Gene TVAG_347940 (T.vaginalis)
TVAG_347940
Species: T.vaginalis
Alias: TvagK1066, TVAG_347940
External Links:
Annotation:
Group:
TKL
Family:
TKL-Unique
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| TVAG_347940.AA | Protein | None | 915 | None | Fasta, JSON |
| TVAG_347940.kin_dom | Protein Kinase Domain | None | 152 | None | Fasta, JSON |
Protein domains of TVAG_347940.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | TVAG_347940.AA | Pkinase | 250-306 | 18 | 4.7e-07 | 26.04 | Pfam | 194-293 (293) | Show / Hide |
Range on Protein: 250-306 Range on HMM: 194-293/293 Sequence Identity: 18% (18 aa) DIYSYGAILACLATKSQCFSPN----------LLNEDIK-------------------------------PEIKSLISKCLDEEPSNRPKIEDILSS--F |..|.| ||...... |. ..... . .| |..|..||. |. || .|.|| . | DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| S_TKc | TVAG_347940.AA | S_TKc | 68-307 | 17 | 8.1e-07 | -76.93 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 68-307
Range on HMM: 1-231/231
Sequence Identity: 17% (48 aa)
IRQIKQLAL------RKGRNTDLIQDLVDGRILVLSSFAIKLPNNAKSINPDDYYRKYALISHPCLACPHGEYLFDFSEAGSMRYM-MPYYLK--GSLGN
. .... .|.|... .||| . .. .| .. .. .|. |.|. . . || | | |.|
YEILRKIGKGAFGKVYKCRHKK-----------TGRIVAIKIIK-------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFD
ILQLESQGKHPFQWTSTAKSICSFGILVGLKGLHLKKIVHGLLNPNNILLNRKLEPKISEYWMSELYDKESIDMEYDSNFIDKSTSQG------------
... .. .|. . |. .|. .| ..|.| | | ||||.. . ||. .. .. .| |
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVLGY
-E-FNDIYSYGAILACLATKSQCFSPNLLNEDI------KPEIKSLISKCLDEEPSNRPKIEDILS--------SFV
|..| | ||. ... |. ... || |..|.|||. .|..|| . ..| ..
GKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | TVAG_347940.AA | TKL | 274-306 | 33 | 9.8e-07 | 20.29 | In-house | 332-364 (364) | Show / Hide |
Range on Protein: 274-306 Range on HMM: 332-364/364 Sequence Identity: 33% (11 aa) NEDIKPEIKSLISKCLDEEPSNRPKIEDILSSF ..|. |..|.|. .| |..|..|| ..||. . CPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | TVAG_347940.AA | ARK | 279-305 | 40 | 2e-06 | 19.99 | In-house | 254-280 (280) | Show / Hide |
Range on Protein: 279-305 Range on HMM: 254-280/280 Sequence Identity: 40% (11 aa) PEIKSLISKCLDEEPSNRPKIEDILSS . |.||..|.|..|.||| |.|... EQLKNLIQCCWDQDPDNRPSCEEIMEE |
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| Kinase | TVAG_347940.AA | MLK | 279-306 | 25 | 2e-06 | 18.54 | In-house | 264-291 (291) | Show / Hide |
Range on Protein: 279-306 Range on HMM: 264-291/291 Sequence Identity: 25% (7 aa) PEIKSLISKCLDEEPSNRPKIEDILSSF . .|.|...| ...|..||. |.. . EHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | TVAG_347940.AA | PIM | 279-303 | 44 | 2e-06 | 17.96 | In-house | 231-255 (260) | Show / Hide |
Range on Protein: 279-303 Range on HMM: 231-255/260 Sequence Identity: 44% (11 aa) PEIKSLISKCLDEEPSNRPKIEDIL .|.. ||..|| .|| |...|.|| HECCQLIRWCLTFKPSHRCSLEQIL |
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| Kinase | TVAG_347940.AA | Dicty3 | 282-303 | 22 | 6e-06 | 15.42 | In-house | 330-351 (351) | Show / Hide |
Range on Protein: 282-303 Range on HMM: 330-351/351 Sequence Identity: 22% (5 aa) KSLISKCLDEEPSNRPKIEDIL | .| .|....|..|.... .. KNFIQHCWQIDPNHRWDMHELI |
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| Kinase | TVAG_347940.AA | CAMK | 274-307 | 31 | 7e-06 | 14.16 | In-house | 392-425 (425) | Show / Hide |
Range on Protein: 274-307 Range on HMM: 392-425/425 Sequence Identity: 31% (11 aa) NEDIKPEIKSLISKCLDEEPSNRPKIEDILS-SFV . . .| |.||.|.| .|..|..||..|. .. H-FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | TVAG_347940.AA | NAK | 280-306 | 29 | 7e-06 | 15.46 | In-house | 273-299 (299) | Show / Hide |
Range on Protein: 280-306 Range on HMM: 273-299/299 Sequence Identity: 29% (8 aa) EIKSLISKCLDEEPSNRPKIEDILSSF ....||...|...|..||.|...|. QMHDLIRYMLTPDPEQRPNIYQVLNQL |
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| Kinase | TVAG_347940.AA | Dicty4 | 279-309 | 34 | 1e-05 | 15.21 | In-house | 246-277 (277) | Show / Hide |
Range on Protein: 279-309 Range on HMM: 246-277/277 Sequence Identity: 34% (11 aa) PEIKSLISKCLDEEPSNRPKIEDILSS-FVNG | .|.|| .|.|..|..|| | |.. . PSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| TyrKc | TVAG_347940.AA | TyrKc | 68-306 | 15 | 1.7e-05 | -133.89 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 68-306
Range on HMM: 1-280/280
Sequence Identity: 15% (47 aa)
IRQIKQL------ALRKGRNTDLIQDLVDGRILVLSSFAIKLPNNAKSINPDDYYRKYAL---------I--SHPCLACPHGEYLFD---FSEAGSMRYM
|. .|.| .||. . | | |.| .. . . .. . .||.. . .| . . | ... .
ITLGKKLGEGAFGEVYKGTWK----------IQV----AVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIV
MPYYLKGSLGNILQLESQGKHPFQWTSTAKSICSFGILVGLKGLHLKKIVHGLLNPNNILLNRKLEPKISEYWMSELYDKE----SIDMEYDSNF--IDK
| | .|.| . |. . . .. | | || |...| | |.|..... ||| .| . . . |.. |
MEYMPHGDLKDYLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK
-----------STSQGEFN---DIYSYG-------------------------AILACLATKSQCFSPNL-LNEDI-----KPEIKSLISKCLDEEPSNR
. |.|. |..|.| ..... . | . . . .|. .....| .|.|..|
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDR
PKIEDILSSF
| ..| . |
PTFSEIHECF
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| Kinase | TVAG_347940.AA | TK-Unique | 279-306 | 28 | 0.000128 | 11.99 | In-house | 267-294 (294) | Show / Hide |
Range on Protein: 279-306 Range on HMM: 267-294/294 Sequence Identity: 28% (8 aa) PEIKSLISKCLDEEPSNRPKIEDILSSF .|. .|.. |. .||. || ...|.. . HEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | TVAG_347940.AA | TBCK | 184-211 | 46 | 0.000451 | 10.35 | In-house | 89-116 (346) | Show / Hide |
Range on Protein: 184-211 Range on HMM: 89-116/346 Sequence Identity: 46% (13 aa) ILVGLKGLHLKKIVHGLLNPNNILLNRK || || .| . |||. | |.||.|... ILCGLSYMHKHHIVHRFLHPHNIYLDDN |
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| Kinase | TVAG_347940.AA | Pkinase_Tyr | 279-306 | 28 | 0.000774 | 13.62 | Pfam | 243-270 (270) | Show / Hide |
Range on Protein: 279-306 Range on HMM: 243-270/270 Sequence Identity: 28% (8 aa) PEIKSLISKCLDEEPSNRPKIEDILSSF .|| .|. .| ...|..|| ..|.. . DEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | TVAG_347940.AA | TBCK | 280-308 | 24 | 0.008303 | 5.75 | In-house | 318-346 (346) | Show / Hide |
Range on Protein: 280-308 Range on HMM: 318-346/346 Sequence Identity: 24% (7 aa) EIKSLISKCLDEEPSNRPKIEDILSSFVN . ...| ||| |. || .. . . . WLIQIIRKCLQMCPMKRPSPTELMEHPMF |
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| Kinase | TVAG_347940.AA | TK-Unique | 193-233 | 33 | 0.026565 | 3.89 | In-house | 151-192 (294) | Show / Hide |
Range on Protein: 193-233 Range on HMM: 151-192/294 Sequence Identity: 33% (14 aa) LKKIVHGLLNPNNILLNRKLEPKISEYWMS-ELYDKESIDME .|||||. | |.||..... ||. . |. ..|. . ..|. RKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMM |
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| Kinase | TVAG_347940.AA | Dicty3 | 187-209 | 29 | 0.145693 | 0.7 | In-house | 123-146 (351) | Show / Hide |
Range on Protein: 187-209 Range on HMM: 123-146/351 Sequence Identity: 29% (7 aa) GLKGLHLK-KIVHGLLNPNNILLN .|. .| . .|.|. ....||.|. TLNYIHKNCHIIHRDIKCDNIMLD |
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| Sel1 | TVAG_347940.AA | Sel1 | 437-472 | 33 | 1.9e-08 | 31.16 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 437-472 Range on HMM: 1-43/43 Sequence Identity: 33% (15 aa) VDAQYRLAGFLY---TGQ-N--FPK-N-FEL-SEKYYLLAVEQGH . |||.|. ..| .|| . |. . .|. . ..| .| |||| P-AQYNLG-MYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_347940.AA | Sel1 | 365-400 | 20 | 0.00156 | 14.87 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 365-400 Range on HMM: 1-43/43 Sequence Identity: 20% (9 aa) ARCQFLFGCFR--REGV--G-ISV-N-KNA-ALKSFKAAADQGI . |. |... .| | . . .. |.. .. ||.|| P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_347940.AA | Sel1 | 473-507 | 29 | 0.00591 | 12.95 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 473-507 Range on HMM: 1-43/43 Sequence Identity: 29% (13 aa) LDSLLKLA--ENYQNKQFPG-G-----EEK-AKKYYRLAALQGN . ..|. . |.. || | || | ..|..|| ||. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_347940.AA | Sel1 | 401-436 | 24 | 2.104662 | 4.48 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 401-436 Range on HMM: 1-43/43 Sequence Identity: 24% (11 aa) PEAQYLVS--I--IMGA----KPK-NQNIRQEANNYLVDAADNGF | ||| . | |. . ....|| .. ||..| P-AQYNLGMYYMYYHGQFGGCVPQDD-DYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_347940.AA | Sel1 | 508-539 | 15 | 11.430679 | 2.04 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 508-539 Range on HMM: 1-43/43 Sequence Identity: 15% (7 aa) SDSIFKYGNYLV--EEGK----------LEE-ASDFLIRSADQGN . . ...| .. ..|. .|. | .. ..|.||. P-AQYNLG-MYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_347940.AA | Sel1 | 561-574 | 28 | 0.718231 | 6.03 | Pfam | 30-43 (43) | Show / Hide |
Range on Protein: 561-574 Range on HMM: 30-43/43 Sequence Identity: 28% (4 aa) NAIKYIKKACDSGD .|... .||.. |. EAFYWYQKAAEQGH |
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| Sel1 | TVAG_347940.AA | Sel1 | 611-646 | 11 | 0.127689 | 8.52 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 611-646
Range on HMM: 1-43/43
Sequence Identity: 11% (5 aa)
ETCLLRYA--DLLLDGK-Y--VQH-D-ENK-AIECFKRSWKEHN
.... ....|. . | | .| |....... . .
P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH
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| Sel1 | TVAG_347940.AA | Sel1 | 776-811 | 31 | 2.6e-08 | 30.71 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 776-811 Range on HMM: 1-43/43 Sequence Identity: 31% (14 aa) PRAQLKYG--QMLMDGD--G-VER-D-IAL-AVTNFEKAAQFGI | ||...| .|...|. | |.. | ... |. ..|||. | P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_347940.AA | Sel1 | 812-838 | 28 | 0.007854 | 12.54 | Pfam | 1-34 (43) | Show / Hide |
Range on Protein: 812-838 Range on HMM: 1-34/43 Sequence Identity: 28% (10 aa) AQANFELS--YIYERGL-LG--ER-D-EEK-AKKY . | ..| |.|..|. | .. | || | .. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYW |
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| Sel1 | TVAG_347940.AA | Sel1 | 708-739 | 22 | 0.087189 | 9.07 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 708-739 Range on HMM: 1-43/43 Sequence Identity: 22% (10 aa) LLAQYDLANYK---LKT--G-H-----KQE-AYKLLEDAANKGN ||| |. | | ... |..... ||..|. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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| Sel1 | TVAG_347940.AA | Sel1 | 740-775 | 18 | 0.240044 | 7.61 | Pfam | 1-43 (43) | Show / Hide |
Range on Protein: 740-775 Range on HMM: 1-43/43 Sequence Identity: 18% (8 aa) VEAMSRFA--RLGLNGKFD--TED-D-EVF--IEWLKKASDLGD . |. . . .. ..|.|. .. | ..|..|| ..|. P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH |
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