Gene 88471.m00086 (T.vaginalis)

88471.m00086

Species: T.vaginalis
Alias: TvagK0476, 88471.m00086
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
88471.m00086.AA Protein None 342 None Fasta, JSON
88471.m00086.kin_dom Protein Kinase Domain None 117 None Fasta, JSON

Protein domain

Protein domains of 88471.m00086.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 88471.m00086.AA CK1 1-236 27 1e-78 267.85 In-house 25-339 (339) Show / Hide 
Range on Protein: 1-236
Range on HMM: 25-339/339
Sequence Identity: 27% (88 aa)

MDPNTS-----KMCAMKIEYLDIH--KSSLKLETSILQELAG--------------------CKYFPQIIDHGKTHT-IRYLVMEILGASLQNMRA--IA
.| ...     . .|||.|  .    ...|. |  ....| |                    |........||...   .|.||. || .|.  |.    
KDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEEDDYYNYMVMTLLGPNLEDLRKQNRM

PRKRFSMYTTLRIALESLIAIEEFHKHGYVHRDIKPGNFLIRN-------------DPKYP-ICLIDFGLCR-KYIDENG------------KIIPPRD-
....||| |.|.||.  | |.|. | .|..||||||.||..               ....  . .||||..| ||.| .|            ...|||. 
CNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYRDKDGHNRWNGPRDKTWQHRPPREH

--EPGFTG-TCRYASVHAHNYNELGRRDDIISWLYTIVELADSR--LPWPGTKDRVA-----TRQMKNDISATTLLKS------------FPDEILDIYR
    ||.| |.||.|...|.  |.|||||. ||.|...|. .    ||| . ||         ..|| .. ......             .|.|  .|. 
KKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKMSTPFFLCCPKKDHDCPQEF-KIMK

EVRKLKYEDQPDYELY
 .|.|||.| ||||  
YIRSLKYYDRPDYEMI
Kinase 88471.m00086.AA Worm6 2-236 34 5e-75 255.58 In-house 20-279 (279) Show / Hide 
Range on Protein: 2-236
Range on HMM: 20-279/279
Sequence Identity: 34% (89 aa)

DPNTSK--MCAMKIEY--LDIHKSSLKLETSILQELAGCK--YFPQIIDHGKTHT--IRYLVMEILGASLQNMRAIAPRKRFSMYTTLRIALESLIAIEE
|  . |  . ||| |      ... ||.| ..|.... .|  .|..|.|.||.     .|.||...| .|...|. .| ..||| |.|.||...|.|||.
DKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIED

FHKHGYVHRDIKPGNFLI-R-----NDPKYPICLIDFGLCR--KYIDENGKIIPPR-DEPGFTGTCRYASVHAHNYNELGRRDDIISWLYTIVELADSRL
 |..|..|||.||||| | |     ..    |...|||.||  ||.........|| .. || || |||....|.  |..|.||. ||.| .||.   .|
LHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCL

PWPGTKDRVATRQMKNDISATT-------LLKSFPD-EILDIYREVRKLKYEDQPDYELY
|| . ||. .  . |  .  .|       ... .|  |  ||   . ...|.| |||.  
PWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 88471.m00086.AA TTBKL 10-239 32 9.1e-72 241.57 In-house 29-288 (288) Show / Hide 
Range on Protein: 10-239
Range on HMM: 29-288/288
Sequence Identity: 32% (84 aa)

AMKIEYLD-IHK-SSLKLETSILQELA--GCKYFPQIIDHGKTHTIRYLVMEILGASLQNMRAIAPRKR-FSMYTTLRIALESLIAIEEFHKHGYVHRDI
|||.|.    .. | .|.|  .| .|.  |...||.... ||..  ...||. .| .||  |.  |.|. ||  |..||.   | |. . | .|..|||.
AMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDV

KPGNFLIRND---PKY--PICLIDFGLCRKYIDENG-----------KIIPPRD---EPGFTGTCRYASVHAHNYNELGRRDDIISWLYTIVELADSRLP
||.|. . .     ..   . |||||..|.|....|           .. .||.    ..| || ||.|. .|.  |.|| ||. ||.|.|.||... ||
KPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LP

WPGTKDRVATRQMKNDISATTLLKS------FPDEILDIYREVRKLKYEDQPDYE-LYKRL
| . .|.  . .||.. . ..| |       .|.| ..... .| |.| |.|||| .|. .
WTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 88471.m00086.AA TTBK 10-236 40 8.2e-59 201.7 In-house 29-257 (257) Show / Hide 
Range on Protein: 10-236
Range on HMM: 29-257/257
Sequence Identity: 40% (92 aa)

AMKIEYLDIHKSSLKLETSILQELAGCKYFPQIIDHGKTHTIRYLVMEILGASLQNMRAIAPRKRFSMYTTLRIALESLIAIEEFHKHGYVHRDIKPGNF
|.|.|  .  |  ||.|  .|. | ||..  . |  |      |.||...| .| ..|  .||  ||. ||||. .  | .||. |  |. |||||| ||
AIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNF

LI-RNDPKYPIC-LIDFGLCRKYIDENGKIIPPRDEPGFTGTCRYASVHAHNYNELGRRDDIISWLYTIVELADSRLPWPGTKDRVATRQMKNDISATTL
 . ||  .. .| ..|||| |.|.   | . |||   || || ||||. ||   |.||.||  |  |  || .   |||   ||.    .||.      |
AMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWRKIKDKDQVGEMKEKYDHRML

LKSFPDEILDIYREVRKLKYEDQPDYELY
||  | |.      .. |.|||.||| | 
LKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 88471.m00086.AA CK1-Unclassified 1-168 35 1.7e-41 120.24 In-house 19-198 (244) Show / Hide 
Range on Protein: 1-168
Range on HMM: 19-198/244
Sequence Identity: 35% (64 aa)

MDPNTSKMCAMKIEYLDIHKSSLKLETSILQELAGCK-------YFPQIIDHGKT--HTIRYLVMEILGASLQNMRAIAPRKRFSMYTTLRIALESLIAI
.. .| .  |.|.|  .   . |. |  |.|.| ...       ..| ..  |.    .. ..||. || ||     .  || ||..|.| ||   .  |
INMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK-FSLKTVLMIADQMIQRI

EEFHKHGYVHRDIKPGNFLI--RNDPKYPICLIDFGLCRKYI--DENGKIIPPRDEPGFTGTCRYASVHAHNYNELGRRDD
| .|.....|||||| |||.  ..  .. . .|||||  .||  |..|| || |.. ..|||.||||. ||   | .||||
EYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDD
Kinase 88471.m00086.AA CK1-A 10-236 34 1.2e-38 134.09 In-house 28-261 (261) Show / Hide 
Range on Protein: 10-236
Range on HMM: 28-261/261
Sequence Identity: 34% (81 aa)

AMKIEYLDIHKSSLKLETSILQELAGCKYFPQIIDHGKTHTIRYLVMEILGASLQNMRAIAPRKRFSMYTTLRIALESLIAIEEFHKHGYVHRDIKPGNF
|.|.|  . .   |  |. . . |.||  .|..  .|. .    .||..|| || ..  .  | ||.| | | .|   .  ||  |.....|||||| ||
AIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKR-RFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNF

LIRNDPK-YPICLIDFGLCRKYIDENGKI-IPPRDEPGFTGTCRYASVHAHNYNELGRRDDIISWLYTIVELADSRLPWPGTKDRVATRQM------KND
|.  .     . |||||| .|| |.. .. || |..   ||| ||||..||   |  ||||. |  | ..     .||| | |      .       |  
LMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMS

ISATTLLKSFPDEILDIYREVRKLKYEDQPDYELY
..   | | || |   .   .|.|..|.||||   
TPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 88471.m00086.AA CK1 10-168 35 6.3e-36 121.25 In-house 30-198 (271) Show / Hide 
Range on Protein: 10-168
Range on HMM: 30-198/271
Sequence Identity: 35% (61 aa)

AMKIEYLDIHKSSLKLETSILQELAG------CKYFPQIIDHGKT--HTIRYLVMEILGASLQNMRAIAPRKRFSMYTTLRIALESLIAIEEFHKHGYVH
|.|.|  .   . |. |  |...| |      |...|...  |.       ..||. || ||     .  || ||..|.| ||   .  || .|.....|
AIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNRK-FSLKTVLMIADQMIQRIEYVHNKNFIH

RDIKPGNFLI-R-NDPKYPICLIDFGLCRKYID-ENGKIIPPRDEPGFTGTCRYASVHAHNYNELGRRDD
||||| |||. | .  .  . .|||||  .|.| .... || |.  ..|||.||||. .|   | .||||
RDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD
Kinase 88471.m00086.AA CK1-D 10-236 33 2.4e-33 114.92 In-house 28-261 (261) Show / Hide 
Range on Protein: 10-236
Range on HMM: 28-261/261
Sequence Identity: 33% (79 aa)

AMKIEYLDIHKSSLKLETSILQELAGCKYFPQIIDHGKTHTIRYLVMEILGASLQNMRAIAPRKRFSMYTTLRIALESLIAIEEFHKHGYVHRDIKPGNF
|.|.| .  .   |..|  . . . |    |.|   |.      .||..|| ||  .     || ||. | | .|.  .  ||  | . ..|||||| ||
AIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRK-FSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNF

LIRNDPK-YPICLIDFGLCRKYIDEN-GKIIPPRDEPGFTGTCRYASVHAHNYNELGRRDDIISWLYTIVELADSRLPWPGTK--------DRVATRQMK
|.    .   . .||||| ..| | .  . || |..   ||| ||||.  |   |  ||||. |  | ..  .   ||| | |        .|.. ..|.
LMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMS

NDISATTLLKSFPDEILDIYREVRKLKYEDQPDYELY
  |   || | .| |  .    .|.||..|.|||   
TKI--DTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 88471.m00086.AA Dual 35-240 28 1.9e-26 85.82 In-house 68-282 (282) Show / Hide 
Range on Protein: 35-240
Range on HMM: 68-282/282
Sequence Identity: 28% (62 aa)

GCKYFPQIIDHGKTHT--IRYLVMEILGASLQNMRAIAPRKRFSMYTTLRIALESLIAIEEFHKHGYVHRDIKPGNFLI-RNDPKYPICLIDFGLCRKYI
| | |.  .| ||  .  . |.||   |.|||  |  .  . .|| .   .|.  | ||   |  ||.||.||| || .  ..    . . ||.. ||||
GDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYI

D-ENGKIIPPRDEPGFTGTCRYASVHAHNYNELGRRDDIISWLYTIVELADSRL--PWPGTKDRVATRQMKNDISATTLLKSFPDEIL----DIYREVRK
| ||.|  ..|    . |. |||.    .  . || ||. .| |..  | |     .|    |..  .. |.   .. . ... ..|.    ..   |  
DPENKKHRTARKKVKMYGCGRYACRACMMQKDQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQY-SHIPRRLKPLVSYVNG

LKYEDQPDYELYKRLI
. |.  |||.     .
YQYDSTPDYDYFRNCL
Kinase 88471.m00086.AA CK1-Unique 6-186 24 4.3e-26 87.46 In-house 30-232 (337) Show / Hide 
Range on Protein: 6-186
Range on HMM: 30-232/337
Sequence Identity: 24% (51 aa)

SKMCAMKIEYLDIHKS--SLKLETSILQELAGCK-------YFPQIIDHGKTHTIRYLVMEILGASLQNMRAIAPRK-RFSMY------TTLRIALESLI
..| .|| |.  . |    |. | ... ..  |         |....| . .    ..|| ..| |.   . ....   |         . .. ..  | 
DDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC-MMMKNFQFTLNEKKNQLCAIQCGYQCLN

AIEEFHKHGYVHRDIKPGNFLIRNDPK----YPICLIDFGLCRK--YIDENGKIIPPRDEPGFTGTCRYASVHAHNYNELGRRDDIISWLYTIVELADSR
.||  |.||. ||..||.|.    .|.      .  .|.| ||.   .. |. | .||    | |. .|..   |   |.|||||  ||.|... | .  
VIECMHWHGFHHRHMKPNNYCY-MAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCSCHQCREHGRRDDMESWFYMLYHLVHNT

--LPW
  | |
RGLSW
Kinase 88471.m00086.AA S_TKc 1-259 15 1.2e-11 -5.87 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-259
Range on HMM: 19-231/231
Sequence Identity: 15% (46 aa)

MDPNTSKMCAMKIEYLDIHKSSLKLETSILQELAGCKYFPQIIDHGKTHTIRYLVMEILGA---SLQNMRAIAPRKR----FSMYTTLRIALESLIAIEE
 . .| . .|.||        ... | .||..  ....  ...|.  . .  |.||| ..    .|  .    .|..    |.  .. ... . . |.| 
RHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEY

FHKHGYVHRDIKPGNFLIRNDPKYPICLIDFGLCRKYIDENGKIIPPRDEPGFTGTCRYAS--VHAHNYNELGRRDDIISWLY----------TIVELAD
 |.|| .|||.|| | |. .     | ..||||.|..               | ||  | .  |               .. .          .. |.. 
CHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL--------------GYGKCKCDWWSCGCILYEMLC

SRLPWPGTKDRVATRQMKNDISATTLLKSFPDEILDIYREVRKLKYEDQPDYELYKRLIREAINQSPQ----KKSGFD-------WEYF
 . |.|   . .  ....                                  .  | .||   .  |.        .         ..|
GYPPFP--QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 88471.m00086.AA Pkinase 1-135 24 6.1e-11 39.77 Pfam 19-167 (293) Show / Hide 
Range on Protein: 1-135
Range on HMM: 19-167/293
Sequence Identity: 24% (37 aa)

MDPNTSKMCAMKIEYLDIHKSSLKL-------ETSILQELAGCKYFPQIIDHGKTHTIRYLVMEILGASL---QNMRAIA--PRKRF--SMYTTLRIALE
.. .|.|. |.||  .. |..| |.       | .|...| ....  ...|   ...  |.||| ..  |     .. |    ...|  |. .  .....
HHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQ

SLIAIEEFHKHGYVHRDIKPGNFLIRNDPKYP---ICLIDFGLCRKY-IDENG
 | ..|  |..| .|||.|| |.||  .  ..   ....||||.... .  |.
ILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS
Kinase 88471.m00086.AA CK1 198-234 31 6e-06 16.71 In-house 234-271 (271) Show / Hide 
Range on Protein: 198-234
Range on HMM: 234-271/271
Sequence Identity: 31% (12 aa)

MKNDISATTLLKS-FPDEILDIYREVRKLKYEDQPDYE
.|  ..  .| |  || |  .  . .|.|..|..|||.
KKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM