Gene 85876.m00236 (T.vaginalis)
85876.m00236
Species: T.vaginalis
Alias: 85876.m00236, TvagK0469
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
85876.m00236.AA | Protein | None | 310 | None | Fasta, JSON |
85876.m00236.kin_dom | Protein Kinase Domain | None | 188 | None | Fasta, JSON |
Protein domains of 85876.m00236.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 85876.m00236.AA | CK1 | 5-259 | 28 | 1.8e-81 | 276.99 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 5-259 Range on HMM: 1-339/339 Sequence Identity: 28% (97 aa) YRIDRLIGKGSYG-QVYLV-----NDIGTP-----DYFALKVEHNESA--RNSLTNEINELEQLQ----------ESPYFPK----------LVTHGILF ... ..||.|..| |.|.| |. .. . .|.|||...|. .| |.. ...|| ....|.| .. || WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED NSQ-YYIMELLGSSVAAMRS--ELDTKRFSRYTTLFIVTEMLKCIKVLHQKGFIHRDIKPSNFLLRP------GKNN--------PICLIDFGLSV-SYI . | .|.||| . | . ...|| |.| | ||. ....| .|||||||||.||.. ||.. . .||||.. |. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR DP-----------STNEHLPFRN---DIGFVG-SKRYASVNAHERNQLSRRDDMLSWFYSCVELYTGD--LPWSNTN---------VSETIYNLKKN--- |. .|..| |.|. ||.| ||.|.|.|.. ..||||. |||| .|. | |||.| . | . |. ... DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM INPPELCSG-----MPSEFTEIYRRIRDLRYEDCPPYDYI .|..|| . .|.|| .|. || |.|.| |.|..| STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | 85876.m00236.AA | TTBKL | 5-263 | 31 | 1.5e-76 | 257.98 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 5-263 Range on HMM: 1-288/288 Sequence Identity: 31% (91 aa) YRIDRLIGKGSYGQVYLVNDIGTPDY-FALKVEHNESARNS--LTNEINELEQLQ--ESPYFPKLVTHGILFNSQYYIMELLGSSVAAMRSELDTKR-FS ..| ..||.| .||||.| |...... .|.|.| |. .... . |.. | .|| ||.|||.. | . .. .|.|.| .. . |. . .|. || WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS RYTTLFIVTEMLKCIKVLHQKGFIHRDIKPSNFLLRPGKNN-----PICLIDFGLSVSYIDPSTN----------EHLPFRN---DIGFVGSKRYASVNA . |...| |...| .| .||||||.||.|. . ... . |||||.. |.... . .. . || .| |. ||.|.|. DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HERNQLSRRDDMLSWFYSCVELYTGDLPWSNTNVSETIYNLKKNINPPELCSG------MPSEFTEIYRRIRDLRYEDCPPYDYILRLL |.| ..| ||. ||.|. .||. | |||.| . . |. .||| . |... .||||..... .| ||| | |.|..|. .. HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | 85876.m00236.AA | Worm6 | 5-259 | 30 | 2.6e-60 | 206.69 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 5-259 Range on HMM: 1-279/279 Sequence Identity: 30% (84 aa) YRIDRLIGKGSYGQVYLVNDIGTPD--YFALKVEH--NESARNSLTNEINELEQL--QESPYFPKLVTHGILFN--SQYYIMELLGSSVAAMRSELDTKR . ....||.|..| ||.|.| . ||.|.| ...|. | |.. | . . ...|.|.. .| .| | .|.|.| . . .| .. ... WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FSRYTTLFIVTEMLKCIKVLHQKGFIHRDIKPSNFLLRP------GKNNPICLIDFGLSV--SYIDPSTNEHLPFR-NDIGFVGSKRYASVNAHERNQLS || |.| | ..|. | .||. ||||||.||.|| .. |...|||.. |.. . . | | ...||.| |||....| . .. FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTP-RWTACGFRGTVRYAPLACHKGQEQC RRDDMLSWFYSCVELYTGDLPWSNTNVSETIYNLKKNI--NPP----ELCSG-MPS-EFTEIYRRIRDLRYEDCPPYDYI |.||. |||| ||. .|.||| . . . .|| . . .. | | ||..| .| ..|.| | |..| RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | 85876.m00236.AA | CK1-A | 5-259 | 36 | 1.3e-53 | 184.43 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 5-259 Range on HMM: 1-261/261 Sequence Identity: 36% (96 aa) YRIDRLIGKGSYGQVYLVNDIGTPDYFALKVEHNESARNSLTNEINELEQLQESPYFPKLVTHGILFNSQYYIMELLGSSVAAMRSELDTKRFSRYTTLF ||. | || ||.| .|| | . |.|.| |. | | ..|| . .|.. .| . .|.||| |. . . ..||. | | YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLF-NFCKRRFTMKTVLM IVTEMLKCIKVLHQKGFIHRDIKPSNFLLRPGKN-NPICLIDFGLSVSYIDPSTNEHLPFRNDIGFVGSKRYASVNAHERNQLSRRDDMLSWFYSCVELY .. |. | .|.|.|||||||| |||. |. | . ||||||. | |. | .|.|.|.| .| ||||.||| |||||| | | . LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN TGDLPWSNTNVS------ETIYNLKKNINPPELCSGMPSEFTEIYRRIRDLRYEDCPPYDYI | ||| | | | . .|| |.|.||. . .|.||.|. | | |. RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | 85876.m00236.AA | CK1-Unclassified | 5-192 | 36 | 2.9e-51 | 149.57 | In-house | 1-199 (244) | Show / Hide |
Range on Protein: 5-192 Range on HMM: 1-199/244 Sequence Identity: 36% (72 aa) YRIDRLIGKGSYGQVYLVNDIGTPDYFALKVEHNESARNSLTNEINELEQLQESP-------YFPKLVTHGIL--FNSQYYIMELLGSSVAAMRSELDTK ||. . || || |..|.. .. | . .|.|.| . | |. |. . .|| ..||. . | . .. .|.|||.| . YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCN-R RFSRYTTLFIVTEMLKCIKVLHQKGFIHRDIKPSNFLL--RPGKNNPICLIDFGLSVSYIDP-STNEHLPFRNDIGFVGSKRYASVNAHERNQLSRRDDM .|| .|.| |. |.. | .|| |.|||||||| ||| . .. . . .|||||| |||. .|..| |.|.. ...| ||||.||| |||||. KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL |
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Kinase | 85876.m00236.AA | CK1-D | 5-259 | 34 | 5.4e-46 | 159.13 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 5-259 Range on HMM: 1-261/261 Sequence Identity: 34% (91 aa) YRIDRLIGKGSYGQVYLVNDIGTPDYFALKVEHNESARNSLTNEINELEQLQESPYFPKLVTHGILFNSQYYIMELLGSSVAAMRSELDTKRFSRYTTLF ||| | || ||.|..|. .| | . |.|.| . | | .| |.. | . .|.||| |. . ..|| | |. YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLF-NYCHRKFSLKTVLM IVTEMLKCIKVLHQKGFIHRDIKPSNFLLRPGKN-NPICLIDFGLSVSYIDPSTNEHLPFRNDIGFVGSKRYASVNAHERNQLSRRDDMLSWFYSCVELY . |.. |. .| . |||||||| |||. || | . .|||||. | |. | .|.|.| . | ||||.| | |||||. | | . LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN TGDLPW------SNTNVSETIYNLKKNINPPELCSGMPSEFTEIYRRIRDLRYEDCPPYDYI | ||| . | | . | ... .||.|.||||.. | |...| | | |. RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | 85876.m00236.AA | TTBK | 5-259 | 32 | 1.8e-44 | 154.05 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 5-259 Range on HMM: 1-257/257 Sequence Identity: 32% (85 aa) YRIDRLIGKGSYGQVYLVNDIGTP-DYFALKVEHNESARNSLTNEINELEQLQESPYFPKLVTHGILFNSQYYIMELLGSSVAAMRSELDTKRFSRYTTL .. . || | .| .| |. . |.||| . . | |. | .|| .. . .. | . | .|.|.| . | .| . || ||| WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL FIVTEMLKCIKVLHQKGFIHRDIKPSNFL--LRPGKNNPICLIDFGLSVSYIDPSTNEHLPFRNDIGFVGSKRYASVNAHERNQLSRRDDMLSWFYSCVE . .|. |. |. || ||||||||| . | . . . ..|||| |. .. | | |. || | ||||.||| . |.||. | || || RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE LYTGDLPWSNTNVSETIYNLKKNINPPELCSGMPSEFTEIYRRIRDLRYEDCPPYDYI | ||| . . ..|. . . | .|.|| |. | ||| | | | FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | 85876.m00236.AA | CK1 | 5-192 | 36 | 2.1e-44 | 150.81 | In-house | 1-199 (271) | Show / Hide |
Range on Protein: 5-192 Range on HMM: 1-199/271 Sequence Identity: 36% (73 aa) YRIDRLIGKGSYGQVYLVNDIGTPDYF---ALKVEHNESARNSLTNEINELEQLQE------SPYFPKLVTHGIL--FNSQYYIMELLGSSVAAMRSELD ||. | || || |..||. .. | . | |.| | | | |. . .|| ....|.. . | . . .|.||| | . YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLF-NFC TKRFSRYTTLFIVTEMLKCIKVLHQKGFIHRDIKPSNFLLRP-GKN-NPICLIDFGLSVSYIDPSTNEHLPFRNDIGFVGSKRYASVNAHERNQLSRRDD ..|| .|.| |. |.. | ..| |.|||||||| ||| ||. . . .|||||. |.|..|..| |.|.. ...| ||||.|.| ||||| NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD M | M |
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Kinase | 85876.m00236.AA | CK1-G | 5-259 | 30 | 1.1e-35 | 118.36 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 5-259 Range on HMM: 1-266/266 Sequence Identity: 30% (82 aa) YRIDRLIGKGSYGQVYLVNDIGTPDYFALKVEHNESARNSLTNEINELEQLQESP-------YFPKLVTHGILFNSQYYIMELLGSSVAAMRSELDTKRF ||. . || |..| ... . . . | | | | | | .| | || . |. .|.||| | . .. .| YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIM------VMDLLGPSLEDLF-DWCDRKF SRYTTLFIVTEMLKCIKVLHQKGFIHRDIKPSNFLL-RPGKNNP--ICLIDFGLSVSYIDPSTNEHLPFRNDIGFVGSKRYASVNAHERNQLSRRDDMLS | |.. . . |.. .. .|.. | ||.|| ||| ||..... | .||||. |||| |. | |.| | || |.| | |||||| . SVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEA WFYSCVELYTGDLPW------SNTNVSETIYNLKKNINPPELCSG--MPSEFTEIYRRIRDLRYEDCPPYDYI | ||| | . | . |...|. || . .| .| | .| | ...|| |||. LGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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Kinase | 85876.m00236.AA | Ciliate-E2 | 5-149 | 19 | 7e-24 | 78.85 | In-house | 1-203 (365) | Show / Hide |
Range on Protein: 5-149 Range on HMM: 1-203/365 Sequence Identity: 19% (40 aa) YRIDRLIGKGSYGQVYLVNDIGTPD-----------------------YFALKVEHNE--SARNSLTNEINELE----QLQE--------SPYFPKLVTH | . ..||.|..|.||..... .. ..|.|. .. . .. ....|.. ...| .|. |.. . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC GI--LFNSQYYIMELLGS--------SVAAMR----------SELDTKRFSRYTTL-------FIVTEMLKCIKVLHQKG-FIHRDIKPSNFLLRPGKNN . |. |..||.. . | .| |..... . |.......... ||.|. |||||||.| |. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ PICLIDFGLS |..|||||| -IKIIDFGLS |
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Kinase | 85876.m00236.AA | S_TKc | 5-282 | 17 | 2.6e-21 | 78.03 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 5-282 Range on HMM: 1-231/231 Sequence Identity: 17% (52 aa) YRIDRLIGKGSYGQVYLVNDIGTPDYFALKVEHNESARNSLTNEINELEQLQESPYFPKLVTHGILFNSQYYIMELLGS---SVAAMRSELDTKR----F |.| |.||||..|.||.. ...| ..|.|. . ... .||. |.. |. || . .. | .||... .. . . ... | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF SRYTTLFIVTEMLKCIKVLHQKGFIHRDIKPSNFLLRPGKNNPICLIDFGLSVSYIDPSTNEHLPFRNDIGFVGSKRYASVNAHERNQLSR-RDDMLSWF . .. |.. .... .. .|..|.||||.||.| || | ..||||. . |.|. | . . .. . |. | PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG YSCVELYTGDLPWSNTNVSETIYNLKKNINPPELCSGMPSEFTEIYRRIRDLRYEDCPPYDYILRLLVNLLN---NSRKSSQVLD-------WEYF |...| |.. .. ... ... . . .. ..|. . | . ..| ..| CILYEMLCGYPPFP--QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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Kinase | 85876.m00236.AA | Pkinase | 95-249 | 18 | 1.3e-15 | 56.25 | Pfam | 101-257 (293) | Show / Hide |
Range on Protein: 95-249 Range on HMM: 101-257/293 Sequence Identity: 18% (31 aa) KRF--SRYTTLFIVTEMLKCIKVLHQKGFIHRDIKPSNFLLRPGKNNP---ICLIDFGLSVSYIDPSTNEHLPFRNDIGFVGSKRYASVNAHE-RNQLSR ..| | . |.....|. .. .|..|.||||.||.|.|. .... ....||||. . . . . .|.|. .|.. . .. .. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP RDDMLSWFYSCVELYTGDLPWSNT------NVSETIYNLKK---NINPPELCSGMPSEFTEIYRRIRDLR . || | . |...| .|... . . |.. .. . |..||..... . . . . .. KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HW |
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Kinase | 85876.m00236.AA | CK1 | 216-257 | 32 | 1.4e-08 | 25.85 | In-house | 229-271 (271) | Show / Hide |
Range on Protein: 216-257 Range on HMM: 229-271/271 Sequence Identity: 32% (14 aa) ETIYNLKKNINPPELCSG-MPSEFTEIYRRIRDLRYEDCPPYD | | . | .... .||.| |.||.. . .| |..|..| |. EKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | 85876.m00236.AA | Pkinase | 5-60 | 29 | 6.9e-08 | 28.97 | Pfam | 1-61 (293) | Show / Hide |
Range on Protein: 5-60 Range on HMM: 1-61/293 Sequence Identity: 29% (18 aa) YRIDRLIGKGSYGQVYLVNDIGTPDYFALKVEHNESARNSLT------NEINELEQLQESPY |.| | ||.||.|.||. ..||.. .|.|. .... . .|| . | .|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPN |
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Kinase | 85876.m00236.AA | TyrKc | 5-263 | 16 | 9.9e-05 | -146.15 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 5-263 Range on HMM: 1-280/280 Sequence Identity: 16% (52 aa) YRIDRLIGKGSYGQVYL-VNDIGTPDYFALKVEHNESARNSLTNEINELEQL--QESPYFPKLVT-HGILF---------NSQYYIMEL--LGSSVAAMR . .. .| | .|.||. . . | |. .... | . .|.. . .| . | .| .|. . .||. .|. | ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGH----HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR SELDTKRFSRYTTLFIVTEMLKCIKVLHQKGFIHRDIKPSNFLLRPGKNNPICLIDFGLSV------------SYIDPST--NEH--LPFRNDIGFVGSK . .. .. . | . . . ||.|..||||. | |. .. . ||||| .|..... ... || KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI---------- RYASVNAHERNQLSRRDDMLSWFYS----------CVELYT-GDLPWSN-----TNVSETIYNLKKN--INPPEL-CSG-----MPSEFTEIYRRIRDLR | . . . . | . . |..| |. |... . .| | ..|. .|. . .|.| .| .. . RWMAPECI----------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHED YEDCPPYDYILRLL || | | ... PEDRPTFSEIHECF |
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Kinase | 85876.m00236.AA | APH | 118-150 | 20 | 0.000694 | 14.13 | Pfam | 169-203 (248) | Show / Hide |
Range on Protein: 118-150 Range on HMM: 169-203/248 Sequence Identity: 20% (7 aa) QKGFIHRDIKPSNFLLR--PGKNNPICLIDFGLSV . ...|.| .| |.... |... . .||.. .. PPCWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDAC |