82538.m00104

Species: T.vaginalis
Alias: 82538.m00104, TvagK0447
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
82538.m00104.AA Protein None 338 None Fasta, JSON
82538.m00104.kin_dom Protein Kinase Domain None 172 None Fasta, JSON

Protein domain

Protein domains of 82538.m00104.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 82538.m00104.AA CK1 24-277 27 2.1e-81 276.77 In-house 1-339 (339) Show / Hide
Range on Protein: 24-277
Range on HMM: 1-339/339
Sequence Identity: 27% (92 aa)

YQIINLLGQGGYG-DVYKA-----KNLNDG-----KYYALKTEYLDAPKKA--IDKEITFIKSLN---------------------SPYFPKIYANGQSS
.... ..|.||.| ..||.     |.....     . ||.|.|  .. ..     .|. ..| |.                     .|......  |   
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

N-FKYAVMDLFGKSISDYKK-SLF-SKTITGPILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSK-------------NKECP-IALIDFGLAR-KFI
. ..| ||.|.|....|..| . .  . .. .  ..|.| |..|..  |  |.|||||||.||...              |.|.  . .||||.|| |..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DP-----------ETNQPIPPAE---KPHFGG-TKKYVSIRLHEHKDSSFADDLASWFYTMVECWRGR--LPWANIRDKDD-----VGERKKSISPGDLC
|.           .|.|..|| |   |  | | | .|.||. |..|. .  ||| ||||...|. .|   ||| |..|..      |.. |. .   ...
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

SS------------MPTPFRDLYSYIFSLEYYDVPDYDKI
|             .|  | ... || ||.||| |||..|
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI

Kinase 82538.m00104.AA TTBKL 24-281 29 1.1e-69 234.48 In-house 1-288 (288) Show / Hide
Range on Protein: 24-281
Range on HMM: 1-288/288
Sequence Identity: 29% (85 aa)

YQIINLLGQGGYGDVYKAKNLND-GKYYALKTEYL--DAPKKAIDKEITFIKSLN---SPYFPKIYANGQSSNFKYAVMDLFGKSISDYKKSLFSKT-IT
..|. ..|.||.| ||......| ....|.| |.   .   . . .|.   . |.   ||.|||... |.  .. . || | |....| .| .  |  ..
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

GPILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKNKE----CP-IALIDFGLARKFIDPETNQP----------IPPAE---KPHFGGTKKYVSIRL
      |||  ..|..  |  |.||||.||.|. .  ...    |  . |||||.||...... ...           .| .   |. | || .|.|.. 
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HEHKDSSFADDLASWFYTMVECWRGRLPWANIRDKDDVGERKKSISPGDLCSS------MPTPFRDLYSYIFSLEYYDVPDYDKIISTL
|..|. .  ||| ||.|...|.  | ||| |. ||..... ||. .  ||..       .|  | . . .. ||.||| |||..|.  .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF

Kinase 82538.m00104.AA Worm6 24-277 30 2.7e-57 196.66 In-house 1-279 (279) Show / Hide
Range on Protein: 24-277
Range on HMM: 1-279/279
Sequence Identity: 30% (85 aa)

YQIINLLGQGGYGDVYKAKNLNDGK--YYALKTEY--LDAPKKAIDKEITFIKSL---NSPYFPKIYANGQSSN--FKYAVMDLFGKSISDYKKSLFSKT
...  ..|.||.|.|||...  |.|   .|.| |     ....  . |.   | .   ....|.||   |.  |  |.| || |.||. .|..| .  . 
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

ITGPILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSK------NKECPIALIDFGLAR-KFIDPETNQPIPPA-EKPHFGGTKKYVSIRLHEHKDSSF
.. .  ..|.|....||.  |. |.||||.||.|| .        |..  | ..|||..| |. . . |. ..|  .. .| || .| ..  | ... . 
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

ADDLASWFYTMVECWRGRLPWANIRDKDDVG-ERKKSISPGD----LCSSMPTP---FRDLYSYIFSLEYYDVPDYDKI
 ||. |||| |||  .|.|||....|.|.|. ..|. .   .     .   |.|   |.|   || .. |.| |||..|
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI

Kinase 82538.m00104.AA TTBK 24-277 33 7.1e-47 162.05 In-house 1-257 (257) Show / Hide
Range on Protein: 24-277
Range on HMM: 1-257/257
Sequence Identity: 33% (86 aa)

YQIINLLGQGGYGDVYKAKNLNDG-KYYALKTEYLDAPKKAIDKEITFIKSLN-SPYFPKIYANGQSSNFKYAVMDLFGKSISDYKKSLFSKTITGPILI
 ...   |.||.| .| ||..       |.| |  ..||     |.   | |   ..  . .  |   .| | ||.| ||. .|   .    . .    .
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

HIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKN--KECPIALIDFGLARKFIDPETNQPIPPAEKPHFGGTKKYVSIRLHEHKDSSFADDLASWFYTMVE
 .|. ....|.. |  |. |||||||||   .|  .   . ..||||||...   . .  || |   | ||  | ||  |  ..    ||| | || .||
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

CWRGRLPWANIRDKDDVGERKKSISPGDLCSSMPTPFRDLYSYIFSLEYYDVPDYDKI
   | |||  |.|||.||| |.     .|   .|  |.     | ||.| | |||  |
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI

Kinase 82538.m00104.AA CK1-A 24-277 31 3e-38 132.69 In-house 1-261 (261) Show / Hide
Range on Protein: 24-277
Range on HMM: 1-261/261
Sequence Identity: 31% (82 aa)

YQIINLLGQGGYGDVYKAKNLNDGKYYALKTEYLDAPKKAIDKEITFIKSLN-SPYFPKIYANGQSSNFKYAVMDLFGKSISDYKKSLFSKTITGPILIH
|...  .| | .||.| . |...|.  |.| |  .|    .  |    . |.  . .|..   |.  ..   |||| | |. |    . ..  |    . 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFN-FCKRRFTMKTVLM

IGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKNKEC-PIALIDFGLARKFIDPETNQPIPPAEKPHFGGTKKYVSIRLHEHKDSSFADDLASWFYTMVECW
.   ||  |   |. ..||||||| |||   .. |  . |||||||.|. |..| | ||  |  .  || .| ||  |   . |  ||. |  | |.   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

RGRLPWANIRDK------DDVGERKKSISPGDLCSSMPTPFRDLYSYIFSLEYYDVPDYDKI
||.|||  .. .      . . |.| |..   ||  .|. |  . .|. .| . ..|||  .
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL

Kinase 82538.m00104.AA CK1-D 24-277 33 4.5e-34 117.53 In-house 1-261 (261) Show / Hide
Range on Protein: 24-277
Range on HMM: 1-261/261
Sequence Identity: 33% (90 aa)

YQIINLLGQGGYGDVYKAKNLNDGKYYALKTEYLDAPKKAIDKEITFIKSLNSPY-FPKIYANGQSSNFKYAVMDLFGKSISD---YKKSLFS-KTITGP
| |   .| | .||.|  .|.. .   |.| | . .    .. |  | | ..     |.|   ||  ..   |||| | |. |   | .  || ||.   
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTV---

ILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKNKECP-IALIDFGLARKFIDPETNQPIPPAEKPHFGGTKKYVSIRLHEHKDSSFADDLASWFYTM
  . ..  ||. |   | . .||||||| |||    |    . .||||||... |..| | ||  |.    || .| ||  |   . |  ||| |  | .
--LMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL

VECWRGRLPW-----ANIRDK-DDVGERKKSISPGDLCSSMPTPFRDLYSYIFSLEYYDVPDYDKI
.   || |||     |. |.| . . |.| |..  .||. .|  | .   |  .|.. | |||  .
MYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL

Kinase 82538.m00104.AA CK1-G 24-277 30 2.1e-30 100.22 In-house 1-266 (266) Show / Hide
Range on Protein: 24-277
Range on HMM: 1-266/266
Sequence Identity: 30% (81 aa)

YQIINLLGQGGYGDVYKAKNLNDGKYYALKTEYLDAPKKAIDKEITFIKSLNSPY--FPKIYANGQSSNFKYAVMDLFGKSISDYKKSLFSKTITGPILI
|..    | | .| ..  ||.  . . | | |           |  | | ||.     |..|  ||   .   |||| | |  |    .   . .    .
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFD-WCDRKFSVKTVC

HIGIEMIKAIRAFHKEGYIHRDIKPSNFLF---SKNKECPIALIDFGLARKFIDPETNQPIPPAEKPHFGGTKKYVSIRLHEHKDSSFADDLASWFYTMV
 . | ||. ... |.   | ||.|| |||    |....  | .||||.|...|||||.| ||  |.    ||  | ||  |  .  |  ||. .      
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM

ECWRGRLPW-----ANIRDK-DDVGERKKSISPGDLCSS--MPTPFRDLYSYIFSLEYYDVPDYDKI
   || |||      | . . . .|..|... . ||| .  .|  |     |. .|.. . |||| .
YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL

Kinase 82538.m00104.AA CK1 127-275 36 6.9e-26 86.23 In-house 114-271 (271) Show / Hide
Range on Protein: 127-275
Range on HMM: 114-271/271
Sequence Identity: 36% (57 aa)

MIKAIRAFHKEGYIHRDIKPSNFLFSK-NKECP-IALIDFGLARKFIDPETNQPIPPAEKPHFGGTKKYVSIRLHEHKDSSFADDLASWFYTMVECWRGR
||. |  .|. ..||||||| |||    .|.|  . .|||||| ...|..|.| ||  |.  . ||  | ||  |  .  |  ||. |  | ..   || 
MIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGS

LPWANIR--DKDD----VGERKKSISPGDLCSS-MPTPFRDLYSYIFSLEYYDVPDYD
||| ...   |..     .| | |... .||.   |  | ..  |. .|.... |||.
LPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM

Kinase 82538.m00104.AA CK1-Unique 24-218 22 1e-25 86.18 In-house 1-221 (337) Show / Hide
Range on Protein: 24-218
Range on HMM: 1-221/337
Sequence Identity: 22% (50 aa)

YQIINLLGQGGYGDVYKAKNLNDG------KYYALKTEYLDAPKK-----AIDKEITFIKSLN-----SPYFPKIYANGQSSNFKYAVMDLFGKSISDYK
...| ..| ||||.|..   .|.|      . |. |||.  . |         ..  ||  .      .  |... . .|.   .. || . |.|.   .
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

KSLFSKTITGP------ILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKNK---ECPIALIDFGLARK--FIDPETNQPIPPAEKPHFGGTKKYVSI
  .    .|         .|  |     .|.  |. |..||..|| |.    ..   .  .  .|.|  |.  |...  .|  .|...  | |.|.| ..
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSN-NHQIRQPRPITPFRGCKDYCPC

RLHEHKDSSFADDLASWFYTMV
  |. .. .  ||. ||||...
SCHQCREHGRRDDMESWFYMLY

Kinase 82538.m00104.AA Pkinase 24-195 23 1.4e-22 80.93 Pfam 1-179 (293) Show / Hide
Range on Protein: 24-195
Range on HMM: 1-179/293
Sequence Identity: 23% (45 aa)

YQIINLLGQGGYGDVYKAKNLNDGKYYALKTEYLDAPKKAIDK------EITFIKSLNSPYFPKIYANGQSSNFKYAVMDLFGKS---ISDYKKSLF---
|.|.  .|.|..| |||... ..|| .|.|.  ..  |.  |.      ||   |.||.|.  ..|   ....  | ||.. ..    .. .   .    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-DYISTWR

SKTI--TGPILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKNKEC--PIALIDFGLARKFIDPETNQPIPPAEKPHFGGTKKYVS
....  .   ....  ......   |..| ||||.||.|.|...| ..  .. ..|||||..|         .     .| ||  |..
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMA

Kinase 82538.m00104.AA CK1-Unclassified 127-249 37 2.1e-21 59.97 In-house 113-244 (244) Show / Hide
Range on Protein: 127-249
Range on HMM: 113-244/244
Sequence Identity: 37% (49 aa)

MIKAIRAFHKEGYIHRDIKPSNFLF--SKNKECPIALIDFGLARKFIDP-ETNQPIPPAEKPHFGGTKKYVSIRLHEHKDSSFADDLASWFYTMVECWRG
||. |  .|. ..||||||| |||   . ..   . .|||||. ..||. .|.. ||  |.  . ||  | ||. |  .  |  ||| |  |...   .|
MIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLESLGYVLIYFLKG

RLPWANIR--DKDD----VGERKKSISPGDLC
.||| ||.  .|..      | | |...  ||
SLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC

Kinase 82538.m00104.AA CK1-Unclassified 24-108 27 1.7e-19 54.24 In-house 1-95 (244) Show / Hide
Range on Protein: 24-108
Range on HMM: 1-95/244
Sequence Identity: 27% (26 aa)

YQIINLLGQGGYGDVYKAKNLNDGKYYALKTEYLDAPKKAIDKEITFIKSLNSP--------YFPKIYANGQS--SNFKYAVMDLFGKSISDYKK
|..|  .|||  |..||..|..... .|.| |  ..  . ...|. . . |.          ..||.|  ||   ... . |||| |.|. |...
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFN

Kinase 82538.m00104.AA S_TKc 24-301 17 4.3e-18 67.35 SMART 1-231 (231) Show / Hide
Range on Protein: 24-301
Range on HMM: 1-231/231
Sequence Identity: 17% (55 aa)

YQIINLLGQGGYGDVYKAKNLNDGKYYALKTEYLDAPKKAIDKEITFIKSLNSPYFPKIYANGQSSNFKYAVMDLFGK---SISDYKKSLFS----KTIT
|.|....|.|..| |||... ..|...|.|        . | .||   |. . |.  |.|   |. .. | ||.. .    .  || |.  .    . ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

GPILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKNKECPIALIDFGLARKFIDPETNQPIPPAEKPHFGGTKKYVSIRLHEHKDSSFADDLASWFYT
     ..  ....|.   |. | ||||.||.| |...     | ..||||||..               .| ||  |..  .                |.
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--------------GYG

M------------VECWRGRLPWANIRDKDDVGERKKSISPGDLCSSMPTPFRDLYSYIFSLEYYDVPDYDKIISTLEGILNTNYS---SAQVNLH----
              |.  |. |.    . . . .. .                                 .  .. ....|. . .   .|   |.    
KCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---ELYF
     .|
IKCHPWF

Kinase 82538.m00104.AA CK1 24-108 27 1.6e-16 53.57 In-house 1-96 (271) Show / Hide
Range on Protein: 24-108
Range on HMM: 1-96/271
Sequence Identity: 27% (26 aa)

YQIINLLGQGGYGDVYKAKNLNDGKY--YALKTEYLDAPKKAIDKEITFIKSLNS-------PYFPKIYANGQS--SNFKYAVMDLFGKSISDYKK
|...  .|||  ||.|...|...|..  .| | |  ..    ...|. . | |.        ...|..|  ||   ... . |||| |.|  |...
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFN

Kinase 82538.m00104.AA TyrKc 24-236 13 7e-06 -127.82 SMART 1-280 (280) Show / Hide
Range on Protein: 24-236
Range on HMM: 1-280/280
Sequence Identity: 13% (41 aa)

YQIINLLGQGGYGDVYKAKNLNDGKYYALKTEYLDAPKKAIDKEITFIKSL--NSPYFPKIYANGQSS-------NFKYAVMDL-----FGKSISDYKKS
 . .  || | .| |||..        | |.   || .... .|.   ..|  . |   ..|.   ..          . || .       . . .... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LFSKTITGPILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKNKECPIALIDFGLARKFIDP-------ETNQP----IPP-----------------
     .. . |... .   .  .  |. ..||||.   | | ..|. . |.  ||||.|.  |        ..  .                        
-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKIS--DFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

--------------------AEKPHFG-----GTKKYVSIRLHEH-KDSSFAD--------DLASWFYTMVECWRG----RLPWANIRDKDDV
                     ..|. |      . . |  .. .       ..          .  .  | .||.     |   ..|  ... 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF