Gene 95887.m00086 (T.vaginalis)

95887.m00086

Species: T.vaginalis
Alias: 95887.m00086, TvagK0977
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
95887.m00086.AA Protein None 520 None Fasta, JSON
95887.m00086.kin_dom Protein Kinase Domain None 221 None Fasta, JSON

Protein domain

Protein domains of 95887.m00086.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 95887.m00086.AA TKL 94-267 18 1.3e-28 100.1 In-house 105-364 (364) Show / Hide 
Range on Protein: 94-267
Range on HMM: 105-364/364
Sequence Identity: 18% (50 aa)

NP------IIIATNYISNGNLYEAIKSGRLNPTDKTKIAMGIAYALRRLHKMH--------IIHGDLKSKNIMLGDDMR--------------PLVSDFG
.|      . | . |...|.|.. .      .  . ..|..|| ..  || |.        ||| |||||||.. ....              . ..|||
HPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFG

----------YGAIALA--------LQVPIQYRIN-DPYWCAPEVLTGG----------------VPTSASDVYSFGTLISELYNEHIPAQGA-------
            ... .        ..    ...   |.|.||||| |                   . ..|||||| .. |..   .| ..        
LSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIF

--------AVLARTSQE-FIP------------STAPKILQALVKCCTLENPARRPDFRKIYRLF
        .. .  ..   ||            ...|. .  | ..|  ..|  || | .|   .
QDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 95887.m00086.AA TK 92-267 13 8.1e-27 86.3 In-house 121-486 (486) Show / Hide 
Range on Protein: 92-267
Range on HMM: 121-486/486
Sequence Identity: 13% (48 aa)

FN-----NPIIIATNYISNGN----LYEAIKSGR------------------------------------------------------------------
|.      |..| . | ..|.    | .  .. |                                                                  
FEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQM

-----------LNPTDKTKIAMGIAYALRRLHKM------HIIHGDLKSKNIMLGDDMR-----------PLVSDFGYGAIA---LALQVP---IQYRIN
           |.. ..  ... || ... ||..      ...|.||   |...|....             ..|||        ||  ..     || .
AWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKS

DPY----------------------------WCAPEVLTGGV---------PTSASDVYSFGTLISELYN--EHIPAQG------------AAVLARTSQ
...                            |.|||.|...|          |..|||.||| |. |..   .  .. |            . |. .  .
SYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRR

E--------------FIPS---TAP--------------KILQALVKCCTLENPARRPDFRKIYRLF
.              . .     .|              .... | ..|  ..|..||.|. ... .
GGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 95887.m00086.AA TKL-Unique 97-267 25 1e-15 52.05 In-house 76-290 (290) Show / Hide 
Range on Protein: 97-267
Range on HMM: 76-290/290
Sequence Identity: 25% (54 aa)

IIATNYISNGNLYEAIK-----------SGRLNPTDKTKIAMGIAYALRRLHKMH--IIHGDLKSKNIMLGDD-----MRPLVSDFGYGAIAL-ALQVPI
.| . |.. |.||. .            .  ||.  . |.|  || .. .||     |||.||||.|. .  .     ..  ..|||   ..   .. ..
CIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTN

Q--------YRINDPYWCAPEVLTG--GVPTSASDVYSFGTLISELYNEHI------PAQGAAVL--A-------RTSQEFIPSTAPKILQALVKCCTLE
          |.  . | |||||..     .  |||||||.   |... .|      | || .    .       . ... ||.  ||... | . |   
NEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHH

NPARRPDFRKIYRLF
.|  || |  |.   
DPSQRPSFDEIIHRL
Kinase 95887.m00086.AA TK-Unique 125-210 31 9.4e-15 47.4 In-house 136-229 (294) Show / Hide 
Range on Protein: 125-210
Range on HMM: 136-229/294
Sequence Identity: 31% (31 aa)

IAMGIAYALRRLHK--MHIIHGDLKSKNIMLGDDMRPLVSDFGYGA--------IALALQVPIQYRINDPYWCAPEVLT--GGVP-TSASDVYSFGTLI
.| .|| ..  |..  ..|.|.|| ..|..|..| .  ..|||           .    | .|..|     |.|||.|   .|.  |. |||.||| |.
FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIR-----WMAPESLKCYHGMYHTTKSDVWSFGVLM
Kinase 95887.m00086.AA UTK 95-214 24 1.4e-14 46.28 In-house 84-234 (296) Show / Hide 
Range on Protein: 95-214
Range on HMM: 84-234/296
Sequence Identity: 24% (38 aa)

PIIIATNYISNGNLYEAIKSGRL---------NPTDKTKIAMGIAYALRRLHKMHIIHGDLKSKNIMLGDD-------MRPLVSDFGYGAIALALQVP--
|..|.| | .||.|     . |          . ..... |. || ..  || ....|.||  .|. ....       |   ..||| |.  .. .|.  
PWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGG--MSRRVNTF

--------IQYRINDP------YWCAPEVLTGG-VPTSASDVYSFGTLISELY
         .|   ..       |.|||.|| .  .|..|||.||| .  |..
HFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIW
S_TKc 95887.m00086.AA S_TKc 25-267 18 5.1e-14 28.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-267
Range on HMM: 1-231/231
Sequence Identity: 18% (48 aa)

TIPIQKLETGDYGYSNISKYTVTNRNIVIKQIYYTDSDQEKLNKLFSQYILLMRATNRYLNPPIGFIFN-NPIIIATNYISN--GNLYEAIKSGR-----
   ..|.  | .|     . . |.|   ||.|           . . . | ...  .      .  .|  . . . . |...  |.|.. ||. .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LNPTDKTKIAMGIAYALRRLHKMHIIHGDLKSKNIMLGDDMRPLVSDFGYGAIALALQVPIQYRINDPYWCAPEVLTGGVPTSASDVYSFGTLISELY
  ... .  ...  |. ||  .|...||| |||  ||.| .  .  ..|||  ..           .  |...|||||  |  . ..|..|.| .. |..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEML

NEHIPAQGAAVLARTSQEFIPSTAPKILQALVKCCTLENPARRPDFRKIYR---------LF
    | .    .... .       .. .  ... |   .|..||   .. .          |
CGYPPFP---QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 95887.m00086.AA RTKE 185-267 23 5.9e-14 43.95 In-house 192-293 (293) Show / Hide 
Range on Protein: 185-267
Range on HMM: 192-293/293
Sequence Identity: 23% (24 aa)

YWCAPEVLTGGVPTSASDVYSFGTLISELY-NEHI-----PAQGAAVLARTSQE-------------FIPSTAPKILQALVKCCTLENPARRPDFRKIYR
.| ||||.  ......|||...| |  |.. |. .     . |  .   .. |                |...|  ...| . |.  ||..||.|. .|.
RWWAPEVWKDQHFSFKSDVWAYGCLCWEVWNNGQMPYAHMDDQQFMQRIVQCQMPSGGHLGDHEPVHAPPVHCPPWADRLMQWCLCINPEHRPNFAQLYQ

LF
  
MW
TyrKc 95887.m00086.AA TyrKc 25-267 19 2.7e-13 -7.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-267
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

TIPIQKLETGDYGYSNISKYTVTNRNIVIKQIYYTDSDQEKLNKLFSQYILLMRA--TNRYLNPPIGFIFN--------NPIIIATNYISNGNLYEAIKS
   ..||  | .|   . | | . ..  .| .         .  . .   ....    .  .   .| .           |. | . | ..|.| . ...
ITLGKKLGEGAFG--EVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

GR--LNPTDKTKIAMGIAYALRRLHKMHIIHGDLKSKNIMLGDDMRPLVSDFGYGAIALALQVPIQ---------YRI----NDP-----YWCAPEVLTG
 |  |.. |. ...  ||   . ||....|| ||   |...|.. .  .||||     |.  .            ||     .        |.|||..  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG-----LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

GVPTSASDVYSFG-------TLISELYNE-----HIPAQGAAVLARTSQEFIPST--------APKILQALVKCCTLENPARRPDFRKIYRLF
|. |..|||.|||       |.  . | .       ...  . . .     .|          .|. .  . |.|  |.|. || |. |...|
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 95887.m00086.AA LRRK 94-157 31 3.4e-12 39.44 In-house 128-204 (351) Show / Hide 
Range on Protein: 94-157
Range on HMM: 128-204/351
Sequence Identity: 31% (24 aa)

NPIIIATNYISNGNLYEAIK----SG------RLNPTDKTKIAMGIAYALRRLHKMH--IIHGDLKSKNIML-GDDM
.|..... |...|.||. ..    .|      ..... | |||. || ... ||. .  ||| |||| || | . ..
HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQ
Kinase 95887.m00086.AA MLK 186-267 30 3.9e-12 38.52 In-house 199-291 (291) Show / Hide 
Range on Protein: 186-267
Range on HMM: 199-291/291
Sequence Identity: 30% (28 aa)

WCAPEVL---TGGVPTSASDVYSFGTLISEL------YN-EHIPAQGAAVLARTS-QEFIPSTAPKILQALVKCCTLENPARRPDFRKIYRLF
| ||||.    ..  . ..||.|.| .. |.      |  .. |.. |.  | ..    ||||.|...  | |.|  ..|..||.|| |   .
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 95887.m00086.AA Pkinase 102-267 18 9.8e-12 42.58 Pfam 81-293 (293) Show / Hide 
Range on Protein: 102-267
Range on HMM: 81-293/293
Sequence Identity: 18% (40 aa)

YISNG----NLYEAIK---SGRL--NPTDKTKIAMGIAYALRRLHKMHIIHGDLKSKNIMLGDDMRP----LVSDFGYGAIA-LALQVPIQYRINDPYWC
|  .|     |.. |.   .|..   . .  ...  |. .|  .|.| ||| |||. ||.. ... .     ..|||  . . .  ..  . .   |...
YCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYM

APEVLT-GGVPTSASDVYSFGTLISELYNEHIPAQGA---------AVLARTSQ------EFIPSTAP-----------------KILQALVKCCTLENP
||||.  |   ....|..|.| .. |... . | .|.         ....|. .      .. ... .                 . .. ..|.|   .|
APEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP

ARRPDFRKIYRL--F
..|| .. |     |
KKRPTAEQILQHPWF
Kinase 95887.m00086.AA LISK 102-165 38 1.3e-10 30.46 In-house 78-150 (296) Show / Hide 
Range on Protein: 102-165
Range on HMM: 78-150/296
Sequence Identity: 38% (28 aa)

YISNGNLYEAIKSG-----RLNPTDKTKIAMGIAYALRRLHKMHIIHGDLKSKNIMLG----DDMRPLVSDFG
||. |.| . .|.       |  . . ||| .|| ... || | ||| ||||||. ..    .. |  | |||
YINGGDLHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFG
Kinase 95887.m00086.AA NZAK 96-165 32 4.9e-10 29.39 In-house 77-150 (329) Show / Hide 
Range on Protein: 96-165
Range on HMM: 77-150/329
Sequence Identity: 32% (24 aa)

IIIATNYISNGNLYEAI----KSGRLNPTDKTKIAMGIAYALRRLHKMHIIHGDLKSKNIMLGDDMRPLVSDFG
. |   ... ||| . .    | .| ..    |.   ||  .  ||| |||| |.|| |..|      .  |||
HCIYMEWMEGGNLTQFLMNDKKQLRFKEHRIIKMIADIAETMSYLHKHHIIHRDIKSNNVILDFNKNLKLIDFG
Kinase 95887.m00086.AA NZAK 188-267 21 2.4e-07 20.19 In-house 240-329 (329) Show / Hide 
Range on Protein: 188-267
Range on HMM: 240-329/329
Sequence Identity: 21% (19 aa)

APEVLTGGVPTSASDVYSFGTLISELYNEHIP------AQGAAVLARTSQEF---IPSTAPKILQALVKCCTLENPARR-PDFRKIYRLF
|||.. .   .  |||.||| .. ..     |         |.. .   ..    ||   | ..  ... |   .| .|  || ..  . 
APENKNNHRINEKSDVWSFGCTVWQMFGYNPPNTIYSPKEMASMVSDQKFNYIPQIPFHVPDKMKDFITQCWDIDPKKRPKDFSHMIEKL
Kinase 95887.m00086.AA MLK 102-165 25 5.4e-07 20.43 In-house 91-178 (291) Show / Hide 
Range on Protein: 102-165
Range on HMM: 91-178/291
Sequence Identity: 25% (22 aa)

YISNGNLYEAIKSGR---------------LNPTDKTKIAMGIAYALRRLHKMH---IIHGDLKSKNIMLGD------DMRPLVSDFG
|...| ||. ....|                 .  . ..|. .| ..  ||.|    ||| ||||.||.. .      ..   ..|||
YCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFG
Kinase 95887.m00086.AA Pkinase_Tyr 186-214 48 1e-06 23.06 Pfam 180-208 (270) Show / Hide 
Range on Protein: 186-214
Range on HMM: 180-208/270
Sequence Identity: 48% (14 aa)

WCAPEVLTGGVPTSASDVYSFGTLISELY
|.|||..  |. |..|||.||| |. |..
WMAPECINYGKFTTKSDVWSFGVLMWEIF
Pkinase_Tyr 95887.m00086.AA Pkinase_Tyr 88-165 22 1e-05 19.99 Pfam 70-156 (270) Show / Hide 
Range on Protein: 88-165
Range on HMM: 70-156/270
Sequence Identity: 22% (20 aa)

IGFIF--NNP--IIIATNYISNGNLYEAIKSG-----RLNPTDKTKIAMGIAYALRRLHKMHIIHGDLKSKNIMLGDDMRPLVSDFG
.| .     |  |.| . |  .|.|..  ..      .|.. |. .... || ..  |. ...|| ||  .|.......   ..|||
YGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 95887.m00086.AA LISK 184-213 46 5.5e-05 11.92 In-house 203-232 (296) Show / Hide 
Range on Protein: 184-213
Range on HMM: 203-232/296
Sequence Identity: 46% (14 aa)

PYWCAPEVLTGGVPTSASDVYSFGTLISEL
||| |||.|.|   . ..||.||| .  |.
PYWMAPEMLLGQSYDESCDVFSFGIVLCEI
Kinase 95887.m00086.AA LRRK 184-207 40 0.001191 8.77 In-house 243-269 (351) Show / Hide 
Range on Protein: 184-207
Range on HMM: 243-269/351
Sequence Identity: 40% (11 aa)

PYWCAPEVLTGG---VPTSASDVYSFG
| |.|||.. ..   . |  .|.||||
PGWMAPEIMRYNGEEEYTEKVDCYSFG
Kinase 95887.m00086.AA TK-Unique 247-267 38 0.02283 4.12 In-house 274-294 (294) Show / Hide 
Range on Protein: 247-267
Range on HMM: 274-294/294
Sequence Identity: 38% (8 aa)

KCCTLENPARRPDFRKIYRLF
|.|. ..|  ||.||.|   .
KSCWQWEPEERPSFRQIKHRL
Kinase 95887.m00086.AA LISK 231-267 27 0.027225 3.02 In-house 260-296 (296) Show / Hide 
Range on Protein: 231-267
Range on HMM: 260-296/296
Sequence Identity: 27% (10 aa)

QEFIPSTAPKILQALVKCCTLENPARRPDFRKIYRLF
|...|.. |. .  |.  |.  .|  || | .| . .
QKICPDDCPPPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase 95887.m00086.AA Pkinase_Tyr 252-267 31 0.07622 6.87 Pfam 255-270 (270) Show / Hide 
Range on Protein: 252-267
Range on HMM: 255-270/270
Sequence Identity: 31% (5 aa)

ENPARRPDFRKIYRLF
..|..|| |. |.. .
YDPEDRPTFSEIHEQL
Kinase 95887.m00086.AA UTK 235-267 27 0.157792 1.0 In-house 264-296 (296) Show / Hide 
Range on Protein: 235-267
Range on HMM: 264-296/296
Sequence Identity: 27% (9 aa)

PSTAPKILQALVKCCTLENPARRPDFRKIYRLF
|   |  .  |.. |   .|..||||. ..  .
PWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase 95887.m00086.AA LRRK 234-269 26 0.17885 0.96 In-house 310-351 (351) Show / Hide 
Range on Protein: 234-269
Range on HMM: 310-351/351
Sequence Identity: 26% (11 aa)

IPST-APK-----ILQALVKCCTLENPARRPDFRKIYRLFKN
||..  |       .|.| . |  ..| .|| | .|    . 
IPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ