Gene 95287.m00227 (T.vaginalis)

95287.m00227

Species: T.vaginalis
Alias: 95287.m00227, TvagK0776
External Links:
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK1

Sequence

Name Sequence Type Origin Length Description Download
95287.m00227.AA Protein None 544 None Fasta, JSON
95287.m00227.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of 95287.m00227.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 95287.m00227.AA PLK 23-277 43 5.8e-109 355.95 In-house 1-258 (258) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-258/258
Sequence Identity: 43% (112 aa)

YKRHEELGKGGFAIAYRVSDVNTGQDYAMKVISKDKYTKPKSLEKLKSEISIQASLNHPNILRSYAHYEDFKYYYILLELAPGKSVRDMVRAQ-RRLPEK
|.| . |||||||  |.. |. |.| || ||..|   .||.  ||.|.|| |. .|.||||.. . . ||  . ||.||.....|  .. ..  .|| | 
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

KVAQFTKDILRGVGYLHDNRIIHRDLKLENYLIGADGKIKVADFGLSAKLDYDDEKKFTVCGTPNYLCPEIL--RSKGHSYEVDIWAIGVSVYVMLFGRQ
 | ...  |  |. |||..||||||||| | ..  .  .|..||||...|.||.|.| |.||||||  ||.|    .|||||||.|..|. .|..|.|. 
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFDCIKTKLLYEHIKSGNYTFPLEPKVSKAATDFIKSTLQVNPALRPSVQQLLSHPFI
||.    |  |. ||  .|.|| .. .|..| |.|.. |. ||. ||.  |.|.||| 
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase 95287.m00227.AA PLK-Unclassified 23-277 43 4.9e-98 331.99 In-house 1-264 (264) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-264/264
Sequence Identity: 43% (114 aa)

YKRHEELGKGGFAIAYRVSDVNTGQDYAMKVISKDKYTKPKSLEKLKSEISIQASLNHPNILRSYAHYEDFKYYYILLELAPGKSVRDMVRAQ-------
|.| . |||||||  | | .. | . || |.| |   || .  .||.||| |. ||.|.|| . .   ||  . |||||. |.... .. .         
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

RRLPEKKVAQFTKDILRGVGYLHDNRIIHRDLKLENYLIGADGKIKVADFGLSAKLDYDDEKKFTVCGTPNYLCPEIL--RSKGHSYEVDIWAIGVSVYV
 || |  |  .|  |. .. |||.|||||||||| | ... . ..| .||||..|| .| ||| |.||||||  ||||  . .|||||||.|..|. .| 
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

MLFGRQPFDCIKTKLLYEHIKSGNYTFPLEPKVSKAATDFIKSTLQVNPALRPSVQQLLSHPFI
.| |. ||     |  |. ||. .| || ....|..| |.|.. |. ||. ||.  |...||| 
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase 95287.m00227.AA CAMK 28-277 21 4.7e-95 306.71 In-house 1-425 (425) Show / Hide 
Range on Protein: 28-277
Range on HMM: 1-425/425
Sequence Identity: 21% (91 aa)

ELGKGGFAIAYRVSDVNTG------------QDYAMKVISKDKYTK-------------------------PKSLEKLKSEISIQAS-------LNHPNI
.||.|.|.. ... . ||.            | .|.|.|.|.| ..                         ||.......||.|  .       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRSYAHYE------------DFKY--------YYILL---ELAPGK----SVRDMVRAQ---------------RRLPEKKVAQFTKDILRGVGYLHDNR
.. | .||              ..        .|. .   |...|      . |.....               .|..|. .... . |. .| |.|.. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDLKLENYLIGAD-----------------GKIKVADFGLSAKLDY-----------------------DDEKKFTVCGTPNYLC-PEILRS-----
|.|||||.|| |.  .                 ..||..|||...|.|                        ...|  |.|||| | . ||.|..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KGHSYEVDIWAIGVSVYVMLFGRQPFDCI-------------KTKLLYEHIKSGNYTFPLEP----------------------KVSKAAT
         .......|.|..||  |.|| |. ||.                 . |.| |..|.|.|| ..                      .||. . 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DFIKSTLQVNPALRPSVQQLLSHPFI
|.|.. |||.|  |....| |.||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 95287.m00227.AA AGC 23-277 21 1.7e-94 244.04 In-house 1-395 (395) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-395/395
Sequence Identity: 21% (84 aa)

YKRHEELGKGGFAIAYRVSDV------NTGQDYAMKVISKDK--------YTKPKSLEK-------LKSEISIQASLN----------HPNILR-SYAHY
.. .  .|||.|   | | ..       ||. |||||..|..          .    |        ...|  | . .|          ||.| .  .  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDFKY--YYILLELAP----------G-KSVRDMV-R-AQRRLPEKKVAQFTKD-------ILRGVGYLHD-NRIIHRD-LKLENYLIGADGKIKVADFG
.| ..   |...|..|          |  .   .  |  ..|..|. .  ..         |. .. |||. . ||||| ||.|| |. .|| || .|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSAKLDYDD--------------------------------------------------EKKFTVCG--TPNYLCPEILRSKGHSYEVDIWA--IGVSVY
|. ..  |.                                                  ..  | ||  ||.|. ||||    .....|.|.   |.  |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

VMLFGRQPFDCI----------KTKLLYEHIKSGNYTFPLE--------------PKVSKAATDFIKSTLQVNPALRPS----------VQQLLSHPFI
 ||.|. ||               . ... |..|.|... .              ...|. | |.||  |...|. |.           .... .||. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 95287.m00227.AA S_TKc 23-277 29 1e-91 311.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-231/231
Sequence Identity: 29% (81 aa)

YKRHEELGKGGFAIAYRVSDVNTGQDYAMKVISKDKYTKPKSLEKLKSEISIQASLNHPNILRSYAHYEDFKYYYILLELAPG--KSVRDMVRAQRR---
|. ....|||.|.  |.. ...||. .|.|.|.          |....||.|  . .|||| . | ...| ...|. .|...|   ...|. . ..|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPEKKVAQFTKDILRGVGYLHDNRIIHRDLKLENYLIGADGKIKVADFGLSAKLDYDDEKKFTVCGTPNYLCPEILRSKGHSY-EVDIWAIGVSVYV
   .||  .. ... |.... |.|...||||||| || |.     ||..||||...|        |.||||.|. ||.|   |... ..|.|..|. .| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLFGRQPFDCIKTKLLYEHIKSGNYTFPLEPKVSKAATDFIKSTLQVNPALRPSVQQLLS-------HPFI
|| |. ||.    ......|.            |. | |||.  ||..|. ||.. ..|        ||..
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 95287.m00227.AA PLK1 23-277 39 5.1e-86 282.72 In-house 1-253 (253) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-253/253
Sequence Identity: 39% (100 aa)

YKRHEELGKGGFAIAYRVSDVNTGQDYAMKVISKDKYTKPKSLEKLKSEISIQASLNHPNILRSYAHYEDFKYYYILLELAPGKSVRDMVRAQRRLPEKK
|.. . |||||||  | ..|..| . .| ||..|    |..  .|.  ||.|  .|.|..| . . ..|| .. ||.|||   .|. .. .  . . |  
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

VAQFTKDILRGVGYLHDNRIIHRDLKLENYLIGADGKIKVADFGLSAKLDYDDEKKFTVCGTPNYLCPEILRSKGHSYEVDIWAIGVSVYVMLFGRQPFD
   ... |..|. |||.|.|||||||| |  .  . ..|. ||||  |..|| |.| | ||||||. ||.|  ||||.|||||.||  .|..|||. ||.
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFE

CIKTKLLYEHIKSGNYTFPLEPKVSKAATDFIKSTLQVNPALRPSVQQLLSHPFI
  . |  | .||  .|. | .  .|..| ..|.. |. .|  || ..|.|.  |.
TKCLKETYSRIKKNEYRIPSH--ISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase 95287.m00227.AA CAMKL 23-277 31 2.1e-84 269.28 In-house 1-297 (297) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-297/297
Sequence Identity: 31% (94 aa)

YKRHEELGKGGFAIAYRVSD-VNTGQDYAMKVISKDKYT-KPKSLEK-----------LKSEISIQASLN---HPNILRSYAHY-------EDFKYYYIL
|.  ..||||.|.      .  .||. .|.|.| |.| . .|... .           .. ||.|. .||   |||| . | ..       |  |..|. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV

LELAPGKS--VRDMVRAQ----RRLPEKKVAQFTKDILRGVGYLHDNRIIHRDLKLENYLIGADG--KIKVADFGLSAKLD-Y---DDEKKFTVCGTPNY
.|...| .    |.....    .|.||.   .. . |. .| |.|...|.|||.|.|| |.  .|  .||..|||.|.. . .   ...|  | ||.|.|
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

LCPEILRS--KGHS-YEVDIWAIGVSVYVMLFGRQPFDCIKTK-------LLYEHIKSGNYTFPLEPKVSKAATDFIKSTLQVNPALRPSVQQLLSHPFI
 .|||. .  | .  ..||||..||  |.|..|. |||.   .       .||. |..| | .|  ..||  . |.|.. |||||  ||...|...||. 
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 95287.m00227.AA Pkinase 23-277 30 1.7e-82 285.17 Pfam 1-293 (293) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

YKRHEELGKGGFAIAYRVSDVNTGQDYAMKVISKDKYTKPKSLEKLK-SEISIQASLNHPNILRSYAHYEDFKYYYILLELAPGK----SVRDMVR--AQ
|.... .|.|.|.  |.  ...||. .|.|.|.|..  . |  .... |||.| ..||||||.| |  .|| ...|. .|...|     .  |...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RRL--PEKKVAQFTKDILRGVGYLHDNRIIHRDLKLENYLIGADGKI----KVADFGLSAKL-DYDDEKKFTVCGTPNYLCPEILR-SKGHSYEVDIWAI
...  .|. .  . . ||||. |.|...|||||||.|| ||  .| |    |..||||....    ..   |.||||.|. ||..| .......||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVSVYVMLFGRQPFDCI------KTKLLYEHIKSGNYTFPLEPKVS-------------------KAATDFIKSTLQVNPALRPSVQQLLSHPFI
|. .| ||.|| ||.          . ... |... . |. . . |                   ... ||||. |...|. ||. .|.| ||..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 95287.m00227.AA Ciliate-E2 23-277 25 5.4e-81 275.39 In-house 1-365 (365) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-365/365
Sequence Identity: 25% (96 aa)

YKRHEELGKGGFAIAYRVSDVNTGQDYAMKVISKDK------------------YTKPKSLEKLKSEISIQ----------------ASLNHPNILRSYA
|| .. .|.|.|.. |.... ......|.|.|  .|                  . |.. .| .|.||.|                  .||||||.. | 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

HYE--DFKYYYILLELAPGKSVRDMVR------------AQRRLPEKKVAQFTKDILR---------------GVGYLHDNR-IIHRDLKLENYLIGADG
...  | ...|. .|.. |.. .|  .            .  .. ||......| ||.               .. ||| .  |||||.|.|| |.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

KIKVADFGLSAKLDYDDEKK-------------------------------FTVCGTPNYLCPEILRSKG---------HSYEVDIWAIGVSVYVMLFGR
 ||..||||| |.| | ...                               .|.||||.|..||||..|.         ..|..|||..||  | ||||.
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

QPFDCIKTKLLYEHIKSGNYTFPLE----------------PKVSKAATDFIKS----TLQVNPALRPS-VQQLLSHPFI
 ||        .. || ... || .                 |.|. . |.||      ||..|  |..  .|.| ||..
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 95287.m00227.AA Ciliate-E2-Unclassified 23-277 24 9.3e-76 258.0 In-house 1-352 (352) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-352/352
Sequence Identity: 24% (88 aa)

YKRHEELGKGGFAIAYRVSDVNTGQDY-----AMKVISKD-KYTKPKSLEKLKSEISIQ------------------ASLNHPNILRSYAHYEDFKYYYI
|| .. .|.|||.. |.. . ...  |     ..|..... |. . |  |.. ... ..                   ...||.|.. . . .| .. ||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

LLELAPGKSVRDMVRAQ-----------------RRLPEKKVA-----QFTKDILRGVGYLHDN-RIIHRDLKLENYLIGADG---KIKVADFGLSAKLD
 .|...|.. ... . .                 ....|....     .... || |  ||| .  |||||.|.|| |.  .|   .||..|||.| |..
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

YD---------------DEKKFTVCGTPNYL----CPEILRSKGHS----YEVDIWAIGVSVYVMLFGRQPFDCIKTKL----------------LYEHI
..               ...  |.||||||.     ||.|......    |..|||. ||  | ||||. ||.. . .                 ||. |
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

KSGNYTFPLEP------KVSKAATDFIK----STLQVNPALRPSVQQLLSHPFI
| .|. || .|      ..|. | |||.    . |..||  |.. .|.| ||..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 95287.m00227.AA MARK 23-277 34 7.2e-73 237.56 In-house 1-262 (262) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-262/262
Sequence Identity: 34% (92 aa)

YKRHEELGKGGFAIAYRVSDVNTGQDYAMKVISKDKYTKPKSLEKLKSEISIQASLNHPNILRSYAHYE--DFKY-YYILLELAPGKSVRDMVRAQ--RR
||   ..|.|..|  . . ...||. .| |.. | | ..|........||.|  .|.|||| . .   |  . .   |. .|.|.|....| ..|.  .|
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LPEKKVAQFTKDILRGVGYLHDNRIIHRDLKLENYLIGADG--KIKVADFGLSAKLDYDDEKKFTVCGTPNYLCPEILRSKGHS-YEVDIWAIGVSVYVM
|.|.   .. . |. .| |.|...|.|||.|.|| || ..|  .|| .|||.|..    ..|  | |||| | .|||. .|    ..||||. ||  |.|
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIP-PGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM

LFGRQPFD--CIKTKLLYEHIKSGNYTFPLEPKVSKAATDFIKSTLQVNPALRPSVQQLLSHPFI
. |. |||  ..  | ||. | .|.|..|    ||| . ..|.. |.|||  ||.......||..
VCGYFPFDGDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 95287.m00227.AA STE 23-277 23 1.6e-69 237.27 In-house 1-359 (359) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-359/359
Sequence Identity: 23% (85 aa)

YKRHEELGKGGFAIAYRVSDVN---------------TGQDYAMKVISKDKYTK--------------PKSLEKLKSEISIQASLN--HPNILRSYAHYE
... |..|||.|   |.  ...               ||. .|.|...... ..              .. ..... ||.|   .|  |||| . | .|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DF-------KYYYILLELAPGKSVRDMVR--------------AQRRLPEKKVAQFTKDILRG-VGYLHDNRIIHRDLKLENYLIGADGKIKVADFGLSA
.         . .| .|. .| |..|...              .| |.||. .| ....||.|   |||...|||||.|  | |.     .| .|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KLDYD----------------DEKKFTVCGTPNYLCPEILRS------KGHSYEVDIWAIGVSVYVMLFGRQPF-DCIKTKLLYEHIKSG----------
.|. .                ..|  |..||| .  ||...       ||... .||| .|  .  |. |. |. |   .. ... ....          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---NYTFPLEP-------------------KVSKAATDFIKSTLQVNPALRPSVQQLLS--HPFI
   .   ||..                   |.|.   |||.  || .|  ||...|||.  ||||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 95287.m00227.AA TyrKc 23-277 21 1.1e-17 63.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

YKRHEELGKGGF-----AIAYRVSDVNTGQDYAMKVISKDKYTKPKSLEKLKSEISIQASL--NHPNILRSYAHYEDF-------KYYYILLELAPGKSV
 .  ..|| | |     ....        .. | |.. .|.      .| . .|..|  .|  .||||.| |.   .        . ..|..|..|. . 
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

RDMVRAQRR-LPEKKVAQFTKDILRGVGYLHDNRIIHRDLKLENYLIGADGKIKVADFGLSAKLDYD-------DEKKFTV--CGTP----NYLCPEILR
.|  |. |. |. |.  .|  .| .|  |||....|||||   | |.|... .|..||||| ... |       | .. .   .|        . || ..
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

SKGHSYEVDIWAIGVSVY-VMLFGRQPFDC-----IKTKLLYEHIKSGNYTFPLEP--------KVSKAATDFIKSTLQVNPALRPSVQQLLSHPFI
 .  . . |.|. ||  . .. .| ||        .. . ..|..|.|..  . .           ..  .  .|.  . .|. ||. ...  | ..
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase 95287.m00227.AA Pkinase_Tyr 50-176 29 9.8e-16 53.92 Pfam 32-165 (270) Show / Hide 
Range on Protein: 50-176
Range on HMM: 32-165/270
Sequence Identity: 29% (40 aa)

AMKVISKDKYTKPK-SLEKLKSEISIQASL-NHPNILRSYAHYE-DFKY--YYILLELAPGKSVRDMVRA----QRRLPEKKVAQFTKDILRGVGYLHDN
| |.. |......   .|.. .|..|  .| .||||.| |.    . .   .|| .|..|. . .|  |.    ...|. |   |.  .| .|  ||...
AVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK

RIIHRDLKLENYLIGADGKIKVADFGLSAKLDYDDE
..|||||   | |.. ....|..||||.  . |.|.
NCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDD