Gene 128305.m00006 (T.vaginalis)

128305.m00006

Species: T.vaginalis
Alias: TvagK0889, 128305.m00006
External Links:
Annotation:

Classification

Group: Other
Family: Other-Tvag2

Sequence

Name Sequence Type Origin Length Description Download
128305.m00006.AA Protein None 212 None Fasta, JSON
128305.m00006.kin_dom Protein Kinase Domain None 204 None Fasta, JSON

Protein domain

Protein domains of 128305.m00006.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 128305.m00006.AA Ciliate-E2 29-208 18 1.6e-21 70.61 In-house 120-365 (365) Show / Hide 
Range on Protein: 29-208
Range on HMM: 120-365/365
Sequence Identity: 18% (49 aa)

NLETLINEG-------------ISIRDALHIAKHILC---------------GLYQLYSHG-YIWLDCNPRNILMGDNMIPQFTDIGNASKVDNSNE---
.|. .|..              .... ...| |.||                .|  | | .  |  |  | |||.     .  .| |.. |.|..|.   
DLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRT

------LQDIDK-------------------NKTICTPLYAAPEVILYYK---------ASYKSDIFSWGVLLYQLLTQKYALLSEEFYDSESNDYITEY
      .    |                   | ...|| | |||.. . |          .||.||.| ||.||..|. |.               . . 
HKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------QQQI

LKFQVNVDCAE--------------FQCLDKLTKSVILG----CLSMNPYERMS-FSDIFGSGIF
.. ... .|.|              .. ... .|  |      .|  .| .|.. ...|.   .|
KQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 128305.m00006.AA Ciliate-E2-Unclassified 43-208 23 5.3e-20 66.1 In-house 140-352 (352) Show / Hide 
Range on Protein: 43-208
Range on HMM: 140-352/352
Sequence Identity: 23% (51 aa)

AL-----HIAKHILCGL-YQLYSHGYIWLDCNPRNILMGDNM---IPQFTDIGNASKVDNSNELQDI-----------DKNKTIC-TPLYA----APEVI
|.     .....||.|| |  .... |  |  | |||. .|.    .  .| |...| ...|. .             .. .|.| || |     ||||.
AKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL

LY--YKAS--YKSDIFSWGVLLYQLLTQKYALLSEEFYDSESND----------------YITEYLKFQVNVDCAEF----QCLDKLTKSVIL----GCL
    |  |  ||.||.| ||.||..|...|      |||  ...                .. . .. .........    . ...  |  |      .|
QGQNYDHSKAYKCDIWSLGVILYEMLFGYYP-----FYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKML

SMNPYERMSFSDIFGSGIF
  || .|..|..|.   .|
KKNPNKRITFEQILNHPWF
Kinase 128305.m00006.AA ULK 43-208 23 1.1e-18 61.93 In-house 132-329 (329) Show / Hide 
Range on Protein: 43-208
Range on HMM: 132-329/329
Sequence Identity: 23% (46 aa)

ALHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDN------------MIPQFTDIGNASKVDNSNELQDIDKNKTI-----CTPLYAAPEVILYY----K
|... |.|| |.  |..|..|  |  | |||. ..            ..   .| | | .|||.|. |.. .  .      .|||| ||...       .
AIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKP

AS-YKSDIFSWGVLLYQLLTQKYA----LLSEE--FYDSESNDYITEY-----LKFQVNVDCAEFQCLDKLTKSVILGCLSMNPYERMSFSDIFGSGIF
 . ||.||.| |...|..|. |.       ..   .. .. |.. . .      ..| . |  . . . . .|. | ..|  .. .|.|. ..|   .|
YYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDG-NDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 128305.m00006.AA ULK 43-208 24 7e-17 56.48 In-house 128-324 (324) Show / Hide 
Range on Protein: 43-208
Range on HMM: 128-324/324
Sequence Identity: 24% (48 aa)

ALHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDN------------MIPQFTDIGNASKVDNSNELQDIDKNKTI-----CTPLYAAPEVILYY----K
|... |.|. |.  |..|..|  |  | |||. ..             .   .| | | .||| |. |.. .         .|||| ||...       .
AIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKP

AS-YKSDIFSWGVLLYQLLTQKYALLSEEFYDSESN--DYIT-----EYLKFQVNVDCA---EFQCLDKLTKSVILGCLSMNPYERMSFSDIFGSGIF
 . ||.||.| |...|..|. ||   |  |.| . .  . |      ...  . ....    . . . . .|. | ..|  .. .|.|. .||   .|
YYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 128305.m00006.AA AGC 71-140 20 1e-11 25.07 In-house 185-300 (395) Show / Hide 
Range on Protein: 71-140
Range on HMM: 185-300/395
Sequence Identity: 20% (24 aa)

NILMGDNMIPQFTDIGNASKVDNSNELQ---------------------------------------------DIDKNKTIC---TPLYAAPEVILYYKA
|||. ..     || | . .. |..| .                                             . |...|.|   || | |||..     
NILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----Y

SYKSDIFS--WGVLLYQLLT
..  |. |   |.|.|..||
GKACDWWSFGLGCLMYEMLT
Kinase 128305.m00006.AA Pkinase 37-208 22 2.1e-11 41.37 Pfam 102-293 (293) Show / Hide 
Range on Protein: 37-208
Range on HMM: 102-293/293
Sequence Identity: 22% (45 aa)

GI--SIRDALHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDNMIP----QFTDIGNASKVDNSNELQDIDKNKTIC-TPLYAAPEVIL-YYKASYKSDI
..  | ... .... ||.||. ..|.| |  |  | |||. .|. .      .| | | ..|    .     ..|.| || |.|||||. . . ..|.|.
CFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

FSWGVLLYQLLTQKYALLSE----EFYDSESNDYITEYLKFQVNVDCAEFQCLD-----------------KLTKSVILGCLSMNPYERMSFSDIFGSGI
.| |..||..|. .    ..    . .|     . .  .. ..  |. .  .                   .  |..| .|| ..|..| .. .|. .  
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRI--MGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F
Kinase 128305.m00006.AA TKL 68-142 20 3.7e-11 36.45 In-house 167-286 (364) Show / Hide 
Range on Protein: 68-142
Range on HMM: 167-286/364
Sequence Identity: 20% (24 aa)

NPRNILMGDNMI--------------PQFTDIGNASKVDNSNELQDID--------------KNKTIC-TPLYAAPEVILY----------------YKA
...|||  .|.               .  .| | .  ...|.. .|.               .. |.| || . ||||.                  ...
KSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEY

SYKSDIFSWGVLLYQLLTQK
| |.|..|.|..|. .|| .
SEKCDVYSFGIVLWEILTRC
S_TKc 128305.m00006.AA S_TKc 1-208 18 2.8e-10 -26.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-208
Range on HMM: 1-231/231
Sequence Identity: 18% (49 aa)

EEIC--------------------------------------------YIIPSYDVLYINDSFGLTMKFFPY---NLETLINEG--------ISIRDALH
 ||                                             .|.  ||| .  |.. . | . .    .| ..| .         ..  .| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

IAKHILCGLYQLYSHGYIWLDCNPRNILMGDNMIPQFTDIGNASKVDNSNELQDIDKNKTICTPLYAAPEVILYYKASY-KSDIFSWGVLLYQLLTQKYA
... |.|.|  . ||| |  |  | |||. .      .| | | ..           .  . || | ||||.   . .. |.|. | |..|| .|.  | 
YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYP

LLSEEFYDSESNDYITEYLKFQVNVDCAEFQCLDKLTKSVILGCLSMNPYERMSFSDIFG-------SGIF
. .            .... |.. .        ..  |. | .|| ..| .|..  ...           |
PFP------------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 128305.m00006.AA Ciliate-E3 66-139 30 5.5e-10 27.62 In-house 128-202 (202) Show / Hide 
Range on Protein: 66-139
Range on HMM: 128-202/202
Sequence Identity: 30% (25 aa)

DCNPRNILMGDNM---IPQFTDIGNASKVDNSNELQDIDK--NKTI---CTPLYAAPEVILYYKASYKSDIFSWGVLLYQLL
| .| ||| . |    | .. | | . .  .       .|  . |    .||.|||||.  . . |  ||. | |. . || 
DIKPDNILVDKNNNQLIIKICDFGESKQLRK-------NKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQLC
Kinase 128305.m00006.AA SAK 41-140 32 1e-09 29.01 In-house 100-195 (254) Show / Hide 
Range on Protein: 41-140
Range on HMM: 100-195/254
Sequence Identity: 32% (33 aa)

RDALHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDNMIPQFTDIGNASKVDNSNELQDIDKNKTIC-TPLYAAPEVILYYKASYKSDIFSWGVLLYQLL
..| |. ..|. |.  | ||| .  |    |||.  .|  .  | | |...   .|     |  |.| || | .||..       .||..| | .|| ||
EEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHE-----KHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLL

T
.
I
Kinase 128305.m00006.AA DRAK 36-140 29 1.1e-09 25.64 In-house 94-196 (259) Show / Hide 
Range on Protein: 36-140
Range on HMM: 94-196/259
Sequence Identity: 29% (32 aa)

EGISIRDALHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDNMIPQ---FTDIGNASKVDNSNELQDIDKNKTICTPLYAAPEVILYYKASYKSDIFSWG
|... .|. .. . || |.. | .   . ||  | |||.    .       | | . .. |. |. .|       || | |||.  |   .   |. | |
ECFCEKDVQRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREI-----MGTPDYVAPEILNYDPITMATDMWSIG

VLLYQLLT
|| | .||
VLTYVMLT
Kinase 128305.m00006.AA Frk 38-140 29 1.7e-09 28.75 In-house 95-197 (260) Show / Hide 
Range on Protein: 38-140
Range on HMM: 95-197/260
Sequence Identity: 29% (30 aa)

ISIRDALHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDNMIPQFTDIGNASKVDNSNELQDIDKNKTICTPLYAAPEVILYYKASYKSDIFSWGVLLYQ
. ..  . .|  .  |.  | |. ||  |   ||.|.|.. | .  | | |  .   ||     .        . ||| . | | . |||..|.|.||. 
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE

LLT
..|
IIT
TyrKc 128305.m00006.AA TyrKc 12-208 17 6.9e-05 -143.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-208
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

VLYIND---------------------------------------SF------------------------GLTMKFFPY----NLETLI--NEG-ISIR
.  .                                         ..                        .  |  . |    .|   .  ... .. .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

DALHIAKHILCGLYQLYSHGYIWLDCNPRNILMGDNMIPQFTDIGNASKVDNS----NELQDIDKNKTICTP--L---YAAPEVILYYKASYKSDIFSWG
| |...  | ||   | |...|  |   ||.| |.| .   .| | . ....      . . ..| .. ..   |     |||.| |.| . |||..|.|
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFG

VLLYQLLTQKYALLSEEFYDS-----ESNDYITEYLKFQVNVDCAEFQ--------CLDKLTKSVILGCLSMNPYERMSFSDIFGSGIF
|... ..|     . .. |        ||. . ||.| | .               | |.. . ... |   .| .| .||.|    .|
VCMWEIFT-----YGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF