Gene 90093.m00071 (T.vaginalis)

90093.m00071

Species: T.vaginalis
Alias: TvagK0480, 90093.m00071
External Links:
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
90093.m00071.AA Protein None 378 None Fasta, JSON
90093.m00071.kin_dom Protein Kinase Domain None 221 None Fasta, JSON

Protein domain

Protein domains of 90093.m00071.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 90093.m00071.AA CK1-Unclassified 10-242 52 6.2e-151 448.67 In-house 1-244 (244) Show / Hide 
Range on Protein: 10-242
Range on HMM: 1-244/244
Sequence Identity: 52% (128 aa)

YEILSKIGAGSFGEIYTAKNLQNGKTYAIKSEPATSTAPQLLRETRIYKLLNGEA-------GFPNCYGYFIDDD--FNCLAMDLLGKSLETYHTIAPQV
|... |||.||||||| ..|.|... .||| | ..|  |||..| .|.. |....       |.|..| .. ...  .| . |||||.||| .  .  . 
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

FDVPTVATLAYQMISRVQFLHSKGFIHQDIKPDNFVLG-QGKDNNIIYLIDFGLSKRYIDV-KTKSHIQYREGRSLTGTARYASLNTHLGIEQSRRDDIE
| . ||  .| |||.|...||.|.||| |||||||. |  ||  ...|.|||||||||||  ||..||.|||...|||||||||.|.||||||||||| |
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE

SIAYVLVYLLKGKLPWQGIKAKTKKEKYEHIAQKKFATNAEMLC
|..|||.|.|||.||||.|||..|||||| |. .|  |  |.||
SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 90093.m00071.AA CK1 10-268 52 4.4e-150 504.91 In-house 1-271 (271) Show / Hide 
Range on Protein: 10-268
Range on HMM: 1-271/271
Sequence Identity: 52% (141 aa)

YEILSKIGAGSFGEIYTAKNLQNGKT--YAIKSEPATSTAPQLLRETRIYKLLNG------EAGFPNCYGYFID--DDFNCLAMDLLGKSLETYHTIAPQ
|..  |||.||||.|| ..|..||.   .||| |...| .|||..| .||| |.|      . |.|..| .  .   |.| . |||||.||| .  .  .
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNR

VFDVPTVATLAYQMISRVQFLHSKGFIHQDIKPDNFVLGQ-GKDNNIIYLIDFGLSKRYIDVKTKSHIQYREGRSLTGTARYASLNTHLGIEQSRRDDIE
 | . ||  .| |||.|....|.|.||| |||||||. |  ||. ...|.|||||.|||.| ||..||.|||...|||||||||.||||||||||||| |
KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDME

SIAYVLVYLLKGKLPWQGIKAKTKKEKYEHIAQKKFATNAEMLCEG-LPQEFIAFVNEARKLDFTERPNYE
|..|||.|.|.|.|||||.||.|||.||| |. ||  |. |.||.| .| ||. . | .|.|.| |.|.|.
SLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 90093.m00071.AA CK1-D 10-270 50 6.7e-118 397.99 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-261/261
Sequence Identity: 50% (132 aa)

YEILSKIGAGSFGEIYTAKNLQNGKTYAIKSEPATSTAPQLLRETRIYKLLNGEAGFPNCYGYFIDDDFNCLAMDLLGKSLETYHTIAPQVFDVPTVATL
| |  |||.||||.||  .|.|..   ||| |.. .  |||  | ..||...|  | |.   .  . |.| . ||||| |||         | . ||  |
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

AYQMISRVQFLHSKGFIHQDIKPDNFVLGQGKDNNIIYLIDFGLSKRYIDVKTKSHIQYREGRSLTGTARYASLNTHLGIEQSRRDDIESIAYVLVYLLK
| |||.|....|.. ||| |||||||..| ||  |..|.|||||.||| | .|. || ||| ..|||||||||.|||.|||||||||.||. |||.|  .
ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR

GKLPWQGIKAKTKKEKYEHIAQKKFATNAEMLCEGLPQEFIAFVNEARKLDFTERPNYEKY
| |||||.|| ||..|||.|..||  |. . ||.|.|.||  ..| .|.| | ..|.|   
GSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 90093.m00071.AA CK1-A 10-270 51 2.3e-112 379.6 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-261/261
Sequence Identity: 51% (135 aa)

YEILSKIGAGSFGEIYTAKNLQNGKTYAIKSEPATSTAPQLLRETRIYKLLNGEAGFPNCYGYFIDDDFNCLAMDLLGKSLETYHTIAPQVFDVPTVATL
| .. |||.||||.|| . |..||.  ||| | .    |||. |...|..|.|  |.|.   |  . |.| . ||||| |||    .    | . ||  |
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

AYQMISRVQFLHSKGFIHQDIKPDNFVLGQGKDNNIIYLIDFGLSKRYIDVKTKSHIQYREGRSLTGTARYASLNTHLGIEQSRRDDIESIAYVLVYLLK
| |||.|. ..| |.||| |||||||..| |.  | ..||||||.|.| | .|. ||.||| . |||||||||.| |||||||||||.||..||..|  .
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR

GKLPWQGIKAKTKKEKYEHIAQKKFATNAEMLCEGLPQEFIAFVNEARKLDFTERPNYEKY
|||||||.||.||| ||| |  || .|  |.|| | | ||  ..| .|.| | | |.|   
GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 90093.m00071.AA CK1-G 10-270 48 1.7e-111 376.7 In-house 1-266 (266) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-266/266
Sequence Identity: 48% (128 aa)

YEILSKIGAGSFGEIYTAKNLQNGKTYAIKSEPATSTAPQLLRETRIYKLLNGEA-GFPNCYGYFIDDDFNCLAMDLLGKSLETYHTIAPQVFDVPTVAT
| .  ||| |.|||..  ||. |.   ||| ||  | ||||  | | ||.||| . | |. | .     .| . ||||| |||    .    | | ||. 
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

LAYQMISRVQFLHSKGFIHQDIKPDNFVLGQ--GKDNNIIYLIDFGLSKRYIDVKTKSHIQYREGRSLTGTARYASLNTHLGIEQSRRDDIESIAYVLVY
.| |||.|.. .||.  |  |.|||||  |.   ||...|..||||. | ||| .|| || ||| .|||||||| | ||||| |||||||.|..  .  |
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY

LLKGKLPWQGIKAKTKKEKYEHIAQKKFATNAEMLCEG--LPQEFIAFVNEARKLDFTERPNYEKY
 | |.||||| || . ||.|. | ..| .|| | ||..  .|..|  .   .|.||| | | |.  
FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 90093.m00071.AA CK1 10-270 33 1.9e-110 373.22 In-house 1-339 (339) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-339/339
Sequence Identity: 33% (115 aa)

YEILSKIGAGSFG-EIYTA-----KNLQNG-----KTYAIKSEPATST--APQLLRETRIYKLLNGE-------------------AGFPNCYGYFIDDD
...  ||| |.|| .|| .     |...|.     . ||.| ||..|    |||..| ..||.|.|                     ..|  |.|   .|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--FNCLAMDLLGKSLETYHT---IAPQVFDVPTVATLAYQMISRVQFLHSKGFIHQDIKPDNFVLGQ------GKDNN--------IIYLIDFGLSK-RY
  .| . |.|||..|| .        . | ..|.  .|.||.......|..|||| |||||||..|       ||. .        ..|.||||... .|
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY

IDV-----------KTKSHIQYRE---GRSLTG-TARYASLNTHLGIEQSRRDDIESIAYVLVYLLKGK--LPWQGIKAKTK-------KEKYEHIAQKK
.|            ||. |...||    ....| ||||.|.|.|||.||.||||..| .|.|...|||.  ||||..|...|       |.|||.|. ||
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK

FATNAEMLCEG-----LPQEFIAFVNEARKLDFTERPNYEKY
. |  . ||..     .||||  ...  |.|.. .||.||. 
MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 90093.m00071.AA TTBKL 10-274 27 7.1e-57 190.56 In-house 1-288 (288) Show / Hide 
Range on Protein: 10-274
Range on HMM: 1-288/288
Sequence Identity: 27% (80 aa)

YEILSKIGAGSFGEIYTAKNLQNGKTYAIKSEPATS-TAPQ--LLRETRIYKLLN--GEAGFPNCYGYFIDDDFNCLAMDLLGKSLETYHTIAPQV--FD
..|  .|| | ||..| ...... |..|.. |. ..       .  |  . ..|.  |   ||.|...   .|.| ..| |.|..|       |.   | 
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

VPTVATLAYQMISRVQFLHSKGFIHQDIKPDNFVLGQGKDN----NIIYLIDFGLSKRYIDV----------KTKSHIQYRE---GRSLTGTARYASLNT
. |.. ...| .  .. .|..|||| |.|| |...|  ...     ..||||||....|..           ... .   |.     .. || ||.|.| 
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLGIEQSRRDDIESIAYVLVYLLKGKLPWQGIKAKTKKEKYEHIAQKKFATNAEMLCEG------LPQEFIAFVNEARKLDFTERPNYEKYREMF
|.. ||.| ||. |  |....|..| |||.... |      . |...| ... | |. .      .|.||  |.   | |.. .||.||. .| |
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDK------MEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 90093.m00071.AA Worm6 10-270 27 2.8e-53 183.33 In-house 1-279 (279) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-279/279
Sequence Identity: 27% (78 aa)

YEILSKIGAGSFGEIYTAKNLQNGK--TYAIKSEP--ATSTAPQLLRETRIYKLLNGEA--GFPNCYGY-FIDDD-FNCLAMDLLGKSLETYHTIAP-QV
.... ||| |.|| .| ... ...|   .|.| |   ...  ..| .|  . |... .   .|..   .  .| . || . | |.||.|. .   .| . 
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FDVPTVATLAYQMISRVQFLHSKGFIHQDIKPDNFVLGQ-----GKDNNIIYLIDFGLSK--RYIDVKT-----K-SHIQYREGRSLTGTARYASLNTHL
| ..|   .| |.. ... ||. |||| |.|| ||  |.      ..  .||..|||...  .|.. ..     .  ....|      || |||.|. | 
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFR------GTVRYAPLACHK

GIEQSRRDDIESIAYVLVYLLKGKLPWQGIKAKTKKE-KYEHIAQKKFATNAEMLCEGLPQ-EFIAFVNEARKLDFTERPNYEKY
|.||.|.||.||  |..| ...|.|||...|..  .|  .. .  .. |. ..|. .. |. || .      .... .||.|.. 
GQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 90093.m00071.AA TTBK 10-270 34 8.4e-48 165.13 In-house 1-257 (257) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-257/257
Sequence Identity: 34% (92 aa)

YEILSKIGAGSFGEIYTAKNLQNG-KTYAIKSEPATSTAPQLLR-ETRIYKLLNGEAGFPNCYGYFIDDDFNCLAMDLLGKSLETYHTIAP-QVFDVPTV
  .. ||| | ||||| ||...|     ||| | |  .  | |. |  . | | |       .|   .|.|| . |.|.||.|      .| . | . | 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPK-QVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTT

ATLAYQMISRVQFLHSKGFIHQDIKPDNFVLGQGKDN-NIIYLIDFGLSKRYIDVKTKSHIQYREGRSLT---GTARYASLNTHLGIEQSRRDDIESIAY
  |  |..  ..  || || | |||| || .|.   . ...|..||||  .|    | .. . |  |. .   ||.|||| | |.  |  |.||  |. |
LRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQY----TNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFY

VLVYLLKGKLPWQGIKAKTKKEKYEHIAQKKFATNAEMLCEGLPQEFIAFVNEARKLDFTERPNYEKY
.||  ..| |||  || |      . . . |   .  || . .|.||  |..  . |.. .||.|   
MLVEFVQGQLPWRKIKDK------DQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 90093.m00071.AA Pkinase 10-274 20 1.6e-36 130.24 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-274
Range on HMM: 1-293/293
Sequence Identity: 20% (64 aa)

YEILSKIGAGSFGEIYTAKNLQNGKTYAIKSEPATSTAPQLLR------ETRIYKLLNGEAGFPNCYGYFIDDDFNCLAMDLLGKSL---ETYHTIA---
|.|..|||.||||. | ...  .||..|.|  .  .. .. ..      | .| | || .     .|..| |.|  .. |..... |   . .. |    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

PQVF--DVPTVATLAYQMISRVQFLHSKGFIHQDIKPDNFVLGQGKDNNI---IYLIDFGLSKRYIDVKTKSHIQYREGRSLTGTARYASLNTHL-GIEQ
  .|  .  ..   .||... ....||.|.|| |.||.|. .   ....|   . ..||||.| .       .  ..   ...|| .|..   .. | . 
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

SRRDDIESIAYVLVYLLKGKLPWQGI----KAKTKKEKYEHIAQKKFATNAEMLCEGL----------------PQEFIAFVNEARKLDFTERPNYEKYR
... |. |.  .| ..| |..|..|     .  ....... | ....  . . .|..                 ..|.. |..   ..| ..||. |   
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

EM--F
.   |
QHPWF
Kinase 90093.m00071.AA CMGC 10-157 16 1.7e-23 73.27 In-house 1-254 (513) Show / Hide 
Range on Protein: 10-157
Range on HMM: 1-254/513
Sequence Identity: 16% (42 aa)

YEILSKIGAGSFGEIYTAKN--------------LQNGKTYAIK----SEPATSTAP----------QLLRETRIYKLLN----------------GEAG
|||..||| |..|. | ...               .... .|||     .  . .|             ||| .| | ||                 .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

FPNCYGYFIDDDFN-----------------CLAMDLLGKSLETYHTIAP---------------------------QVFDVPTVATLAYQMISRVQ--F
  ..| .| ... .                 .| .......|  |    .                           . | .  .   .||..  .   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LHSKG--FIHQDIKPDN-FVLGQGK----------------DNNIIYLIDFGLSKRY
.||..  .|| |.|| |  .  ...                .| .. ..||||.. |
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWY
Kinase 90093.m00071.AA S_TKc 10-274 21 1.1e-22 82.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-274
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

YEILSKIGAGSFGEIYTAKNLQNGKTYAIKSEPATSTAPQLLRETRIYKLLNGEAGFPNCYGYFIDDDFNCLAMDLLGK---SLETYHTIAPQV-----F
|||| ||| |.||. | ...   |. .|||  .      ...|| .| |   .     ..|..| | |. .. |....    .| .|    .       |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

DVPTVATLAYQMISRVQFLHSKGFIHQDIKPDNFVLGQGKDNNIIYLIDFGLSKRYIDVKTKSHIQYREGRSLTGTARYASLNTHLGIEQSR-RDDIESI
.  ... ..||... ....||.|.|| |.||.|  | .      | ..||||....              ... ||  | .         .. . |. |.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

AYVLVYLLKGKLPWQGIKAKTKKEKYEHIAQKKFATNAEMLCEGLPQEFIAFVNEARKLDFTERPNYEKYRE---------MF
  .|  .| |. |..     . .. ...|                ..|.. |..   . | ..||   .  .          |
GCILYEMLCGYPPFP-----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 90093.m00071.AA TyrKc 10-274 18 5e-06 -125.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-274
Range on HMM: 1-280/280
Sequence Identity: 18% (58 aa)

YEILSKIGAGSFGEIYTAKNLQNGKTYAIKSEPATSTAPQLLRETRIYKLL--NGEAGFPN---CYGYFIDD-------DFNCLAMDLLGK-SLETYHTI
 . . |.| | |||.| ..      . |.|.  . .    ..|| || . |  .     ||   .||. ...       .  .. | .  . .|  |   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGH----HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

APQVFDVPTVATLAYQMISRVQFLHSKGFIHQDIKPDNFVLGQGKDNNIIYLIDFGLSKRYIDV---KTKSHIQYREGR--SLT--GTARYASLNTHLGI
    . ...    ..|  .  ..||||..|| |.   |  .| ..   ..   |||||.   |       |.  ||     .       |  .       
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMA-------

EQSRRDDIESIAY-------------VLVY--LLKGKLPWQGIKA--KTKKEKYEHIAQKKFATNAEMLCEGL-----PQEFIAFVNEARKLDFTERPNY
       .|.| |             |. .  .  |. |. |.    .. .| .|.. | .     .  .. .     |.|      .  . |  .||. 
-------PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTF

EKYREMF
.  .| |
SEIHECF