Gene 89698.m00088 (T.vaginalis)

89698.m00088

Species: T.vaginalis
Alias: 89698.m00088, TvagK0479
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
89698.m00088.AA Protein None 362 None Fasta, JSON
89698.m00088.kin_dom Protein Kinase Domain None 175 None Fasta, JSON

Protein domain

Protein domains of 89698.m00088.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 89698.m00088.AA CK1 19-275 28 1.1e-90 307.59 In-house 1-339 (339) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-339/339
Sequence Identity: 28% (98 aa)

YRIIKHIGSGGFG-DIYTV-----VDTTASD---NKHYAMKVEYLEAEKQG--LVDEIAFLEQLQD----------SSYFPK----------LLDKGQND
....|.||.|||| .|| |     .|.. ..   ...||||||  ....|.  | .|. ....||.          . .|.|          . ..| .|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

K-CRYFVMDLFGPSVSNMRR--ACEGRHYSNYSMLRLSLEMAKCIEEFHRHGFVHRDIKPANFLIRA--------------NRERPVCLIDFGLSK-SYI
. ..| ||.|.||. .  |.  .. .|. |  . |.. . | . .|. |..||.||||||.||.. .              |..| | .||||...  |.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

NQ-----------LTGEHIPFSR---DAGFTG-TCRYASINAHDSFELSRRDDMLSWFYSVIELAEGR--VPWPGSKDREA-----TEQLKRRTRAADLC
.             |..|.|. .    .||.| |.||.|||.|.  |..||||. |||| .||.  |    || . || .       |. |.  .. ...
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

SG------------LPEEFIDIYRRLRALDFEEVPQYSHI
|             .|.|| .|.  .|.|.... | |  |
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 89698.m00088.AA TTBKL 19-279 30 2.4e-68 229.86 In-house 1-288 (288) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-288/288
Sequence Identity: 30% (89 aa)

YRIIKHIGSGGFGDIYTVVDTTASDNKHYAMKVEYLEAEKQG--LVDEIAFLEQLQ--DSSYFPKLLDKGQNDKCRYFVMDLFGPSVSNMRRACEGRH-Y
..|.| ||.|||| .| |.|.. . ....|||.|. . |. .  .  |.  | .||  .|..|||... |........|| | ||...  |.    ..  
WMIVKMIGEGGFGQVYHVWDMK-DKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRF

SNYSMLRLSLEMAKCIEEFHRHGFVHRDIKPANFLIRAN-----RERPVCLIDFGLSKSYINQLTG----------EHIPFSR---DAGFTGTCRYASIN
|  . .|..    ... . |..||.|||.||.|. . ..     |.| | |||||... |..   .          .. .  .    |.| || ||.|.|
SDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPN

AHDSFELSRRDDMLSWFYSVIELAEGRVPWPGSKDREATEQLKRRTRAADLCSG------LPEEFIDIYRRLRALDFEEVPQYSHIYFLI
.||  |..| ||. ||.|..|||..|  || ...|.. .|..|. .   ||...      .| || .... ||.|.. . | |. || ..
MHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 89698.m00088.AA Worm6 19-275 31 3.6e-67 229.47 In-house 1-279 (279) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-279/279
Sequence Identity: 31% (87 aa)

YRIIKHIGSGGFGDIYTVVDTTASDNKHYAMKVEY--LEAEKQGLVDEIAFLEQL--QDSSYFPKLLDKGQNDK--CRYFVMDLFGPSVSNMRRACEGRH
. . | ||.||||..| | |..   .|..|||.|    ....| |  |.. |  .  . . .|.|. |.|. |.   .| || |.|.. ...|.....|.
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

YSNYSMLRLSLEMAKCIEEFHRHGFVHRDIKPANFLIRA------NRERPVCLIDFGLSK--SYINQLTGEHIPFSRDAGFTGTCRYASINAHDSFELSR
.|    |...... . ||. |..||.|||.||.|| |        | .. ....|||...   |.|. .  . |   ..|| || |||....|.  |..|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

RDDMLSWFYSVIELAEGRVPWPGSKDREATEQLKRR----TR---AADLCSGLPE-EFIDIYRRLRALDFEEVPQYSHI
.||. |||| ..|.  |. || ..||. . |..|..    ||   ....  . |  || ||  ..  ..... | | .|
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 89698.m00088.AA CK1-Unclassified 19-208 39 1.5e-63 186.4 In-house 1-199 (244) Show / Hide 
Range on Protein: 19-208
Range on HMM: 1-199/244
Sequence Identity: 39% (79 aa)

YRIIKHIGSGGFGDIYTVVDTTASDNKHYAMKVEYLEAEKQGLVDEIAFLEQLQDSS-------YFPKLLDKGQNDK--CRYFVMDLFGPSVSNMRRACE
||.|. ||.| ||.|| ....   .|...|.|.|   ..   |. |. .. .||. .       ..||.   ||...  . . |||| |||       | 
YRVIEKIGQGSFGEIYKCINMQ--TNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC-

GRHYSNYSMLRLSLEMAKCIEEFHRHGFVHRDIKPANFLI--RANRERPVCLIDFGLSKSYINQ-LTGEHIPFSRDAGFTGTCRYASINAHDSFELSRRD
.|  | .  | .   | . || .|...|.|||||| |||.  . ..   | .||||||| ||    ||.|||. .. ..|||.||||||||   | ||||
NRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRD

DM
|.
DL
Kinase 89698.m00088.AA TTBK 19-275 36 7.6e-61 208.45 In-house 1-257 (257) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-257/257
Sequence Identity: 36% (96 aa)

YRIIKHIGSGGFGDIYTVVDTTAS-DNKHYAMKVEYLEAEKQGLVDEIAFLEQLQDSSYFPKLLDKGQNDKCRYFVMDLFGPSVSNMRRACEGRHYSNYS
 ...| || |||| ||   |      .   |.|||  .. || |  |.| | .||   .  .    | |||  | ||.| | . ...||.     .|  .
WKVVKKIGGGGFGEIYEAKDMINHHEQ--VAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLST

MLRLSLEMAKCIEEFHRHGFVHRDIKPANFLI--RANRERPVCLIDFGLSKSYINQLTGEHIPFSRDAGFTGTCRYASINAHDSFELSRRDDMLSWFYSV
.||| . . . ||. |  || |||||| || .   . . | . ..||||   |.|  .||  |    ||| || |||||||| . |. |.||. | ||  
TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNA-CGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML

IELAEGRVPWPGSKDREATEQLKRRTRAADLCSGLPEEFIDIYRRLRALDFEEVPQYSHI
.| ..|  ||   ||..   ..| .    .|   .|.||      .. |..|. | |  |
VEFVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 89698.m00088.AA CK1-A 19-275 38 6.3e-59 202.09 In-house 1-261 (261) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-261/261
Sequence Identity: 38% (102 aa)

YRIIKHIGSGGFGDIYTVVDTTASDNKHYAMKVEYLEAEKQGLVDEIAFLEQLQDSSYFPKLLDKGQNDKCRYFVMDLFGPSVSNMRRACEGRHYSNYSM
||....|||| |||||  . .|  . .  |.|.|  .|    |. |    ..||    .|...  |..     .|||| |||. ..   |. |...   .
YRLVRKIGSGSFGDIYLGINIT--NGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCK-RRFTMKTV

LRLSLEMAKCIEEFHRHGFVHRDIKPANFLIRANRE-RPVCLIDFGLSKSYINQLTGEHIPFSRDAGFTGTCRYASINAHDSFELSRRDDMLSWFYSVIE
| |   |   ||  | ..|.|||||| |||.  .|    . ||||||.| |  . | .|||.  |   ||| ||||||||   | |||||| |  | .. 
LMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMY

LAEGRVPWPGSKDR------EATEQLKRRTRAADLCSGLPEEFIDIYRRLRALDFEEVPQYSHI
   |..|| | |        |     |  |  . || | | ||  .    |.| |||.| | ..
FNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 89698.m00088.AA CK1 19-208 37 1.2e-57 196.97 In-house 1-199 (271) Show / Hide 
Range on Protein: 19-208
Range on HMM: 1-199/271
Sequence Identity: 37% (76 aa)

YRIIKHIGSGGFGDIYTVVDTTASDNK-HYAMKVEYLEAEKQGLVDEIAFLEQLQD------SSYFPKLLDKGQN--DKCRYFVMDLFGPSVSNMRRACE
||... ||.| ||||| . ..  . .. |.|.|.|   .. . |..|. .. .||.      . ..|..   ||.   .. . |||| |||       | 
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC-

GRHYSNYSMLRLSLEMAKCIEEFHRHGFVHRDIKPANFLI-R-ANRERPVCLIDFGLSKSYINQLTGEHIPFSRDAGFTGTCRYASINAHDSFELSRRDD
.|. | .  | .   | . || .| ..|.|||||| |||. |  ...  | .|||||.| |.   |..|||.  . ..|||.||||||.|   | |||||
NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD

M
|
M
Kinase 89698.m00088.AA CK1-D 19-275 38 2.1e-51 177.08 In-house 1-261 (261) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-261/261
Sequence Identity: 38% (101 aa)

YRIIKHIGSGGFGDIYTVVDTTASDNKHYAMKVEYLEAEKQGLVDEIAFLEQLQDSSYFPKLLDKGQNDKCRYFVMDLFGPSVSNMRRACEGRHYSNYSM
||| . |||| |||||    |. . |   |.|.| . ..   |  |  |   .|     |..   ||.      |||| |||.  .   |. |..|   .
YRIGRKIGSGSFGDIY--HGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCH-RKFSLKTV

LRLSLEMAKCIEEFHRHGFVHRDIKPANFLIR-ANRERPVCLIDFGLSKSYINQLTGEHIPFSRDAGFTGTCRYASINAHDSFELSRRDDMLSWFYSVIE
| |.. | . ||  | . |.|||||| |||.    |   | .|||||.| |    | .|||.  .   ||| |||||| |   | |||||. |  | .. 
LMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMY

LAEGRVPWPGSK---DREATEQL---KRRTRAADLCSGLPEEFIDIYRRLRALDFEEVPQYSHI
 . | .|| | |    |.  |..   |  |.  .||.|.|.|| .     | | |.. | |...
FNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 89698.m00088.AA CK1-G 19-275 34 2.4e-40 134.42 In-house 1-266 (266) Show / Hide 
Range on Protein: 19-275
Range on HMM: 1-266/266
Sequence Identity: 34% (94 aa)

YRIIKHIGSGGFGDIYTVVDTTASDNKHYAMKVEYLEAEKQGLVDEIAFLEQLQDSS-YFPKLLDKGQNDKCRYFVMDLFGPSVSNMRRACEGRHYSNYS
||. | || | || ..         | | | | |    .   | ||  |  .|   .   |.    ||  |    |||| |||   .   | .|..|  .
YRVGKKIGCGNFGELFEGKNMYN--NEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWC-DRKFSVKT

MLRLSLEMAKCIEEFHRHGFVHRDIKPANFLI---RANRERPVCLIDFGLSKSYINQLTGEHIPFSRDAGFTGTCRYASINAHDSFELSRRDDMLSWFYS
 . ..  | . .|. | |  . ||.|| ||||     .... . .||||. | ||   |. |||.      ||| || ||| |   | |||||| .    
VCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHM

VIELAEGRVPWPGSKDREATEQ------LKRRTRAADLCSG--LPEEFIDIYRRLRALDFEEVPQYSHI
 .    |  || | |     |.       ||.|   ||| .  .||.|    |  | |||.| | | ..
FMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 89698.m00088.AA CK1-Unique 19-218 24 9.8e-31 103.78 In-house 1-223 (337) Show / Hide 
Range on Protein: 19-218
Range on HMM: 1-223/337
Sequence Identity: 24% (55 aa)

YRIIKHIGSGGFGDIYTVVDTTAS----DNKHYAMKVEYLEAEKQ--------GLVDEIAFLE-QLQDSSYFPKLLDKGQNDKCRYFVMDLFGPSVSNMR
. .|||||.||.|. . | .        | . |.|| |.  . |             .|  .| |....  |... | .| .   . || . |||    .
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

RACEGRHYSNY------SMLRLSLEMAKCIEEFHRHGFVHRDIKPANFLIRANR---ERPVCLIDFGLSKS-YINQLTGEHIPFSRDAGFTGTCRYASIN
..  .  .           .....     ||  | ||| ||..||.|.   |.    ..    .|.| ...  .    ..  .    . | |. .|... 
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

AHDSFELSRRDDMLSWFYSVIEL
 |   |..||||| ||||. . |
CHQCREHGRRDDMESWFYMLYHL
Kinase 89698.m00088.AA S_TKc 19-277 19 8e-18 66.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-277
Range on HMM: 1-231/231
Sequence Identity: 19% (52 aa)

YRIIKHIGSGGFGDIYTVVDTTASDNKHYAMKVEYLEAEKQGLVDEIAFLEQLQDSSYFPKLLDKGQNDKCRYFVMDLFGP---SVSNMRRACEGRH---
|.|...||.|.||  | ....   .....|.|.       . .  ||. |..  .  .  ||.|  |. .. |.||.. .    ..  . . . ..    
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-YSNYSMLRLSLEMAKCIEEFHRHGFVHRDIKPANFLIRANRERPVCLIDFGLSKSYINQLTGEHIPFSRDAGFTGTCRYASINAHDSFELSR-RDDMLS
 ..     ..  .... .|  |.||..|||.||.| |.       . ..||||.. .                | ||  | .         .. . |. |
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWS

WFYSVIELAEGRVPWPGSKDREATEQLKRRTRAADLCSGLPEEFIDIYRRLRALDFEE--VPQYSHIYF
    ..|.. |. |.|   . .  ....    | |. ... .   |  .|. | .  .  .   .| .|
CGCILYEMLCGYPPFP--QMQMMFKKIG-SPEAKDFIRKCLQ--KDPEKRPTA-EALQDEWDIKCHPWF
Kinase 89698.m00088.AA Pkinase 19-171 25 1.5e-15 56.09 Pfam 1-166 (293) Show / Hide 
Range on Protein: 19-171
Range on HMM: 1-166/293
Sequence Identity: 25% (43 aa)

YRIIKHIGSGGFGDIYTVVDTTASDNKHYAMKVEYLEAEKQGLVD------EIAFLEQLQDSSYFPKLLDKGQNDKCRYFVMDLFGPSVSNMRRAC----
|.|.. ||||.||  |  ..   ...| .|.|.  .. || .         ||. .  | .. .  .|.|  ....  |.||.. .  ..     .    
YHIGRKIGSGSFGCVYKCHH--KGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYIS

--EGRHY--SNYSMLRLSLEMAKCIEEFHRHGFVHRDIKPANFLIRANRERP---VCLIDFGLSKS--YINQ
  ... .  |     .  ..... .|  |..|..|||.||.|.||  |.  .   |...||||.|   | |.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NN
Kinase 89698.m00088.AA CK1 238-273 40 3.3e-09 28.07 In-house 235-271 (271) Show / Hide 
Range on Protein: 238-273
Range on HMM: 235-271/271
Sequence Identity: 40% (15 aa)

KRRTRAADLCSG-LPEEFIDIYRRLRALDFEEVPQYS
|. |   .||.| .|.||..  .  | |.||| | | 
KMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM