Gene 82762.m00244 (T.vaginalis)

82762.m00244

Species: T.vaginalis
Alias: 82762.m00244, TvagK0650
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
82762.m00244.AA Protein None 393 None Fasta, JSON
82762.m00244.kin_dom Protein Kinase Domain None 289 None Fasta, JSON

Protein domain

Protein domains of 82762.m00244.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 82762.m00244.AA CMGC 104-392 18 1.5e-86 284.33 In-house 1-513 (513) Show / Hide 
Range on Protein: 104-392
Range on HMM: 1-513/513
Sequence Identity: 18% (95 aa)

YEQIELCGRGSFGTVLKCFD--------------HKEKTYVAIKIIANSEEYNSLAE-------------REVRFLETLSTNKETQS-----------ET
|| |. .|.|..|.| ||.|              |. . .||||.| | . |   |              ||...|. |. |...             . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

HIIELIDTFSDSK-----------------FTYIVTKFYKQNLYDYIKSKF--------------------------VAGIPFRDIRHIAKSVAKAMQ--
.|. |.| | ...                   |.|. .  ..||.|||..                           .  ..  .|| ... . ...   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

LIHSCG--IIHSDLKPENIMLEGTNP---------------------YIIDFGCSSFDDEC------------------------TSDTVQGLYYRAPEV
 .|| .  ||| |||||||..  ..                       |.||| . . ..                          .. |. ..|||||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

IFNNG----------YNSSIDVWSFGCLLFELITG--------TPLFESKNE-----------TDLIRQITKVLGDP----------------SQELINS
... .          |...||.||.|| ..|..||         |||  ..|            | . .| |||| |                ..| .| 
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNM

SK-------------------KMKRYWFRKQIHVDNDESQKNSFLGEFLGNTN----------------------------------TEIISVISACLKW
.|                   ... ..  .|.  .  . .....   | .. |                                   . |  .. .|..
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

DPNERPTFNELLEYPFF
||..|.|  . |. |.|
DPDKRITAEQALQHPYF
Kinase 82762.m00244.AA DYRK 104-392 32 1.1e-82 280.97 In-house 1-320 (320) Show / Hide 
Range on Protein: 104-392
Range on HMM: 1-320/320
Sequence Identity: 32% (105 aa)

YEQIELCGRGSFGTVLKCFDHKEKTYVAIKIIANSEEYNSLAEREVRFLETLSTNKETQSETHIIELIDTFSDSKFTYIVTKFYKQNLYDYIKSKFVAGI
|| .| .|.|||| | ||.||| . .|||||| | ...   | .|.. || |...   . ..|.. . | |   ....||.  . .|||...|     | 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ-DPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

-PFRDIRHIAKSVAKAMQLIHSC-GIIHSDLKPENIMLEGT-NPY---IIDFGCSSFDDECTSDTVQGLYYRAPEVIFNNGYNSSIDVWSFGCLLFELIT
 ... .| .|... ... ..|..  ||| |||||||||    |..   .|||| |.| ..  .  .|  .|||||||    |. .||.||.|| | || |
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFT

GTPLFESKNETDLIRQITKVLGDPSQELINSS-KKMKRYWFRK--QIHVDNDESQKN-----------------------SFLGEFLGNTNTEIISVISA
| |||  .|| |... |  ||| |....|... .. |.. | .  . ..|. . |..                       . .. ..     . .  |  
GWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKK

CLKWDPNERPTFNELLEYPFF
||.|||..|.| .. |. |.|
CLQWDPHKRITPSQALQHPWF
Kinase 82762.m00244.AA S_TKc 104-392 27 7.5e-73 249.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 104-392
Range on HMM: 1-231/231
Sequence Identity: 27% (84 aa)

YEQIELCGRGSFGTVLKCFDHKEKTYVAIKIIANSEEYNSLAEREVRFLETLSTNKETQSETHIIELIDTFSDSKFTYIVTKFYKQ---NLYDYIKSKFV
|| ... |.|.||.| || ..| . .||||||         ..||.. |.            .|. |.|.| | .. |.|. .  .   .|.||||..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

AG----IPFRDIRHIAKSVAKAMQLIHSCGIIHSDLKPENIMLEGTNPYIIDFGCSSFDDECTSDTVQGLYYRAPEVIFNNGYNS-SIDVWSFGCLLFEL
 |    .|  ..|.... ...|.. .|| |||| |||||||.|   .  |.||| . .     .  .  ..|.||||.   ||.  ..|.||.||.|.|.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

ITGTPLFESKNETDLIRQITKVLGDPSQELINSSKKMKRYWFRKQIHVDNDESQKNSFLGEFLGNTNTEIISVISACLKWDPNERPTFNELLE-------
..| |.|.  ..  ....|                                                 | .. |. ||..||..|||  |.|.       
LCGYPPFP--QMQMMFKKIG----------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

YPFF
 |.|
HPWF
Kinase 82762.m00244.AA DYRK2 104-337 36 1.9e-66 214.95 In-house 1-241 (318) Show / Hide 
Range on Protein: 104-337
Range on HMM: 1-241/318
Sequence Identity: 36% (89 aa)

YEQIELCGRGSFGTVLKCFDHKEKTYVAIKIIANSEEYNSLAEREVRFLETLSTNKETQSETHIIELIDTFSDSKFTYIVTKFYKQNLYDYIKSKFVAGI
||  |  |.|||| |.||.||| |..||||.| |   . . | .|.| |. ... .  .. . .. . | |   ....|..  .  |||.||| .   |.
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRR-QDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGF

PFRDIRHIAKSVAKAMQLIHSCGIIHSDLKPENIMLEGTNPY---IIDFGCSSFDDE-CTSDTVQGLYYRAPEVIFNNGYNSSIDVWSFGCLLFELITGT
  . .|  |.|. ..... |   ||| |||||||.|   |.    .|||| | |...      .| ..|||||||    |. .|| ||||| . || ||.
SLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGY

PLFESKNETDLIRQITKVLGDPSQELINSS----KKMKRYWF
|||   || | .  .  ||| |...... .    .. ..| |
PLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFF
Kinase 82762.m00244.AA Pkinase 104-392 26 5e-65 227.13 Pfam 1-293 (293) Show / Hide 
Range on Protein: 104-392
Range on HMM: 1-293/293
Sequence Identity: 26% (83 aa)

YEQIELCGRGSFGTVLKCFDHKEKTYVAIKIIANSEEYNSLAER-----EVRFLETLSTNKETQSETHIIELIDTFSDSKFTYIVTKFYKQ-----NLYD
|. ..  |.||||.| || ....   ||.|||  ..|  .  ..     |.. .  |.      ..  |..|.|.| |..  |.|. .         |.|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPN-IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

YIK---SKFVAGIPFRDIRHIAKSVAKAMQLIHSCGIIHSDLKPENIMLE-GTNP----YIIDFGCS----SFDDECTSDTVQGLYYRAPEVIF-NNGYN
||.   .. .   . ........ ...... .||.|||| |||||||..    ..     |.|||..       .. ... .  ..|.|||||  ...| 
YISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

SSIDVWSFGCLLFELITGTPLFESK----NETDLIRQITKVLG-DPSQELINSSKKMKRYWFRKQIHVDNDESQKNSFLGEFLGNTNTEIISVISACLKW
...|.||.||.|.|...| |.| ..    |  | .  | ...| ... .  ... .. .. || . |           . .|  |.. | ...|. ||..
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHW-H---------F-HWTF-HNWSEECKDFIKWCLCK

DPNERPTFNELLEYPFF
||..|||. ..|. |.|
DPKKRPTAEQILQHPWF
Kinase 82762.m00244.AA HIPK 104-342 36 1.8e-58 182.57 In-house 1-244 (329) Show / Hide 
Range on Protein: 104-342
Range on HMM: 1-244/329
Sequence Identity: 36% (90 aa)

YEQIELCGRGSFGTVLKCFDHKEKTYVAIKIIANSEEYNSLAEREVRFLETLSTNKETQSETHIIELIDTFSDSKFTYIVTKFYKQNLYDYIKSKFVAGI
|| .|. ||| || | ||  .  .  |||||. |   |.   . ||. |. ||.  |   | |..   . | . . |..|  .  |||||. |    . .
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQ--ENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPL

PFRDIRHIAKSVAKAMQLIHSCGIIHSDLKPENIML--EGTNPY---IIDFGCSSFDDECTSDT-VQGLYYRAPEVIFNNGYNSSIDVWSFGCLLFELIT
| . || | . |..|.  . . |.|| |||||||||  .   ||   .||||  |   .   .| .|  ||||||.|    .. ..|.|| || . ||. 
PLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFL

GTPLFESKNETDLIRQITKVLGDPSQELINSSKKMKRYW-FRKQIH
| ||..  .| |.|| | .  . | . |...  | .|.. . ||..
GWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSK
Kinase 82762.m00244.AA DYRK1 104-342 36 5.8e-51 175.62 In-house 1-243 (321) Show / Hide 
Range on Protein: 104-342
Range on HMM: 1-243/321
Sequence Identity: 36% (89 aa)

YEQIELCGRGSFGTVLKCFDHKEKTYVAIKIIANSEEYNSLAEREVRFLETLSTNKETQSETHIIELIDTFSDSKFTYIVTKFYKQNLYDYIKSKFVAGI
|| . | |.|||| | | .||.|. ||||||| |   .   |  |.| || |  ....... .|..|   |       .|. .   |||| ..     |.
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLE-LMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGV

PFRDIRHIAKSVAKAMQLIHS--CGIIHSDLKPENIMLEGTNP-----YIIDFGCSSFDDECTSDTVQGLYYRAPEVIFNNGYNSSIDVWSFGCLLFELI
    .| .|. ...|.  . .    ||| |||||||.|   ||      ||||| |   ..     .|  .||.|||. .  |. .||.|| ||.| |. 
SLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILL--CNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMH

TGTPLFESKNETDLIRQITKVLGDPSQELINSSKKMKRYWFRKQIH
|| |||  .|| | . .|  ||| | ...|... | ..|. .....
TGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDN
Kinase 82762.m00244.AA Ciliate-E2 104-392 19 1.9e-49 167.89 In-house 1-365 (365) Show / Hide 
Range on Protein: 104-392
Range on HMM: 1-365/365
Sequence Identity: 19% (79 aa)

YEQIELCGRGSFGTVLKCFDHKEKT-----------------------YVAIKIIANSE-EYNSLAEREVRFLE----TLSTNKETQSET---HIIELID
|. |...|.|.||.| || . |..                        ..|.||. ... |. .  ... | ..     .  .|. ...    .||....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

TFS--DSKFTYIVTKFYKQ-NLYDYIK---SKFVAGIP------FRDIRHIAKSVAK---------------AMQLIHSCG-IIHSDLKPENIMLEGTNP
.|   | .  |.|. .... .|.||||    |.   |.       . |..| | ...               |.. .|| . ||| |.|||||..    .
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I

YIIDFGCSSFDDECTSD----------------------------------TVQGLYYRAPEVIFNNG---------YNSSIDVWSFGCLLFELITGTPL
 ||||| | . |..  .                                  ..  ..| |||.. . .         |. ..|.||.|..|.|...| | 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FESKNETDLIRQITKVLGDPSQELINSSKKMKRYWFRKQIHVDNDESQKNSFLGEF------LGNTNTEIISVISA----CLKWDPNERPT-FNELLEYP
|                               .    ..|  .. |.||. .. .         .   | .  |.     .|. ||..|.| ....|. |
F------------------------------QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHP

FF
.|
WF
Kinase 82762.m00244.AA Ciliate-E2-Unclassified 104-392 19 7.4e-49 167.6 In-house 1-352 (352) Show / Hide 
Range on Protein: 104-392
Range on HMM: 1-352/352
Sequence Identity: 19% (74 aa)

YEQIELCGRGSFGTVLKCFDHKEKTYVAIKIIANSEEYNSLAEREV----RFLETLSTNKETQSET----------------HIIELIDTFSDSKFTYIV
|. |. .|.|.||.| || . |.| | |.|..  . .|...  ...    . ....  .|.  .                  .|. ....| | .  |||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TKFYKQ-NLYDYIKSKFV---------------AGIPFRDIR-----HIAKSVAKAMQLIHSCG-IIHSDLKPENIML-EGT---NPYIIDFGCSSFDDE
. . .. .| .|||..                   .. . ..     .... . .. . .|. . ||| |.|||||.. ..    .. ||||| |.. ..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

C------------------TSDTVQGLYYR----APEVIFNNGYNSS----IDVWSFGCLLFELITGTPLFESKNETD----------------LIRQI-
.                  ...... ..|     ||||. ...|. |    .|.||.|..|.|...|.. |...|...                |...| 
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

TKVLGDPSQELINSSKKMKRYWFRKQIHVDNDESQKNSFLGEFLGNTNTEIISVIS----ACLKWDPNERPTFNELLEYPFF
 | .  |...  .                             .  . . | .  |.     .||..||.|.||...|. |.|
QKNIQFPKFPWQQ-----------------------------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 82762.m00244.AA STE 104-300 22 1.6e-31 108.6 In-house 1-266 (359) Show / Hide 
Range on Protein: 104-300
Range on HMM: 1-266/359
Sequence Identity: 22% (62 aa)

YEQIELCGRGSFGTVLKCFDHK---------------EKTYVAIKIIANSEE------------YNSLAEREVRFLETLSTNKETQS-ETHIIELIDTFS
.| ||  |.|.|||| |. .||                ....|||..  ...             |.  | . ..|. ... |. ..   .|.. .... 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DS-------KFTYIVTKFYK-QNLYDYIKSKFVAGIP------------FRDIRHIAKSVAKA-MQLIHSCGIIHSDLKPENIMLEGTNPYIIDFGCSSF
.           .|.  .     | | ||.|.  | |               |..|.... |. ....|| .||| |.|| ||.|      ..|||... 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

DDE-------------------CTSDTVQGLYYRAPEVIFN------NGYNSSIDVWSFGCLLFELITGTP
 ..                    .   |    . ||||| .      .||. . |.||.||.. |..|| |
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKP
Kinase 82762.m00244.AA CLK 104-240 32 3.3e-30 87.18 In-house 1-148 (350) Show / Hide 
Range on Protein: 104-240
Range on HMM: 1-148/350
Sequence Identity: 32% (48 aa)

YEQIELCGRGSFGTVLKCFDHKE-KTYVAIKIIANSEEYNSLAEREVR-FLETLSTN--KETQSETHIIELIDTFSD-SKFTYIVTKFYKQNLYDYIKSK
|| .   | | ||.|..| |||  |.|||.|||.| |.|   |  |..  .... ..  .. ..  |.. ..|.|        ||.. |  ..|| .|| 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

F------VAGIPFRDIRHIAKSVAKAMQLIHSCGIIHSDLKPENIMLE
        .. | . |||.|.   .|..  |. ...| ||||||| ..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFV
Kinase 82762.m00244.AA CLK 246-392 29 4.3e-24 68.51 In-house 188-350 (350) Show / Hide 
Range on Protein: 246-392
Range on HMM: 188-350/350
Sequence Identity: 29% (49 aa)

IIDFGCSS---FDDECTSDTVQGLYYRAPEVIFNNGYNSSIDVWSFGCLLFELITGTPLFESKNETDLIRQITKVLG-----DPSQELINSSKKMKRYWF
.||||      ||.|  |. |.   |||||||   |..   ||||.|| |||| ||  ||   .. .    . ...|      ..|  ..  |  ..|. 
VIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRR-FKVKQKYFY

RKQIHVDNDESQKNSF------LGEFLGNTNTE---IISVISACLKWDPNERPTFNELLEYPFF
. .   |.. |.  .       | ...  .  |    .  |. .|  ||. |.|  . |  |||
HNRLDWDWHNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 82762.m00244.AA RCK 104-250 27 1.3e-19 58.61 In-house 1-159 (298) Show / Hide 
Range on Protein: 104-250
Range on HMM: 1-159/298
Sequence Identity: 27% (46 aa)

YEQIELCGRGSFGTVLKCFDHKEKTYVAIKIIANSEEYNSLAE----REVRFLETLSTNKETQSETHIIELIDTFSDSK--FTYIVTKFYKQNLYDYIKS
|  |.  |.|..|.|.|  . ... .||||      ...|. |    ||...|  |. ..      .||.|.. . |..    |.|  . ..||| ..|.
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHP------NIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKD

--KFVAG-IPFRD--IRHIAKSVAKAMQLIHSCGIIHSDLKPENIMLEG----------TNPYIIDFG
  .     .| .   |..| . .....  .|. |. | ||||||||. |           .  |.|||
FKE-RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFG
Kinase 82762.m00244.AA RCK 267-324 42 1.7e-15 45.33 In-house 178-236 (298) Show / Hide 
Range on Protein: 267-324
Range on HMM: 178-236/298
Sequence Identity: 42% (25 aa)

YYRAPEVIFNN-GYNSSIDVWSFGCLLFELITGTPLFESKNETDLIRQITKVLGDPSQE
.|||||..     ||| .|.|..||  .|| .  |||   .| | | .|.||.| |...
WYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKK
Kinase 82762.m00244.AA TyrKc 104-392 19 4.5e-13 -11.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 104-392
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

YEQIELCGRGSFGTVLKCFDHKEKTYVAIKIIANSEEYNSLAEREVRFLETL--STNKETQSETHIIELIDTFSDS-------KFTYIVTKFYKQ-NLYD
 . ..  |.| ||.| |.      . ||.| . ..        || | .  |  .         .|. |.   ...       .  .||. . .  .| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YIKSKFVAGIPFRDIRHIAKSVAKAMQLIHSCGIIHSDLKPENIMLEGTN-PYIIDFGCSSFDDEC-------TSDTV----QG-----LYYRAPEVIFN
|....    .. .|  ...  .|. |. .|| ..|| ||   |...   .   | ||| | . ..           ..    .|     .   |||.|. 
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

NGYNSSIDVWSFGCLLFELIT-GTPLFES-----KNETDLIRQITKVLGDPSQEL---INSSKKMKRYWFRKQIHVDNDESQKNSFLGEFLGNTNTEIIS
. ...  |||||| ...|. | | .  .      .. ...|... .    |  .    .                              |     .|. .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------F-VCCPDEMYQ

VISACLKWDPNERPTFNELLEYPFF
... | . ||..||||.|.  . .|
IMKQCWHEDPEDRPTFSEI--HECF
Kinase 82762.m00244.AA RCK 360-392 33 8.8e-13 36.6 In-house 266-298 (298) Show / Hide 
Range on Protein: 360-392
Range on HMM: 266-298/298
Sequence Identity: 33% (11 aa)

NTNTEIISVISACLKWDPNERPTFNELLEYPFF
| . . |...  .|.|||..|.| ...|..|.|
NCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 82762.m00244.AA STE 369-392 50 2.6e-08 25.57 In-house 334-359 (359) Show / Hide 
Range on Protein: 369-392
Range on HMM: 334-359/359
Sequence Identity: 50% (13 aa)

ISACLKWDPNERPTFNELLE--YPFF
|. ||. |||.||| ..||.   ||.
INKCLQKDPNKRPTASQLLKSEHPFI
Kinase 82762.m00244.AA Pkinase_Tyr 270-297 46 1e-06 23.29 Pfam 182-209 (270) Show / Hide 
Range on Protein: 270-297
Range on HMM: 182-209/270
Sequence Identity: 46% (13 aa)

APEVIFNNGYNSSIDVWSFGCLLFELIT
|||.|... ...  |||||| |..|..|
APECINYGKFTTKSDVWSFGVLMWEIFT
Kinase 82762.m00244.AA DYRK2 369-392 41 5.8e-05 11.71 In-house 295-318 (318) Show / Hide 
Range on Protein: 369-392
Range on HMM: 295-318/318
Sequence Identity: 41% (10 aa)

ISACLKWDPNERPTFNELLEYPFF
|. |..||| || |  . |. |..
IKRCFEWDPSERMTPSQALKHPWI
Kinase 82762.m00244.AA Pkinase_Tyr 364-388 44 0.025164 8.5 Pfam 244-268 (270) Show / Hide 
Range on Protein: 364-388
Range on HMM: 244-268/270
Sequence Identity: 44% (11 aa)

EIISVISACLKWDPNERPTFNELLE
|| ...  | ..||..|||| |..|
EIYDLMKQCWHYDPEDRPTFSEIHE
Kinase 82762.m00244.AA HIPK 364-392 34 0.130709 0.28 In-house 301-329 (329) Show / Hide 
Range on Protein: 364-392
Range on HMM: 301-329/329
Sequence Identity: 34% (10 aa)

EIISVISACLKWDPNERPTFNELLEYPFF
| ..|  . . ||...| |  | |. || 
EFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase 82762.m00244.AA Pkinase_Tyr 104-135 27 1.156422 2.87 Pfam 1-36 (270) Show / Hide 
Range on Protein: 104-135
Range on HMM: 1-36/270
Sequence Identity: 27% (10 aa)

YEQIELCGRGSFGTVLKCFDH----KEKTYVAIKII
 . ..  |.|.||.| |.  .    ..|. ||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML
Kinase 82762.m00244.AA Pkinase_Tyr 190-232 26 3.1844 1.38 Pfam 93-137 (270) Show / Hide 
Range on Protein: 190-232
Range on HMM: 93-137/270
Sequence Identity: 26% (12 aa)

NLYDYIKSK--FVAGIPFRDIRHIAKSVAKAMQLIHSCGIIHSDL
.|.|| ...      ..  |. ...  .||.|.  .| ..|| ||
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL