Gene 85357.m00065 (T.vaginalis)

85357.m00065

Species: T.vaginalis
Alias: 85357.m00065, TvagK0586
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
85357.m00065.AA Protein None 282 None Fasta, JSON
85357.m00065.kin_dom Protein Kinase Domain None 273 None Fasta, JSON

Protein domain

Protein domains of 85357.m00065.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 85357.m00065.AA CMGC 8-280 20 4.1e-79 259.41 In-house 1-513 (513) Show / Hide 
Range on Protein: 8-280
Range on HMM: 1-513/513
Sequence Identity: 20% (108 aa)

YEKTTDLQQGTFGIVYLCKD--------------LLTKKTVVCK---ESDIDEISAQ--------------EIETLKSLK-----------------HPN
||.   . .||.|.|| |.|                |.. |  |   .   .|. |.              ||. || |.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIQMLDSFKDFM-----------------SEFIIMEYGGKDLLQILEDNP---------KMDIKE------------IKYIT------REVLKGVE--YI
|....|.|..                   . ....|| ..||.|....|.         ...  .            |||..      . .|.|..  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSMG--YIHRDLKSSNILVSETNE--------------------IKIIDFGYCRKIKGR-----------------------PLTPCRFTNQFAPLDCLL
||..   |||||| .|||.....|                    .||.||| .|..  .                       |.|.   |    .   ||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GFIDYN---------EKMDIWGVGCILGHMLAG--------KLLFEGDSQ-----------ISVLMNILQVLGTPK---------------AEDWPEMKS
|  .|.         ...|.|.||||.. |. |        | || |.|            |  |  | .|||||                 |.||.|..
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

IEYFESFQ-------------------------LPEYK-STLDTILPK----------------------------------DVDPQAVDLLLKMLEPSQ
  ... |                          .|...  ..  . |.                                  . ||||.||| |||.   
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

SKRISAHEALQHPFL
.|||.| .|||||..
DKRITAEQALQHPYF
Kinase 85357.m00065.AA S_TKc 8-280 27 2.7e-72 247.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-280
Range on HMM: 1-231/231
Sequence Identity: 27% (80 aa)

YEKTTDLQQGTFGIVYLCKDLLTKKTVVCKESDIDEISAQEIETLKSLKHPNIIQMLDSFKDFMSEFIIMEYGGK---DLLQILEDNPK------MDIKE
||.   . .|.|| ||.|..  |.. | .|. .  |   .||. ||. .||||....|.| |  . ...||| .    ||.........      ..  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

IKYITREVLKGVEYIHSMGYIHRDLKSSNILVSETNEIKIIDFGYCRKIKGRPLTPCRFTNQFAPLDCLLGFIDYNE-KMDIWGVGCILGHMLAGKLLFE
............||.||.| |||||| .|||..|  .|||.||| .|..     | .  |  . .   |     |.  | |.| .||||  ||.|. .|.
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP

GDSQISVLMNILQVLGTPKAEDWPEMKSIEYFESFQLPEYKSTLDTILPKDVDPQAVDLLLKMLEPSQSKRISAHEALQ-------HPFL
   |. ......                                        .|.| |.. |.|.   .||..| ||||       ||..
---QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 85357.m00065.AA Pkinase 8-280 29 8.5e-71 246.31 Pfam 1-293 (293) Show / Hide 
Range on Protein: 8-280
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

YEKTTDLQQGTFGIVYLCKDLLTKKTVVCKESDIDEISA---------QEIETLKSLKHPNIIQMLDSFKDFMSEFIIMEYGGK-----DLLQILE--DN
|..   . .|.|| ||.|..  | |.|..|. . ....          .||. .|.|.||||....|.| |  .  ..||| ..     ||  ...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PKM--DIKEIKYITREVLKGVEYIHSMGYIHRDLKSSNILVSETNEI----KIIDFGYCR---KIKGRPLTPCRFTNQFAPLDCLLGFIDYNEKMDIWGV
 ..  . .|.| . ...|.|.||.|||| ||||||..|||......|    ||.||| ..     ... .|    |  ...   ..|  .|  | |.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILGHMLAGKLLFEGD----SQISVLMNILQVLGTPKAEDWPEMKSIEYFESFQLPEYKSTLDTILPKDVDPQAVDLLLKMLEPSQSKRISAHEALQHP
||||  || |...| |.    . .. .  | ...|.|  .|||.  || ||. |.  . . .  . . . ... . |.. ..|..  .||..|...||||
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

FL
..
WF
Kinase 85357.m00065.AA Ciliate-E2 8-280 21 5.2e-55 187.27 In-house 1-365 (365) Show / Hide 
Range on Protein: 8-280
Range on HMM: 1-365/365
Sequence Identity: 21% (87 aa)

YEKTTDLQQGTFGIVYLCKDLLTKKTV-------------------------VCKESDIDEISAQEIETLK----------------SLKHPNIIQMLDS
|..   . ||.||.||.||. ...| .                          ... .  |.  |||  ..                .|.|||||.| ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FK--DFMSEFIIMEY-GGKDLLQILEDN-----------PKMDIKEIKYITREVLK---------------GVEYIHSMG-YIHRDLKSSNILVSETNEI
|.  |  . ...|||  |.||......|            ....||||||....|.               ..||.|| .  ||||.| .|||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIIDFGYCRKIKGR-----------PLTPCR-----------------------FTNQFAPLDCLLG--------FIDYNEKMDIWGVGCILGHMLAGKL
||||||...|..              ..  .                        |  . .   | |        . .|..| ||| .|.||  || ||.
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

LFEGDSQISVLMNILQVLGTPKAEDWPEMKSIEYFESFQLPEYKSTLDTIL--------PKDVDPQAVDLLLK----MLEPSQSKRIS-AHEALQHPFL
 |                             .     ...|......|  .        .|...... ||. |    ||.  ..|||. . ..|.||..
PF---------------------------QQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 85357.m00065.AA Ciliate-E2-Unclassified 8-280 22 4e-49 168.55 In-house 1-352 (352) Show / Hide 
Range on Protein: 8-280
Range on HMM: 1-352/352
Sequence Identity: 22% (84 aa)

YEKTTDLQQGTFGIVYLCKDLLTKKTVVCKESDIDEISA-----------QEIETLKSLK-------------------HPNIIQMLDSFKDFMSEFIIM
|..   . || ||.||.|..  .|.  . |.     | .           .|.......|                   ||.|. |.. |.|    .|.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYG-GKDLLQILEDNPK-----------------MDIKEIK-----YITREVLKGVEYIHSMG-YIHRDLKSSNILVSETN---EIKIIDFGYCRKIKGR
||  |.||.|......|                  . ...|     ......|.| ||.|. .  ||||.| .|||... .   .||||||| ..|..  
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

P-----------------LTPCRFTNQFAPLD-----CLLG-FIDYN--EKMDIWGVGCILGHMLAGKLLFEGDSQIS----------------VLMNIL
.                 .. .  |... |       .| |   |    .| |||..|.||  || |.. |.. ....                .. ||.
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-QYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

Q----VLGTPKAEDWPEMKSIEYFESFQLPEYKSTLDTILPKDVDPQAVDLLL----KMLEPSQSKRISAHEALQHPFL
|    .   |. .                           ||...|.| |..     |||.  ..|||.. ..|.||..
QKNIQFPKFPWQQ--------------------------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 85357.m00065.AA CAMK 13-280 18 7.7e-49 155.1 In-house 1-425 (425) Show / Hide 
Range on Protein: 13-280
Range on HMM: 1-425/425
Sequence Identity: 18% (83 aa)

DLQQGTFGIVYLCKDLLTK------------KTVVCKE--------------------------------SDIDEISAQ-EIETLKS-------LKHPNI
 | .|.||.|.||.. .|.            . | .|                                 .. |. . . ||| .|.       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQMLDSFKD----------------FMS----EFIIM---EYGGK-----DLLQILEDNPK---------------MDIKEIKYITREVLKGVEYIHSMG
|.... . |                | .     ...|   ||        ||.. . ....               .. .| ... | .. .|.|.||..
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

YIHRDLKSSNILVSET-----------------NEIKIIDFGYCRKIK-------------------------GRPLTPCRFTNQFAP-LDCLLGF----
 .|||||  |||...                  | |||||||  .|..                         | ... .  |  ...    |.|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------IDY-NEKMDIWGVGCILGHMLAGKLLFEGDSQISVL---------MNILQVLGTPKAE-DWPEMK--------------SIEYFESFQLPEY
        ..| ..| |.| .|.||  || |.. |.||.. . .          ....   . | . ..|...              | |          
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDE----------

KSTLDTILPKDVDPQAVDLLLKMLEPSQSKRISAHEALQHPFL
      . .  |.... ||. |||..  .||......|.||..
------FHH-FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 85357.m00065.AA p38 48-280 35 1.3e-46 157.24 In-house 51-289 (289) Show / Hide 
Range on Protein: 48-280
Range on HMM: 51-289/289
Sequence Identity: 35% (87 aa)

EIETLKSLKHPNIIQMLDSFKD-------FMSEFIIMEYGGKDLLQILEDNPKMDIKEIKYITREVLKGVEYIHSMGYIHRDLKSSNILVSETNEIKIID
|.  || ..| |.|..|| |         |   .....  | || .|.    ..   .|...   .|.|  |||| | |||||| ||| | |  |..| |
ELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKCQ-RLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILD

FGYCRKIKGRPLTPCRFTNQFAPLDCLLGFIDYNEKMDIWGVGCILGHMLAGKLLFEGDSQISVLMNILQVLGTPKAEDWPEMKSIE---YFESFQLPEY
||  |  .   .|    |  .     .|  ..|... ||| ||||.  .. |. || ||  |. |  |..|.|||..| |  ..| |   | .|    . 
FGLAR-HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPR

KSTLDTILPKDVDPQAVDLLLKMLEPSQSKRISAHEALQHPFL
.  . .....  .|||.||| ||||    |||.| ||.|||..
RD-FHHVFMG-ANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 85357.m00065.AA MAPK 167-280 37 3.2e-37 126.16 In-house 203-328 (328) Show / Hide 
Range on Protein: 167-280
Range on HMM: 203-328/328
Sequence Identity: 37% (47 aa)

LLG--FIDYNEKMDIWGVGCILGHMLA-GKLLFEGDSQISVLMNILQVLGTPKAEDWPEMK-S---IEYFESFQ-LPEYKS-TLDTILPK---DVDPQAV
.|.    .|....|.| ||||.. ||  .| || |.. |  .  |..|||||. |..  .. |    .|..|.. || |.  ......|.   ...|||.
MLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAI

DLLLKMLEPSQSKRISAHEALQHPFL
||| |||. . .|||.. ||||||..
DLLEKMLVFDPDKRITVEEALQHPYF
Kinase 85357.m00065.AA CDC2 167-280 37 5.1e-34 101.56 In-house 177-301 (301) Show / Hide 
Range on Protein: 167-280
Range on HMM: 177-301/301
Sequence Identity: 37% (47 aa)

LLGFIDYNEKMDIWGVGCILGHM---LAGKLLFEGDSQISVLMNILQVLGTPKAEDWPEMKSIE-YFESFQLPEYKSTLDTILPKD---------VDPQA
|||  .|.   |.| .|||.  |      | || |||.|  |  | ..||||. ..||....   | ..|  |..| .  ... ..         .||..
LLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTF--PRWKPQDLSKICPNNQKKKNQSCLDPEG

VDLLLKMLEPSQSKRISAHEALQHPFL
.||| .||    .||||| ||||||..
IDLLMQMLQYDPQKRISAKEALQHPYF
Kinase 85357.m00065.AA STE 8-147 21 1.8e-33 115.58 In-house 1-197 (359) Show / Hide 
Range on Protein: 8-147
Range on HMM: 1-197/359
Sequence Identity: 21% (44 aa)

YEKTTDLQQGTFGIVYLCKDLL---------------TKKTVVCKESDIDEISA----------------------QEIETLKSLK--HPNIIQMLDSFK
.|.   . .|.|| ||....                 |.. .  |. .... ..                      .||...| ..  ||||.. .... 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DF-------MSEFIIMEYGG-KDLLQILEDNPKMDI--------------KEIKYITREVLKG-VEYIHSMGYIHRDLKSSNILVSETNEIKIIDFGYCR
.         . .|.||| .   | .|.. . ..                ..|.||.|..|||  .|.||...||||.|..|||.     .|..||| | 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KI
..
QL
Kinase 85357.m00065.AA CDK 8-142 27 3.1e-32 100.32 In-house 1-158 (284) Show / Hide 
Range on Protein: 8-142
Range on HMM: 1-158/284
Sequence Identity: 27% (47 aa)

YEKTTDLQQGTFGIVYLCKDLLTK-----KTVVCKES---------D---IDEISAQEIETLKSLKHPNIIQMLDSFKDF-----------MSEFIIMEY
|||   . .||.|.|| ..|..|.     . |  |.          .   .   .  || .|| | ||||.. .| . .             . ....||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

GGKDLLQILEDNPKMDIKEIKYITREVLKGVEYIHSMGYIHRDLKSSNILVSETNE-----IKIIDFG
   || ....         || ...  |.|..|.|| . .||||| .|||.... |     .|| |||
MDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFG
Kinase 85357.m00065.AA CDK 167-280 34 3e-30 93.85 In-house 191-284 (284) Show / Hide 
Range on Protein: 167-280
Range on HMM: 191-284/284
Sequence Identity: 34% (41 aa)

LLGFIDYN--EKMDIWGVGCILGHMLA---GKLLFEGDSQISVLMNILQVLGTPKAEDWPEMKSIEYFESFQLPEYKSTLDTILPKDVDPQAVDLLLKML
|||  .|.     |.|.||||.. |.    .| || ||| |  |  | ...|||  ..||....  ..                         ||| |||
LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKML

EPSQSKRISAHEALQHPFL
    .||||| .|||||..
CYDPKKRISAEQALQHPYF
Kinase 85357.m00065.AA CDC2 8-142 34 7.1e-29 85.45 In-house 1-148 (301) Show / Hide 
Range on Protein: 8-142
Range on HMM: 1-148/301
Sequence Identity: 34% (51 aa)

YEKTTDLQQGTFGIVYLCKDLLTKKTVVCK------ESDID---EISAQEIETLKSLK-HPNIIQMLDSFKDFMSEFIIMEYGGKDLLQILE-DNP---K
|.|   .  ||.|.|| |||. |.. |. |      |...|   . .  || .|| || ||||..  | ..   . ... ||   || . ..  .|   .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

MDIKEIKYITREVLKGVEYIHSMGYIHRDLKSSNILVSETNEIKIIDFG
|.   .| ..   |.||.. |... .||||| .|||.... .||| |||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFG
Kinase 85357.m00065.AA RCK 173-280 37 1.3e-25 77.96 In-house 191-298 (298) Show / Hide 
Range on Protein: 173-280
Range on HMM: 191-298/298
Sequence Identity: 37% (41 aa)

YNEKMDIWGVGCILGHMLAGKLLFEGDSQISVLMNILQVLGTPKAEDWPEMKSIEYFESFQLPEYKST-LDTILPKDVDPQAVDLLLKMLEPSQSKRISA
||..||||.||||       . || | | |  .. |..|.|||. .|||. .       | .| .|.. |....|    .....|. |||    .|||.|
YNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPN-CSQDCIELMEKMLQWDPQKRITA

HEALQHPFL
..|||||. 
QQALQHPYF
Kinase 85357.m00065.AA RCK 8-151 29 5.4e-21 63.08 In-house 1-168 (298) Show / Hide 
Range on Protein: 8-151
Range on HMM: 1-168/298
Sequence Identity: 29% (49 aa)

YEKTTDLQQGTFGIVYLCKDLLTKKTVVCKE-----SDIDE-ISAQEIETLKSLK-HPNIIQMLDSFKDFM--SEFIIMEYGGKDLLQILED----NPKM
|  .. |  ||.| | . ... |.. | .|      ....| ..  ||  |. |. |||||. .. ..|    . ....||  ..| | ..|    . ..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

DIKE--IKYITREVLKGVEYIHSMGYIHRDLKSSNILVSE---------TNEIKIIDFGYCRKIKGRP
  ..  || |   .|.| ...|. |. |||||  ||....         .. |||.||| || |  .|
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKP
Kinase 85357.m00065.AA MAPK 52-142 39 1.3e-19 64.25 In-house 58-162 (328) Show / Hide 
Range on Protein: 52-142
Range on HMM: 58-162/328
Sequence Identity: 39% (41 aa)

LKSL-KHPNIIQMLDSFKDFM----SE-------FIIMEYGGKDLLQILEDNPKMDIKEIKYITREVLKG--VEYIHSMGYIHRDLKSSNILVSETNEIK
|. . .|.||| .|| |. .|    ..        |.||. . || ||.. ..... . |.|..  .|.|  . ||||.. |||||| ||||| |  . |
LRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLK

IIDFG
| |||
ICDFG
Kinase 85357.m00065.AA Pkinase_Tyr 8-147 29 8.5e-13 43.97 Pfam 1-161 (270) Show / Hide 
Range on Protein: 8-147
Range on HMM: 1-161/270
Sequence Identity: 29% (48 aa)

YEKTTDLQQGTFGIVYLCKDL----LTKKTVVCKES--DIDEIS------AQEIETLKSL-KHPNIIQMLDSFK-DFMS--EFIIMEYGGK-DLLQILED
 ..   | .| || ||...       || .|  |    . ..         .|....|.| .||||....     .  .   .|.|||  . |||  | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----NPKMDIKEIKYITREVLKGVEYIHSMGYIHRDLKSSNILVSETNEIKIIDFGYCRKI
    ... ..|..  . ... || || .|...|||||   |.||.|.| .|| ||| .| |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase 85357.m00065.AA STE 172-280 20 1.5e-11 37.17 In-house 244-359 (359) Show / Hide 
Range on Protein: 172-280
Range on HMM: 244-359/359
Sequence Identity: 20% (27 aa)

DYNEKMDIWGVGCILGHMLAGKLLFEGDSQISVLMNIL-------QVLGTPKAEDWPEMKSIEYFESFQLPEYKSTLD------------TILPKDVDPQ
.|..| ||| .|| . .|. ||  .   .  .....|.       |            .  . .   .. |  ...|.            | .|. . | 
GYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ------------FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTT-YPHKWSPE

AVDLLLKMLEPSQSKRISAHEALQ--HPFL
  | . | |.   .|| .|.. |.  |||.
FKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 85357.m00065.AA TyrKc 8-232 20 2.4e-11 -39.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 8-232
Range on HMM: 1-280/280
Sequence Identity: 20% (58 aa)

YEKTTDLQQGTFGIVYLCKDLLTKKTVVCKESD---IDEISAQEIETLKSL--KHPNIIQML-DSFKDF------MSEFIIMEYGGK-DLLQILEDNPK-
 ..   |  | ||.||...      .|  |      . ..  .|.. ...|  .||||....    ...         .|.|||  . ||.. | .. . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

MDIKEIKYITREVLKGVEYIHSMGYIHRDLKSSNILVSETNEIKIIDFGYCRKIKGR-------PLTP------CR--FTNQFAPLDCLLGFIDYNEKMD
   |.  ..   . .| ||.||...|||||   |.||.| . .|| ||| .|.|.                   ..  .     .. |.   . ...| |
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK-FTTKSD

IWGVGCIL-----------GHM----LAGKLLFEGDSQISVLMNILQVLGTP--------------------KAEDWPEMKSIEYFESF
.|  |  .             |    .  . ..|   |   ..    ..  |                    ..|| | .. |   | |
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 85357.m00065.AA MAPK 8-35 23 0.045803 2.67 In-house 1-34 (328) Show / Hide 
Range on Protein: 8-35
Range on HMM: 1-34/328
Sequence Identity: 23% (8 aa)

YEKTTDLQQGTFGIVYLCKDLL------TKKTVV
|.    ..|| .|.|  ..| .      ..|.|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVA