Gene 82538.m00104 (T.vaginalis)
82538.m00104
Species: T.vaginalis
Alias: 82538.m00104, TvagK0447
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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82538.m00104.AA | Protein | None | 338 | None | Fasta, JSON |
82538.m00104.kin_dom | Protein Kinase Domain | None | 172 | None | Fasta, JSON |
Protein domains of 82538.m00104.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 82538.m00104.AA | CK1 | 24-277 | 27 | 2.1e-81 | 276.77 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 24-277 Range on HMM: 1-339/339 Sequence Identity: 27% (92 aa) YQIINLLGQGGYG-DVYKA-----KNLNDG-----KYYALKTEYLDAPKKA--IDKEITFIKSLN---------------------SPYFPKIYANGQSS .... ..|.||.| ..||. |..... . ||.|.| .. .. .|. ..| |. .|...... | WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED N-FKYAVMDLFGKSISDYKK-SLF-SKTITGPILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSK-------------NKECP-IALIDFGLAR-KFI . ..| ||.|.|....|..| . . . .. . ..|.| |..|.. | |.|||||||.||... |.|. . .||||.|| |.. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR DP-----------ETNQPIPPAE---KPHFGG-TKKYVSIRLHEHKDSSFADDLASWFYTMVECWRGR--LPWANIRDKDD-----VGERKKSISPGDLC |. .|.|..|| | | | | | .|.||. |..|. . ||| ||||...|. .| ||| |..|.. |.. |. . ... DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM SS------------MPTPFRDLYSYIFSLEYYDVPDYDKI | .| | ... || ||.||| |||..| STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | 82538.m00104.AA | TTBKL | 24-281 | 29 | 1.1e-69 | 234.48 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 24-281 Range on HMM: 1-288/288 Sequence Identity: 29% (85 aa) YQIINLLGQGGYGDVYKAKNLND-GKYYALKTEYL--DAPKKAIDKEITFIKSLN---SPYFPKIYANGQSSNFKYAVMDLFGKSISDYKKSLFSKT-IT ..|. ..|.||.| ||......| ....|.| |. . . . .|. . |. ||.|||... |. .. . || | |....| .| . | .. WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS GPILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKNKE----CP-IALIDFGLARKFIDPETNQP----------IPPAE---KPHFGGTKKYVSIRL ||| ..|.. | |.||||.||.|. . ... | . |||||.||...... ... .| . |. | || .|.|.. DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HEHKDSSFADDLASWFYTMVECWRGRLPWANIRDKDDVGERKKSISPGDLCSS------MPTPFRDLYSYIFSLEYYDVPDYDKIISTL |..|. . ||| ||.|...|. | ||| |. ||..... ||. . ||.. .| | . . .. ||.||| |||..|. . HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | 82538.m00104.AA | Worm6 | 24-277 | 30 | 2.7e-57 | 196.66 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 24-277 Range on HMM: 1-279/279 Sequence Identity: 30% (85 aa) YQIINLLGQGGYGDVYKAKNLNDGK--YYALKTEY--LDAPKKAIDKEITFIKSL---NSPYFPKIYANGQSSN--FKYAVMDLFGKSISDYKKSLFSKT ... ..|.||.|.|||... |.| .|.| | .... . |. | . ....|.|| |. | |.| || |.||. .|..| . . WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK ITGPILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSK------NKECPIALIDFGLAR-KFIDPETNQPIPPA-EKPHFGGTKKYVSIRLHEHKDSSF .. . ..|.|....||. |. |.||||.||.|| . |.. | ..|||..| |. . . |. ..| .. .| || .| .. | ... . FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR ADDLASWFYTMVECWRGRLPWANIRDKDDVG-ERKKSISPGD----LCSSMPTP---FRDLYSYIFSLEYYDVPDYDKI ||. |||| ||| .|.|||....|.|.|. ..|. . . . |.| |.| || .. |.| |||..| KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | 82538.m00104.AA | TTBK | 24-277 | 33 | 7.1e-47 | 162.05 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 24-277 Range on HMM: 1-257/257 Sequence Identity: 33% (86 aa) YQIINLLGQGGYGDVYKAKNLNDG-KYYALKTEYLDAPKKAIDKEITFIKSLN-SPYFPKIYANGQSSNFKYAVMDLFGKSISDYKKSLFSKTITGPILI ... |.||.| .| ||.. |.| | ..|| |. | | .. . . | .| | ||.| ||. .| . . . . WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL HIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKN--KECPIALIDFGLARKFIDPETNQPIPPAEKPHFGGTKKYVSIRLHEHKDSSFADDLASWFYTMVE .|. ....|.. | |. ||||||||| .| . . ..||||||... . . || | | || | || | .. ||| | || .|| RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE CWRGRLPWANIRDKDDVGERKKSISPGDLCSSMPTPFRDLYSYIFSLEYYDVPDYDKI | ||| |.|||.||| |. .| .| |. | ||.| | ||| | FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | 82538.m00104.AA | CK1-A | 24-277 | 31 | 3e-38 | 132.69 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 24-277 Range on HMM: 1-261/261 Sequence Identity: 31% (82 aa) YQIINLLGQGGYGDVYKAKNLNDGKYYALKTEYLDAPKKAIDKEITFIKSLN-SPYFPKIYANGQSSNFKYAVMDLFGKSISDYKKSLFSKTITGPILIH |... .| | .||.| . |...|. |.| | .| . | . |. . .|.. |. .. |||| | |. | . .. | . YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFN-FCKRRFTMKTVLM IGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKNKEC-PIALIDFGLARKFIDPETNQPIPPAEKPHFGGTKKYVSIRLHEHKDSSFADDLASWFYTMVECW . || | |. ..||||||| ||| .. | . |||||||.|. |..| | || | . || .| || | . | ||. | | |. LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN RGRLPWANIRDK------DDVGERKKSISPGDLCSSMPTPFRDLYSYIFSLEYYDVPDYDKI ||.||| .. . . . |.| |.. || .|. | . .|. .| . ..||| . RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | 82538.m00104.AA | CK1-D | 24-277 | 33 | 4.5e-34 | 117.53 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 24-277 Range on HMM: 1-261/261 Sequence Identity: 33% (90 aa) YQIINLLGQGGYGDVYKAKNLNDGKYYALKTEYLDAPKKAIDKEITFIKSLNSPY-FPKIYANGQSSNFKYAVMDLFGKSISD---YKKSLFS-KTITGP | | .| | .||.| .|.. . |.| | . . .. | | | .. |.| || .. |||| | |. | | . || ||. YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTV--- ILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKNKECP-IALIDFGLARKFIDPETNQPIPPAEKPHFGGTKKYVSIRLHEHKDSSFADDLASWFYTM . .. ||. | | . .||||||| ||| | . .||||||... |..| | || |. || .| || | . | ||| | | . --LMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL VECWRGRLPW-----ANIRDK-DDVGERKKSISPGDLCSSMPTPFRDLYSYIFSLEYYDVPDYDKI . || ||| |. |.| . . |.| |.. .||. .| | . | .|.. | ||| . MYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | 82538.m00104.AA | CK1-G | 24-277 | 30 | 2.1e-30 | 100.22 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 24-277 Range on HMM: 1-266/266 Sequence Identity: 30% (81 aa) YQIINLLGQGGYGDVYKAKNLNDGKYYALKTEYLDAPKKAIDKEITFIKSLNSPY--FPKIYANGQSSNFKYAVMDLFGKSISDYKKSLFSKTITGPILI |.. | | .| .. ||. . . | | | | | | ||. |..| || . |||| | | | . . . . YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFD-WCDRKFSVKTVC HIGIEMIKAIRAFHKEGYIHRDIKPSNFLF---SKNKECPIALIDFGLARKFIDPETNQPIPPAEKPHFGGTKKYVSIRLHEHKDSSFADDLASWFYTMV . | ||. ... |. | ||.|| ||| |.... | .||||.|...|||||.| || |. || | || | . | ||. . MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM ECWRGRLPW-----ANIRDK-DDVGERKKSISPGDLCSS--MPTPFRDLYSYIFSLEYYDVPDYDKI || ||| | . . . .|..|... . ||| . .| | |. .|.. . |||| . YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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Kinase | 82538.m00104.AA | CK1 | 127-275 | 36 | 6.9e-26 | 86.23 | In-house | 114-271 (271) | Show / Hide |
Range on Protein: 127-275 Range on HMM: 114-271/271 Sequence Identity: 36% (57 aa) MIKAIRAFHKEGYIHRDIKPSNFLFSK-NKECP-IALIDFGLARKFIDPETNQPIPPAEKPHFGGTKKYVSIRLHEHKDSSFADDLASWFYTMVECWRGR ||. | .|. ..||||||| ||| .|.| . .|||||| ...|..|.| || |. . || | || | . | ||. | | .. || MIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGS LPWANIR--DKDD----VGERKKSISPGDLCSS-MPTPFRDLYSYIFSLEYYDVPDYD ||| ... |.. .| | |... .||. | | .. |. .|.... |||. LPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | 82538.m00104.AA | CK1-Unique | 24-218 | 22 | 1e-25 | 86.18 | In-house | 1-221 (337) | Show / Hide |
Range on Protein: 24-218 Range on HMM: 1-221/337 Sequence Identity: 22% (50 aa) YQIINLLGQGGYGDVYKAKNLNDG------KYYALKTEYLDAPKK-----AIDKEITFIKSLN-----SPYFPKIYANGQSSNFKYAVMDLFGKSISDYK ...| ..| ||||.|.. .|.| . |. |||. . | .. || . . |... . .|. .. || . |.|. . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC KSLFSKTITGP------ILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKNK---ECPIALIDFGLARK--FIDPETNQPIPPAEKPHFGGTKKYVSI . .| .| | .|. |. |..||..|| |. .. . . .|.| |. |... .| .|... | |.|.| .. MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSN-NHQIRQPRPITPFRGCKDYCPC RLHEHKDSSFADDLASWFYTMV |. .. . ||. ||||... SCHQCREHGRRDDMESWFYMLY |
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Kinase | 82538.m00104.AA | Pkinase | 24-195 | 23 | 1.4e-22 | 80.93 | Pfam | 1-179 (293) | Show / Hide |
Range on Protein: 24-195 Range on HMM: 1-179/293 Sequence Identity: 23% (45 aa) YQIINLLGQGGYGDVYKAKNLNDGKYYALKTEYLDAPKKAIDK------EITFIKSLNSPYFPKIYANGQSSNFKYAVMDLFGKS---ISDYKKSLF--- |.|. .|.|..| |||... ..|| .|.|. .. |. |. || |.||.|. ..| .... | ||.. .. .. . . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-DYISTWR SKTI--TGPILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKNKEC--PIALIDFGLARKFIDPETNQPIPPAEKPHFGGTKKYVS .... . .... ...... |..| ||||.||.|.|...| .. .. ..|||||..| . .| || |.. HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMA |
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Kinase | 82538.m00104.AA | CK1-Unclassified | 127-249 | 37 | 2.1e-21 | 59.97 | In-house | 113-244 (244) | Show / Hide |
Range on Protein: 127-249 Range on HMM: 113-244/244 Sequence Identity: 37% (49 aa) MIKAIRAFHKEGYIHRDIKPSNFLF--SKNKECPIALIDFGLARKFIDP-ETNQPIPPAEKPHFGGTKKYVSIRLHEHKDSSFADDLASWFYTMVECWRG ||. | .|. ..||||||| ||| . .. . .|||||. ..||. .|.. || |. . || | ||. | . | ||| | |... .| MIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLESLGYVLIYFLKG RLPWANIR--DKDD----VGERKKSISPGDLC .||| ||. .|.. | | |... || SLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC |
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Kinase | 82538.m00104.AA | CK1-Unclassified | 24-108 | 27 | 1.7e-19 | 54.24 | In-house | 1-95 (244) | Show / Hide |
Range on Protein: 24-108 Range on HMM: 1-95/244 Sequence Identity: 27% (26 aa) YQIINLLGQGGYGDVYKAKNLNDGKYYALKTEYLDAPKKAIDKEITFIKSLNSP--------YFPKIYANGQS--SNFKYAVMDLFGKSISDYKK |..| .||| |..||..|..... .|.| | .. . ...|. . . |. ..||.| || ... . |||| |.|. |... YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFN |
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Kinase | 82538.m00104.AA | S_TKc | 24-301 | 17 | 4.3e-18 | 67.35 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 24-301 Range on HMM: 1-231/231 Sequence Identity: 17% (55 aa) YQIINLLGQGGYGDVYKAKNLNDGKYYALKTEYLDAPKKAIDKEITFIKSLNSPYFPKIYANGQSSNFKYAVMDLFGK---SISDYKKSLFS----KTIT |.|....|.|..| |||... ..|...|.| . | .|| |. . |. |.| |. .. | ||.. . . || |. . . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP GPILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKNKECPIALIDFGLARKFIDPETNQPIPPAEKPHFGGTKKYVSIRLHEHKDSSFADDLASWFYT .. ....|. |. | ||||.||.| |... | ..||||||.. .| || |.. . |. E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--------------GYG M------------VECWRGRLPWANIRDKDDVGERKKSISPGDLCSSMPTPFRDLYSYIFSLEYYDVPDYDKIISTLEGILNTNYS---SAQVNLH---- |. |. |. . . . .. . . .. ....|. . . .| |. KCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD ---ELYF .| IKCHPWF |
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Kinase | 82538.m00104.AA | CK1 | 24-108 | 27 | 1.6e-16 | 53.57 | In-house | 1-96 (271) | Show / Hide |
Range on Protein: 24-108 Range on HMM: 1-96/271 Sequence Identity: 27% (26 aa) YQIINLLGQGGYGDVYKAKNLNDGKY--YALKTEYLDAPKKAIDKEITFIKSLNS-------PYFPKIYANGQS--SNFKYAVMDLFGKSISDYKK |... .||| ||.|...|...|.. .| | | .. ...|. . | |. ...|..| || ... . |||| |.| |... YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFN |
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Kinase | 82538.m00104.AA | TyrKc | 24-236 | 13 | 7e-06 | -127.82 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 24-236 Range on HMM: 1-280/280 Sequence Identity: 13% (41 aa) YQIINLLGQGGYGDVYKAKNLNDGKYYALKTEYLDAPKKAIDKEITFIKSL--NSPYFPKIYANGQSS-------NFKYAVMDL-----FGKSISDYKKS . . || | .| |||.. | |. || .... .|. ..| . | ..|. .. . || . . . .... ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK LFSKTITGPILIHIGIEMIKAIRAFHKEGYIHRDIKPSNFLFSKNKECPIALIDFGLARKFIDP-------ETNQP----IPP----------------- .. . |... . . . |. ..||||. | | ..|. . |. ||||.|. | .. . -----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKIS--DFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK --------------------AEKPHFG-----GTKKYVSIRLHEH-KDSSFAD--------DLASWFYTMVECWRG----RLPWANIRDKDDV ..|. | . . | .. . .. . . | .||. | ..| ... FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |