Gene 94962.m00245 (T.vaginalis)

94962.m00245

Species: T.vaginalis
Alias: TvagK0504, 94962.m00245
External Links:
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
94962.m00245.AA Protein None 320 None Fasta, JSON
94962.m00245.kin_dom Protein Kinase Domain None 204 None Fasta, JSON

Protein domain

Protein domains of 94962.m00245.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 94962.m00245.AA CK1 15-272 39 1.4e-95 323.89 In-house 1-271 (271) Show / Hide 
Range on Protein: 15-272
Range on HMM: 1-271/271
Sequence Identity: 39% (106 aa)

YKVIKEIGTGSFSSVFIGFDEHNKRE--VAIKFESLNSKTPSLMYEYDIYQSMKN------SKTIPQIYYCGST--NHHIVMVMELMGNSLYKLLQICGG
|.|.. ||.|||  .. | . .|. |  ||||.|. .|| | |.||. ||. ...      .. ||..|.||    ... .|||.| | || .|...|..
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNR

KFSLYTTLTVATKMLKCVEDLHRHGYIHHDIKPENFLI-R-KDNPSEICLIDFGLSQRYIDPSSGSHVGYTTGCPFVGNARFASINSLSGVSSSRRDDIE
||||.|.| .|  |.. .| .| ...|| ||||.|||. |   .   . .|||||. ||.|.....|. | .. ...| ||.||||.  |.  ||||| |
KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDME

SLLYIWVYFLRGDLPWIALGGSNPKENQNLVLDIKQKVKPEKLFKD-CPQEFYKIYFYIKQMRFNDPPNYK
|| |. .||||| |||  |   . |.  .  ...|... .| |.|. .| ||.    |..|..|.. |.|.
SLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 94962.m00245.AA CK1-Unclassified 15-246 41 2.8e-94 278.63 In-house 1-244 (244) Show / Hide 
Range on Protein: 15-246
Range on HMM: 1-244/244
Sequence Identity: 41% (102 aa)

YKVIKEIGTGSFSSVFIGFDEHNKREVAIKFESLNSKTPSLMYEYDIYQSMKNSK-------TIPQIYYCGST--NHHIVMVMELMGNSLYKLLQICGGK
|.||. ||.|||  .. . . ....|||||.|. ||| | |.||  |.| ..| .        || .|.||     .. .|||.| | || .|...|..|
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

FSLYTTLTVATKMLKCVEDLHRHGYIHHDIKPENFLI--RKDNPSEICLIDFGLSQRYIDP-SSGSHVGYTTGCPFVGNARFASINSLSGVSSSRRDDIE
|||.|.|  |  |.. .| ||....|| ||||.|||.  .  |   . .|||||| ||||. . |.|. |  . ...| ||.||||.  |.  ||||| |
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE

SLLYIWVYFLRGDLPWIALGGSNPKENQNLVLDIKQKVKPEKLF
|| |. .|||.| |||. .   | || ..  ...|. . .| |.
SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 94962.m00245.AA CK1 15-274 26 2e-86 293.45 In-house 1-339 (339) Show / Hide 
Range on Protein: 15-274
Range on HMM: 1-339/339
Sequence Identity: 26% (91 aa)

YKVIKEIGTGSFS-SVFIG-----FDEHNK-----REVAIKFESLNSK--TPSLMYEYDIYQSMKNS-------------------KTIPQIYYCGSTNH
.||.| ||.|.|   .. .      |. |.      |.|.| |. .|.   |.||.|| .|. ...                    . .| .|...  ..
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--HIVMVMELMGNSLYKLLQ---ICGGKFSLYTTLTVATKMLKCVEDLHRHGYIHHDIKPENFLIRK--------------DNPSEICLIDFGLSQ-RYI
  . .|||.| | .| .|..    |..|||. |.| .|  ||. .|..|..|.|| ||||.||..                ..   . .||||..  .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DP-----------SSGSHVGYTT---GCPFVG-NARFASINSLSGVSSSRRDDIESLLYIWVYFLRGD--LPWIALGGSNP-------KENQNLVLDIKQ
|.           . . |  . .    ..|.|  ||..|||.  |.  .||||..|..|  ...|.|   |||  .   .        |. ..   . | 
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

KVKPEKLFKD-----CPQEFYKIYFYIKQMRFNDPPNYKKI
..... | .      ||||| ||. ||..... | |.|..|
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 94962.m00245.AA CK1-A 15-274 36 1.8e-72 247.09 In-house 1-261 (261) Show / Hide 
Range on Protein: 15-274
Range on HMM: 1-261/261
Sequence Identity: 36% (95 aa)

YKVIKEIGTGSFSSVFIGFDEHNKREVAIKFESLNSKTPSLMYEYDIYQSMKNSKTIPQIYYCGSTNHHIVMVMELMGNSLYKLLQICGGKFSLYTTLTV
|.....|| |||  ...|   .|  ||||| || . . | |.||  .|. ..    ||.. . |.   . ||||.|.| ||  |  .|  .|.. | | .
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

ATKMLKCVEDLHRHGYIHHDIKPENFLIRKD-NPSEICLIDFGLSQRYIDPSSGSHVGYTTGCPFVGNARFASINSLSGVSSSRRDDIESLLYIWVYFLR
| .|.  .| .| ...|| ||||.|||.  .    .. ||||||...| |. .  |. | .    .| ||.||||   |.  |||||.||. |. .|| |
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR

GDLPWIALGGSNPKENQNLVLDIKQKVKPEKLFKDCPQEFYKIYFYIKQMRFNDPPNYKKI
| |||  .   . |     ... |  .  |.| |  | ||  .  |....||...|.|  .
GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 94962.m00245.AA CK1-D 15-274 38 1.4e-71 244.14 In-house 1-261 (261) Show / Hide 
Range on Protein: 15-274
Range on HMM: 1-261/261
Sequence Identity: 38% (101 aa)

YKVIKEIGTGSFSSVFIGFDEHNKREVAIKFESLNSKTPSLMYEYDIYQSMKNSKTIPQIYYCGSTNHHIVMVMELMGNSLYKLLQICGGKFSLYTTLTV
|.. . || |||  .. | . ..  ||||| |.. .| | | .|  .|. |.    ||.| .||.     ||||.|.| ||  |   |. |||| | | .
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

ATKMLKCVEDLHRHGYIHHDIKPENFLI---RKDNPSEICLIDFGLSQRYIDPSSGSHVGYTTGCPFVGNARFASINSLSGVSSSRRDDIESLLYIWVYF
| .|.. .| .| . .|| ||||.|||.   .. |   . .|||||..|| |. .  |. |       | ||.||||   |.  |||||.||| |. .||
ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGN--MVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF

LRGDLPWIALGGSNPKENQNLVLDIKQKVKPEKLFKDCPQEFYKIYFYIKQMRFNDPPNYKKI
 || |||  |   . ..  . . . | ..| ..| |  |.|| .   | ....|.| |.|  .
NRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 94962.m00245.AA CK1-G 15-274 38 1.5e-69 234.84 In-house 1-266 (266) Show / Hide 
Range on Protein: 15-274
Range on HMM: 1-266/266
Sequence Identity: 38% (103 aa)

YKVIKEIGTGSFSSVFIGFDEHNKREVAIKFESLNSKTPSLMYEYDIYQSMKNSK-TIPQIYYCGSTNHHIVMVMELMGNSLYKLLQICGGKFSLYTTLT
|.| | || |.|  .| |    |   ||||||   |. | |  ||  |. .      |||.|| |    . .|||.|.| ||  |  .|. |||. |.. 
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

VATKMLKCVEDLHRHGYIHHDIKPENFLIRK---DNPSEICLIDFGLSQRYIDPSSGSHVGYTTGCPFVGNARFASINSLSGVSSSRRDDIESLLYIWVY
||. |.. .|..| |  |  |.||.|||| .    ..  | .||||.   ||||  . |. |       | ||. |||   |   |||||.|.|  .  |
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY

FLRGDLPWIALGGSNPKENQNLVLDIKQKVKPEKLFKD--CPQEFYKIYFYIKQMRFNDPPNYKKI
|||| |||  |   | ||  . . | |.|. .| | .    |..| .   |. .. |.. | |  .
FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 94962.m00245.AA Worm6 15-274 30 9.1e-55 188.27 In-house 1-279 (279) Show / Hide 
Range on Protein: 15-274
Range on HMM: 1-279/279
Sequence Identity: 30% (85 aa)

YKVIKEIGTGSFSSVFIGFDEHNKR--EVAIKFES--LNSKTPSLMYEYDIYQSMKNSK--TIPQIYYCGSTNH--HIVMVMELMGNSLYKLLQIC-GGK
.|| |.||.|.|..|.   |. .|.  ..|.| |.   |.|.. |  |. . .  |..|    ..|  .| ..      .||.| | .|. | . . ..|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSLYTTLTVATKMLKCVEDLHRHGYIHHDIKPENFLIRK------DNPSEICLIDFGLSQ--RYIDPSSGSHVGYTTGCPFVGNARFASINSLSGVSSSR
||. |.| .|  .|. .||||..|.|| |.|| || |        .. . |...|||..   .|..     .    | |.|.|  |.|.... .|   .|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

RDDIESLLYIWVYFLRGDLPWIALGGSNPKE-NQNLVLDIKQKVKPEKLFKDCPQ-EFYKIYFYIKQMRFNDPPNYKKI
.||.|| .|  | ...|.|||  . ... .| ..    . ....  . .|. ||. || .| .|| |... | |.||.|
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 94962.m00245.AA TTBKL 15-278 24 1.1e-38 128.25 In-house 1-288 (288) Show / Hide 
Range on Protein: 15-278
Range on HMM: 1-288/288
Sequence Identity: 24% (74 aa)

YKVIKEIGTGSFSSVFIGFDEHNKREVAIKFESLNS-K--TPSLMYEYDIYQSMK--NSKTIPQIYYCGSTNHHIVMVMELMGNSLYKLL-QICGGK-FS
....|.|| | | .|. . |  .| ..|.. | .|.    .  .  | ..   .   .|. .|.....| .     |||.| | .| .|  ... .| ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LYTTLTVATKMLKCVEDLHRHGYIHHDIKPENFLIRKDNPSE-------ICLIDFGLSQRYIDPSS------------------GSHVGYTTGCPFVGNA
  |.. .. . |... ..|..|.||.|.|| |. .  .. ..       . |||||....|.....                  .      . .|| |  
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCW--GYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNF-----RHKAPFRGTT

RFASINSLSGVSSSRRDDIESLLYIWVYFLRGDLPWIALGGSNPKENQNLVLDIKQKVKPEKLFKD------CPQEFYKIYFYIKQMRFNDPPNYKKIEN
|..|.|   .   .| ||. |..|. .... | |||  .      |..  .   |.. | |.||||      ||.|| |.. .....|..| |.| .| .
RYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNM------EDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYE

YL
 .
CF
Kinase 94962.m00245.AA TTBK 15-274 31 7.3e-35 120.66 In-house 1-257 (257) Show / Hide 
Range on Protein: 15-274
Range on HMM: 1-257/257
Sequence Identity: 31% (84 aa)

YKVIKEIGTGSFSSVFIGFDEHNK-REVAIKFESLNSKTPSLMYEYDIYQSMKNSKTIPQIYYCGSTNHHIVMVMELMGNSLYKL-LQICGGKFSLYTTL
 ||.| || | |  .. . |  |.  .|||| || . .   |  |  . . .   . . . . ||  ..   |||.| | .|  |  .   |.||| |||
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

TVATKMLKCVEDLHRHGYIHHDIKPENFLIRK--DNPSEICLIDFGLSQRYIDPSSGSHVGYTTGCPFVGNARFASINSLSGVSSSRRDDIESLLYIWVY
 .   .|. .|  |  |. | |||| || . .   .  .. ..||||  .|.  ..|          | | .|.||||.       |.||  || |. | 
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

FLRGDLPWIALGGSNPKENQNLVLDIKQKVKPEKLFKDCPQEFYKIYFYIKQMRFNDPPNYKKI
|. | |||  .         . |  .|.|     | |.||.||      || . . | |.|. |
FVQGQLPWRKI------KDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 94962.m00245.AA Ciliate-E2 15-164 23 1.4e-24 81.27 In-house 1-209 (365) Show / Hide 
Range on Protein: 15-164
Range on HMM: 1-209/365
Sequence Identity: 23% (50 aa)

YKVIKEIGTGSFSSVFIGFD-EHNKRE-----------------VAIKFESLNSKTPS----LMYEYDIYQ---------------SMKNSKTIPQIYYC
||.|| ||.|.|.||. . . . .|..                 |.||.  .... ..    .. | .|..               .  |.. | ..|.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

GS--TNHHIVMVMELM-GNSLYKLLQICGGK----------FSLYTTLTVATKMLK---------------CVEDLHRHG-YIHHDIKPENFLIRKDNPS
    ....| .|||.  |..|.......  |          |...  ... .. |.               ..| ||  .  || |||||| |.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

EICLIDFGLSQRYIDP
 |..||||||..| |.
-IKIIDFGLSKKYDDD
Kinase 94962.m00245.AA Pkinase 15-176 26 2.2e-24 87.29 Pfam 1-172 (293) Show / Hide 
Range on Protein: 15-176
Range on HMM: 1-172/293
Sequence Identity: 26% (47 aa)

YKVIKEIGTGSFSSVFIGFDEHNKREVAIKFESLNSKTPSLMY------EYDIYQSMKNSKTIPQIYYCGSTNHHIVMVMELMGNSLYKLLQIC------
|.... || |||..|... .  . ..||.|  .. .. ..  .      |  | ... |.. | ..|..  .. || ||||.... || ..  .      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTW

-GGKF--SLYTTLTVATKMLKCVEDLHRHGYIHHDIKPENFLIRKDNPSE---ICLIDFGLSQRYIDPSSGSHVGYTTGC
 .|.|  |  .   ... .|. .| .|..| || |.||||.||  .|.     ....||||.  .      . . .|| |
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFC
Kinase 94962.m00245.AA S_TKc 15-219 20 4.1e-16 59.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-219
Range on HMM: 1-231/231
Sequence Identity: 20% (52 aa)

YKVIKEIGTGSFSSVFIGFDEHNKREVAIKFESLNSKTPSLMYEYDIYQSMKNSKTIPQIYYCGSTNHHIVMVMELMGN---SLYKLLQICGGK-----F
|.....|| |.|..|. . . . .|.||||  .      ... | .| ..  . . | ..|..  . .|. ||||....   .|..... .|..     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLYTTLTVATKMLKCVEDLHRHGYIHHDIKPENFLIRKDNPSEICLIDFGLSQRYIDPSSGSHV-------GYTT-----------------GCPFVGNA
.  ..  ..  ... .| .|.|| || |.|||| |. .    .| ..||||. .. .   |.         ||..                 |.|     
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP-Q

RFASINSLSGVSSSRRDDIESLLYI-------WVYFLRGD-----LPWI
 .. .. .   |.. .| |. .|             |...      ||.
MQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 94962.m00245.AA TyrKc 15-278 19 2.4e-08 -87.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-278
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

YKVIKEIGTGSFSSVFIGFDEHNKREVAIKFESLNSKTPSLMYEYDIYQSM--KNSKTIPQIYYCGSTN------HHIVMVMELMGN-SLYKLLQICGGK
 . .|..| | |  |. |      ..||.|    ..    .| |  |  .   ..   .  . .| .        . . .|||.| . .| . |. ...|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FSLYTTLTVATKMLKCVEDLHRHGYIHHDIKPENFLIRKDNPSEICLIDFGLSQRYIDPS---SGSHVGYTT----GCPFVGNARFASINSL-SGVSSSR
... . |  ..   .  | ||....|| |.   | |. ...   .   ||||| |.|.       |.  |..    |. ..   |  .. ..  |. .. 
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

RDDIESLLYIWVY-------FLRGDLPWIA---LGGSNPKENQNLVLDIKQKVKPEKLFKD-------CPQEFYKIYFYIKQMRFNDPPNYKKIENYL
 |       .| .       | .|. |.          ...|| .. ..||   ...   |       ||.| |.|     .   .| |. . |  ..
SD-------VWSFGVCMWEIFTYGQQPYPGMIQQ----MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF