.AA FATC 2174-2206 51 1.6e-14 49.56 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2174-2206
Range on HMM: 1-33/33
Sequence Identity: 51% (17 aa)

PELSVEEHVDSLIRIAADPARYITHYGGWCPFW
 .||||..|| ||. | || ..  .| ||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 91186.m00078.AA SMG1 1867-1953 36 1.3e-13 41.33 In-house 1-87 (242) Show / Hide 
Range on Protein: 1867-1953
Range on HMM: 1-87/242
Sequence Identity: 36% (32 aa)

LQVLSTQQHPRCVLMVDEKGDKVKFLLKGNEDLRLDQRVMQFFVLINSLLNNSRQKREIPAQIAQ-YAIIPLAPTAGLISWVTGADTL
. .| |.  |. .| .   |    .| || ||| || |.|||  ..| .      . | |   |  |.. ||   .||| || ||  |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMF-ATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPL
Kinase 91186.m00078.AA SMG1 2033-2066 64 2.5e-13 40.35 In-house 195-228 (242) Show / Hide 
Range on Protein: 2033-2066
Range on HMM: 195-228/242
Sequence Identity: 64% (22 aa)

ALMSMVGYIIGLGDRHPSNIMVQRDTGRVIHIDF
| ||||||||||||||  |...   || |.|||.
AVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY
Kinase 91186.m00078.AA DNAPK 1891-1947 42 2.1e-09 30.21 In-house 35-91 (301) Show / Hide 
Range on Protein: 1891-1947
Range on HMM: 35-91/301
Sequence Identity: 42% (24 aa)

FLLKGNEDLRLDQRVMQFFVLINSLLNNSRQKREIPAQIAQYAIIPLAPTAGLISWV
|. || ||||.|||. | |   |  .    |      |   | |||.    ||| ||
FCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWV
Kinase 91186.m00078.AA ATM 1890-1949 35 1.7e-08 22.87 In-house 1-60 (304) Show / Hide 
Range on Protein: 1890-1949
Range on HMM: 1-60/304
Sequence Identity: 35% (21 aa)

KFLLKGNEDLRLDQRVMQFFVLINSLLNNSRQKREIPAQIAQYAIIPLAPTAGLISWVTG
. | || .||| |  . | | . | ||      |     |  | ..||.  .| . | ||
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG