Gene 95912.m00236 (T.vaginalis)
95912.m00236
Species: T.vaginalis
Alias: TvagK0795, 95912.m00236
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 95912.m00236.AA | Protein | None | 2247 | None | Fasta, JSON |
| 95912.m00236.kin_dom | Protein Kinase Domain | None | 376 | None | Fasta, JSON |
Protein domains of 95912.m00236.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| FAT | 95912.m00236.AA | FAT | 1300-1446 | 17 | 0.000519 | 13.66 | Pfam | 1-170 (408) | Show / Hide |
Range on Protein: 1300-1446
Range on HMM: 1-170/408
Sequence Identity: 17% (30 aa)
SVHHASALWGLFEMED--FAKTAKKLQ------------TDDI-----DSLFYRAVYCV--LQEQTA--KAKEIIERVQHACADKIIP-TLFHDYNRGFH
. .| | |.| . .. . ... | | |..|. |. .. | |.. |... . ... . . |||
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYP
NFSLLTRFSELEEIIYYH-ELEQLRFNSPELKSKLDPFMKMIVNKWQNRFNYY-AEDLNVLQTSLQIHSLIFK
. .|||||| |. . | ... . .. .|.... |..| ...| | |. ....|.
VMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEK---QKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFS
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| Rapamycin_bind | 95912.m00236.AA | Rapamycin_bind | 1749-1791 | 27 | 1e-06 | 22.77 | Pfam | 44-86 (100) | Show / Hide |
Range on Protein: 1749-1791 Range on HMM: 44-86/100 Sequence Identity: 27% (12 aa) LDKKPQNFYEVSFIRNFGHQLMQSRNWMENYLESKDQMHFENV |.|.|. . |.||. ||..| . . | ..|....|. ..... LEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQA |
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| Kinase | 95912.m00236.AA | FRAP | 1886-2190 | 25 | 1.8e-40 | 140.76 | In-house | 13-251 (251) | Show / Hide |
Range on Protein: 1886-2190
Range on HMM: 13-251/251
Sequence Identity: 25% (79 aa)
RLDVNIMHLFNLINSIIDHSTTVFSTKVSMTTFHVLPIKKRIGLIGWIPQSETLLRAVSTFRQRHNIKVNTEYLKYLKRLNKIDDFEETKSDNESKKLKK
| | .| || ||| .. .. |.. . ..|. . |||||... || . .|....|. | |
RQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIE----------------------------
NSATNSSSVFDPRGFMTRSQSQNLLKVSKQKVTEDDTIIKLERKICYEDISDEDKLYAFNESMKTTKGDDVKKLLLINANSSKDWITRRVEFTVSLAIGS
| ... |. . .| | |. |||.| |||| . .| |. || .| |||. |
------------------------------------YNIMDRMCNDYDHLPLMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMS
VVGYVIFLGNRNPSNILMNINSARISHINFSSALS-TIKEEICADSGKQMPFRLTRMFINALELSKTEGSFQHISEAILSLLQQNKEDILSILEIFVKDP
..||.. || | ||||... . .| || | .. | . ||||||| .||.| || . ..| .. . .|| .. .|| || ||
MAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPE---KIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDP
SLISRK
. |
LFYWRL
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| Kinase | 95912.m00236.AA | PIKK | 1845-2180 | 21 | 1.3e-35 | 124.64 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1845-2180
Range on HMM: 1-290/290
Sequence Identity: 21% (74 aa)
YIQSISKEVAILNNKNRRRLLNFVSNTGRHHLYSL--GNDVCPRLDVNIMHLFNLINSIIDHSTTVFSTKVSMTTFHVLPIKKRIGLIGWIPQSETLLRA
.|... . | .. | . . . . |. . | . . | |.| .| || |.| . .. . . ...|. | | | |||.| . . ||
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDL--RQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEI
VSTFRQRHNIKVNTE---------YLKYLKRLNKIDDFEETKSDNESKKLKKNSATNSSSVFDPRGFMTRSQSQNLLKVSKQKVTEDDTIIKLERKICYE
.|. .|. . | | .||.. . . .. . |
YKQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMS-----------------------------------------------------YYKHQMQQQCMMYQ
DISDEDKLYAFNESMKTTKGDDVKKLLLINANSSKDWITRRVEFTVSLAIGSVVGYVIFLGNRNPSNILMNINSARISHINFSSALSTIKE-----EICA
. ....|. .|.| | |..|. ||... . .. .| .|| .| |.| ..|||.. || |.|.||. . .. | || | . .. |.
HWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEK--
DSGKQMPFRLTRMFINALELSKTEGSFQHISEAILSLLQQNKEDILSILEIF
.||||||...||.. ..|| | . |... .. |..|......| |
-----VPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
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| Kinase | 95912.m00236.AA | PI3_PI4_kinase | 1878-2190 | 13 | 7.1e-21 | 78.88 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1878-2190
Range on HMM: 1-300/300
Sequence Identity: 13% (49 aa)
SL-----GNDVCP-RLDVNIMHLF-----------------------NLINSIIDHSTTVFSTKVSMTTFHVLPIKKRIGLIGWIPQSETLLRAVSTFR-
|.| . | | .|... .|.| . . . . .|... ..| .. |.|.|.|...|. . .|..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV
----QRHNIKVNTEYLKYLKRLNKIDDFEETKSDNESKKLKKNSATNSSSVFDPRGFMTRSQSQNLLKVSKQKVTEDDTIIKLERKICYEDISDEDKLYA
|.. . ........... ..|.
KCKHKHFNKEHKMWMKMWPDWWHLM--------------------------------------------------------------------RMQKVEV
FNESMKTTKGDDVKKLLLINANSS-KDWITRRVEFTVSLAIGSVVGYVIFLGNRNPSNILM--NINSARISHINFSSALS--TIKEEICADSGKQMPFRL
|.. .. |.... .... . . .| ..| |. |.| .||.|.. .| |...||.. . . . || | .. | ... . .|||.
FEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPE---RVPFRW
TR------MFINAL------ELSKTEGSFQHISEAILSLLQQNKEDILSIL-------EIFVKDPSLISRK
|. ....|. . |. .| |... . .. .| .... ... | |..|.|... |.
THWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
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| Kinase | 95912.m00236.AA | ATR | 2067-2180 | 26 | 6.2e-16 | 50.37 | In-house | 157-267 (267) | Show / Hide |
Range on Protein: 2067-2180 Range on HMM: 157-267/267 Sequence Identity: 26% (30 aa) SKDWITRRVEFTVSLAIGSVVGYVIFLGNRNPSNILMNINSARISHINFSSALSTIKEEICADSGKQMPFRLTRMFINALELSKTEGSFQHISEAILSLL ...| . | . | |. ..|||.| || | |||.. . |. . .. . .|||||. .... ||.| | . | |. .. PQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQ---FEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCM QQNKEDILSILEIF .....||.|... | RDHRDDIMSVWDCF |
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| Kinase | 95912.m00236.AA | FATC | 2215-2247 | 45 | 7.8e-16 | 53.76 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2215-2247 Range on HMM: 1-33/33 Sequence Identity: 45% (15 aa) KKLSVTSQINKLIRQATNTKNICSMPKYWNPWW ..|||. |...||..||...|.| | | ||| EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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| Kinase | 95912.m00236.AA | ATM | 2070-2184 | 33 | 5.1e-15 | 44.04 | In-house | 133-244 (304) | Show / Hide |
Range on Protein: 2070-2184 Range on HMM: 133-244/304 Sequence Identity: 33% (38 aa) WITRRVEFTVSLAIGSVVGYVIFLGNRNPSNILMNINSARISHINFSSALSTIKEEICADSGKQMPFRLTRMFINALELSKTEGSFQHISEAILSLLQQN | .|. .| | | |.|||.. || | |||.| || . || | | .|||||| . . . || | | . . WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGK---ILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNS KEDILSILEIFVKDP .| .| | |. . || QETLLTIVEVLLYDP |
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| Kinase | 95912.m00236.AA | PI3Kc | 1879-2236 | 11 | 4.4e-13 | 46.02 | SMART | 4-336 (336) | Show / Hide |
Range on Protein: 1879-2236
Range on HMM: 4-336/336
Sequence Identity: 11% (50 aa)
LGNDVCPRLDVNIMHLFNLINSIIDHSTTVFSTKVSMTTFHVLPIKKRIGLIGWIPQSETLLRAVSTFRQRHNIKVNTE---------------------
. .. | | .| .|.|.| | . . .. |......|. ...|.|.|.| .||| .... .. ...
FKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYMMIW
----------------------------------YLKYLKRLNKIDDFEETKSDNESKKLKKNSATNSSSVFDPRGFMTRSQSQNLLKVSKQKVTEDDTI
....... .. ..
HQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN-----------------------------------------------------
IKLERKICYEDISDEDKLYAFNESMKTTKGDDVKKLLLINANSSKDWITRRVEFTVSLAIGSVVGYVIFLGNRNPSNILMNINSARISHINFSSALSTIK
|| ..| || |.| ..|.|. .| | ..||.. ... . || | ... .
--------------------------------------------EDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHGP
EEICADSGKQ------MPFRLTRMFINALE----LSKTEGSFQHISEAILSLLQQNKEDILSILEIFVKDPSLISRKSG----TNIEEYISGV-EKKLDG
. | . .|||||...... . |. .| |. . . .. .. .... |....|..|.|| ... ... ...... . .
KKP----GFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDEEA
YEYPSK------KKLSVTSQINKLIRQATNTKNI
..| . . |. |...... .. | ..
AQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | 95912.m00236.AA | DNAPK | 2134-2190 | 29 | 3e-06 | 18.62 | In-house | 245-301 (301) | Show / Hide |
Range on Protein: 2134-2190 Range on HMM: 245-301/301 Sequence Identity: 29% (17 aa) MPFRLTRMFINALELSKTEGSFQHISEAILSLLQQNKEDILSILEIFVKDPSLISRK ||||||| ||| . | | . | . ... . . ..|..|||. . MPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWKN |
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| Kinase | 95912.m00236.AA | ATR | 1845-1939 | 21 | 0.003637 | 6.15 | In-house | 2-96 (267) | Show / Hide |
Range on Protein: 1845-1939 Range on HMM: 2-96/267 Sequence Identity: 21% (20 aa) YIQSISKEVAILNNKNRRRLLNFVSNTGRHHLYSLGNDVCPRLDVNIMHLFNLINSIIDHSTTVFSTKVSMTTFHVLPIKKRIGLIGWIPQSETL || . | || . . . . |. .. | | |. .||| . | |. |.|. . ..| |. . || YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATL |
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| Kinase | 95912.m00236.AA | DNAPK | 1886-1939 | 27 | 0.016476 | 4.73 | In-house | 44-97 (301) | Show / Hide |
Range on Protein: 1886-1939 Range on HMM: 44-97/301 Sequence Identity: 27% (15 aa) RLDVNIMHLFNLINSIIDHSTTVFSTKVSMTTFHVLPIKKRIGLIGWIPQSETL |.| | || | |.. . . |. . | | ||| |. . .| RQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVL |
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