Gene 85876.m00198 (T.vaginalis)
85876.m00198
Species: T.vaginalis
Alias: 85876.m00198, TvagK0468
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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85876.m00198.AA | Protein | None | 325 | None | Fasta, JSON |
85876.m00198.kin_dom | Protein Kinase Domain | None | 232 | None | Fasta, JSON |
Protein domains of 85876.m00198.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 85876.m00198.AA | CK1 | 5-254 | 25 | 8.8e-69 | 234.82 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 5-254 Range on HMM: 1-339/339 Sequence Identity: 25% (87 aa) YIIGEKIGRGTFG-EVYNA-----KDTKTG-----EIVAIKIEPHTSRKRY--LEHEFKILTHLQS----------SLMFPR----------CGIFGVTP . ...||| | || ..| . ||.|.. | .|.|.|| .|.... |..|.... || . |. ... | .. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED EFR-FYSMELLGPSITQIFK-------KIPIESGIIVMQESLKALEQLHLRGFVHRDIKPGNIITRN--------------KRDTPICIIDFGLTR-QYI .. . |.||||.. ...| |. ... ... |.|||..| .||.||||||.|. .. . .||||. | .|. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR DT-----------ETGKHCLHEE---NAGFRG-SKAYASINAHHFCTVSRKDDLISWYYVMIELLCGK--LPWRGVQDNDE-----LIYLKSQFNVKKFT | .|..| | ..|||| |.|||.| . .|.||| || |..||.| |. |||... |... . | .| .| DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM HN------------VGPELADIWTSISYLHFDEKPNYKYI .. . .|. .|.. |. | ....|.|..| STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | 85876.m00198.AA | TTBKL | 5-258 | 28 | 4.7e-53 | 177.48 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 5-258 Range on HMM: 1-288/288 Sequence Identity: 28% (81 aa) YIIGEKIGRGTFGEVYNAKDTKTGEIVAIKIEPHTSRK---RYLEHEFKILTHLQ--SSLMFPRCGIFGVTPEFRFYSMELLGPSITQIFKKIPIE---- . | ..||.| ||.|| ..|.|. . .|...|. ... . .. | ..|..|| .| ||.| | .. ..| |.|.||.. . |..| WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS --SGIIVMQESLKALEQLHLRGFVHRDIKPGNIITRNKRD-----TPICIIDFGLTRQYIDTETG----------KHCLHEE---NAGFRGSKAYASINA . .. |.|| |.| ||.|||.||.|. . .. . . .||||..|||.. . . .. . . |.|||. |.|.|. DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HHFCTVSRKDDLISWYYVMIELLCGKLPWRGVQDNDELIYLKSQFNVKKFTHN------VGPELADIWTSISYLHFDEKPNYKYIYEKI | . .|.||| ||.|..|||.|| |||... | .|.. .| . . ... . .|.... . .. | . . |.| .||| . HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | 85876.m00198.AA | Worm6 | 5-254 | 28 | 9e-48 | 165.02 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 5-254 Range on HMM: 1-279/279 Sequence Identity: 28% (79 aa) YIIGEKIGRGTFGEVYNAKDTKTGE--IVAIKIEP--HTSRKRYLEHEFKILTHL--QSSLMFPRCGIFGVTPE--FRFYSMELLGPSITQIFKKIP--- . ...||| |.|| || ..|..... .|.| | .. .. | .| .|. . . . |.. | ... |.. |.|.|.. . | | WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK --IESGIIVMQESLKALEQLHLRGFVHRDIKPGNI-ITR-----NKRDTPICIIDFGLTR--QYIDTETGKHCLHEENAGFRGSKAYASINAHHFCTVSR |. . ...|.|.|.|| ||.|||.|||| | | .. |...|||..| .|..... . ...|||| ||....| .. .| FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR KDDLISWYYVMIELLCGKLPWRGVQDNDELI-YLKSQFNVKK------FTHNVGP-ELADIWTSISYLHFDEKPNYKYI |||. || |.|.|...|.||||.. | |. . | . . .. | .. . |. || . | . . ..|.||.| KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | 85876.m00198.AA | CK1-D | 5-254 | 32 | 1.3e-45 | 157.89 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 5-254 Range on HMM: 1-261/261 Sequence Identity: 32% (86 aa) YIIGEKIGRGTFGEVYNAKDTKTGEIVAIKIEPHTSRKRYLEHEFKILTHLQSSLMFPRCGIFGVTPEFRFYSMELLGPSITQIF----KKIPIESGIIV | || ||| | ||..| .. .|.| ||||.|. .. |. | |. .| . |. .| .. |.|||||. .| .| . ... YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML MQESLKALEQLHLRGFVHRDIKPGN-IITRNKRDTPICIIDFGLTRQYIDTETGKHCLHEENAGFRGSKAYASINAHHFCTVSRKDDLISWYYVMIELLC . .. .| .| | |.|||||| | .. || . ||||||...| |..| .| || | ||||| |. ||.||| | ||.. ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR GKLPWRGV------QDNDELIYLKSQFNVKKFTHNVGPELADIWTSISYLHFDEKPNYKYI | ||| |. | . .. | . .... . | .. |.||.||.| |. GSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | 85876.m00198.AA | CK1-A | 5-254 | 31 | 7e-43 | 148.78 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 5-254 Range on HMM: 1-261/261 Sequence Identity: 31% (82 aa) YIIGEKIGRGTFGEVYNAKDTKTGEIVAIKIEPHTSRKRYLEHEFKILTHLQSSLMFPRCGIFGVTPEFRFYSMELLGPSITQIF----KKIPIESGIIV | . ||| | ||..| . .. || ||||.| . | | | |. . || .|. .| .. |.|||||. ..| .. . ... YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML MQESLKALEQLHLRGFVHRDIKPGNIITRNKRD-TPICIIDFGLTRQYIDTETGKHCLHEENAGFRGSKAYASINAHHFCTVSRKDDLISWYYVMIELLC . .| .| ..|.|||||| | . | . .|||||...| | .| .| | | ||||||| ||.||. | |||. ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR GKLPWRGV------QDNDELIYLKSQFNVKKFTHNVGPELADIWTSISYLHFDEKPNYKYI ||||| |. | . . | ... |.. . . . | |.|.|.| |. GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | 85876.m00198.AA | CK1-G | 5-254 | 33 | 1.9e-35 | 117.51 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 5-254 Range on HMM: 1-266/266 Sequence Identity: 33% (88 aa) YIIGEKIGRGTFGEVYNAKDTKTGEIVAIKIEPHTSRKRYLEHEFKILTHLQSSL-MFPRCGIFGVTPEFRFYSMELLGPSITQIF----KKIPIESGII | .| ||| | |||.. | ..| ||||.|| || | |.. | . |. || . |.||||| | | . . .. YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM VMQESLKALEQLHLRGFVHRDIKPGN-IITR--NKRDTPICIIDFGLTRQYIDTETGKHCLHEENAGFRGSKAYASINAHHFCTVSRKDDLISWYYVMIE | .. .|..| . . ||.|| | | | ||.. | |||||. .|||| ||..| | | | ||| | || ||. . . . VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY LLCGKLPWRGVQ-DNDELIY-----LKSQFNVKKFTHN--VGPELADIWTSISYLHFDEKPNYKYI | |.||| | || . | | . |.. .| . ..| . | |.|.| | |. FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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Kinase | 85876.m00198.AA | TTBK | 105-254 | 37 | 1.5e-32 | 112.4 | In-house | 107-257 (257) | Show / Hide |
Range on Protein: 105-254 Range on HMM: 107-257/257 Sequence Identity: 37% (57 aa) LKALEQLHLRGFVHRDIKPGNI-ITRNKRDTPIC-IIDFGLTRQYIDTETGKHCLHEENAGFRGSKAYASINAHHFCTVSRKDDLISWYYVMIELLCGKL |...|. | || |||||| | . || . .| ..|||| |||. . .| | ||||| ||||||| |.||| | .|...| . | | LQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNA-CGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQL PWRGVQDNDELIYLKSQFNVKKFTHNVGPELADIWTSISYLHFDEKPNYKYI ||| . | |. .| ... . .. .|. |. | . ..|.|. | PWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | 85876.m00198.AA | CK1-Unclassified | 105-208 | 45 | 6.9e-26 | 73.4 | In-house | 114-220 (244) | Show / Hide |
Range on Protein: 105-208 Range on HMM: 114-220/244 Sequence Identity: 45% (49 aa) LKALEQLHLRGFVHRDIKPGNI-IT-RNKRDTPICIIDFGLTRQYIDT-ETGKHCLHEENAGFRGSKAYASINAHHFCTVSRKDDLISWYYVMIELLCGK .. .|.|| ..|.|||||| |. . ..|. . . |||||| ||| .|||| || .. | ||||||| ||.||| | ||.| .| |. IQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLESLGYVLIYFLKGS LPWRGVQ ||| ... LPWQNIK |
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Kinase | 85876.m00198.AA | CK1-Unclassified | 5-91 | 34 | 1.6e-24 | 69.33 | In-house | 1-96 (244) | Show / Hide |
Range on Protein: 5-91 Range on HMM: 1-96/244 Sequence Identity: 34% (33 aa) YIIGEKIGRGTFGEVYNAKDTKTGEIVAIKIEPHTSRKRYLEHEFKILTHLQSSL-------MFPRCGIFGVT--PEFRFYSMELLGPSITQIFKK | ..|||| | |||.| .....|.| ||||.| .|. . | | ||.. || .|.. .| .. . |.|||||. ..|.. YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNM |
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Kinase | 85876.m00198.AA | CK1 | 105-208 | 41 | 4.7e-22 | 72.85 | In-house | 115-220 (271) | Show / Hide |
Range on Protein: 105-208 Range on HMM: 115-220/271 Sequence Identity: 41% (44 aa) LKALEQLHLRGFVHRDIKPGNI-ITR-NKRDTPICIIDFGLTRQYIDTETGKHCLHEENAGFRGSKAYASINAHHFCTVSRKDDLISWYYVMIELLCGKL .. .| .| ..|.|||||| |. . | .|. . . |||||| .|.| .|..| || .. | |||||.| ||.||. | ||.. .| |.| IQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGSL PWRGVQ || |.. PWQGLK |
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Kinase | 85876.m00198.AA | CK1 | 5-91 | 32 | 1.2e-19 | 64.46 | In-house | 1-97 (271) | Show / Hide |
Range on Protein: 5-91 Range on HMM: 1-97/271 Sequence Identity: 32% (32 aa) YIIGEKIGRGTFGEVYNAKDTKTGEI--VAIKIEPHTSRKRYLEHEFKILTHLQS------SLMFPRCGIFGVT--PEFRFYSMELLGPSITQIFKK | .|.||| | ||..| ......|| ||||.|. .|. | | ||.. || . .|.. .| .. . |.||||| . |.. YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNF |
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Kinase | 85876.m00198.AA | S_TKc | 5-276 | 20 | 4.7e-17 | 63.91 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 5-276 Range on HMM: 1-231/231 Sequence Identity: 20% (63 aa) YIIGEKIGRGTFGEVYNAKDTKTGEIVAIKIEPHTSRKRYLEHEFKILTHLQSSLMFPRCGIFGVTPEFRFYSMELLGP---SITQIFKK---------I | |..|||.|.||.|| ....|||.|||||| . . .. | .|| . . ..| .. . ||... . .. || . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF PIESGIIVMQESLKALEQLHLRGFVHRDIKPGNIITRNKRDTPICIIDFGLTRQYIDTETGKHCLHEENAGFRGSKAYASINAHHFCTVSRKDDLISWYY | .|.. ..||| .| .|..|||.|| || . | |.|||| ||. | |. | . .. . PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL------------GYGK ----------VMIELLCGKLPWRGVQDNDELIYLKSQFNVKKFTHNVGPELADIWTSISYLHFDEKPNYKYIYEKID-DMKRRIGITGNEH-------HV ...|.|||. |.. ...... | .. | . | ..|... . | CKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHP WE | WF |
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Kinase | 85876.m00198.AA | CMGC | 5-35 | 40 | 1.2e-12 | 37.01 | In-house | 1-45 (513) | Show / Hide |
Range on Protein: 5-35 Range on HMM: 1-45/513 Sequence Identity: 40% (18 aa) YIIGEKIGRGTFGEVYNAKD--------------TKTGEIVAIKI | | .|||.||.|.|| ..| ..|.||||||. YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKK |
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Kinase | 85876.m00198.AA | Pkinase | 5-57 | 37 | 5.1e-12 | 43.59 | Pfam | 1-59 (293) | Show / Hide |
Range on Protein: 5-57 Range on HMM: 1-59/293 Sequence Identity: 37% (22 aa) YIIGEKIGRGTFGEVYNAKDTKTGEIVAIKIEPHTSRKR----YLEH--EFKILTHLQS | ||.|||.|.||.|| ... .||.|||.|| . ..| .. . | .|. .|.. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNH |
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Kinase | 85876.m00198.AA | TTBK | 5-56 | 43 | 3.3e-11 | 35.9 | In-house | 1-53 (257) | Show / Hide |
Range on Protein: 5-56 Range on HMM: 1-53/257 Sequence Identity: 43% (23 aa) YIIGEKIGRGTFGEVYNAKDTKTG-EIVAIKIEPHTSRKRYLEHEFKILTHLQ . ||| | |||.|.||| . | ||||.| | | | .| || WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQ |
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Kinase | 85876.m00198.AA | CMGC | 105-147 | 26 | 4.7e-11 | 31.62 | In-house | 190-254 (513) | Show / Hide |
Range on Protein: 105-147 Range on HMM: 190-254/513 Sequence Identity: 26% (17 aa) LKALE--QLHLRG--FVHRDIKPGNIITRNKRDTP------------------ICIIDFGLTRQY |..|. .| .. ..|||.|| || .. . . . |.|||| |.| LRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWY |
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Kinase | 85876.m00198.AA | Pkinase | 105-217 | 26 | 1.4e-09 | 34.95 | Pfam | 118-230 (293) | Show / Hide |
Range on Protein: 105-217 Range on HMM: 118-230/293 Sequence Identity: 26% (32 aa) LKALEQLHLRGFVHRDIKPGNIITRNKRDTP---ICIIDFGLTRQYIDTETGKHCLHEENAGFRGSKAYASINAHH-FCTVSRKDDLISWYYVMIELLCG |..|| .| .|..|||.|| || ..... ..|.|||| .|. . . . .| |. |.. . ..| | | ...|.||| LRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCG KLPWRGV-----QDNDELIYLK ..|..| | ...|... RPPFPGHCWHDNHDQMQMICRI |
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Kinase | 85876.m00198.AA | TyrKc | 5-258 | 18 | 5e-06 | -124.99 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 5-258 Range on HMM: 1-280/280 Sequence Identity: 18% (58 aa) YIIGEKIGRGTFGEVYNAKDTKTGEIVAIKIEPHTSRKRYLEHEFKILTHL---------------------------------------QSSLMFPRCG |.|.|.| ||||| .. . . ||.| . . .. . .| .|...| .. | .| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK IFGVTPEFRFYSMELLGPSITQIFKKIPIESGIIVMQESLKALEQLHLRGFVHRDIKPGNI-ITRNKRDTPICIIDFGLTRQYIDT-ETGKHCLHEENAG .. . . . . | || ....|||. |. ...|. . | ||||.| | ..| .. --------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG----ESKDYY FR----GSKA------YA--SINAHHFCTVSRKDDLISWYYVMIELL-CGKLPWRGV----QDNDELIYLKSQFNVKKFTHN--------VGPELADIWT |.|. .| .|| . | | | | |. .| |.. |. |. |. .|.|.| . | . . .| .|. .| . RKKEHKGGKTMLPIRWMAPECINYGKFTTKS---DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMK SISYLHFDEKPNYKYIYEKI . .. |. . |.|.. QCWHEDPEDRPTFSEIHECF |
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Kinase | 85876.m00198.AA | Pkinase_Tyr | 5-56 | 27 | 1.1e-05 | 19.93 | Pfam | 1-62 (270) | Show / Hide |
Range on Protein: 5-56 Range on HMM: 1-62/270 Sequence Identity: 27% (17 aa) YIIGEKIGRGTFGEVYNAKDT----KTGEIVAIKIEPHTSRKRY-----LEHEFKILTHL-Q ..|.|.|.| ||||| .. . .|. ||.|. .... .. . .| ||...| . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGH |
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Kinase | 85876.m00198.AA | CK1 | 243-252 | 70 | 0.004994 | 6.5 | In-house | 262-271 (271) | Show / Hide |
Range on Protein: 243-252 Range on HMM: 262-271/271 Sequence Identity: 70% (7 aa) LHFDEKPNYK |||.|||.|. LHFEEKPDYM |